Genomes and Genes
Gene Symbol: Slk
Description: STE20-like kinase
Alias: Stk2, STE20-like serine/threonine-protein kinase, STE20-related kinase, STE20-related serine/threonine-protein kinase, serine/threonine kinase 2
- Guilluy C, Rolli Derkinderen M, Loufrani L, Bourgé A, Henrion D, Sabourin L, et al. Ste20-related kinase SLK phosphorylates Ser188 of RhoA to induce vasodilation in response to angiotensin II Type 2 receptor activation. Circ Res. 2008;102:1265-74 pubmed publisher..We identify the Ser/Thr kinase Ste20-related kinase SLK as a new kinase phosphorylating RhoA on Ser188...
- Fokin A, Klementeva T, Nadezhdina E, Burakov A. SLK/LOSK kinase regulates cell motility independently of microtubule organization and Golgi polarization. Cytoskeleton (Hoboken). 2016;73:83-92 pubmed publisher..Such extensive rearrangement is closely related to cell polarization as a whole. The serine/threonine kinase SLK/LOSK is a potential regulator of cell motility, as it phosphorylates a series of cytoskeleton-bound proteins that ..
- Hao W, Takano T, Guillemette J, Papillon J, Ren G, Cybulsky A. Induction of apoptosis by the Ste20-like kinase SLK, a germinal center kinase that activates apoptosis signal-regulating kinase and p38. J Biol Chem. 2006;281:3075-84 pubmedExpression and activity of the germinal center kinase, Ste20-like kinase (SLK), are increased during kidney development and recovery from ischemic acute renal failure...
- Baron K, Al Zahrani K, Conway J, LabrÃ¨che C, Storbeck C, Visvader J, et al. Recruitment and activation of SLK at the leading edge of migrating cells requires Src family kinase activity and the LIM-only protein 4. Biochim Biophys Acta. 2015;1853:1683-92 pubmed publisherThe Ste20-like kinase SLK plays a pivotal role in cell migration and focal adhesion turnover and is regulated by the LIM domain-binding proteins Ldb1 and Ldb2...