Slco1a2

Summary

Gene Symbol: Slco1a2
Description: solute carrier organic anion transporter family, member 1A2
Alias: Oatp2, Slc21a5, Slco1a4, solute carrier organic anion transporter family member 1A4, OATP-B1, brain digoxin carrier protein, brain-specific organic anion transporter, organic anion transporter 2, sodium-independent organic anion-transporting polypeptide 2, solute carrier family 21 (organic anion transporter), member 5, solute carrier family 21 member 5, solute carrier organic anion transporter family, member 1a4
Species: rat
Products:     Slco1a2

Top Publications

  1. Ronaldson P, Finch J, Demarco K, Quigley C, Davis T. Inflammatory pain signals an increase in functional expression of organic anion transporting polypeptide 1a4 at the blood-brain barrier. J Pharmacol Exp Ther. 2011;336:827-39 pubmed publisher
    ..Our findings indicate that BBB transporters (i.e., Oatp1a4) can be targeted during drug development to improve CNS delivery of highly promising therapeutics. ..
  2. Abe T, Kakyo M, Sakagami H, Tokui T, Nishio T, Tanemoto M, et al. Molecular characterization and tissue distribution of a new organic anion transporter subtype (oatp3) that transports thyroid hormones and taurocholate and comparison with oatp2. J Biol Chem. 1998;273:22395-401 pubmed
    Two complementary DNAs for the organic anion transporter subtypes oatp2 and oatp3, which transport thyroid hormones as well as taurocholate, were isolated from a rat retina cDNA library...
  3. Dietrich C, Martin I, Porn A, Voigt S, Gartung C, Trautwein C, et al. Fasting induces basolateral uptake transporters of the SLC family in the liver via HNF4alpha and PGC1alpha. Am J Physiol Gastrointest Liver Physiol. 2007;293:G585-90 pubmed
    ..In rats, mRNA of Ntcp, Oatp1, and Oatp2 were significantly increased after 48 h of fasting...
  4. Geier A, Dietrich C, Trauner M, Gartung C. Extrahepatic cholestasis downregulates Oatp1 by TNF-alpha signalling without affecting Oatp2 and Oatp4 expression and sodium-independent bile salt uptake in rat liver. Liver Int. 2007;27:1056-65 pubmed
    ..In contrast, Oatp2/Oatp1a4 and Oatp4/Oatp1b2 protein expression was not affected by CBDL as compared with controls...
  5. Kuroda M, Kobayashi Y, Tanaka Y, Itani T, Mifuji R, Araki J, et al. Increased hepatic and renal expressions of multidrug resistance-associated protein 3 in Eisai hyperbilirubinuria rats. J Gastroenterol Hepatol. 2004;19:146-53 pubmed
    ..The aim of the present study was to investigate adaptive expressions of mrp1, mrp3, mrp6, organic anion transporting polypeptide 1 (oatp1) and oatp2 in liver and kidney of EHBR.
  6. Geier A, Dietrich C, Grote T, Beuers U, Prüfer T, Fraunberger P, et al. Characterization of organic anion transporter regulation, glutathione metabolism and bile formation in the obese Zucker rat. J Hepatol. 2005;43:1021-30 pubmed
    ..Alterations in hepatobiliary transporters may render fatty livers more vulnerable against various toxic insults...
  7. Nakakariya M, Shimada T, Irokawa M, Koibuchi H, Iwanaga T, Yabuuchi H, et al. Predominant contribution of rat organic anion transporting polypeptide-2 (Oatp2) to hepatic uptake of beta-lactam antibiotics. Pharm Res. 2008;25:578-85 pubmed
    ..nafcillin was transported by multiple Oatps with Km values of 4120 microM (Oatp1/Oatp1a1), 198 microM (Oatp2/Oatp1a4), and 1,570 microM (Oatp4/Oatp1b2), though it was not transported by hOAT2...
  8. Guo Y, Jiang L. Organic anion transporting polypeptide 2 transports valproic acid in rat brain microvascular endothelial cells. Neurol Res. 2016;38:634-9 pubmed publisher
    ..We previously showed the influx transporter organic anion transport polypeptide 2 (Oatp2) was expressed in rat brain microvascular endothelial cells (BMECs)...
  9. Hotta K, Ueyama J, Tatsumi Y, Tsukiyama I, Sugiura Y, Saito H, et al. Lack of Contribution of Multidrug Resistance-associated Protein and Organic Anion-transporting Polypeptide to Pharmacokinetics of Regorafenib, a Novel Multi-Kinase Inhibitor, in Rats. Anticancer Res. 2015;35:4681-9 pubmed
    ..The involvement of organic anion-transporting polypeptide 1 (OATP1; OATP in humans) and OATP2 in the hepatic uptake of regorafenib and their protein levels in the liver were also investigated in the two rat ..

More Information

Publications18

  1. Harati R, Benech H, Villegier A, Mabondzo A. P-glycoprotein, breast cancer resistance protein, Organic Anion Transporter 3, and Transporting Peptide 1a4 during blood-brain barrier maturation: involvement of Wnt/?-catenin and endothelin-1 signaling. Mol Pharm. 2013;10:1566-80 pubmed publisher
    ..These findings shed light on the role of an interaction between ?-catenin and endothelin-1 signaling in the regulation of these transporters at the BBB...
  2. Guo Y, Jiang L. Drug transporters are altered in brain, liver and kidney of rats with chronic epilepsy induced by lithium-pilocarpine. Neurol Res. 2010;32:106-12 pubmed publisher
    ..Another transmembrane drug transporter is the organic anion transporting polypeptide 2 (Oatp2), which is colocalized with P-gp in many polarized tissues...
  3. van Montfoort J, Schmid T, Adler I, Meier P, Hagenbuch B. Functional characterization of the mouse organic-anion-transporting polypeptide 2. Biochim Biophys Acta. 2002;1564:183-8 pubmed
    ..Northern blot analysis demonstrated a predominant expression in the liver with additional signals in kidney and brain. Using fluorescence in situ hybridization, the Oatp2 gene (gene symbol Slc21a5) was mapped to chromosome 6G1-G3.
  4. Shih D, Bussen M, Sehayek E, Ananthanarayanan M, Shneider B, Suchy F, et al. Hepatocyte nuclear factor-1alpha is an essential regulator of bile acid and plasma cholesterol metabolism. Nat Genet. 2001;27:375-82 pubmed
    ..Tcf1-/- liver has decreased expression of the basolateral membrane bile acid transporters Slc10a1, Slc21a3 and Slc21a5, leading to impaired portal bile acid uptake and elevated plasma bile acid concentrations...
  5. Sakamoto K, Mikami H, Kimura J. Involvement of organic anion transporting polypeptides in the toxicity of hydrophilic pravastatin and lipophilic fluvastatin in rat skeletal myofibres. Br J Pharmacol. 2008;154:1482-90 pubmed publisher
    ..This is probably why hydrophilic pravastatin affects skeletal muscle, but not skeletal myoblasts. ..
  6. Ohtsuki S, Ito S, Matsuda A, Hori S, Abe T, Terasaki T. Brain-to-blood elimination of 24S-hydroxycholesterol from rat brain is mediated by organic anion transporting polypeptide 2 (oatp2) at the blood-brain barrier. J Neurochem. 2007;103:1430-8 pubmed
    ..Pre-administration of digoxin completely inhibited the elimination. Xenopus laevis oocytes expressing rat oatp2 exhibited significant transport of [(3)H]24S-OH-chol, and this was inhibited by unlabeled 24S-OH-chol and digoxin, ..
  7. Thiebaud N, Menetrier F, Belloir C, Minn A, Neiers F, Artur Y, et al. Expression and differential localization of xenobiotic transporters in the rat olfactory neuro-epithelium. Neurosci Lett. 2011;505:180-5 pubmed publisher
    ..The pattern of expression and the distinct localization of the olfactory transporters showed in this work may highlight on their specific function in the whole olfactory epithelium...
  8. Meng L, Wang P, Wolkoff A, Kim R, Tirona R, Hofmann A, et al. Transport of the sulfated, amidated bile acid, sulfolithocholyltaurine, into rat hepatocytes is mediated by Oatp1 and Oatp2. Hepatology. 2002;35:1031-40 pubmed
    ..63 and 10.3 micromol/L for BSP. In expression systems, SLCT was taken up by Oatp1 and Oatp2 expressed in HeLa cells with similar K(m) values (12.6 +/- 6.2 and 14.6 +/- 1.9 micromol/L)...
  9. Noe B, Hagenbuch B, Stieger B, Meier P. Isolation of a multispecific organic anion and cardiac glycoside transporter from rat brain. Proc Natl Acad Sci U S A. 1997;94:10346-50 pubmed
    A novel multispecific organic anion transporting polypeptide (oatp2) has been isolated from rat brain. The cloned cDNA contains 3,640 bp. The coding region extends over 1,983 nucleotides, thus encoding a polypeptide of 661 amino acids...