Smad7

Summary

Gene Symbol: Smad7
Description: SMAD family member 7
Alias: Madh7, mothers against decapentaplegic homolog 7, MAD (mothers against decapentaplegic, Drosophila) homolog 7, MAD homolog 7, SMAD 7, mothers against DPP homolog 7
Species: rat
Products:     Smad7

Top Publications

  1. Meng M, Li Y, Yan M, Kou Y, Ren H. Effects of epigallocatechin gallate on diethyldithiocarbamate-induced pancreatic fibrosis in rats. Biol Pharm Bull. 2007;30:1091-6 pubmed
    ..EGCG suppressed the expression of Smad3 and enhanced the expression of Smad7. In conclusion, our results demonstrated that EGCG attenuated rat pancreatic fibrosis induced by DDC and therefore ..
  2. Wang W, Soltero L, Zhang P, Huang X, Lan H, Adrogue H. Renal inflammation is modulated by potassium in chronic kidney disease: possible role of Smad7. Am J Physiol Renal Physiol. 2007;293:F1123-30 pubmed
    ..effects were associated with downregulation of renal transforming growth facto-beta, upregulation of renal Smad7, and lower blood pressure...
  3. Bian E, Huang C, Wang H, Chen X, Zhang L, Lv X, et al. Repression of Smad7 mediated by DNMT1 determines hepatic stellate cell activation and liver fibrosis in rats. Toxicol Lett. 2014;224:175-85 pubmed publisher
    ..5-AzadC also rescued TGF-?1-induced suppression of Smad7 expression which occurs during HSC activation...
  4. Murugaiyan G, da Cunha A, Ajay A, Joller N, Garo L, Kumaradevan S, et al. MicroRNA-21 promotes Th17 differentiation and mediates experimental autoimmune encephalomyelitis. J Clin Invest. 2015;125:1069-80 pubmed publisher
    ..Thus, we have characterized a T cell-intrinsic miRNA pathway that enhances TGF-β signaling, limits the autocrine inhibitory effects of IL-2, and thereby promotes Th17 differentiation and autoimmunity. ..
  5. Xin Y, Yuan G, Lu Y, Yang Y, Zhang X, Li Y, et al. [Explorative study on mechanism and drug intervention for chronic allograft nephropathy induced by renal ischemia-reperfusion injury]. Sichuan Da Xue Xue Bao Yi Xue Ban. 2007;38:918-23 pubmed
    ..model showed that the up-regulated expressions of TGF-P, and Smad2 and the down-regulated expression of Smad7 in Group A and Group B were statistically significant, which meant that the difference was obvious when Group A ..
  6. Ning W, Tao L, Liu C, Sun J, Xiao Y, Hu J, et al. [Effect of enalapril on the expression of TGF-beta1, p-Smad2/3 and Smad7 in renal interstitial fibrosis in rats]. Zhong Nan Da Xue Xue Bao Yi Xue Ban. 2009;34:27-34 pubmed
    ..observing the effect of enalapril on the expression of transforming growth factor-beta1(TGF-beta1), p-Smad2/3 and Smad7 in renal tissuess of unilateral urethral obstruction (UUO) rat model...
  7. Ito Y, Zhao J, Mogharei A, Shuler C, Weinstein M, Deng C, et al. Antagonistic effects of Smad2 versus Smad7 are sensitive to their expression level during tooth development. J Biol Chem. 2001;276:44163-72 pubmed
    ..Here we tested the hypothesis that antagonistic effects between Smad2 and Smad7 regulate TGF-beta signaling during tooth development...
  8. Dooley S, Said H, Gressner A, Floege J, En Nia A, Mertens P. Y-box protein-1 is the crucial mediator of antifibrotic interferon-gamma effects. J Biol Chem. 2006;281:1784-95 pubmed
    ..via the Jak1 signaling pathway is required and sufficient to confer interferon-gamma-dependent activation of the smad7 gene...
  9. Gonzalez A, Le Bellego F, Ludwig M. Imbalance of receptor-regulated and inhibitory Smads in lung fibroblasts from bleomycin-exposed rats. Am J Respir Cell Mol Biol. 2007;36:206-12 pubmed
    ..Western blot analysis was performed to measure levels of phosphorylated Smad3 (p-Smad3) and Smad7. Real-time PCR was used to determine changes in Smad7 mRNA after TGF-beta stimulation...

More Information

Publications74

  1. Liu Y, Liu R, Liu W, Liu L, Wu Z, Chen Y. [Effects of Chinese herbal medicine Yiqi Huoxue Formula on TGF-?/smad signal transduction pathway and connective tissue growth factor in rats with renal interstitial fibrosis]. Zhong Xi Yi Jie He Xue Bao. 2010;8:1165-73 pubmed
    ..Kidneys of the rats were taken out, and mRNA and protein expressions of TGF-?, smad2, smad7 and CTGF were measured with real-time fluorescent quantitative reverse transcription-polymerase chain reaction and ..
  2. Suzuki C, Murakami G, Fukuchi M, Shimanuki T, Shikauchi Y, Imamura T, et al. Smurf1 regulates the inhibitory activity of Smad7 by targeting Smad7 to the plasma membrane. J Biol Chem. 2002;277:39919-25 pubmed
    Smad ubiquitin regulatory factor 1 (Smurf1), a HECT-type E3 ubiquitin ligase, interacts with inhibitory Smad7 and induces cytoplasmic localization of Smad7...
  3. Zhang B, Zhou M, Li C, Zhou J, Li H, Zhu D, et al. MicroRNA-92a inhibition attenuates hypoxia/reoxygenation-induced myocardiocyte apoptosis by targeting Smad7. PLoS ONE. 2014;9:e100298 pubmed publisher
    ..the potential anti-apoptotic effects of miR-92a in a rat myocardiocyte cell line, and the possible role of Smad7 in such actions. ..
  4. Zhang S, Tsui N, Li D, Yao G, Wang Y. Expression of transforming growth factor beta1/Sma- and Mad-related proteins in rat with chronic pancreatitis induced by dibutyltin dichloride. Pancreas. 2010;39:252-3 pubmed publisher
  5. Nie J, Hao W, Dou X, Wang X, Luo N, Lan H, et al. Effects of Smad7 overexpression on peritoneal inflammation in a rat peritoneal dialysis model. Perit Dial Int. 2007;27:580-8 pubmed
    ..effects of the TGF-beta signaling pathway on peritoneal inflammation associated with PD in rats by over-expressing Smad7, an inhibitor of TGF-beta/Smad signaling...
  6. Massague J. TGFbeta in Cancer. Cell. 2008;134:215-30 pubmed publisher
    ..The mechanistic basis and clinical relevance of TGFbeta's role in cancer is becoming increasingly clear, paving the way for a better understanding of the complexity and therapeutic potential of this pathway. ..
  7. Topper J, Cai J, Qiu Y, Anderson K, Xu Y, Deeds J, et al. Vascular MADs: two novel MAD-related genes selectively inducible by flow in human vascular endothelium. Proc Natl Acad Sci U S A. 1997;94:9314-9 pubmed
    ..Utilizing a differential display approach, we have identified two genes, Smad6 and Smad7, encoding members of the MAD-related family of molecules, selectively induced in cultured human vascular ..
  8. Shukla M, Rose J, Ray R, Lathrop K, Ray A, Ray P. Hepatocyte growth factor inhibits epithelial to myofibroblast transition in lung cells via Smad7. Am J Respir Cell Mol Biol. 2009;40:643-53 pubmed publisher
    ..HGF induced expression of Smad7, an inhibitor of TGF-beta signaling, in a mitogen-activated protein kinase-dependent manner...
  9. Song L, Ma Y, Wu C, Wang C, Fang W, Liu S. MicroRNA-195 Activates Hepatic Stellate Cells In Vitro by Targeting Smad7. Biomed Res Int. 2017;2017:1945631 pubmed publisher
    ..Dual luciferase reporter assays were performed to verify that Smad7 was the target of miRNA-195...
  10. Liu W, Rui H, Wang J, Lin S, He Y, Chen M, et al. Axin is a scaffold protein in TGF-beta signaling that promotes degradation of Smad7 by Arkadia. EMBO J. 2006;25:1646-58 pubmed
    ..Here, we show that Axin activates TGF-beta signaling by forming a multimeric complex consisting of Smad7 and ubiquitin E3 ligase Arkadia...
  11. Bilezikjian L, Corrigan A, Blount A, Chen Y, Vale W. Regulation and actions of Smad7 in the modulation of activin, inhibin, and transforming growth factor-beta signaling in anterior pituitary cells. Endocrinology. 2001;142:1065-72 pubmed
    ..Smad2 and Smad3 are two cellular mediators of activin/TGF beta signaling, whereas Smad7 is as an inducible, negative modulator of the pathway...
  12. Cárdenas A, Campos J, Ehrenfeld P, Mezzano S, Ruiz Ortega M, Figueroa C, et al. Up-regulation of the kinin B2 receptor pathway modulates the TGF-β/Smad signaling cascade to reduce renal fibrosis induced by albumin. Peptides. 2015;73:7-19 pubmed publisher
    ..expression of α-smooth muscle actin (α-SMA) and vimentin, reduced Smad3 phosphorylation and increase of Smad7. These cellular and molecular effects were reversed by HOE-140, a specific B2R antagonist...
  13. Zhang C, Zhang Y, Zhong B, Luo C. SMAD7 prevents heterotopic ossification in a rat Achilles tendon injury model via regulation of endothelial-mesenchymal transition. FEBS J. 2016;283:1275-85 pubmed publisher
    ..Based on the ability of SMAD7 (mothers against decapentaplegic homolog 7) to block EndMT-related processes such as myofibroblast transformation, we hypothesized that ..
  14. Li B, Su Y, Zheng X, Yang Y, Jiang S, Jiang L. Evidence for an Important Role of Smad-7 in Intervertebral Disc Degeneration. J Interferon Cytokine Res. 2015;35:569-79 pubmed publisher
    ..Interference on Smad-7 might be a potential therapeutic method for the prevention and treatment of degenerative disc diseases. ..
  15. Park D, Lee C, Sol M, Suh K, Yoon S, Kim J. Expression and localization of the transforming growth factor-beta type I receptor and Smads in preneoplastic lesions during chemical hepatocarcinogenesis in rats. J Korean Med Sci. 2003;18:510-9 pubmed
    ..We investigated expressions and localizations of TGR1, Smad2, Smad4, and Smad7 by using semi-quantitative RT-PCR and immunohistochemistry in preneoplastic lesions during rat chemical ..
  16. Zhang Q, Wang W, Li J, Tian S, Zhang T. Decreased miR-187 induces retinal ganglion cell apoptosis through upregulating SMAD7 in glaucoma. Biomed Pharmacother. 2015;75:19-25 pubmed publisher
    ..This correlation is associated with down-regulation of Smad7 induced by miR-187 via targeting Smad7 3'-UTR...
  17. Wang H, Song K, Krebs T, Yang J, Danielpour D. Smad7 is inactivated through a direct physical interaction with the LIM protein Hic-5/ARA55. Oncogene. 2008;27:6791-805 pubmed publisher
    ..We now show that Hic-5 can also control TGF-beta responses through an alternative mechanism involving Smad7, a key negative regulator of TGF-beta signaling. Hic-5 binds directly to Smad7...
  18. Lin N, Ji Z, Huang C. Smad7 alleviates glomerular mesangial cell proliferation via the ROS-NF-?B pathway. Exp Cell Res. 2017;361:210-216 pubmed publisher
    ..The aim of this study was to demonstrate that altered gene expression of Smad7regulated NF-?B expression and ROS production on Ang II (Angiotensin II)-induced rat glomerular mesangial cell (GMC) proliferation...
  19. Stopa M, Benes V, Ansorge W, Gressner A, Dooley S. Genomic locus and promoter region of rat Smad7, an important antagonist of TGFbeta signaling. Mamm Genome. 2000;11:169-76 pubmed
    ..This process involves phosphorylation of these proteins by activated TGFbeta receptors. Recently, Smad6 and Smad7 were identified; they antagonize TGFbeta signaling by preventing the activation of signal-transducing SMAD ..
  20. Soto P, Price Schiavi S, Carraway K. SMAD2 and SMAD7 involvement in the post-translational regulation of Muc4 via the transforming growth factor-beta and interferon-gamma pathways in rat mammary epithelial cells. J Biol Chem. 2003;278:20338-44 pubmed
    ..activates and relocalizes signal transducer and activator of transcription-1 (STAT-1) to induce an inhibitor SMAD, SMAD7. SMAD7 antisense oligonucleotide prevents IFN-gamma from blocking the TGF-beta inhibition of Muc4/SMC expression...
  21. Zhang H, Xin H, Zhang W, Xu S, Zhang Y, Jia Q. [Effect of Chinese herbal drugs and tetrandrine on TGF-beta1 signaling pathway]. Zhonghua Lao Dong Wei Sheng Zhi Ye Bing Za Zhi. 2007;25:336-40 pubmed
    ..The gene expressions of transforming growth factor-beta1, transcription factor Smad 3 and Smad 7 in lung were analyzed by using immunohistochemical technique (SP) and the image analysis...
  22. Kanamaru C, Yasuda H, Takeda M, Ueda N, Suzuki J, Tsuchida T, et al. Smad7 is induced by norepinephrine and protects rat hepatocytes from activin A-induced growth inhibition. J Biol Chem. 2001;276:45636-41 pubmed
    ..that NE inhibits activin A-induced nuclear accumulation of Smad2/3 and that NE rapidly induces inhibitory Smad7 mRNA expression...
  23. Ellis L, Warner D, Greene R, Pisano M. Interaction of Smads with collagen types I, III, and V. Biochem Biophys Res Commun. 2003;310:1117-23 pubmed
    ..Moreover, TGFbeta is a potent regulator of collagen synthesis and turnover during mammalian orofacial development. These data thus suggest an important means of feedback regulation of the TGFbeta signaling cascade. ..
  24. Liu W, Shi R, Yang W, Zhao N, Du Y, Zou Y, et al. Synchronous alteration pattern between serine-threonine kinase receptor-associated protein and Smad7 in pilocarpine-induced rats of epilepsy. Synapse. 2014;68:275-82 pubmed publisher
    ..Serine-threonine kinase receptor-associated protein (STRAP) and Smad7 synergize in the inhibition of the TGF? signaling...
  25. Chen Q, Chen H, Zheng D, Kuang C, Fang H, Zou B, et al. Smad7 is required for the development and function of the heart. J Biol Chem. 2009;284:292-300 pubmed publisher
    ..These effects are largely mediated by Smad proteins. Smad7 is a negative regulator for the signaling of TGF-beta family members...
  26. Berg D, Gupta A, Richardson M, O Brien L, Calnek D, Grinnell B. Negative regulation of inducible nitric-oxide synthase expression mediated through transforming growth factor-beta-dependent modulation of transcription factor TCF11. J Biol Chem. 2007;282:36837-44 pubmed
    ..contrast, the up-regulation of TCF11/MafG binding could be suppressed by overexpression of the TGF-beta inhibitor Smad7, and a small interfering RNA to TCF11 blocked the suppression of iNOS by TGF-beta...
  27. Dowdy S, Mariani A, Reinholz M, Keeney G, Spelsberg T, Podratz K, et al. Overexpression of the TGF-beta antagonist Smad7 in endometrial cancer. Gynecol Oncol. 2005;96:368-73 pubmed
    We have shown that HER2/Neu may activate the Smad7 promoter in endometrial, ovarian, and breast cancer cell lines...
  28. Wang T, Zhou X, Yu Y, Zhu J, Dai J, Qu X, et al. Inhibition of corneal fibrosis by Smad7 in rats after photorefractive keratectomy. Chin Med J (Engl). 2013;126:1445-50 pubmed
    ..Haze directly resulted from corneal fibrosis mediated by transforming growth factor ? (TGF?). Smad7, an inhibitory Smad, can inhibit TGF? signal transduction...
  29. Wang B, Hao J, Jones S, Yee M, Roth J, Dixon I. Decreased Smad 7 expression contributes to cardiac fibrosis in the infarcted rat heart. Am J Physiol Heart Circ Physiol. 2002;282:H1685-96 pubmed
    We examined the role of the transforming growth factor (TGF)-beta(1) signaling inhibitor Smad 7 in cardiac fibrosis...
  30. Tang Y, Liu Z, Zhao L, Clemens T, Cao X. Smad7 stabilizes beta-catenin binding to E-cadherin complex and promotes cell-cell adhesion. J Biol Chem. 2008;283:23956-63 pubmed publisher
    ..Here we show that Smad7 promotes cell-cell adhesion by stabilizing beta-catenin and consequently increases the beta-catenin-E-cadherin ..
  31. McClelland A, Herman Edelstein M, Komers R, Jha J, Winbanks C, Hagiwara S, et al. miR-21 promotes renal fibrosis in diabetic nephropathy by targeting PTEN and SMAD7. Clin Sci (Lond). 2015;129:1237-49 pubmed publisher
    ..phosphoinositide 3-kinase (PI3K)-dependent signalling pathways via co-ordinated repression of mothers against decapentaplegic homolog 7 (SMAD7) and phosphatase and tensin homologue (PTEN) respectively...
  32. Uchida K, Nitta K, Kobayashi H, Kawachi H, Shimizu F, Yumura W, et al. Localization of Smad6 and Smad7 in the rat kidney and their regulated expression in the anti-Thy-1 nephritis. Mol Cell Biol Res Commun. 2000;4:98-105 pubmed
    Under normal conditions, kidney expresses Smad6 and Smad7 most abundantly among the organs of the body...
  33. Morty R, Nejman B, Kwapiszewska G, Hecker M, Zakrzewicz A, Kouri F, et al. Dysregulated bone morphogenetic protein signaling in monocrotaline-induced pulmonary arterial hypertension. Arterioscler Thromb Vasc Biol. 2007;27:1072-8 pubmed
    ..BMP signaling and BMP-regulated physiological phenomena are perturbed in MCT-treated rats, lending solid support to the proposed roles for BMP signaling in the pathogenesis of human PAH. ..
  34. Wang D, Kanuma T, Mizumuma H, Ibuki Y, Takenoshita S. Mutation analysis of the Smad6 and Smad7 gene in human ovarian cancers. Int J Oncol. 2000;17:1087-91 pubmed
    The Smad6 and Smad7 genes are members of the Smad family, involved in the transforming growth factor-beta (TGF-beta) signaling pathway...
  35. Liu X, Nagarajan R, Vale W, Chen Y. Phosphorylation regulation of the interaction between Smad7 and activin type I receptor. FEBS Lett. 2002;519:93-8 pubmed
    ..We report here that activin-induced signaling is negatively regulated by another Smad molecule, Smad7. When expressed in Chinese hamster ovary cells, Smad7 inhibited the transcriptional response induced by either ..
  36. Yamaguchi T, Kurisaki A, Yamakawa N, Minakuchi K, Sugino H. FKBP12 functions as an adaptor of the Smad7-Smurf1 complex on activin type I receptor. J Mol Endocrinol. 2006;36:569-79 pubmed
    ..FKBP12 also interacted with another inhibitory molecule of activin signal, Smad7, in an activin-dependent manner, and formed a complex with Smad7 on the type I receptor...
  37. Wu X, Zeng W, Jiang M, Qin J, Xu H. Effect of Oxymatrine on the TGFbeta-Smad signaling pathway in rats with CCl4-induced hepatic fibrosis. World J Gastroenterol. 2008;14:2100-5 pubmed
    ..034 +/- 0.090 vs 0.167 +/- 0.092, P < 0.05). Contrarily, the A value of Smad 7 mRNA was increased considerably in the treated animals (0.175 +/- 0.065 vs 0.074 +/- 0.012, P < 0.05)...
  38. Asano Y, Ihn H, Yamane K, Kubo M, Tamaki K. Impaired Smad7-Smurf-mediated negative regulation of TGF-beta signaling in scleroderma fibroblasts. J Clin Invest. 2004;113:253-64 pubmed
    ..In this study, we focused on Smad7 and Smurfs, principal molecules in the negative regulation of TGF-beta signaling, to further understand the ..
  39. Ebisawa T, Fukuchi M, Murakami G, Chiba T, Tanaka K, Imamura T, et al. Smurf1 interacts with transforming growth factor-beta type I receptor through Smad7 and induces receptor degradation. J Biol Chem. 2001;276:12477-80 pubmed
    b>Smad7 is an inhibitory Smad that acts as a negative regulator of signaling by the transforming growth factor-beta (TGF-beta) superfamily proteins...
  40. Denecke B, Wickert L, Liu Y, Ciuclan L, Dooley S, Meindl Beinker N. Smad7 dependent expression signature highlights BMP2 and HK2 signaling in HSC transdifferentiation. World J Gastroenterol. 2010;16:5211-24 pubmed
    To analyse the influence of Smad7, antagonist of transforming growth factor (TGF)-? canonical signaling pathways on hepatic stellate cell (HSC) transdifferentiation in detail...
  41. Vrljicak P, Myburgh D, Ryan A, Van Rooijen M, Mummery C, Gupta I. Smad expression during kidney development. Am J Physiol Renal Physiol. 2004;286:F625-33 pubmed
    ..Expression of the I-Smad Smad7 was also seen in mesenchymal cells in the interstitium...
  42. Li X, Feng J, Hu C, Chen Z, Gu Q, Nie H. Effects of Arkadia on airway remodeling through enhancing TGF-beta signaling in allergic rats. Lab Invest. 2010;90:997-1003 pubmed publisher
    ..An increased subepithelial collagen deposition was associated with high expression levels of Smad7, SnoN and Ski mRNAs, Arkadia, Smurf2, and TGF-beta type I receptor (TbetaRI), but low expression levels of Smad7, ..
  43. Shi Y, Massague J. Mechanisms of TGF-beta signaling from cell membrane to the nucleus. Cell. 2003;113:685-700 pubmed
    ..This article reviews these latest advances and presents our current understanding on the mechanisms of TGF-beta signaling from cell membrane to the nucleus. ..
  44. Li Q, Kong P, Wu C, Sun C, Chen Y, Xu X, et al. [Effects of intranasal interferon gamma on transforming growth factor-?1/Smad in rats with allergic rhinitis]. Zhonghua Er Bi Yan Hou Tou Jing Wai Ke Za Zhi. 2011;46:59-62 pubmed
    ..gamma (IFN-?) on nasal mucosa remodeling and expression of transforming growth factor-?1 (TGF-?1), Smad2, Smad3, Smad7 in allergic rhinitis (AR) rat model. Ovalbumin (OVA) and aluminum hydroxide were used to construct the AR model...
  45. Hou C, Wang W, Huang X, Fu P, Chen T, Sheikh Hamad D, et al. Ultrasound-microbubble-mediated gene transfer of inducible Smad7 blocks transforming growth factor-beta signaling and fibrosis in rat remnant kidney. Am J Pathol. 2005;166:761-71 pubmed
    ..of six rats were subjected to 5/6 nephrectomy and received renal arterial injection of a doxycycline-regulated Smad7 gene or control empty vector using an ultrasound-microbubble-mediated system...
  46. Qian Z, Peng Q, Zhang Z, Zhou L, Miao Y. Roles of Smad3 and Smad7 in rat pancreatic stellate cells activated by transforming growth factor-beta 1. Hepatobiliary Pancreat Dis Int. 2010;9:531-6 pubmed
    ..This study aimed to determine the expression of the Smad3 and Smad7 genes in the process of PSC activation, and explore the mechanisms of chronic pancreatitis...
  47. Hazen V, Phan K, Hudiburgh S, Butler S. Inhibitory Smads differentially regulate cell fate specification and axon dynamics in the dorsal spinal cord. Dev Biol. 2011;356:566-75 pubmed publisher
    ..To address this question, we have examined both the distribution of the inhibitory Smads (I-Smads), Smad6 and Smad7 in the spinal cord and the consequence of ectopically expressing the I-Smads in chicken embryos...
  48. Yu H, Huang J, Wang S, Zhao G, Jiao X, Zhu L. Overexpression of Smad7 suppressed ROS/MMP9-dependent collagen synthesis through regulation of heme oxygenase-1. Mol Biol Rep. 2013;40:5307-14 pubmed publisher
    ..blocker effectively inhibited TGF-?1-mediated epithelial-to-mesenchymal transition progress through regulating Smad7. However, the underlying mechanism by which Smad7 exerted in regulating MMP9 and fibrogenic response has not been ..
  49. Guo H, Leung J, Lam M, Chan L, Tsang A, Lan H, et al. Smad7 transgene attenuates peritoneal fibrosis in uremic rats treated with peritoneal dialysis. J Am Soc Nephrol. 2007;18:2689-703 pubmed
    ..pathway in peritoneal fibrosis induced in uremic rats treated with PD and explored the therapeutic potential of Smad7 to prevent fibrogenesis. After subtotal nephrectomy, uremic rats were treated with peritoneal dialysis using 4...
  50. Zhou H, Zou S, Lan Y, Fei W, Jiang R, Hu J. Smad7 modulates TGF? signaling during cranial suture development to maintain suture patency. J Bone Miner Res. 2014;29:716-24 pubmed publisher
    ..The suppression of Smad2/3 activation in the CS correlated with upregulation of Smad7 expression...
  51. Zhang L, Gao J, Cui S. miR-21 is involved in norepinephrine-mediated rat granulosa cell apoptosis by targeting SMAD7. J Mol Endocrinol. 2017;58:199-210 pubmed publisher
    ..is involved in NE-mediated rat granulosa cells apoptosis and blocks granulosa cell apoptosis by targeting Smad7, a transforming growth factor-beta-inducible mediator of apoptosis in granulosa cells...
  52. Yang J, Kan M, Wu G. Bergenin ameliorates diabetic nephropathy in rats via suppressing renal inflammation and TGF-β1-Smads pathway. Immunopharmacol Immunotoxicol. 2016;38:145-52 pubmed publisher
    ..reduced transforming growth factor-β1 (TGF-β1) production, down-regulated p-Smad2/3 expression and promoted Smad7 expression both in vivo and in vitro...
  53. Wang L, Zhang L, Zhang R, Li S. [Relationship between expression of Smad and ventricular remodeling after myocardial infarction in rats]. Zhonghua Xin Xue Guan Bing Za Zhi. 2005;33:932-5 pubmed
    To investigate the relationship between expression of Smad3, Smad7 and ventricular remodeling in rats after myocardial infarction...
  54. Wang L, Ning W, Tao L, Wang L, Peng Z. [Dynamic observation of enalapril on the expression of TGF-beta1, CTGF, Smad7 and alpha-SMA in rats with unilateral ureteral obstruction]. Zhong Nan Da Xue Xue Bao Yi Xue Ban. 2009;34:252-8 pubmed
    ..factor beta1 (TGF-beta1), connective tissue growth factor (CTGF), alpha-smooth muscle actin (alpha-SMA), and Smad7 in the obstructed kidney after unilateral ureteral obstruction (UUO) in rats, and to investigate the effect of ..
  55. Yu F, Guo Y, Chen B, Dong P, Zheng J. MicroRNA-17-5p activates hepatic stellate cells through targeting of Smad7. Lab Invest. 2015;95:781-9 pubmed publisher
    ..Furthermore, Smad7, a negative regulator of the TGF-β/Smad pathway, was confirmed as a direct target of miR-17-5p...
  56. Bai G, Yan G, Wang G, Wan P, Zhang R. Anti-hepatic fibrosis effects of a novel turtle shell decoction by inhibiting hepatic stellate cell proliferation and blocking TGF-?1/Smad signaling pathway in rats. Oncol Rep. 2016;36:2902-2910 pubmed publisher
    ..decreased the transforming growth factor beta 1 (TGF-?1) and Smad3 gene expression and increased inhibitory Smad7 gene expression in liver tissues of HF rats, suggesting that NTSD inhibited the ECM expression of HSC by ..
  57. Okuyama N, Kiryu Seo S, Kiyama H. Altered expression of Smad family members in injured motor neurons of rat. Brain Res. 2007;1132:36-41 pubmed
    ..Immunohistochemistry and Western blotting analysis confirmed the alterations of Smad1, 2 and 4 in injured neurons. These results suggest that the Smad signaling may be important for nerve regeneration. ..
  58. Okado T, Terada Y, Tanaka H, Inoshita S, Nakao A, Sasaki S. Smad7 mediates transforming growth factor-beta-induced apoptosis in mesangial cells. Kidney Int. 2002;62:1178-86 pubmed
    ..Smad proteins are the downstream effectors of TGF-beta signaling. Among them, Smad7 exerts negative feedback control over the action of TGF-beta...
  59. Wang J, Gao Y, Zhang N, Zou D, Wang P, Zhu Z, et al. miR-21 overexpression enhances TGF-?1-induced epithelial-to-mesenchymal transition by target smad7 and aggravates renal damage in diabetic nephropathy. Mol Cell Endocrinol. 2014;392:163-72 pubmed publisher
    ..b>Smad7 (a inhibitory smad), a downstream signaling molecules of TGF-?1, represses the EMT...
  60. Yang Q, Han B, Xie R, Cheng M. [Changes of bone morphogenetic protein-7 and inhibitory Smad expression in streptozotocin-induced diabetic nephropathy rat kidney]. Sheng Li Xue Bao. 2007;59:190-6 pubmed
    ..weight and 24-hour urine protein in the control and DN rats were examined; the expressions of BMP-7, Smad6 and Smad7 were detected by using immunohistochemical techniques, Western blot and real-time PCR...
  61. Bao J, Shi J, Xu S. [Dynamic expression of TGF-beta1/Smad protein in CCl4-induced liver fibrosis and its significance in rats]. Zhonghua Shi Yan He Lin Chuang Bing Du Xue Za Zhi. 2011;25:334-7 pubmed
    ..Meanwhile, the expression of TGF-beta1, TP3R-I, Smad2/3 and Smad7 proteins was detected by immunohistochemistry...
  62. Zhang S, Fei T, Zhang L, Zhang R, Chen F, Ning Y, et al. Smad7 antagonizes transforming growth factor beta signaling in the nucleus by interfering with functional Smad-DNA complex formation. Mol Cell Biol. 2007;27:4488-99 pubmed
    b>Smad7 plays an essential role in the negative-feedback regulation of transforming growth factor beta (TGF-beta) signaling by inhibiting TGF-beta signaling at the receptor level...
  63. Liu F, Li X, Peng Y, Liu H, Liu Y. Arkadia-Smad7-mediated positive regulation of TGF-beta signaling in a rat model of tubulointerstitial fibrosis. Am J Nephrol. 2007;27:176-83 pubmed
    ..In this study, we focused on Arkadia, Smurf2, Smad7, and TGF-beta type I receptor (TbetaRI), principal molecules in the regulation of TGF-beta signaling, to ..
  64. Tu Q, Qin J, Dong H, Lu F, Guan W. Effects of Panax notoginoside on the expression of TGF-?1 and Smad-7 in renal tissues of diabetic rats. J Huazhong Univ Sci Technolog Med Sci. 2011;31:190 pubmed publisher
    ..Meanwhile, the expressions of TGF-?1 and Smad7 in renal tissues were immunohistochemically dectected...
  65. Liu Q, He N, Liu S, Wang L, Shi Y, Duan H. [Tubular epithelial-myofibroblast transdifferentiation and expressions of hepatocyte growth factor and Smad7 in renal tissues of rat with experimental diabetes]. Zhongguo Wei Zhong Bing Ji Jiu Yi Xue. 2005;17:675-8 pubmed
    ..of tubular epithelial-myofibroblast transdifferentiation and the expressions of hepatocyte growth factor (HGF) and Smad7, and to elucidate the role of HGF and Smad7 in diabetic nephropathy...