Slc6a4

Summary

Gene Symbol: Slc6a4
Description: solute carrier family 6 member 4
Alias: SERT, sodium-dependent serotonin transporter, 5HT transporter, 5HTT, Solute carrier family 6 (neurotransmitter transporter serotonin) member 4 (5-hydroxytryptamine (serotonin) transporter), serotonin transporter, solute carrier family 6 (neurotransmitter transporter serotonin) member 4 (5-hydroxytryptamine (serotonin) transporter), solute carrier family 6 (neurotransmitter transporter), member 4, solute carrier family 6 (neurotransmitter transporter, serotonin), member 4
Species: rat
Products:     Slc6a4

Top Publications

  1. Hoffman B, Mezey E, Brownstein M. Cloning of a serotonin transporter affected by antidepressants. Science. 1991;254:579-80 pubmed
    ..The 5HT transporter has significant homology to the gamma-aminobutyric acid, dopamine, and norepinephrine transporters...
  2. Brenner B, Harney J, Ahmed B, Jeffus B, Unal R, Mehta J, et al. Plasma serotonin levels and the platelet serotonin transporter. J Neurochem. 2007;102:206-15 pubmed
    ..The actions of 5HT are mediated by different types of receptors and terminated by a single 5HT transporter (SERT)...
  3. Chanrion B, Mannoury la Cour C, Bertaso F, Lerner Natoli M, Freissmuth M, Millan M, et al. Physical interaction between the serotonin transporter and neuronal nitric oxide synthase underlies reciprocal modulation of their activity. Proc Natl Acad Sci U S A. 2007;104:8119-24 pubmed
    ..Using a proteomic approach, we identified several proteins that interact with the C terminus of the serotonin transporter (SERT)...
  4. Ramamoorthy S, Samuvel D, Buck E, Rudnick G, Jayanthi L. Phosphorylation of threonine residue 276 is required for acute regulation of serotonin transporter by cyclic GMP. J Biol Chem. 2007;282:11639-47 pubmed
    Cellular protein kinases, phosphatases, and other serotonin transporter (SERT) interacting proteins participate in several signaling mechanisms regulating SERT activity...
  5. Magnani F, Tate C, Wynne S, Williams C, Haase J. Partitioning of the serotonin transporter into lipid microdomains modulates transport of serotonin. J Biol Chem. 2004;279:38770-8 pubmed
    The serotonin transporter (SERT) is an integral membrane protein responsible for the clearance of serotonin from the synaptic cleft following the release of the neurotransmitter...
  6. Ozaki N, Goldman D, Kaye W, Plotnicov K, Greenberg B, Lappalainen J, et al. Serotonin transporter missense mutation associated with a complex neuropsychiatric phenotype. Mol Psychiatry. 2003;8:933-6 pubmed
    Two common serotonin transporter (SERT) untranslated region gene variants have been intensively studied, but remain inconclusively linked to depression and other neuropsychiatric disorders...
  7. Blakely R, Berson H, Fremeau R, Caron M, Peek M, Prince H, et al. Cloning and expression of a functional serotonin transporter from rat brain. Nature. 1991;354:66-70 pubmed
    ..3-kilobase brainstem complementary DNA clone is sufficient to confer expression of a Na(+)-dependent 5HT transporter upon nonneural cells, with transport selectively and potently antagonized by 5HT uptake-specific ..
  8. Qian Y, Galli A, Ramamoorthy S, Risso S, DeFelice L, Blakely R. Protein kinase C activation regulates human serotonin transporters in HEK-293 cells via altered cell surface expression. J Neurosci. 1997;17:45-57 pubmed
    ..To explore protein kinase C-mediated SERT regulation, we generated a stable human SERT (hSERT)-expressing cell line (293-hSERT) and evaluated modulation of 5-..
  9. Bengel D, Murphy D, Andrews A, Wichems C, Feltner D, Heils A, et al. Altered brain serotonin homeostasis and locomotor insensitivity to 3, 4-methylenedioxymethamphetamine ("Ecstasy") in serotonin transporter-deficient mice. Mol Pharmacol. 1998;53:649-55 pubmed
    ..Together, these data suggest that the presence of a functional 5-HTT is essential for brain 5-HT homeostasis and for 3,4-methylenedioxymethamphetamine-induced hyperactivity. ..

More Information

Publications62

  1. Ozaslan D, Wang S, Ahmed B, Kocabas A, McCastlain J, Bene A, et al. Glycosyl modification facilitates homo- and hetero-oligomerization of the serotonin transporter. A specific role for sialic acid residues. J Biol Chem. 2003;278:43991-4000 pubmed
    The serotonin transporter (SERT) is an oligomeric glycoprotein with two sialic acid residues on each of two complex oligosaccharide molecules...
  2. Ahmed B, Jeffus B, Bukhari S, Harney J, Unal R, Lupashin V, et al. Serotonin transamidates Rab4 and facilitates its binding to the C terminus of serotonin transporter. J Biol Chem. 2008;283:9388-98 pubmed publisher
    The serotonin transporter (SERT) on the plasma membrane is the major mechanism for the clearance of plasma serotonin (5-hydroxytryptamine (5HT)). The uptake rates of cells depend on the density of SERT molecules on the plasma membrane...
  3. Zhang Y, Rudnick G. The cytoplasmic substrate permeation pathway of serotonin transporter. J Biol Chem. 2006;281:36213-20 pubmed
    b>Serotonin transporter (SERT) catalyzes reuptake of the neurotransmitter serotonin (5-HT) and is a target for antidepressant drugs and psychostimulants. It is a member of a large family of neurotransmitter and amino acid transporters...
  4. Müller H, Wiborg O, Haase J. Subcellular redistribution of the serotonin transporter by secretory carrier membrane protein 2. J Biol Chem. 2006;281:28901-9 pubmed
    The serotonin transporter (SERT) belongs to the SLC6 family of sodium- and chloride-dependent neurotransmitter transporters responsible for uptake of amino acids and biogenic amines from extracellular spaces...
  5. Haase J, Killian A, Magnani F, Williams C. Regulation of the serotonin transporter by interacting proteins. Biochem Soc Trans. 2001;29:722-8 pubmed
    The serotonin transporter (SERT) plays a critical role in the maintenance of normal neurotransmission by serotonin [5-hydroxytryptamine (5-HT)]...
  6. Mochizuki H, Amano T, Seki T, Matsubayashi H, Mitsuhata C, Morita K, et al. Role of C-terminal region in the functional regulation of rat serotonin transporter (SERT). Neurochem Int. 2005;46:93-105 pubmed
    Previously, we revealed that the state of the actin cytoskeleton affects the uptake activity of the serotonin transporter (SERT)...
  7. Samuvel D, Jayanthi L, Bhat N, Ramamoorthy S. A role for p38 mitogen-activated protein kinase in the regulation of the serotonin transporter: evidence for distinct cellular mechanisms involved in transporter surface expression. J Neurosci. 2005;25:29-41 pubmed
    The serotonin transporter (SERT) is regulated by various signaling mechanisms that may operate to maintain appropriate levels of synaptic serotonin (5-HT)...
  8. Quick M. Regulating the conducting states of a mammalian serotonin transporter. Neuron. 2003;40:537-49 pubmed
    ..The present data show that the SNARE protein syntaxin 1A binds the N-terminal tail of SERT, and this interaction regulates two SERT-conducting states...
  9. Mujakovic S, Ter Linde J, de Wit N, Van Marrewijk C, Fransen G, Onland Moret N, et al. Serotonin receptor 3A polymorphism c.-42C > T is associated with severe dyspepsia. BMC Med Genet. 2011;12:140 pubmed publisher
    ..A functional polymorphism in the serotonin transporter (5-HTT), which terminates serotonergic signalling, was also found associated with these psychiatric ..
  10. Owashi T, Iritani S, Niizato K, Ikeda K, Kamijima K. The distribution of serotonin transporter immunoreactivity in hippocampal formation in monkeys and rats. Brain Res. 2004;1010:166-8 pubmed
    To elucidate the anatomical distribution of the serotonergic neurotransmitter system, we identified serotonin transporter (5-HTT) in the hippocampus of rats and monkeys by immunohistochemistry...
  11. Wixey J, Reinebrant H, Buller K. Evidence that the serotonin transporter does not shift into the cytosol of remaining neurons after neonatal brain injury. Neurosci Res. 2012;73:252-6 pubmed publisher
    ..The regulation of brain 5-HT is dependent on the serotonin transporter (SERT) localised at the neuronal pre-synaptic cell membrane...
  12. Chan J, Snoeren E, Cuppen E, Waldinger M, Olivier B, Oosting R. The serotonin transporter plays an important role in male sexual behavior: a study in serotonin transporter knockout rats. J Sex Med. 2011;8:97-108 pubmed publisher
    Serotonin (5-HT) is an important neurotransmitter for sexual behaviors. Heterozygous (+/-) serotonin transporter (SERT) rats and SERT knockout rats (-/-) have serotonergic disturbances with significant elevations of basal extracellular 5-..
  13. Wang J, Oya S, Parhi A, Lieberman B, Ploessl K, Hou C, et al. In vivo studies of the SERT-selective [18F]FPBM and VMAT2-selective [18F]AV-133 radiotracers in a rat model of Parkinson's disease. Nucl Med Biol. 2010;37:479-86 pubmed publisher
    ..2-(2'-((dimethylamino)methyl)-4'-(3-[(18)F]-fluoropropoxy)phenylthio)benzenamine], a selective serotonin transporter (SERT) tracer, and [(18)F]AV-133 [(+)-2-Hydroxy-3-isobutyl-9-(3-fluoropropoxy)-10-methoxy-1,2,3,4,6,7-..
  14. Ren W, Watts S, Fanburg B. Serotonin transporter interacts with the PDGF? receptor in PDGF-BB-induced signaling and mitogenesis in pulmonary artery smooth muscle cells. Am J Physiol Lung Cell Mol Physiol. 2011;300:L486-97 pubmed publisher
    The serotonin transporter (SERT) and the platelet-derived growth factor receptor (PDGFR) have been implicated in both clinical and experimental pulmonary hypertension (PH) and the facilitation of pulmonary artery smooth muscle cell (..
  15. Molteni R, Cattaneo A, Calabrese F, Macchi F, Olivier J, Racagni G, et al. Reduced function of the serotonin transporter is associated with decreased expression of BDNF in rodents as well as in humans. Neurobiol Dis. 2010;37:747-55 pubmed publisher
    ..identify the molecular mechanisms that may contribute to the enhanced susceptibility to depression under serotonin transporter (SERT) dysfunction, we analyzed the expression of brain-derived neurotrophic factor (BDNF), a key player ..
  16. Lauzurica N, García García L, Pinto S, Fuentes J, Delgado M. Changes in NPY and POMC, but not serotonin transporter, following a restricted feeding/repletion protocol in rats. Brain Res. 2010;1313:103-12 pubmed publisher
    ..5-HT) plays a key role in controlling food intake and feeding behaviour and drugs targeting the 5-HT transporter (SERT) at the synaptic cleft have been used to treat feeding related disorders...
  17. Hofmann A, Friedmacher F, Hunziker M, Takahashi H, Duess J, Gosemann J, et al. Upregulation of serotonin-receptor-2a and serotonin transporter expression in the pulmonary vasculature of nitrofen-induced congenital diaphragmatic hernia. J Pediatr Surg. 2014;49:871-4; discussion 874-5 pubmed publisher
    ..vessels via Serotonin receptor 2A (5-HT2A) and induces pulmonary smooth muscle cell proliferation via the serotonin transporter (5-HTT)...
  18. O Reilly K, Trent S, Bailey S, Lane M. 13-cis-Retinoic acid alters intracellular serotonin, increases 5-HT1A receptor, and serotonin reuptake transporter levels in vitro. Exp Biol Med (Maywood). 2007;232:1195-203 pubmed
    ..serotonin (5-hydroxytryptamine, 5-HT) and expresses the 5-HT(1A) receptor and the serotonin reuptake transporter (SERT). Cells were treated with 0, 2...
  19. Homberg J, de Boer S, Raasø H, Olivier J, Verheul M, Ronken E, et al. Adaptations in pre- and postsynaptic 5-HT1A receptor function and cocaine supersensitivity in serotonin transporter knockout rats. Psychopharmacology (Berl). 2008;200:367-80 pubmed publisher
    ..To study the rewarding and motivational properties of cocaine in the serotonin transporter knockout (SERT-/-) rat and the involvement of compensatory changes in 5-HT1A receptor function are the ..
  20. Linder A, DAVIS R, Burnett R, Watts S. Comparison of the function of the serotonin transporter in the vasculature of male and female rats. Clin Exp Pharmacol Physiol. 2011;38:314-22 pubmed publisher
    1. The serotonin transporter (SERT) handles serotonin (5-hydroxytryptamine (5-HT)) and is blocked by the antidepressant SERT inhibitors fluoxetine and fluvoxamine...
  21. Ylmaz M, Bayazit Y, Ciftci T, Erdal M, Urhan M, Kokturk O, et al. Association of serotonin transporter gene polymorphism with obstructive sleep apnea syndrome. Laryngoscope. 2005;115:832-6 pubmed
    ..The synaptic 5-hydroxytryptamine (HT) is inactivated by presynaptic reuptake, which is mediated by the serotonin transporter. Blockage of the serotonin transporter leads to increased extracellular 5-HT...
  22. Abe K, Shimada R, Okada Y, Kibayashi K. Traumatic brain injury decreases serotonin transporter expression in the rat cerebrum. Neurol Res. 2016;38:358-63 pubmed publisher
    An association has been postulated between traumatic brain injury (TBI) and depression. The serotonin transporter (SERT) regulates the concentration of serotonin in the synaptic cleft and represents a molecular target for antidepressants...
  23. Cao H, Gu H, Qiu W, Zuo W, Zheng L, Wang Z, et al. Association study of serotonin transporter gene polymorphisms and ventricular septal defects related possible pulmonary arterial hypertension in Chinese population. Clin Exp Hypertens. 2009;31:605-14 pubmed publisher
    Polymorphisms of serotonin transporter (5-HTT) gene were hypothesized to be associated with ventricular septal defects (VSD) related ultrasonographic pulmonary arterial hypertension (PAH) susceptibility...
  24. Linder A, Beggs K, Burnett R, Watts S. Body distribution of infused serotonin in rats. Clin Exp Pharmacol Physiol. 2009;36:599-601 pubmed publisher
    ..5-HT) in rats infused with 5-HT (25 microg/kg per min) for 7 days and the contribution of the 5-HT transporter (SERT) for 5-HT uptake into the tissues. 2...
  25. Homberg J, Pattij T, Janssen M, Ronken E, de Boer S, Schoffelmeer A, et al. Serotonin transporter deficiency in rats improves inhibitory control but not behavioural flexibility. Eur J Neurosci. 2007;26:2066-73 pubmed
    ..In the present study we addressed the effect of lifelong reduced or absent serotonin transporter (SERT) function, which is associated with constitutively increased extracellular 5-HT levels, on ..
  26. Eddahibi S, Adnot S, Frisdal E, Levame M, Hamon M, Raffestin B. Dexfenfluramine-associated changes in 5-hydroxytryptamine transporter expression and development of hypoxic pulmonary hypertension in rats. J Pharmacol Exp Ther. 2001;297:148-54 pubmed
    ..01) than in rats pretreated with the vehicle. These data show that, in rats, the increased 5-HTT expression that follows dexfenfluramine discontinuation promotes the development of hypoxic pulmonary hypertension...
  27. Villa E, Albano C, Cappelli A, Favale E, Fugassa E, Gerdoni E, et al. Is the platelet serotonin transporter different in venous vs. arterial blood?. Neurochem Res. 2005;30:1365-7 pubmed
    The binding of labelled paroxetine to the serotonin transporter (SERT) of platelet membranes has been studied in both venous and mixed venous/arterial blood of the rat...
  28. Ahmed B, Bukhari I, Jeffus B, Harney J, Thyparambil S, Ziu E, et al. The cellular distribution of serotonin transporter is impeded on serotonin-altered vimentin network. PLoS ONE. 2009;4:e4730 pubmed publisher
    The C-terminus of the serotonin transporter (SERT) contains binding domains for different proteins and is critical for its functional expression...
  29. Bijlsma E, Hendriksen H, Baas J, Millan M, Groenink L. Lifelong disturbance of serotonin transporter functioning results in fear learning deficits: Reversal by blockade of CRF1 receptors. Eur Neuropsychopharmacol. 2015;25:1733-43 pubmed publisher
    ..e. fear learning) may lead to maladaptive anxiety. To further study the role of the serotonin transporter (SERT) in fear learning, classical fear conditioning was studied in SERT knockout rats (SERT(-/-)) using ..
  30. Nonkes L, Tomson K, Maertin A, Dederen J, Maes J, Homberg J. Orbitofrontal cortex and amygdalar over-activity is associated with an inability to use the value of expected outcomes to guide behaviour in serotonin transporter knockout rats. Neurobiol Learn Mem. 2010;94:65-72 pubmed publisher
    ..5-HT levels are tightly controlled by the serotonin transporter (5-HTT). We and others have observed that 5-HTT availability affects reversal learning...
  31. Ishii T, Wakabayashi R, Kurosaki H, Gemma A, Kida K. Association of serotonin transporter gene variation with smoking, chronic obstructive pulmonary disease, and its depressive symptoms. J Hum Genet. 2011;56:41-6 pubmed publisher
    A serotonin transporter gene, SLC6A4, is thought to be related to nicotine dependence and depression, one of the comorbidities of chronic obstructive pulmonary disease (COPD)...
  32. van der Doelen R, Robroch B, Arnoldussen I, Schulpen M, Homberg J, Kozicz T. Serotonin and urocortin 1 in the dorsal raphe and Edinger-Westphal nuclei after early life stress in serotonin transporter knockout rats. Neuroscience. 2017;340:345-358 pubmed publisher
    The interaction of early life stress (ELS) and the serotonin transporter (5-HTT) gene-linked polymorphic region (5-HTTLPR) has been associated with increased risk to develop depression in later life...
  33. Schipper P, Lopresto D, Reintjes R, Joosten J, Henckens M, Kozicz T, et al. Improved Stress Control in Serotonin Transporter Knockout Rats: Involvement of the Prefrontal Cortex and Dorsal Raphe Nucleus. ACS Chem Neurosci. 2015;6:1143-50 pubmed publisher
    Variations in serotonin transporter (5-HTT) expression have been associated with altered sensitivity to stress...
  34. Ngai Y, Sulistyoningrum D, O Neill R, Innis S, Weinberg J, Devlin A. Prenatal alcohol exposure alters methyl metabolism and programs serotonin transporter and glucocorticoid receptor expression in brain. Am J Physiol Regul Integr Comp Physiol. 2015;309:R613-22 pubmed publisher
    ..metabolism (including Mtr, Mat2a, Mthfr, and Cbs mRNA) and programming of HPA function genes (Nr3c1, Nr3c2, and Slc6a4) in offspring from ethanol-fed (E), pair-fed (PF), and ad libitum-fed control (C) dams...
  35. Shih J, Ma K, Chen C, Cheng C, Pao L, Weng S, et al. Evaluation of brain SERT occupancy by resveratrol against MDMA-induced neurobiological and behavioral changes in rats: A 4-[¹⁸F]-ADAM/small-animal PET study. Eur Neuropsychopharmacol. 2016;26:92-104 pubmed publisher
    ..long-term serotonergic neurotoxicity, which is associated with reduced density of cerebral serotonin transporters (SERT) and depressive disorders...
  36. Ramamoorthy S, Bauman A, Moore K, Han H, Yang Feng T, Chang A, et al. Antidepressant- and cocaine-sensitive human serotonin transporter: molecular cloning, expression, and chromosomal localization. Proc Natl Acad Sci U S A. 1993;90:2542-6 pubmed
    ..The brain 5HT transporter appears to be a principal site of action of therapeutic antidepressants and may mediate behavioral and/or ..
  37. Bartlett C, Gharani N, Millonig J, Brzustowicz L. Three autism candidate genes: a synthesis of human genetic analysis with other disciplines. Int J Dev Neurosci. 2005;23:221-34 pubmed
    ..From this body of work we highlight results from three candidate genes, REELIN (RELN), SEROTONIN TRANSPORTER (5HTT), and ENGRAILED 2 (EN2) and discuss the relevant neuroscience, molecular genetics, and statistical ..
  38. Liu Q, Wong Riley M. Postnatal changes in tryptophan hydroxylase and serotonin transporter immunoreactivity in multiple brainstem nuclei of the rat: implications for a sensitive period. J Comp Neurol. 2010;518:1082-97 pubmed publisher
    ..we conducted a large-scale investigation of the 5-HT-synthesizing enzyme tryptophan hydroxylase (TPH) and serotonin transporter (SERT) with semiquantitative immunohistochemistry in multiple brainstem nuclei of normal rats aged P2-21...
  39. Yue W, Liu H, Zhang J, Zhang X, Wang X, Liu T, et al. Association study of serotonin transporter gene polymorphisms with obstructive sleep apnea syndrome in Chinese Han population. Sleep. 2008;31:1535-41 pubmed
    Since the serotonin (5-HT) is associated with circadian rhythm and breathing regulation, the serotonin transporter (5-HTT), which plays an important role in serotoninergic transmission, might be a strong candidate gene in the ..
  40. Nonkes L, van de Vondervoort I, Homberg J. The attribution of incentive salience to an appetitive conditioned cue is not affected by knockout of the serotonin transporter in rats. Behav Brain Res. 2014;259:268-73 pubmed publisher
    ..We have previously shown that behaviour of serotonin transporter knockout (5-HTT(-/-)) rats-mimicking the common 5-HTT promoter polymorphism in humans-is strongly driven ..
  41. Zusso M, Debetto P, Guidolin D, Barbierato M, Manev H, Giusti P. Fluoxetine-induced proliferation and differentiation of neural progenitor cells isolated from rat postnatal cerebellum. Biochem Pharmacol. 2008;76:391-403 pubmed publisher
    ..RT-PCR and immunostaining revealed the expression of serotonin transporter (SERT), 5HT(1A) receptors, tryptophan hydroxylase (TPH), and serotonin (5HT)...
  42. Page D, Kuti O, Prestia C, Sur M. Haploinsufficiency for Pten and Serotonin transporter cooperatively influences brain size and social behavior. Proc Natl Acad Sci U S A. 2009;106:1989-94 pubmed publisher
    ..Two genes that have been implicated as conferring susceptibility to ASD are PTEN and Serotonin transporter (SLC6A4)...
  43. Zhu S, Mao Z, Huang J, Wang J. Continuous fluoxetine administration prevents recurrence of pulmonary arterial hypertension and prolongs survival in rats. Clin Exp Pharmacol Physiol. 2009;36:e1-5 pubmed publisher
    1. The serotonin transporter (SERT) is strongly implicated in the pathogenesis of pulmonary arterial hypertension (PAH) in patients and animal models...
  44. Wang L, Mo Z, Wang Y, Ji Y. [Association of 5-hydroxytryptamine transporter gene polymorphism with asthma and comorbid depression]. Zhonghua Yi Xue Yi Chuan Xue Za Zhi. 2009;26:575-9 pubmed publisher
    ..The Stin2 polymorphism may play a role in the onset of male asthma. There might be association between the genetic pathogenesis of asthma and depression. ..
  45. Young K, Bonkale W, Holcomb L, Hicks P, German D. Major depression, 5HTTLPR genotype, suicide and antidepressant influences on thalamic volume. Br J Psychiatry. 2008;192:285-9 pubmed publisher
    The 5HTTLPR genetic variant of the serotonin transporter gene (SERT or 5-HTT), which is comprised of a short (SERT-s) and a long (SERT-l) allele, is associated with major depressive disorder and post-traumatic brain disorder...
  46. Luoni A, Hulsken S, Cazzaniga G, Racagni G, Homberg J, Riva M. Behavioural and neuroplastic properties of chronic lurasidone treatment in serotonin transporter knockout rats. Int J Neuropsychopharmacol. 2013;16:1319-30 pubmed publisher
    ..behavioural and molecular defects associated with a genetic model of impaired emotional control, namely serotonin transporter knockout (SERT KO) rats...
  47. Flach C, Qadri F, Bhuiyan T, Alam N, Jennische E, Holmgren J, et al. Differential expression of intestinal membrane transporters in cholera patients. FEBS Lett. 2007;581:3183-8 pubmed
    ..Five other transporters were downregulated; aquaporin 10, SLC6A4, TRPM6, SLC23A1 and SLC30A4, which have specificity for water, serotonin (5-HT), magnesium, vitamin C and zinc, ..
  48. Homberg J, Olivier J, Smits B, Mul J, Mudde J, Verheul M, et al. Characterization of the serotonin transporter knockout rat: a selective change in the functioning of the serotonergic system. Neuroscience. 2007;146:1662-76 pubmed
    ..Here, we describe the functional characterization of the serotonin transporter (SERT) knockout rat model, that is generated by N-ethyl-N-nitrosurea (ENU)-driven target-selected ..
  49. Machado R, Koehler R, Glissmeyer E, Veal C, Suntharalingam J, Kim M, et al. Genetic association of the serotonin transporter in pulmonary arterial hypertension. Am J Respir Crit Care Med. 2006;173:793-7 pubmed
    ..We investigated polymorphic variation of the serotonin transporter gene, a biological candidate for predisposition to this vascular disorder...
  50. Yue W, Liu P, Hao W, Zhang X, Wang X, Zhang J, et al. [Association study of sleep apnea syndrome and polymorphisms in the serotonin transporter gene]. Zhonghua Yi Xue Yi Chuan Xue Za Zhi. 2005;22:533-6 pubmed
    To identify polymorphisms of the serotonin transporter(5-HTT) gene and to find out whether there was relationship between any such polymorphisms and sleep apnea syndrome (SAS)...
  51. Olivier J, Jans L, Blokland A, Broers N, Homberg J, Ellenbroek B, et al. Serotonin transporter deficiency in rats contributes to impaired object memory. Genes Brain Behav. 2009;8:829-34 pubmed publisher
    Serotonin is well known for its role in affection, but less known for its role in cognition. The serotonin transporter (SERT) has an essential role in serotonergic neurotransmission as it determines the magnitude and duration of the ..
  52. Wu Z, Zheng C, Zhu Z, Wu F, Ni G, Liang Y. SiRNA-mediated serotonin transporter knockdown in the dorsal raphe nucleus rescues single prolonged stress-induced hippocampal autophagy in rats. J Neurol Sci. 2016;360:133-40 pubmed publisher
    ..the hypotheses is the dysfunction of serotonin (5-HT) neurotransmission, which is critically regulated by serotonin transporter (SERT)...
  53. Rothman R, Jayanthi S, Wang X, Dersch C, Cadet J, Prisinzano T, et al. High-dose fenfluramine administration decreases serotonin transporter binding, but not serotonin transporter protein levels, in rat forebrain. Synapse. 2003;50:233-9 pubmed
    ..of D-fenfluramine (D-FEN) or parachloroamphetamine (PCA) can produce long-lasting decreases in serotonin transporter (SERT) binding and tissue levels of serotonin (5-HT) in rat forebrain...