Gene Symbol: Slc9a3
Description: solute carrier family 9 member A3
Alias: Nhe3, sodium/hydrogen exchanger 3, NHE-3, Na(+)/H(+) exchanger 3, Solute carrier family 9 (sodium/hydrogen exchanger 3), antiporter 3, Na+/H+ (amiloride insensitive), plasma membrane ion transport protein, solute carrier family 9 (sodium/hydrogen exchanger), member 3, solute carrier family 9 member 3, solute carrier family 9, subfamily A (NHE3, cation proton antiporter 3), member 3
Species: rat
Products:     Slc9a3

Top Publications

  1. Leong P, Yang L, Holstein Rathlou N, McDonough A. Angiotensin II clamp prevents the second step in renal apical NHE3 internalization during acute hypertension. Am J Physiol Renal Physiol. 2002;283:F1142-50 pubmed
    ..Acute hypertension provoked a rapid redistribution of Na(+)/H(+) exchanger isoform 3 (NHE3) out of apical brush-border membranes (21 +/- 4% decrease of total NHE3 abundance) to endosomal/lysosomal membranes ..
  2. Saifur Rohman M, Emoto N, Nonaka H, Okura R, Nishimura M, Yagita K, et al. Circadian clock genes directly regulate expression of the Na(+)/H(+) exchanger NHE3 in the kidney. Kidney Int. 2005;67:1410-9 pubmed
    ..The mRNA expression profiles of NHE3 and clock genes were examined in mice and rat kidneys...
  3. Tureyen K, Kapadia R, Bowen K, Satriotomo I, Liang J, Feinstein D, et al. Peroxisome proliferator-activated receptor-gamma agonists induce neuroprotection following transient focal ischemia in normotensive, normoglycemic as well as hypertensive and type-2 diabetic rodents. J Neurochem. 2007;101:41-56 pubmed
    ..Thus, PPARgamma activation with TZDs might be a potent therapeutic option for preventing inflammation and neuronal damage after stroke with promise in diabetic and hypertensive subjects. ..
  4. Mizumori M, Choi Y, Guth P, Engel E, Kaunitz J, Akiba Y. CFTR inhibition augments NHE3 activity during luminal high CO2 exposure in rat duodenal mucosa. Am J Physiol Gastrointest Liver Physiol. 2008;294:G1318-27 pubmed publisher
    ..We thus examined the effect of inhibition of Na(+)/H(+) exchanger-3 (NHE3), cystic fibrosis transmembrane regulator (CFTR), or apical anion exchangers on transmucosal CO(2) diffusion and ..
  5. Pao A, Bhargava A, Di Sole F, Quigley R, Shao X, Wang J, et al. Expression and role of serum and glucocorticoid-regulated kinase 2 in the regulation of Na+/H+ exchanger 3 in the mammalian kidney. Am J Physiol Renal Physiol. 2010;299:F1496-506 pubmed publisher
    ..tubule cells with aquaporin-2 immunostaining but significant in proximal tubule cells with Na(+)/H(+) exchanger 3 (NHE3) immunostaining...
  6. Eladari D, Leviel F, Pezy F, Paillard M, Chambrey R. Rat proximal NHE3 adapts to chronic acid-base disorders but not to chronic changes in dietary NaCl intake. Am J Physiol Renal Physiol. 2002;282:F835-43 pubmed
    In the proximal tubule, the apical Na(+)/H(+) exchanger identified as NHE3 mediates most NaCl and NaHCO(3) absorption...
  7. Banday A, Lokhandwala M. Angiotensin II-mediated biphasic regulation of proximal tubular Na+/H+ exchanger 3 is impaired during oxidative stress. Am J Physiol Renal Physiol. 2011;301:F364-70 pubmed publisher
    ..AT1Rs) maintains sodium homeostasis by regulating renal sodium transporters including Na(+)/H(+) exchanger 3 (NHE3) in a biphasic manner. Low-ANG II concentration stimulates whereas high concentrations inhibit NHE3 activity...
  8. Linz B, Hohl M, Reil J, Böhm M, Linz D. Inhibition of NHE3-mediated Sodium Absorption in the Gut Reduced Cardiac End-organ Damage Without Deteriorating Renal Function in Obese Spontaneously Hypertensive Rats. J Cardiovasc Pharmacol. 2016;67:225-31 pubmed publisher
    ..The sodium-proton-exchanger subtype 3 (NHE3) is an important mediator of intestinal sodium absorption...
  9. Pessoa T, Campos L, Carraro Lacroix L, Girardi A, Malnic G. Functional role of glucose metabolism, osmotic stress, and sodium-glucose cotransporter isoform-mediated transport on Na+/H+ exchanger isoform 3 activity in the renal proximal tubule. J Am Soc Nephrol. 2014;25:2028-39 pubmed publisher
    Na(+)-glucose cotransporter 1 (SGLT1)-mediated glucose uptake leads to activation of Na(+)-H(+) exchanger 3 (NHE3) in the intestine by a process that is not dependent on glucose metabolism...

More Information


  1. Sonalker P, Tofovic S, Bastacky S, Jackson E. Chronic noradrenaline increases renal expression of NHE-3, NBC-1, BSC-1 and aquaporin-2. Clin Exp Pharmacol Physiol. 2008;35:594-600 pubmed publisher
  2. Ma S, Kang J, Bae E, Choi C, Lee J, Kim S, et al. Effects of volume depletion and NaHCO3 loading on the expression of Na+/H+ exchanger isoform 3, Na+: HCO3- cotransporter type 1 and nitric oxide synthase in rat kidney. Clin Exp Pharmacol Physiol. 2008;35:262-7 pubmed
    1. The effects of volume depletion and NaHCO(3) loading on the expression of Na(+)/H(+) exchanger isoform 3 (NHE3), Na(+) : HCO(3)(-) cotransporter type 1 (NBC1) and neuronal (n) and inducible (i) isoforms of nitric oxide synthase (NOS) ..
  3. Janecke A, Heinz Erian P, Yin J, Petersen B, Franke A, Lechner S, et al. Reduced sodium/proton exchanger NHE3 activity causes congenital sodium diarrhea. Hum Mol Genet. 2015;24:6614-23 pubmed publisher
    ..b>SLC9A3 missense, splicing and truncation mutations, including an instance of uniparental disomy, and whole-gene deletion ..
  4. Ogata T. Bicarbonate secretion by rat bile duct brush cells indicated by immunohistochemical localization of CFTR, anion exchanger AE2, Na+/HCO3 -cotransporter, carbonic anhydrase II, Na+/H+ exchangers NHE1 and NHE3, H+/K+-ATPase, and Na+/K+-ATPase. Med Mol Morphol. 2006;39:44-8 pubmed
    ..the extrusion of H(+), Na(+)/H(+) exchanger 1 (NHE1) was localized along the BLM whereas Na(+)/H(+) exchanger 3 (NHE3) was found on the MV and BLM...
  5. Gattineni J, Sas D, Dagan A, Dwarakanath V, Baum M. Effect of thyroid hormone on the postnatal renal expression of NHE8. Am J Physiol Renal Physiol. 2008;294:F198-204 pubmed
    ..There is a maturational increase in postnatal brush-border membrane (BBM) vesicle NHE3 protein abundance and decrease in NHE8 protein abundance...
  6. Shenolikar S, Voltz J, Minkoff C, Wade J, Weinman E. Targeted disruption of the mouse NHERF-1 gene promotes internalization of proximal tubule sodium-phosphate cotransporter type IIa and renal phosphate wasting. Proc Natl Acad Sci U S A. 2002;99:11470-5 pubmed
    ..were identified as essential factors for protein kinase A-mediated inhibition of the sodium-hydrogen exchanger, NHE3. NHERF-1 and NHERF-2 also bound other cellular targets including the sodium-phosphate cotransporter type IIa ..
  7. Kirchhoff P, Wagner C, Gaetzschmann F, Radebold K, Geibel J. Demonstration of a functional apical sodium hydrogen exchanger in isolated rat gastric glands. Am J Physiol Gastrointest Liver Physiol. 2003;285:G1242-8 pubmed
    ..Furthermore, the gastric NHE-3 appears to work under resting conditions and inactivates during periods of H(+)-K(+)-ATPase activity. ..
  8. Turban S, Wang X, Knepper M. Regulation of NHE3, NKCC2, and NCC abundance in kidney during aldosterone escape phenomenon: role of NO. Am J Physiol Renal Physiol. 2003;285:F843-51 pubmed
    ..demonstrated a paradoxical increase in the protein abundance of the apical Na/H exchanger of the proximal tubule (NHE3)...
  9. Pedrosa R, Gomes P, Zeng C, Hopfer U, Jose P, Soares da Silva P. Dopamine D3 receptor-mediated inhibition of Na+/H+ exchanger activity in normotensive and spontaneously hypertensive rat proximal tubular epithelial cells. Br J Pharmacol. 2004;142:1343-53 pubmed
  10. West C, Verlander J, Wall S, Baylis C. The chloride-bicarbonate exchanger pendrin is increased in the kidney of the pregnant rat. Exp Physiol. 2015;100:1177-86 pubmed publisher
    ..Thus, increased pendrin in pregnant rats may compensate for the decreased NCC and aid in the renal sodium chloride reabsorption of pregnancy. ..
  11. Bobulescu I, Dubree M, Zhang J, McLeroy P, Moe O. Effect of renal lipid accumulation on proximal tubule Na+/H+ exchange and ammonium secretion. Am J Physiol Renal Physiol. 2008;294:F1315-22 pubmed publisher
    ..content, decreased urinary ammonium and pH, and lower levels of brush border membrane Na(+)/H(+) exchanger-3 (NHE3), a major mediator of ammonium excretion...
  12. Lucioni A, Womack C, Musch M, Rocha F, Bookstein C, Chang E. Metabolic acidosis in rats increases intestinal NHE2 and NHE3 expression and function. Am J Physiol Gastrointest Liver Physiol. 2002;283:G51-6 pubmed
    ..Whether this occurs through enhanced expression and/or function of the brush-border Na+/H+ exchangers (NHE)2 and NHE3 is unknown. Metabolic acidosis was induced in rats by feeding ammonium chloride through their drinking water...
  13. Capasso G, Rizzo M, Pica A, Di Maio F, Moe O, Alpern R, et al. Bicarbonate reabsorption and NHE-3 expression: abundance and activity are increased in Henle's loop of remnant rats. Kidney Int. 2002;62:2126-35 pubmed
    ..Such an effect will counterbalance the increased glomerular bicarbonate load, thus preventing urinary bicarbonate loss and mitigating the ensuing metabolic acidosis. ..
  14. Dixit M, Xu L, Xu H, Bai L, Collins J, Ghishan F. Effect of angiotensin-II on renal Na+/H+ exchanger-NHE3 and NHE2. Biochim Biophys Acta. 2004;1664:38-44 pubmed was to determine the effect of angiotensin II (A-II) on membrane expression of Na+/H+ exchange isoforms NHE3 and NHE2 in the rat renal cortex...
  15. Besse Eschmann V, Klisic J, Nief V, Le Hir M, Kaissling B, Ambuhl P. Regulation of the proximal tubular sodium/proton exchanger NHE3 in rats with puromycin aminonucleoside (PAN)-induced nephrotic syndrome. J Am Soc Nephrol. 2002;13:2199-206 pubmed
    ..The regulation of the cortical Na/H exchanger NHE3, the main pathway for Na reabsorption in the proximal tubule (PT), was investigated in rats with puromycin ..
  16. Khan I, Al Qattan K, Alnaqeeb M, Ali M. Altered expression of Na(+)/H(+) exchanger isoforms 1 and 3 in clipped and unclipped kidneys of a 2-kidney-1-clip Goldblatt model of hypertension. Nephron. 2002;92:346-55 pubmed
    ..Thus, the changes in NHE isoforms and sodium pump activity, together, contribute to functional differences that exist in the 2K-1C kidneys. ..
  17. Li X, Zhuo J. Intracellular ANG II directly induces in vitro transcription of TGF-beta1, MCP-1, and NHE-3 mRNAs in isolated rat renal cortical nuclei via activation of nuclear AT1a receptors. Am J Physiol Cell Physiol. 2008;294:C1034-45 pubmed publisher
  18. Riquier Brison A, Leong P, Pihakaski Maunsbach K, McDonough A. Angiotensin II stimulates trafficking of NHE3, NaPi2, and associated proteins into the proximal tubule microvilli. Am J Physiol Renal Physiol. 2010;298:F177-86 pubmed publisher
    ..decreases PT salt and water reabsorption and provokes rapid redistribution of the Na(+)/H(+) exchanger isoform 3 (NHE3), Na(+)/Pi cotransporter 2 (NaPi2), and associated proteins out of the microvilli...
  19. Kersh A, Hartzler L, Havlin K, Hubbell B, Nanagas V, Kalra A, et al. pH regulating transporters in neurons from various chemosensitive brainstem regions in neonatal rats. Am J Physiol Regul Integr Comp Physiol. 2009;297:R1409-20 pubmed publisher
    ..Thus, pH(i) recovery is mediated by different pH-regulating transporters in neurons from different chemosensitive regions, but recovery is suppressed by hypercapnia in all of the neurons. ..
  20. Crajoinas R, Pessoa T, Rodrigues M, Malnic G, Girardi A. Changes in the activity and expression of protein phosphatase-1 accompany the differential regulation of NHE3 before and after the onset of hypertension in spontaneously hypertensive rats. Acta Physiol (Oxf). 2014;211:395-408 pubmed publisher
    The Na(+) /H(+) exchanger NHE3 activity decreases in the proximal tubule of spontaneously hypertensive rats (SHRs) as blood pressure increases, and this reduction is correlated with higher NHE3 phosphorylation levels at the PKA consensus ..
  21. Gekle M, Völker K, Mildenberger S, Freudinger R, Shull G, Wiemann M. NHE3 Na+/H+ exchanger supports proximal tubular protein reabsorption in vivo. Am J Physiol Renal Physiol. 2004;287:F469-73 pubmed
    ..and genetic studies in cultured opossum kidney cells have shown that the apical Na(+)/H(+) exchanger isoform 3 (NHE3) supports RME by interference with endosomal pH homeostasis and endocytic fusion events...
  22. Briffa J, Grinfeld E, Jenkin K, Mathai M, Poronnik P, McAinch A, et al. Diet induced obesity in rats reduces NHE3 and Na(+) /K(+) -ATPase expression in the kidney. Clin Exp Pharmacol Physiol. 2015;42:1118-26 pubmed publisher
    ..In the proximal tubule, the Na(+) /H(+) Exchanger 3 (NHE3) is responsible for normal protein reabsorption and the reabsorption of approximately 70% of the renal sodium load...
  23. Barisic K, Karuzic O, Petrik J, Grubisic T. Regulation of Na+/H+ exchanger by urogastrone, a potent activator of cell proliferation. Physiol Res. 2002;51:483-91 pubmed
    ..The absence of Ca2+ ions produced a 60 % decrease of NHE activity. The chemical modification of histidine residues with diethyl pyrocarbonate or SH groups with N-ethylmaleimide inhibited NHE activity. ..
  24. Oliveira C, Zhou Q, Carnes K, Nie R, Kuehl D, Jackson G, et al. ER function in the adult male rat: short- and long-term effects of the antiestrogen ICI 182,780 on the testis and efferent ductules, without changes in testosterone. Endocrinology. 2002;143:2399-409 pubmed
  25. Abu Ghefreh A, Khan I. A role of intestine in hypertension: mechanism of suppression of intestinal Na-H exchanger isoform-3 in spontaneously hypertensive rats. Clin Exp Hypertens. 2013;35:543-9 pubmed publisher
    ..NHE-3 suppression together with decrease in the sodium pump activity would accumulate intracellular Na(+) and may contribute to the reported hypertension-induced tissue damage in the GI-tract. ..
  26. Krug A, Papavassiliou F, Hopfer U, Ullrich K, Gekle M. Aldosterone stimulates surface expression of NHE3 in renal proximal brush borders. Pflugers Arch. 2003;446:492-6 pubmed
    ..hypothesis that the application of aldosterone results in greater activity of the apical Na(+)/H(+) exchanger-3 (NHE3), we investigated the effect of aldosterone on amiloride-sensitive, proximal tubular volume reabsorption and ..
  27. Kiela P, LeSueur J, Collins J, Ghishan F. Transcriptional regulation of the rat NHE3 gene. Functional interactions between GATA-5 and Sp family transcription factors. J Biol Chem. 2003;278:5659-68 pubmed
    Expression of sodium-hydrogen exchanger isoform 3 (NHE3) in the intestinal and renal epithelium plays a critical role in sodium absorption and acid/base homeostasis...
  28. Musch M, Bookstein C, Rocha F, Lucioni A, Ren H, Daniel J, et al. Region-specific adaptation of apical Na/H exchangers after extensive proximal small bowel resection. Am J Physiol Gastrointest Liver Physiol. 2002;283:G975-85 pubmed
    ..effects of 50% proximal MSBR on the function and expression of the apical membrane Na/H exchangers (NHEs) NHE2 and NHE3. Morphometric analysis confirmed adaptive changes consistent with villus hypertrophy, particularly distal to the ..
  29. Good D, George T, Watts B. Nongenomic regulation by aldosterone of the epithelial NHE3 Na(+)/H(+) exchanger. Am J Physiol Cell Physiol. 2006;290:C757-63 pubmed
    ..In the MTAL, apical NHE3 mediates H(+) secretion necessary for HCO(3)(-) absorption; basolateral NHE1 influences HCO(3)(-) absorption by ..
  30. Gupta N, Dwarakanath V, Baum M. Maturation of the Na+/H+ antiporter (NHE3) in the proximal tubule of the hypothyroid adrenalectomized rat. Am J Physiol Renal Physiol. 2004;287:F521-7 pubmed
    ..studies examining the role of glucocorticoids and thyroid hormone on the maturation of the Na(+)/H(+) antiporter (NHE3), we found attenuation in the maturational increase in proximal tubule apical Na(+)/H(+) antiporter activity but no ..
  31. Nishi E, Martins B, Milanez M, Lopes N, de Melo J, Pontes R, et al. Stimulation of renal afferent fibers leads to activation of catecholaminergic and non-catecholaminergic neurons in the medulla oblongata. Auton Neurosci. 2017;204:48-56 pubmed publisher inhibiting the cAMP/PKA pathway and redistributing the Na+/H+ exchanger isoform 3 (NHE3) to the body of the microvilli in the proximal tubules...
  32. Fan X, Liu K, Cui W, Huang J, Wang W, Gao Y. Novel mechanism of intra‑renal angiotensin II-induced sodium/proton exchanger 3 expression by losartan in spontaneously hypertensive rats. Mol Med Rep. 2014;10:2483-8 pubmed publisher
    ..b>NHE3 and SGK1 were increased at the mRNA and protein level in the SHR group, and losartan reduced the expression of both ..
  33. Gens J, Du H, Tackett L, Kong S, Chu S, Montrose M. Different ionic conditions prompt NHE2 and NHE3 translocation to the plasma membrane. Biochim Biophys Acta. 2007;1768:1023-35 pubmed
    We tested whether NHE3 and NHE2 Na(+)/H(+) exchanger isoforms were recruited to the plasma membrane (PM) in response to changes in ion homeostasis...
  34. Licht C, Laghmani K, Yanagisawa M, Preisig P, Alpern R. An autocrine role for endothelin-1 in the regulation of proximal tubule NHE3. Kidney Int. 2004;65:1320-6 pubmed
    Chronic metabolic acidosis leads to an increase in NHE3 activity that is mediated by endothelin-1 (ET-1) expression and activation of the proximal tubule endothelin B receptor...
  35. Dynia D, Steinmetz A, Kocinsky H. NHE3 function and phosphorylation are regulated by a calyculin A-sensitive phosphatase. Am J Physiol Renal Physiol. 2010;298:F745-53 pubmed publisher
    Na+/H+ exchanger 3 (NHE3) is phosphorylated and regulated by multiple kinases, including PKA, SGK1, and CK2; however, the role of phosphatases in the dephosphorylation and regulation of NHE3 remains unknown...
  36. Orlowski J, Kandasamy R, Shull G. Molecular cloning of putative members of the Na/H exchanger gene family. cDNA cloning, deduced amino acid sequence, and mRNA tissue expression of the rat Na/H exchanger NHE-1 and two structurally related proteins. J Biol Chem. 1992;267:9331-9 pubmed
    ..These data suggest that the molecular basis for the functional diversity of the Na/H exchanger in mammals is based, at least in part, on expression of multiple members of a gene family. ..
  37. Castelo Branco R, Leite Dellova D, Fernandes F, Malnic G, De Mello Aires M. The effects of angiotensin-(1-7) on the exchanger NHE3 and on [Ca2+]i in the proximal tubules of spontaneously hypertensive rats. Am J Physiol Renal Physiol. 2017;313:F450-F460 pubmed publisher
    ..S3226 [10-6 M, a specific Na+-H+ exchanger 3 (NHE3) antagonist] decreased J[Formula: see text] and changed the stimulatory effect of ANG-(1-7) to an inhibitory one ..
  38. Kandasamy R, Orlowski J. Genomic organization and glucocorticoid transcriptional activation of the rat Na+/H+ exchanger Nhe3 gene. J Biol Chem. 1996;271:10551-9 pubmed
    The activity of the apical membrane Na+/H+ exchanger NHE3 isoform of renal or intestinal epithelial cells is chronically regulated by a wide variety of stimuli, including acidosis, cAMP, glucocorticoids, and thyroid hormone...
  39. Wang G, Li C, Kim S, Ring T, Wen J, Djurhuus J, et al. Ureter obstruction alters expression of renal acid-base transport proteins in rat kidney. Am J Physiol Renal Physiol. 2008;295:F497-506 pubmed publisher
    ..immunoblotting revealed that BUO caused a significant reduction in the expression of the type 3 Na+/H+ exchanger (NHE3) in the cortex (21 +/- 4%), electrogenic Na+/HCO3- cotransporter (NBC1; 71 +/- 5%), type 1 bumetanide-sensitive Na+-..
  40. Praetorius J, Andreasen D, Jensen B, Ainsworth M, Friis U, Johansen T. NHE1, NHE2, and NHE3 contribute to regulation of intracellular pH in murine duodenal epithelial cells. Am J Physiol Gastrointest Liver Physiol. 2000;278:G197-206 pubmed
    ..NHE1, NHE2, and NHE3 were expressed at the mRNA level (RT-PCR) as well as at the protein level (Western blot analysis)...
  41. Wang T, Hropot M, Aronson P, Giebisch G. Role of NHE isoforms in mediating bicarbonate reabsorption along the nephron. Am J Physiol Renal Physiol. 2001;281:F1117-22 pubmed
    This study assessed the functional role of Na(+)/H(+) exchanger (NHE) isoforms NHE3 and NHE2 in the proximal tubule, loop of Henle, and distal convoluted tubule of the rat kidney by comparing sensitivity of transport to inhibition by Hoe-..
  42. Thomson R, Wang T, Thomson B, Tarrats L, Girardi A, Mentone S, et al. Role of PDZK1 in membrane expression of renal brush border ion exchangers. Proc Natl Acad Sci U S A. 2005;102:13331-6 pubmed
    Na-H exchanger NHE3 and Cl-anion exchanger CFEX (SLC26A6, PAT1) play principal roles in the reabsorption of Na and Cl in the proximal tubule of the mammalian kidney...
  43. Pontes R, Crajoinas R, Nishi E, Oliveira Sales E, Girardi A, Campos R, et al. Renal nerve stimulation leads to the activation of the Na+/H+ exchanger isoform 3 via angiotensin II type I receptor. Am J Physiol Renal Physiol. 2015;308:F848-56 pubmed publisher
    ..reabsorption, we hypothesized that low-frequency acute electrical stimulation of the renal nerve (ESRN) activates NHE3-mediated sodium reabsorption via ANG II AT1 receptor activation in Wistar rats...
  44. Kiela P, Kuscuoglu N, Midura A, Midura Kiela M, Larmonier C, Lipko M, et al. Molecular mechanism of rat NHE3 gene promoter regulation by sodium butyrate. Am J Physiol Cell Physiol. 2007;293:C64-74 pubmed
    ..induction is Ser/Thr kinase dependent and that NaB-responsive elements were localized within -320/-34 bp of the rat NHE3 promoter. Here we further delineate the mechanism of NaB-mediated NHE3 gene transcription...
  45. Good D, George T, Watts B. High sodium intake increases HCO(3)- absorption in medullary thick ascending limb through adaptations in basolateral and apical Na+/H+ exchangers. Am J Physiol Renal Physiol. 2011;301:F334-43 pubmed publisher
    ..Here, we examined the role of the apical NHE3 and basolateral NHE1 Na(+)/H(+) exchangers in this adaptation. MTALs from rats drinking H(2)O or 0...
  46. Tsuganezawa H, Sato S, Yamaji Y, Preisig P, Moe O, Alpern R. Role of c-SRC and ERK in acid-induced activation of NHE3. Kidney Int. 2002;62:41-50 pubmed
    In the renal proximal tubule, chronic acidosis causes increases in apical membrane NHE3 activity, which serve to increase transepithelial H+ secretion and return systemic pH to normal levels...
  47. Coon S, Kekuda R, Saha P, Talukder J, Sundaram U. Constitutive nitric oxide differentially regulates Na-H and Na-glucose cotransport in intestinal epithelial cells. Am J Physiol Gastrointest Liver Physiol. 2008;294:G1369-75 pubmed publisher
    ..suggest that constitutive nitric oxide (cNO) can regulate Na- glucose cotransport (SGLT1) and Na-H exchange (NHE3) in rabbit intestinal villus cells...
  48. Wang Q, Zhou R, Zhang C, Dong H, Ma J, Wang G. Inhibition of central Na(+)/H(+) exchanger type 3 can alleviate sleep apnea in Sprague-Dawley rats. Chin Med J (Engl). 2014;127:48-53 pubmed
    Recent studies showed the central Na+/H+ exchanger type 3 (NHE3) has a close relationship with ventilation control. The objective of the study is to investigate the role of NHE3 in sleep apnea in Sprague-Dawley (SD) rats...
  49. Riazi S, Khan O, Tiwari S, Hu X, Ecelbarger C. Rosiglitazone regulates ENaC and Na-K-2Cl cotransporter (NKCC2) abundance in the obese Zucker rat. Am J Nephrol. 2006;26:245-57 pubmed
    ..protein abundances of the bumetanide-sensitive Na-K-2Cl cotransporter (NKCC2) and the sodium hydrogen exchanger (NHE3)...
  50. No Y, He P, Yoo B, Yun C. Unique regulation of human Na+/H+ exchanger 3 (NHE3) by Nedd4-2 ligase that differs from non-primate NHE3s. J Biol Chem. 2014;289:18360-72 pubmed publisher
    Na(+)/H(+) exchanger NHE3 expressed in the intestine and kidney plays a major role in NaCl and HCO3 (-) absorption that is closely linked to fluid absorption and blood pressure regulation...
  51. Zhou H, Yuen P, Pisitkun T, Gonzales P, Yasuda H, Dear J, et al. Collection, storage, preservation, and normalization of human urinary exosomes for biomarker discovery. Kidney Int. 2006;69:1471-6 pubmed
    ..These urine collection, storage, and processing conditions may be useful for future biomarker discovery efforts. ..
  52. Inoue H, Nakamura Y, Nagita M, Takai T, Masuda M, Nakamura N, et al. Calcineurin homologous protein isoform 2 (CHP2), Na+/H+ exchangers-binding protein, is expressed in intestinal epithelium. Biol Pharm Bull. 2003;26:148-55 pubmed
    ..These results suggest that CHP2 functions in the absorptive epithelium for the intestine with NHE(s). ..
  53. Ruete M, Carrizo L, Bocanegra M, Valles P. Altered renal expression of Na(+) transporters and ROMK in protein-deprived rats. Nephron Physiol. 2009;111:p17-29 pubmed publisher
    ..A role of aldosterone may be suggested. ..