Gene Symbol: Slc9a1
Description: solute carrier family 9 member A1
Alias: Nhe1, sodium/hydrogen exchanger 1, NHE-1, Na(+)/H(+) exchanger 1, Solute carrier family 9 (sodium/hydrogen exchanger 1), antiporter, Na+/H+, (amiloride sensitive), solute carrier family 9 (sodium/hydrogen exchanger), member 1, solute carrier family 9 member 1, solute carrier family 9, subfamily A (NHE1, cation proton antiporter 1), member 1
Species: rat
Products:     Slc9a1

Top Publications

  1. Cukiernik M, Hileeto D, Downey D, Evans T, Khan Z, Karmazyn M, et al. The role of the sodium hydrogen exchanger-1 in mediating diabetes-induced changes in the retina. Diabetes Metab Res Rev. 2004;20:61-71 pubmed
    ..The results of the study suggest that NHE-1 may be involved in the regulation of several vasoactive modulators that contribute to functional alterations in diabetic retinal microangiopathy. ..
  2. Darmellah A, Baetz D, Prunier F, Tamareille S, Rucker Martin C, Feuvray D. Enhanced activity of the myocardial Na+/H+ exchanger contributes to left ventricular hypertrophy in the Goto-Kakizaki rat model of type 2 diabetes: critical role of Akt. Diabetologia. 2007;50:1335-44 pubmed
    ..Because several studies have suggested that the Na(+)/H(+) exchanger (NHE1) plays a part in the molecular mechanisms involved in cardiac hypertrophy, we investigated its activity and its ..
  3. Yan W, Nehrke K, Choi J, Barber D. The Nck-interacting kinase (NIK) phosphorylates the Na+-H+ exchanger NHE1 and regulates NHE1 activation by platelet-derived growth factor. J Biol Chem. 2001;276:31349-56 pubmed
    ..We now show that NIK binds to and divergently activates the plasma membrane Na(+)-H(+) exchanger NHE1. In a genetic screen, NHE1 interacted with NIK at a site N-terminal (amino acids 407-502) to the Nck-binding domain,..
  4. Lawrence S, Holman G, Koumanov F. Translocation of the Na+/H+ exchanger 1 (NHE1) in cardiomyocyte responses to insulin and energy-status signalling. Biochem J. 2010;432:515-23 pubmed publisher
    The Na+/H+ exchanger NHE1 is a highly regulated membrane protein that is required for pH homoeostasis in cardiomyocytes...
  5. Karmazyn M, Liu Q, Gan X, Brix B, Fliegel L. Aldosterone increases NHE-1 expression and induces NHE-1-dependent hypertrophy in neonatal rat ventricular myocytes. Hypertension. 2003;42:1171-6 pubmed
    ..Our results therefore demonstrate a direct hypertrophic effect of aldosterone on cultured myocytes, which is dependent on NHE-1 activity. ..
  6. Shrode L, Gan B, D Souza S, Orlowski J, Grinstein S. Topological analysis of NHE1, the ubiquitous Na+/H+ exchanger using chymotryptic cleavage. Am J Physiol. 1998;275:C431-9 pubmed
    ..with antibodies to analyze the subcellular distribution and transmembrane disposition of the Na+/H+ exchanger NHE1. Both native human NHE1 in platelets and epitope-tagged rat NHE1 transfected into antiport-deficient cells were ..
  7. Castañeda Corral G, Rocha Gonzalez H, Araiza Saldana C, Vidal Cantú G, Miguel Jiménez Andrade J, Murbartián J, et al. Blockade of peripheral and spinal Na+/H+ exchanger increases formalin-induced long-lasting mechanical allodynia and hyperalgesia in rats. Brain Res. 2012;1475:19-30 pubmed publisher
    ..Since NHE1 regulates pH in neurons and astrocytes and it is expressed in nociceptive nerve fibers, it is likely that NHE may ..
  8. Leite Dellova D, Oliveira Souza M, Malnic G, Mello Aires M. Genomic and nongenomic dose-dependent biphasic effect of aldosterone on Na+/H+ exchanger in proximal S3 segment: role of cytosolic calcium. Am J Physiol Renal Physiol. 2008;295:F1342-52 pubmed publisher
    ..a genomic (1 h, via MR) and a nongenomic action (15 or 2 min, probably via GR) on [Ca2+]i and on the basolateral NHE1 and are compatible with stimulation of the NHE1 by increases in [Ca2+]i in the lower range (at 10(-12) M ..
  9. Sangan P, Rajendran V, Geibel J, Binder H. Cloning and expression of a chloride-dependent Na+-H+ exchanger. J Biol Chem. 2002;277:9668-75 pubmed
    ..Based on these results we predict that chloride-dependent Na(+)-H(+) exchange represents a new class of Na(+)-H(+) exchangers that may regulate ion transport in several organs. ..

More Information


  1. Young M, Funder J. Mineralocorticoid action and sodium-hydrogen exchange: studies in experimental cardiac fibrosis. Endocrinology. 2003;144:3848-51 pubmed
  2. Mukhin Y, Garnovskaya M, Ullian M, Raymond J. ERK is regulated by sodium-proton exchanger in rat aortic vascular smooth muscle cells. J Biol Chem. 2004;279:1845-52 pubmed
    ..These studies identify NHE as a new regulator of ERK activity in RASM cells. ..
  3. Good D, George T, Watts B. High sodium intake increases HCO(3)- absorption in medullary thick ascending limb through adaptations in basolateral and apical Na+/H+ exchangers. Am J Physiol Renal Physiol. 2011;301:F334-43 pubmed publisher
    ..Here, we examined the role of the apical NHE3 and basolateral NHE1 Na(+)/H(+) exchangers in this adaptation. MTALs from rats drinking H(2)O or 0...
  4. Lyall V, Alam R, Malik S, Phan T, Vinnikova A, Heck G, et al. Basolateral Na+-H+ exchanger-1 in rat taste receptor cells is involved in neural adaptation to acidic stimuli. J Physiol. 2004;556:159-73 pubmed
    ..While cAMP enhances TRC apical H(+) entry and CT responses to strong acid, an increase in Ca(2+) activates NHE-1, and increases neural adaptation to all acidic stimuli. ..
  5. Wang Y, Weiss M, Yin J, Frew R, Tenn C, Nelson P, et al. Role of the sodium hydrogen exchanger in maitotoxin-induced cell death in cultured rat cortical neurons. Toxicon. 2009;54:95-102 pubmed publisher
    ..Furthermore, knockdown of NHE1 by SiRNA transfection suppressed MTX-induced cell death in human embryonic kidney (HEK) cells...
  6. Wu D, Dai H, Arias J, Latta L, Abraham W. Low-volume resuscitation from traumatic hemorrhagic shock with Na+/H+ exchanger inhibitor. Crit Care Med. 2009;37:1994-9 pubmed publisher
    ..NHE-1 inhibition facilitated the hemodynamic response to fluid resuscitation, attenuated tissue inflammatory injury, and organ dysfunction, but most importantly improved survival. ..
  7. Gholami K, Muniandy S, Salleh N. Differential expression of Na+/H+-exchanger (NHE-1, 2, and 4) proteins and mRNA in rodent's uterus under sex steroid effect and at different phases of the oestrous cycle. Biomed Res Int. 2013;2013:840121 pubmed publisher
    ..NHE-4 is the main isoform upregulated by E. Differential expressions of uterine NHE isoforms 1, 2, and 4 could explain the observed changes in the uterine fluid pH under these conditions. ..
  8. Praetorius J, Andreasen D, Jensen B, Ainsworth M, Friis U, Johansen T. NHE1, NHE2, and NHE3 contribute to regulation of intracellular pH in murine duodenal epithelial cells. Am J Physiol Gastrointest Liver Physiol. 2000;278:G197-206 pubmed
    ..b>NHE1, NHE2, and NHE3 were expressed at the mRNA level (RT-PCR) as well as at the protein level (Western blot analysis)...
  9. Monazzami A, Rajabi H, Ghrakhanlou R, Yari K, Rahimi Z. Modulation of oxidative and glycolytic skeletal muscle fibers Na+/H+ exchanger1 (NHE1) and Na+/HCO3- co-transporter1 (NBC1) genes and proteins expression in type 2 diabetic rat (Streptozotocin + high fat diet) following long term endurance training. Cell Mol Biol (Noisy-le-grand). 2017;63:11-18 pubmed publisher
    ..The aim of present study was to investigate the effects of endurance training on muscle NHE1 and NBC1 genes and proteins expression in type 2 diabetic rats. Male wistar rats (n=30), 4 weeks old and 95.7±10...
  10. von Lewinski D, Stumme B, Fialka F, Luers C, Pieske B. Functional relevance of the stretch-dependent slow force response in failing human myocardium. Circ Res. 2004;94:1392-8 pubmed
    ..II type-1 (AT1) receptors (candesartan), endothelin (ET) receptors (PD145065 or BQ123), Na+/H+ exchange (NHE1; HOE642), or reverse-mode Na+/Ca+ exchange (NCX; KB-R7493)...
  11. Yao W, Lu J, Qian G, Yang X. [Effects of sodium hydrogen exchanger-1 hammerhead ribozyme on proliferation of pulmonary artery smooth muscle cells in rats in vitro]. Zhongguo Ying Yong Sheng Li Xue Za Zhi. 2003;19:39-42 pubmed
    ..NHE-1 hammerhead ribozyme can cleave the target RNA specifically, reduce the expression of NHE-1 mRNA, induce intracellular acidosis and consequently prohibit the proliferation of PASMCs. ..
  12. Jaballah M, Mohamed I, Alemrayat B, Al Sulaiti F, Mlih M, Mraiche F. Na+/H+ exchanger isoform 1 induced cardiomyocyte hypertrophy involves activation of p90 ribosomal s6 kinase. PLoS ONE. 2015;10:e0122230 pubmed publisher
    ..and genetic approaches have shown that increased activity/expression of the Na+/H+ exchanger isoform 1 (NHE1) play a critical role in the pathogenesis of cardiac hypertrophy...
  13. Nguyen H, Shull G, Melvin J. Muscarinic receptor-induced acidification in sublingual mucous acinar cells: loss of pH recovery in Na+-H+ exchanger-1 deficient mice. J Physiol. 2000;523 Pt 1:139-46 pubmed sublingual acinar cells, pH regulation was investigated in mice lacking Na+-H+ exchanger isoforms 1 and 2 (NHE1 and NHE2, respectively)...
  14. Vial G, Dubouchaud H, Couturier K, Lanson M, Leverve X, Demaison L. Na+/H+ exchange inhibition with cariporide prevents alterations of coronary endothelial function in streptozotocin-induced diabetes. Mol Cell Biochem. 2008;310:93-102 pubmed
    ..The present findings indicate that NHE-1 exchanger inhibition by cariporide protects the coronary endothelium against the deleterious effects of hyperglycemia. ..
  15. Shibata M, Takeshita D, Obata K, Mitsuyama S, Ito H, Zhang G, et al. NHE-1 participates in isoproterenol-induced downregulation of SERCA2a and development of cardiac remodeling in rat hearts. Am J Physiol Heart Circ Physiol. 2011;301:H2154-60 pubmed publisher
    ..Inhibition of NHE-1 ameliorates cardiac Ca(2+)-handling impairment and prevents the development of cardiac dysfunction in ISO-infused rats. ..
  16. Rocha González H, Castañeda Corral G, Araiza Saldaña C, Ambriz Tututi M, Caram Salas N, Torres López J, et al. Identification of the Na+/H+ exchanger 1 in dorsal root ganglion and spinal cord: its possible role in inflammatory nociception. Neuroscience. 2009;160:156-64 pubmed publisher
    mRNA and protein presence of Na+/H+ exchanger (NHE) 1 (NHE1) and 5 (NHE5) in dorsal root ganglion (DRG) and dorsal spinal cord as well as its possible role in three inflammatory nociception tests were determined...
  17. Inoue H, Nakamura Y, Nagita M, Takai T, Masuda M, Nakamura N, et al. Calcineurin homologous protein isoform 2 (CHP2), Na+/H+ exchangers-binding protein, is expressed in intestinal epithelium. Biol Pharm Bull. 2003;26:148-55 pubmed
    ..rCHP2 binds to the juxtamembrane region of plasma membrane-type NHE isoforms (NHE1-5) in vivo and in vitro as well as rCHP1 (original rat CHP)...
  18. Hileeto D, Cukiernik M, Mukherjee S, Evans T, Barbin Y, Downey D, et al. Contributions of endothelin-1 and sodium hydrogen exchanger-1 in the diabetic myocardium. Diabetes Metab Res Rev. 2002;18:386-94 pubmed
    ..These data suggest that NHE-1 may act as a downstream mediator in the production of ET-induced functional and structural changes in the myocardium in diabetes. ..
  19. Huc L, Tekpli X, Holme J, Rissel M, Solhaug A, Gardyn C, et al. c-Jun NH2-terminal kinase-related Na+/H+ exchanger isoform 1 activation controls hexokinase II expression in benzo(a)pyrene-induced apoptosis. Cancer Res. 2007;67:1696-705 pubmed
    ..Although the involvement of the ubiquitous pH(i) regulator Na(+)/H(+) exchanger isoform 1 (NHE1) in tumorigenesis is well documented, less is known about its role and regulation during apoptosis...
  20. Park S, Lee D, Yoo S, Jung Y. The effect of Na(+)/H(+) exchanger-1 inhibition by sabiporide on blood-brain barrier dysfunction after ischemia/hypoxia in vivo and in vitro. Brain Res. 2010;1366:189-96 pubmed publisher
    ..These results suggest that the BBB protective effect of sabiporide may be of therapeutical benefit in brain injury after an ischemic stroke. ..
  21. Willoughby D, Masada N, Crossthwaite A, Ciruela A, Cooper D. Localized Na+/H+ exchanger 1 expression protects Ca2+-regulated adenylyl cyclases from changes in intracellular pH. J Biol Chem. 2005;280:30864-72 pubmed
    ..However, we have found that the Na+/H+ exchanger (NHE), NHE1, is functionally active in these cells, and like AC8 (and AC6) it resides in lipid rafts or caveolae, which may ..
  22. Cengiz P, Kleman N, Uluc K, Kendigelen P, Hagemann T, Akture E, et al. Inhibition of Na+/H+ exchanger isoform 1 is neuroprotective in neonatal hypoxic ischemic brain injury. Antioxid Redox Signal. 2011;14:1803-13 pubmed publisher
    ..These findings suggest that NHE-1-mediated disruption of ionic homeostasis contributes to striatal and CA1 pyramidal neuronal injury after neonatal HI. ..
  23. Paehler Vor der Nolte A, Chodisetti G, Yuan Z, Busch F, Riederer B, Luo M, et al. Na+ /H+ exchanger NHE1 and NHE2 have opposite effects on migration velocity in rat gastric surface cells. J Cell Physiol. 2017;232:1669-1680 pubmed publisher
    ..The role of the basolaterally expressed NHE1 (Slc9a1) and the presumably apically expressed NHE2 (Slc9a2) in epithelial restitution was investigated in the ..
  24. Liu C, Somps C. Na+/H+ exchanger-1 inhibitors reduce neuronal excitability and alter na+ channel inactivation properties in rat primary sensory neurons. Toxicol Sci. 2008;103:346-53 pubmed publisher
    ..Such effects may underlie peripheral neuropathies reported in rats and dogs with NHE-1 inhibitors. ..
  25. Tran P, Tran T, Park J, Lee B. Controlled release systems containing solid dispersions: strategies and mechanisms. Pharm Res. 2011;28:2353-78 pubmed publisher
  26. Nishioka R, Sugimoto K, Aono H, Mise A, Choudhury M, Miyanishi K, et al. Treadmill exercise ameliorates ischemia-induced brain edema while suppressing Na⁺/H⁺ exchanger 1 expression. Exp Neurol. 2016;277:150-161 pubmed publisher
    ..01). Microglia and NG2 glia expressed NHE1 in the peri-ischemic region of rat brains and also in mixed glial cultures...
  27. Kersh A, Hartzler L, Havlin K, Hubbell B, Nanagas V, Kalra A, et al. pH regulating transporters in neurons from various chemosensitive brainstem regions in neonatal rats. Am J Physiol Regul Integr Comp Physiol. 2009;297:R1409-20 pubmed publisher
    ..Thus, pH(i) recovery is mediated by different pH-regulating transporters in neurons from different chemosensitive regions, but recovery is suppressed by hypercapnia in all of the neurons. ..
  28. Lam T, Wise P, O Donnell M. Cerebral microvascular endothelial cell Na/H exchange: evidence for the presence of NHE1 and NHE2 isoforms and regulation by arginine vasopressin. Am J Physiol Cell Physiol. 2009;297:C278-89 pubmed publisher
    ..CMEC) and immunoelectron microscopy of perfusion-fixed rat brain revealed that Na/H exchanger isoforms 1 and 2 (NHE1 and NHE2) are present in BBB endothelial cells...
  29. Mandal A, Shahidullah M, Delamere N, Terán M. Elevated hydrostatic pressure activates sodium/hydrogen exchanger-1 in rat optic nerve head astrocytes. Am J Physiol Cell Physiol. 2009;297:C111-20 pubmed publisher
    ..The MEK/ERK inhibitor U0126 abolished phosphorylation of NHE1 and p90(RSK) as well as ERK1/2...
  30. Darmellah A, Rucker Martin C, Feuvray D. ERM proteins mediate the effects of Na+/H+ exchanger (NHE1) activation in cardiac myocytes. Cardiovasc Res. 2009;81:294-300 pubmed publisher
    ..and the role of these proteins in mediating the downstream effects of the cardiac sarcolemmal Na+/H+ exchanger (NHE1) activation in response to cell acidification...
  31. Mandal A, Delamere N, Shahidullah M. Ouabain-induced stimulation of sodium-hydrogen exchange in rat optic nerve astrocytes. Am J Physiol Cell Physiol. 2008;295:C100-10 pubmed publisher
    ..Western blot analysis showed an NHE1 immunoreactive band but not NHE2, NHE3, or NHE4...
  32. Nakamura T, Iwata Y, Arai Y, Komamura K, Wakabayashi S. Activation of Na+/H+ exchanger 1 is sufficient to generate Ca2+ signals that induce cardiac hypertrophy and heart failure. Circ Res. 2008;103:891-9 pubmed publisher
    ..However, whether NHE1 activation alone is sufficient to induce such remodeling remains unknown...
  33. Javadov S, Rajapurohitam V, Kilic A, Hunter J, Zeidan A, Said Faruq N, et al. Expression of mitochondrial fusion-fission proteins during post-infarction remodeling: the effect of NHE-1 inhibition. Basic Res Cardiol. 2011;106:99-109 pubmed publisher
    ..Our study provides the first evidence linking cardiac hypertrophy with MFF proteins expression that was affected by NHE-1 inhibition, thus suggesting that MFF proteins might be a target for pharmacotherapy with anti-hypertrophic drugs. ..
  34. Feger B, Starnes J. Myocardial Na+/H+ exchanger-1 (NHE1) content is decreased by exercise training. J Physiol Biochem. 2013;69:305-12 pubmed publisher
    The effect of exercise training on myocardial Na(+)/H(+) exchanger-1 (NHE1) protein expression was examined. Adult female Sprague-Dawley rats were randomly divided into sedentary (S; n = 8) and exercised (E; n = 9) groups...
  35. Yamamoto S, Matsumoto Y, Suzuki Y, Tsuboi T, Terakawa S, Ohashi N, et al. An Na+/H+ exchanger inhibitor suppresses cellular swelling and neuronal death induced by glutamate in cultured cortical neurons. Acta Neurochir Suppl. 2003;86:223-6 pubmed
    ..SM-20220, a Na+/H+ exchanger inhibitor, suppressed neuronal death and cellular swelling induced by glutamate through inhibition of both Ca2+ influx and acidification in neurons. ..
  36. Serafino A, Moroni N, Psaila R, Zonfrillo M, Andreola F, Wannenes F, et al. Anti-proliferative effect of atrial natriuretic peptide on colorectal cancer cells: evidence for an Akt-mediated cross-talk between NHE-1 activity and Wnt/?-catenin signaling. Biochim Biophys Acta. 2012;1822:1004-18 pubmed publisher
    ..This provides evidence for a cross-talk between the intracellular alkalinization and the Wnt signaling in tumor cells. ..
  37. Mraiche F, Oka T, Gan X, Karmazyn M, Fliegel L. Activated NHE1 is required to induce early cardiac hypertrophy in mice. Basic Res Cardiol. 2011;106:603-16 pubmed publisher
    The Na+/H+ exchanger isoform 1 (NHE1) has been implicated as being causal in cardiac hypertrophy and the protein level and activity are elevated in the diseased myocardium...
  38. Jinadasa T, Josephson C, Boucher A, Orlowski J. Determinants of Cation Permeation and Drug Sensitivity in Predicted Transmembrane Helix 9 and Adjoining Exofacial Re-entrant Loop 5 of Na+/H+ Exchanger NHE1. J Biol Chem. 2015;290:18173-86 pubmed publisher
    ..Molecular manipulations of the prototypical NHE1 isoform have implicated several predicted membrane-spanning (M) helices, most notably M4, M9, and M11, as important ..
  39. Zaun H, Shrier A, Orlowski J. Calcineurin B homologous protein 3 promotes the biosynthetic maturation, cell surface stability, and optimal transport of the Na+/H+ exchanger NHE1 isoform. J Biol Chem. 2008;283:12456-67 pubmed publisher
    ..Recently another CHP-related protein, termed tescalcin or CHP3, was also shown to interact with the ubiquitous NHE1 isoform, but seemingly suppressed its activity...
  40. Wu S, Song T, Zhou S, Liu Y, Chen G, Huang N, et al. Involvement of Na+/H+ exchanger 1 in advanced glycation end products-induced proliferation of vascular smooth muscle cell. Biochem Biophys Res Commun. 2008;375:384-9 pubmed publisher
    In this present study, we examined the role of Na(+)/H(+) exchanger 1 (NHE1) in the cultured rat vascular smooth muscle cell (VSMC) proliferation induced by advanced glycation end products (AGEs)...
  41. Watts B, George T, Good D. The basolateral NHE1 Na+/H+ exchanger regulates transepithelial HCO3- absorption through actin cytoskeleton remodeling in renal thick ascending limb. J Biol Chem. 2005;280:11439-47 pubmed
    In the renal medullary thick ascending limb (MTAL), inhibiting the basolateral NHE1 Na(+)/H(+) exchanger with amiloride or nerve growth factor (NGF) results secondarily in inhibition of the apical NHE3 Na(+)/H(+) exchanger, thereby ..
  42. Carraro Lacroix L, Ramirez M, Zorn T, Reboucas N, Malnic G. Increased NHE1 expression is associated with serum deprivation-induced differentiation in immortalized rat proximal tubule cells. Am J Physiol Renal Physiol. 2006;291:F129-39 pubmed
    ..the fluorescent probe BCECF, we demonstrated that the IRPTC express both Na+/H+ exchanger and H+-ATPase, but only NHE1 is modulated by serum deprivation. In these cells, 24 h of serum starvation increased pHi from 7.08+/-0...
  43. Karki P, Fliegel L. Overexpression of the NHE1 isoform of the Na(+)/H (+) exchanger causes elevated apoptosis in isolated cardiomyocytes after hypoxia/reoxygenation challenge. Mol Cell Biochem. 2010;338:47-57 pubmed publisher
    The mammalian Na(+)/H(+) exchanger isoform 1 (NHE1) is a ubiquitously expressed membrane protein that regulates intracellular pH in the myocardium and other tissues...
  44. Lin M, Huang X, Tan J, Wang B. [Adenosine alleviates hypoxia-induced rat right ventricular hypertrophy through the NHE-1/CaN signal pathway]. Nan Fang Yi Ke Da Xue Xue Bao. 2012;32:734-7 pubmed
    ..001). Adenosine and its agonist can inhibit hypoxia-induced RVH in rats through the NHE-1/CaN signal pathway. ..
  45. Matsushita M, Tanaka H, Mitsui K, Kanazawa H. Dual functional significance of calcineurin homologous protein 1 binding to Na(+)/H(+) exchanger isoform 1. Am J Physiol Cell Physiol. 2011;301:C280-8 pubmed publisher
    Calcineurin homologous protein 1 (CHP1) binds to the hydrophilic tail of the Na(+)/H(+) exchanger isoform 1 (NHE1)...
  46. Siyanov V, Baltz J. NHE1 is the sodium-hydrogen exchanger active in acute intracellular pH regulation in preimplantation mouse embryos. Biol Reprod. 2013;88:157 pubmed publisher
    ..Of five plasma membrane NHE isoforms, mouse oocytes and preimplantation embryos express mRNAs encoding NHE1 (SLC9A1), NHE3 (SLC9A3), and NHE4 (SLC9A4), with higher mRNA levels for each in oocytes through one-cell stage embryos and ..
  47. Lin X, Li M, Zhou R, Yu H, Zhou L, Li Q, et al. [Cariporide pretreatment attenuated warm ischemia/reperfusion injury in an isolated rat lung: a study on antioxidative mechanism]. Sheng Wu Yi Xue Gong Cheng Xue Za Zhi. 2010;27:132-7 pubmed
    ..peroxidation induced by WI/IR may be: preventing Ca2+ overload via inhibiting the transport of Na+/H2 exchanger-1 (NHE1) in the context of the coupled exchanger, thereby reducing the activation of xanthine oxidase pathway and oxygen ..
  48. Walker J, Undem C, Yun X, Lade J, Jiang H, Shimoda L. Role of Rho kinase and Na+/H+ exchange in hypoxia-induced pulmonary arterial smooth muscle cell proliferation and migration. Physiol Rep. 2016;4: pubmed publisher
    ..We previously demonstrated thatNHEisoform 1 (NHE1) is the predominant isoform expressed inPASMCs...
  49. Lamoureux L, Radhakrishnan J, Mason T, Kraut J, Gazmuri R. Adverse postresuscitation myocardial effects elicited by buffer-induced alkalemia ameliorated by NHE-1 inhibition in a rat model of ventricular fibrillation. J Appl Physiol (1985). 2016;121:1160-1168 pubmed publisher
    ..Zoniporide attenuated these effects and uncovered a complex postresuscitation acid-base physiology whereby blood pH drives NHE-1 activity and compromises mitochondrial function and integrity along with myocardial function and survival. ..
  50. Rutherford P, Pizzonia J, Biemesderfer D, Abu Alfa A, Reilly R, Aronson P. Expression of Na(+)-H+ exchanger isoforms NHE1 and NHE3 in kidney and blood cells of rabbit and rat. Exp Nephrol. 1997;5:490-7 pubmed
    ..We generated isoform-specific antibodies to compare the expression of NHE1 and NHE3 in peripheral blood cell membranes and renal cortical membrane vesicles...
  51. Fujiwara Y, Higuchi K, Takashima T, Hamaguchi M, Hayakawa T, Tominaga K, et al. Roles of epidermal growth factor and Na+/H+ exchanger-1 in esophageal epithelial defense against acid-induced injury. Am J Physiol Gastrointest Liver Physiol. 2006;290:G665-73 pubmed
    ..Deficiency in endogenous EGF is associated with increased severity of esophagitis. EGF and NHE-1 play crucial roles in esophageal epithelial defense against acid. ..
  52. Orlowski J, Kandasamy R, Shull G. Molecular cloning of putative members of the Na/H exchanger gene family. cDNA cloning, deduced amino acid sequence, and mRNA tissue expression of the rat Na/H exchanger NHE-1 and two structurally related proteins. J Biol Chem. 1992;267:9331-9 pubmed
    ..These data suggest that the molecular basis for the functional diversity of the Na/H exchanger in mammals is based, at least in part, on expression of multiple members of a gene family. ..
  53. Li X, Karki P, Lei L, Wang H, Fliegel L. Na+/H+ exchanger isoform 1 facilitates cardiomyocyte embryonic stem cell differentiation. Am J Physiol Heart Circ Physiol. 2009;296:H159-70 pubmed publisher
    ..improving cardiomyocyte development from stem cells, we examined the role of the Na(+)/H(+) exchanger isoform 1 (NHE1) in cardiomyocyte differentiation...