Slco1a1

Summary

Gene Symbol: Slco1a1
Description: solute carrier organic anion transporter family, member 1a1
Alias: OATP-1, Oatp1, Slc21a1, Slc21a3, solute carrier organic anion transporter family member 1A1, organic anion-transporting polypeptide 1, sodium-independent organic anion transporter 1, solute carrier family (organic anion transporter) member 1, solute carrier family (organic anion transporter) member 3, solute carrier family 21 member 1, solute carrier organic anion transporter family member 1A1-like
Species: rat
Products:     Slco1a1

Top Publications

  1. Wang P, Hata S, Xiao Y, Murray J, Wolkoff A. Topological assessment of oatp1a1: a 12-transmembrane domain integral membrane protein with three N-linked carbohydrate chains. Am J Physiol Gastrointest Liver Physiol. 2008;294:G1052-9 pubmed publisher
    ..This was in accord with the finding that fully unglycosylated oatp1a1 was well expressed but located intracellularly with limited transport ability as a consequence of its reduced cell surface expression. ..
  2. Xiao Y, Nieves E, Angeletti R, Orr G, Wolkoff A. Rat organic anion transporting protein 1A1 (Oatp1a1): purification and phosphopeptide assignment. Biochemistry. 2006;45:3357-69 pubmed
    ..Whether phosphorylation near the C-terminus inhibits C-terminal oligomerization of oatp1a1, required for normal transport function, can be speculated upon but is as yet unknown. ..
  3. Shimizu A, Kobayashi A, Motoyama H, Sakai H, Yamada A, Yoshizawa A, et al. Features of acute liver congestion on gadoxetate disodium-enhanced MRI in a rat model: Role of organic anion-transporting polypeptide 1A1. J Magn Reson Imaging. 2015;42:828-36 pubmed publisher
    ..698). The reduced signal intensity in the CL on Gd-EOB-DTPA-enhanced MRI could be explained by the decreased uptake of Gd-EOB-DTPA via Oatp1a1 protein in the congestive area. ..
  4. Hata S, Wang P, Eftychiou N, Ananthanarayanan M, Batta A, Salen G, et al. Substrate specificities of rat oatp1 and ntcp: implications for hepatic organic anion uptake. Am J Physiol Gastrointest Liver Physiol. 2003;285:G829-39 pubmed
    ..HeLa cell lines stably transfected with rat Na+/taurocholate cotransporting polypeptide (ntcp) or organic anion transporting polypeptide 1 (oatp1) in which expression was under regulation of a zinc-inducible promoter...
  5. Maruyama H, Ogura J, Fujikawa A, Terada Y, Tsujimoto T, Koizumi T, et al. Intestinal ischemia-reperfusion suppresses biliary excretion of hepatic organic anion transporting polypeptides substrate. J Pharm Pharm Sci. 2013;16:722-31 pubmed
    ..The decreases in these transporters cause alteration of pharmacokinetics of organic anion compound. The newly found influence of intestinal I/R on the expression and function of Oatps may be a key to perform appropriate drug therapy. ..
  6. Sugiyama D, Kusuhara H, Taniguchi H, Ishikawa S, Nozaki Y, Aburatani H, et al. Functional characterization of rat brain-specific organic anion transporter (Oatp14) at the blood-brain barrier: high affinity transporter for thyroxine. J Biol Chem. 2003;278:43489-95 pubmed
    ..Therefore, it may be speculated that Oatp14 plays a role in maintaining the concentration of T4 and, ultimately, T3 in the brain by transporting T4 from the circulating blood to the brain. ..
  7. Wang P, Wang J, Xiao Y, Murray J, Novikoff P, Angeletti R, et al. Interaction with PDZK1 is required for expression of organic anion transporting protein 1A1 on the hepatocyte surface. J Biol Chem. 2005;280:30143-9 pubmed
    ..Because its ability to transport substances into the cell requires surface expression, this must be considered in any assessment of physiologic function. ..
  8. Jacquemin E, Hagenbuch B, Stieger B, Wolkoff A, Meier P. Expression cloning of a rat liver Na(+)-independent organic anion transporter. Proc Natl Acad Sci U S A. 1994;91:133-7 pubmed
  9. Kimura N, Hakamada K, Ikenaga S, Umehara Y, Toyoki Y, Sasaki M. Gene expression of ATP-binding cassette transporters during liver regeneration after 90% hepatectomy in rats. Int J Mol Med. 2012;30:28-34 pubmed publisher
    ..Changes in the expression pattern of the ABC transporters, therefore, seem to be the key event in liver failure during liver regeneration...

More Information

Publications24

  1. Dietrich C, Martin I, Porn A, Voigt S, Gartung C, Trautwein C, et al. Fasting induces basolateral uptake transporters of the SLC family in the liver via HNF4alpha and PGC1alpha. Am J Physiol Gastrointest Liver Physiol. 2007;293:G585-90 pubmed
    ..In rats, mRNA of Ntcp, Oatp1, and Oatp2 were significantly increased after 48 h of fasting...
  2. Mónica Torres A, Mac Laughlin M, Muller A, Brandoni A, Anzai N, Endou H. Altered renal elimination of organic anions in rats with chronic renal failure. Biochim Biophys Acta. 2005;1740:29-37 pubmed
    ..The lower OAT1 expression in remnant renal mass of CRF rats or/and the lower activity of Na-K-ATPase might justify, at least in part, the diminished secreted load of this organic anion. ..
  3. Kuroda M, Kobayashi Y, Tanaka Y, Itani T, Mifuji R, Araki J, et al. Increased hepatic and renal expressions of multidrug resistance-associated protein 3 in Eisai hyperbilirubinuria rats. J Gastroenterol Hepatol. 2004;19:146-53 pubmed
    ..The aim of the present study was to investigate adaptive expressions of mrp1, mrp3, mrp6, organic anion transporting polypeptide 1 (oatp1) and oatp2 in liver and kidney of EHBR.
  4. Kato Y, Kuge K, Kusuhara H, Meier P, Sugiyama Y. Gender difference in the urinary excretion of organic anions in rats. J Pharmacol Exp Ther. 2002;302:483-9 pubmed
    ..taurocholate, dibromosulfophthalein (DBSP), and zenarestat, all substrates and/or inhibitors of organic anion transporting polypeptide 1 (Oatp1), was much higher in female than in male rats...
  5. Gotoh Y, Kato Y, Stieger B, Meier P, Sugiyama Y. Gender difference in the Oatp1-mediated tubular reabsorption of estradiol 17beta-D-glucuronide in rats. Am J Physiol Endocrinol Metab. 2002;282:E1245-54 pubmed
    ..The concomitant change in the expression of the gene product for organic anion-transporting polypeptide Oatp1, of which E(2)-17betaG is a typical substrate, was found in the kidney membrane fractions after these treatments...
  6. Iwakiri T, Okumura M, Matsunaga N, Ichihara E, Shiotsuki S, Nagata M, et al. Hepatocyte growth factor increases uptake of estradiol 17beta-D-glucuronide and Oatp1 protein level in rat hepatocytes. Eur J Pharmacol. 2008;580:19-26 pubmed
    ..On the other hand, the protein level of organic anion-transporting polypeptide (Oatp1), which is responsible for the uptake of bile salts into hepatocytes, decreases in cholestatic humans and rats...
  7. Meng L, Wang P, Wolkoff A, Kim R, Tirona R, Hofmann A, et al. Transport of the sulfated, amidated bile acid, sulfolithocholyltaurine, into rat hepatocytes is mediated by Oatp1 and Oatp2. Hepatology. 2002;35:1031-40 pubmed
    ..63 and 10.3 micromol/L for BSP. In expression systems, SLCT was taken up by Oatp1 and Oatp2 expressed in HeLa cells with similar K(m) values (12.6 +/- 6.2 and 14.6 +/- 1.9 micromol/L)...
  8. Kim J, Kim T, Hong K, Moon H, Oh I, Lee S, et al. Pre-Hepatectomy Assessment of Bile Transporter Expression by Gadoxetic Acid-Enhanced MRI in a Rat Model of Liver Cirrhosis. J Invest Surg. 2017;30:265-271 pubmed publisher
    ..We hypothesize that hepatocyte expressions of bile transporters (OATP1 and MRP2) correlate with dynamic profile of Gadoxetic acid enhanced (GE)-MR imaging (MRI)...
  9. Choi J, Murray J, Wolkoff A. PDZK1 binding and serine phosphorylation regulate subcellular trafficking of organic anion transport protein 1a1. Am J Physiol Gastrointest Liver Physiol. 2011;300:G384-93 pubmed publisher
    ..Identification of the proteins and motor molecules that mediate these trafficking events represents an important area for future study. ..
  10. Ito A, Yamaguchi K, Onogawa T, Unno M, Suzuki T, Nishio T, et al. Distribution of organic anion-transporting polypeptide 2 (oatp2) and oatp3 in the rat retina. Invest Ophthalmol Vis Sci. 2002;43:858-63 pubmed
    To examine the expression of multifunctional Na(+)-independent organic anion-transporting polypeptides, termed oatp1, oatp2, and oatp3, involving the transport of thyroid hormone in the rat retina at the protein and mRNA levels...
  11. Kwon O, Wang W, Miller S. Renal organic anion transporter 1 is maldistributed and diminishes in proximal tubule cells but increases in vasculature after ischemia and reperfusion. Am J Physiol Renal Physiol. 2008;295:F1807-16 pubmed publisher
    ..Our findings may provide insights of renal OAT1 in its cellular localization and response during ischemic acute kidney injury and recovery from it. ..
  12. Geier A, Dietrich C, Trauner M, Gartung C. Extrahepatic cholestasis downregulates Oatp1 by TNF-alpha signalling without affecting Oatp2 and Oatp4 expression and sodium-independent bile salt uptake in rat liver. Liver Int. 2007;27:1056-65 pubmed
    ..b>Oatp1/Oatp1a1 protein mass remained unchanged after CBDL for 1 day, but then declined by 75+/-7% and 90+/-17%, ..
  13. Geier A, Dietrich C, Voigt S, Kim S, Gerloff T, Kullak Ublick G, et al. Effects of proinflammatory cytokines on rat organic anion transporters during toxic liver injury and cholestasis. Hepatology. 2003;38:345-54 pubmed
    ..Thus, we studied the molecular mechanisms by which Ntcp, Oatp1, Oatp2, and Mrp2 are regulated by proinflammatory cytokines during liver injury...
  14. Lee T, Koh A, Cui Z, Pierce R, Ballatori N. N-glycosylation controls functional activity of Oatp1, an organic anion transporter. Am J Physiol Gastrointest Liver Physiol. 2003;285:G371-81 pubmed
    Rat Oatp1 (Slc21a1) is an organic anion-transporting polypeptide believed to be an anion exchanger. To characterize its mechanism of transport, Oatp1 was expressed in Saccharomyces cerevisiae under control of the GAL1 promoter...
  15. Hotta K, Ueyama J, Tatsumi Y, Tsukiyama I, Sugiura Y, Saito H, et al. Lack of Contribution of Multidrug Resistance-associated Protein and Organic Anion-transporting Polypeptide to Pharmacokinetics of Regorafenib, a Novel Multi-Kinase Inhibitor, in Rats. Anticancer Res. 2015;35:4681-9 pubmed
    ..The involvement of organic anion-transporting polypeptide 1 (OATP1; OATP in humans) and OATP2 in the hepatic uptake of regorafenib and their protein levels in the liver were also ..