Gene Symbol: Smox
Description: spermine oxidase
Alias: spermine oxidase
Vujcic S, Diegelman P, Bacchi C, Kramer D, Porter C. Identification and characterization of a novel flavin-containing spermine oxidase of mammalian cell origin. Biochem J. 2002;367:665-75 pubmed
..enzyme represents a novel mammalian oxidase which, on the basis of substrate specificity, we have designated spermine oxidase in order to distinguish it from the PAO involved in polyamine back-conversion...
Cervelli M, Bellini A, Bianchi M, Marcocci L, Nocera S, Polticelli F, et al
. Mouse spermine oxidase gene splice variants. Nuclear subcellular localization of a novel active isoform. Eur J Biochem. 2004;271:760-70 pubmed
b>Spermine oxidase (SMO) is a flavoenzyme involved in polyamine homeostasis in animal cells. The mouse spermine oxidase gene (mSMO) codes for splice variants, including the previously reported major active isoform, herein named alfa (alpha)...
Murray Stewart T, Wang Y, Goodwin A, Hacker A, Meeker A, Casero R. Nuclear localization of human spermine oxidase isoforms - possible implications in drug response and disease etiology. FEBS J. 2008;275:2795-806 pubmed publisher
The recent discovery of the direct oxidation of spermine via spermine oxidase (SMO) as a mechanism through which specific antitumor polyamine analogues exert their cytotoxic effects has fueled interest in the study of the polyamine ..
Vujcic S, Liang P, Diegelman P, Kramer D, Porter C. Genomic identification and biochemical characterization of the mammalian polyamine oxidase involved in polyamine back-conversion. Biochem J. 2003;370:19-28 pubmed
..ranking is identical to that reported for purified PAO and distinctly different from the recently identified spermine oxidase (SMO), which prefers spermine over N1-acetylspermine...
Wallace H, Fraser A, Hughes A. A perspective of polyamine metabolism. Biochem J. 2003;376:1-14 pubmed
..The future will be in adopting a functional genomics approach to identifying polyamine-regulated genes linked to either carcinogenesis or apoptosis. ..
Ferioli M, Berselli D, Caimi S. Effect of mitoguazone on polyamine oxidase activity in rat liver. Toxicol Appl Pharmacol. 2004;201:105-11 pubmed
..We also evaluated the activity of the newly identified spermine oxidase, which was not significantly changed by mitoguazone treatment...