Slc6a3

Summary

Gene Symbol: Slc6a3
Description: solute carrier family 6 member 3
Alias: Dat1, sodium-dependent dopamine transporter, DA transporter, DAT, solute carrier family 6 (neurotransmitter transporter), member 3, solute carrier family 6 (neurotransmitter transporter, dopamine), member 3
Species: rat
Products:     Slc6a3

Top Publications

  1. Giros B, El Mestikawy S, Bertrand L, Caron M. Cloning and functional characterization of a cocaine-sensitive dopamine transporter. FEBS Lett. 1991;295:149-54 pubmed
    ..In situ hybridization reveals that the mRNA for this transporter is expressed in the substantia nigra and ventral tegmental area, regions that contain dopaminergic cell bodies. ..
  2. Watanabe Y, Fujita M, Ito Y, Okada T, Kusuoka H, Nishimura T. Brain dopamine transporter in spontaneously hypertensive rats. J Nucl Med. 1997;38:470-4 pubmed
    ..The amounts of the dopamine transporter (DAT) and dopamine D1 and D2 receptors in the brain were assessed by in vitro autoradiography with the ligands [125I] ..
  3. Foster J, Vaughan R. Palmitoylation controls dopamine transporter kinetics, degradation, and protein kinase C-dependent regulation. J Biol Chem. 2011;286:5175-86 pubmed publisher
    ..2BP using lower doses or shorter times caused robust inhibition of transport V(max) that occurred with no losses of DAT protein or changes in DAT surface levels, indicating that acute loss of palmitoylation leads to reduction of ..
  4. Torres G, Yao W, Mohn A, Quan H, Kim K, Levey A, et al. Functional interaction between monoamine plasma membrane transporters and the synaptic PDZ domain-containing protein PICK1. Neuron. 2001;30:121-34 pubmed
    ..In dopaminergic neurons, PICK1 colocalizes with the dopamine transporter (DAT) and forms a stable protein complex...
  5. Hong W, Amara S. Membrane cholesterol modulates the outward facing conformation of the dopamine transporter and alters cocaine binding. J Biol Chem. 2010;285:32616-26 pubmed publisher
    Clearance of synaptically released dopamine is regulated by the plasmalemmal dopamine transporter (DAT), an integral membrane protein that resides within a complex lipid milieu...
  6. Salvatore M, Apparsundaram S, Gerhardt G. Decreased plasma membrane expression of striatal dopamine transporter in aging. Neurobiol Aging. 2003;24:1147-54 pubmed
    Aging in rodents, monkeys, and man is correlated with a reduction in dopamine transporter (DAT) ligand binding and DAT function...
  7. Vaughan R, Sakrikar D, Parnas M, Adkins S, Foster J, Duval R, et al. Localization of cocaine analog [125I]RTI 82 irreversible binding to transmembrane domain 6 of the dopamine transporter. J Biol Chem. 2007;282:8915-25 pubmed
    The site of cocaine binding on the dopamine transporter (DAT) was investigated using the photoactivatable irreversible cocaine analog [125I]3beta-(p-chlorophenyl)tropane-2beta-carboxylic acid, 4'-azido-3'-iodophenylethyl ester ([125I]RTI ..
  8. Foster J, Pananusorn B, Cervinski M, Holden H, Vaughan R. Dopamine transporters are dephosphorylated in striatal homogenates and in vitro by protein phosphatase 1. Brain Res Mol Brain Res. 2003;110:100-8 pubmed
    ..with okadaic acid (OA), a broad-spectrum protein phosphatase inhibitor, produces apparent maximal increases in DAT phosphorylation, suggesting that dephosphorylation is a crucial regulator of the DAT phosphorylation state...
  9. EgaƱa L, Cuevas R, Baust T, Parra L, Leak R, Hochendoner S, et al. Physical and functional interaction between the dopamine transporter and the synaptic vesicle protein synaptogyrin-3. J Neurosci. 2009;29:4592-604 pubmed publisher
    Uptake through the dopamine transporter (DAT) represents the primary mechanism used to terminate dopaminergic transmission in brain...

More Information

Publications62

  1. Jiang W, Prokopenko O, Wong L, Inouye M, Mirochnitchenko O. IRIP, a new ischemia/reperfusion-inducible protein that participates in the regulation of transporter activity. Mol Cell Biol. 2005;25:6496-508 pubmed
    ..On the basis of these results, we propose that IRIP regulates the activity of a variety of transporters under normal and pathological conditions. ..
  2. Li Y, Xia B, Li R, Yin D, Liang W. Changes in Expression of Dopamine, Its Receptor, and Transporter in Nucleus Accumbens of Heroin-Addicted Rats with Brain-Derived Neurotrophic Factor (BDNF) Overexpression. Med Sci Monit. 2017;23:2805-2815 pubmed
    ..heroin addiction and observed changes in the expression of BDNF, DA, dopamine receptor (DRD), dopamine transporter (DAT), and other relevant pathways in NAc...
  3. Need A, Ahmadi K, Spector T, Goldstein D. Obesity is associated with genetic variants that alter dopamine availability. Ann Hum Genet. 2006;70:293-303 pubmed
    ..Dopamine availability is controlled largely by three enzymes: COMT, MAOA and MAOB, and by the dopamine transporter SLC6A3, and each gene has a well-characterized functional variant...
  4. du Bois T, Hsu C, Li Y, Tan Y, Deng C, Huang X. Altered dopamine receptor and dopamine transporter binding and tyrosine hydroxylase mRNA expression following perinatal NMDA receptor blockade. Neurochem Res. 2008;33:1224-31 pubmed publisher
    ..examined how perinatal phencyclidine (PCP) treatment would affect dopamine D2 receptor and dopamine transporter (DAT) binding at different stages after treatment cessation. Female rat pups received injections of PCP (10 mg/kg, s.c...
  5. Micheli F, Cavanni P, Arban R, Benedetti R, Bertani B, Bettati M, et al. 1-(Aryl)-6-[alkoxyalkyl]-3-azabicyclo[3.1.0]hexanes and 6-(aryl)-6-[alkoxyalkyl]-3-azabicyclo[3.1.0]hexanes: a new series of potent and selective triple reuptake inhibitors. J Med Chem. 2010;53:2534-51 pubmed publisher
    ..and brain penetration (B/B > 4) in rats associated with high in vitro potency and selectivity at SERT, NET, and DAT. Among these compounds, microdialysis and in vivo experiments confirm that derivative 15 has an appropriate ..
  6. Perry M, Leinninger G, Chen R, Luderman K, Yang H, Gnegy M, et al. Leptin promotes dopamine transporter and tyrosine hydroxylase activity in the nucleus accumbens of Sprague-Dawley rats. J Neurochem. 2010;114:666-74 pubmed publisher
    ..Leptin also increased NAc DA transporter activity in the absence of changes in cell surface or total DA transporter...
  7. Moritz A, Foster J, Gorentla B, Mazei Robison M, Yang J, Sitte H, et al. Phosphorylation of dopamine transporter serine 7 modulates cocaine analog binding. J Biol Chem. 2013;288:20-32 pubmed publisher
    As an approach to elucidating dopamine transporter (DAT) phosphorylation characteristics, we examined in vitro phosphorylation of a recombinant rat DAT N-terminal peptide (NDAT) using purified protein kinases...
  8. Robison L, Ananth M, Hadjiargyrou M, Komatsu D, Thanos P. Chronic oral methylphenidate treatment reversibly increases striatal dopamine transporter and dopamine type 1 receptor binding in rats. J Neural Transm (Vienna). 2017;124:655-667 pubmed publisher
    ..In vitro receptor autoradiography was performed to quantify binding levels of dopamine transporter (DAT), dopamine type 1 (D1R)-like receptors, and dopamine type 2 (D2R)-like receptors using [3H] WIN35,428, [<..
  9. Bosse R, Fumagalli F, Jaber M, Giros B, Gainetdinov R, Wetsel W, et al. Anterior pituitary hypoplasia and dwarfism in mice lacking the dopamine transporter. Neuron. 1997;19:127-38 pubmed
    Deletion of the dopamine transporter (DAT) results in increased dopaminergic tone, anterior pituitary hypoplasia, dwarfism, and an inability to lactate...
  10. Mengual E, Pickel V. Regional and subcellular compartmentation of the dopamine transporter and tyrosine hydroxylase in the rat ventral pallidum. J Comp Neurol. 2004;468:395-409 pubmed
    ..is derived from midbrain dopaminergic neurons that differ in expression levels of the dopamine transporter (DAT) and from brainstem noradrenergic neurons without DAT...
  11. Miranda M, Sorkina T, Grammatopoulos T, Zawada W, Sorkin A. Multiple molecular determinants in the carboxyl terminus regulate dopamine transporter export from endoplasmic reticulum. J Biol Chem. 2004;279:30760-70 pubmed
    The plasma membrane dopamine transporter (DAT) has an essential role in terminating dopaminergic neurotransmission by reuptake of dopamine into the presynaptic neurons...
  12. Boyer F, Dreyer J. The role of gamma-synuclein in cocaine-induced behaviour in rats. Eur J Neurosci. 2008;27:2938-51 pubmed publisher
    ..the rewarding effects of chronic cocaine administration and its putative interaction with the dopamine transporter (DAT)...
  13. Salkovic Petrisic M, Lackovic Z. Intracerebroventricular administration of betacytotoxics alters expression of brain monoamine transporter genes. J Neural Transm (Vienna). 2003;110:15-29 pubmed
    ..b>DAT1 mRNA expression is increased in 1-week alloxan-icv treated rats in arcuate nucleus (+51%) and ventral medial bundle ..
  14. Itokawa M, Lin Z, Uhl G. Dopamine efflux via wild-type and mutant dopamine transporters: alanine substitution for proline-572 enhances efflux and reduces dependence on extracellular dopamine, sodium and chloride concentrations. Brain Res Mol Brain Res. 2002;108:71-80 pubmed
    The dopamine transporter (DAT) can mediate not only inward uptake of dopamine, but also its outward efflux by mechanisms that have been only partially elucidated...
  15. Rodriguez M, Gonzalez S, Morales I, Sabate M, Gonzalez Hernandez T, Gonzalez Mora J. Nigrostriatal cell firing action on the dopamine transporter. Eur J Neurosci. 2007;25:2755-65 pubmed
    The influence of nigrostriatal cell firing on the dopamine transporter (DAT) activity of the rat striatum was studied in vivo with amperometric methods...
  16. Jaubert A, Drutel G, Leste Lasserre T, Ichas F, Bresson Bepoldin L. Tyrosine hydroxylase and dopamine transporter expression in lactotrophs from postlactating rats: involvement in dopamine-induced apoptosis. Endocrinology. 2007;148:2698-707 pubmed
    ..We then determined that this effect was partly mediated by the DA transporter (DAT) rather than the D(2) receptor, as corroborated by the detection of DAT expression exclusively in ..
  17. Speed N, Matthies H, Kennedy J, Vaughan R, Javitch J, Russo S, et al. Akt-dependent and isoform-specific regulation of dopamine transporter cell surface expression. ACS Chem Neurosci. 2010;1:476-81 pubmed publisher
    ..The DA transporter (DAT) is responsible for clearing extracellular DA, thereby terminating DA neurotransmission...
  18. Davis C, DeCicco Skinner K, Hienz R. Deficits in Sustained Attention and Changes in Dopaminergic Protein Levels following Exposure to Proton Radiation Are Related to Basal Dopaminergic Function. PLoS ONE. 2015;10:e0144556 pubmed publisher
    ..g., CNTF). These data support the hypothesis that basal dopaminergic function impacts the severity of radiation-induced deficits in sustained attention. ..
  19. Lonjon M, Quentien M, Risso J, Michiels J, Carre E, Rostain J, et al. Alteration of striatal dopaminergic function induced by glioma development: a microdialysis and immunohistological study in the rat striatum. Neurosci Lett. 2004;354:131-4 pubmed
    ..was performed to investigate changes in neurofilament (NF), tyrosine hydroxylase (TH) and dopamine transporter (DAT) expression. Dopaminergic turnover was assessed using multiprobe microdialysis in freely-moving rat...
  20. Kitayama S, Shimada S, Xu H, Markham L, Donovan D, Uhl G. Dopamine transporter site-directed mutations differentially alter substrate transport and cocaine binding. Proc Natl Acad Sci U S A. 1992;89:7782-5 pubmed
    Polar amino acids lying within three hydrophobic regions of the dopamine transporter (DAT) are analogous to those important for ligand recognition by catecholamine receptors...
  21. Jones S, Gainetdinov R, Jaber M, Giros B, Wightman R, Caron M. Profound neuronal plasticity in response to inactivation of the dopamine transporter. Proc Natl Acad Sci U S A. 1998;95:4029-34 pubmed
    The dopamine transporter (DAT) plays an important role in calibrating the duration and intensity of dopamine neurotransmission in the central nervous system...
  22. Navaroli D, Stevens Z, Uzelac Z, Gabriel L, King M, Lifshitz L, et al. The plasma membrane-associated GTPase Rin interacts with the dopamine transporter and is required for protein kinase C-regulated dopamine transporter trafficking. J Neurosci. 2011;31:13758-70 pubmed publisher
    ..The amphetamine- and cocaine-sensitive dopamine (DA) transporter (DAT) tightly controls extracellular DA concentrations and half-life...
  23. Spadaro P, Naug H, du Toit E, Donner D, Colson N. A refined high carbohydrate diet is associated with changes in the serotonin pathway and visceral obesity. Genet Res (Camb). 2015;97:e23 pubmed publisher
    ..to determine any variation in levels of expression of the serotonin (Slc6A4 or Sert) and dopamine transporter (Slc6A3 or Dat) genes...
  24. Cremona M, Matthies H, Pau K, Bowton E, SPEED N, Lute B, et al. Flotillin-1 is essential for PKC-triggered endocytosis and membrane microdomain localization of DAT. Nat Neurosci. 2011;14:469-77 pubmed publisher
    ..as Reggie-2, was required for PKC-regulated internalization of members of two different NTT families, the DA transporter (DAT) and the glial glutamate transporter EAAT2, and we identified a conserved serine residue in Flot1 that is ..
  25. Rao A, Simmons D, Sorkin A. Differential subcellular distribution of endosomal compartments and the dopamine transporter in dopaminergic neurons. Mol Cell Neurosci. 2011;46:148-58 pubmed publisher
    Dopamine (DA) transporter (DAT) functions at the surface of dopaminergic neurons to clear extracellular DA. DAT surface levels are regulated by endocytosis...
  26. Bello N, Sweigart K, Lakoski J, Norgren R, Hajnal A. Restricted feeding with scheduled sucrose access results in an upregulation of the rat dopamine transporter. Am J Physiol Regul Integr Comp Physiol. 2003;284:R1260-8 pubmed
    ..present study used quantitative autoradiography and in situ hybridization to assess dopamine membrane transporter (DAT) protein density and mRNA expression in restricted-fed and free-fed adult male rats...
  27. Li S, Kim K, Kim J, Kim J, Park M, Bahk J, et al. Chronic nicotine and smoking treatment increases dopamine transporter mRNA expression in the rat midbrain. Neurosci Lett. 2004;363:29-32 pubmed
    ..and electrophysiological results indicated an important role of nicotine in the modulation of dopamine transporter (DAT)...
  28. Afonso Oramas D, Cruz Muros I, Alvarez de la Rosa D, Abreu P, Giraldez T, Castro Hernandez J, et al. Dopamine transporter glycosylation correlates with the vulnerability of midbrain dopaminergic cells in Parkinson's disease. Neurobiol Dis. 2009;36:494-508 pubmed publisher
    The dopamine transporter (DAT) is a membrane glycoprotein responsible for dopamine (DA) uptake, which has been involved in the degeneration of DA cells in Parkinson's disease (PD)...
  29. Wang J, Michelhaugh S, Bannon M. Valproate robustly increases Sp transcription factor-mediated expression of the dopamine transporter gene within dopamine cells. Eur J Neurosci. 2007;25:1982-6 pubmed
    ..in the treatment of mania and bipolar disorders, epilepsies, and addictions, may modulate dopamine transporter (DAT) function, yet the effects of valproate on DAT gene expression have not been directly assessed...
  30. Beard J, Erikson K, Jones B. Neonatal iron deficiency results in irreversible changes in dopamine function in rats. J Nutr. 2003;133:1174-9 pubmed
    ..We measured brain Fe, dopamine transporters (DAT) and dopamine receptor density in rats made iron deficient, or not, from postnatal day (PND) 4 to PND 14 or 21...
  31. Richardson R, Broaddus W, Holloway K, Fillmore H. Grafts of adult subependymal zone neuronal progenitor cells rescue hemiparkinsonian behavioral decline. Brain Res. 2005;1032:11-22 pubmed
    ..Grafted cells continued to express nestin at the survival time point, and dopamine transporter (DAT) immunoreactivity was restored in the graft body...
  32. Owens W, Sevak R, Galici R, Chang X, Javors M, Galli A, et al. Deficits in dopamine clearance and locomotion in hypoinsulinemic rats unmask novel modulation of dopamine transporters by amphetamine. J Neurochem. 2005;94:1402-10 pubmed
    ..and there is converging evidence that this occurs through insulin regulation of the dopamine (DA) transporter (DAT). In rats made hypoinsulinemic by fasting, synaptosomal DA uptake is reduced...
  33. Momosaki S, Ito M, Yamato H, Iimori H, Sumiyoshi H, Morimoto K, et al. Longitudinal imaging of the availability of dopamine transporter and D2 receptor in rat striatum following mild ischemia. J Cereb Blood Flow Metab. 2017;37:605-613 pubmed publisher
  34. Tillerson J, Caudle W, Parent J, Gong C, Schallert T, Miller G. Olfactory discrimination deficits in mice lacking the dopamine transporter or the D2 dopamine receptor. Behav Brain Res. 2006;172:97-105 pubmed
    ..further characterize the role of dopamine in olfactory processing, we subjected dopamine transporter knockout mice (DAT -/-) and dopamine receptor 2 knockout mice (D2 -/-) to a battery of olfactory tests...
  35. Wang D, Wang W, Zhou Y, Wang J, Jia D, Wong H, et al. Studies on the regulatory effect of Peony-Glycyrrhiza Decoction on prolactin hyperactivity and underlying mechanism in hyperprolactinemia rat model. Neurosci Lett. 2015;606:60-5 pubmed publisher
    ..PRL) level in MMQ cells, involving modulating the expression of D2 receptor (DRD2) and dopamine transporter (DAT)...
  36. Pan X, Guo X, Xiong F, Cheng G, Lu Q, Yan H. Acrylamide increases dopamine levels by affecting dopamine transport and metabolism related genes in the striatal dopaminergic system. Toxicol Lett. 2015;236:60-8 pubmed publisher
    ..In addition, dopamine transporter (DAT) and vesicular monoamine transporter 2 (VMAT2) expression levels were both down-regulated in the striatum...
  37. Chotibut T, Apple D, Jefferis R, Salvatore M. Dopamine transporter loss in 6-OHDA Parkinson's model is unmet by parallel reduction in dopamine uptake. PLoS ONE. 2012;7:e52322 pubmed publisher
    The dopamine transporter (DAT) regulates synaptic dopamine (DA) in striatum and modulation of DAT can affect locomotor activity. Thus, in Parkinson's disease (PD), DAT loss could affect DA clearance and locomotor activity...
  38. Ralph R, Paulus M, Fumagalli F, Caron M, Geyer M. Prepulse inhibition deficits and perseverative motor patterns in dopamine transporter knock-out mice: differential effects of D1 and D2 receptor antagonists. J Neurosci. 2001;21:305-13 pubmed
    ..We used dopamine transporter (DAT) (-/-) mice to examine the behavioral consequences of a chronically hyperdopaminergic state, challenging them with ..
  39. Loder M, Melikian H. The dopamine transporter constitutively internalizes and recycles in a protein kinase C-regulated manner in stably transfected PC12 cell lines. J Biol Chem. 2003;278:22168-74 pubmed
    The dopamine transporter (DAT) removes dopamine from the extracellular milieu and is potently inhibited by number of psychoactive drugs, including cocaine, amphetamines, and methylphenidate (Ritalin)...
  40. Bailey A, Metaxas A, Yoo J, McGee T, Kitchen I. Decrease of D2 receptor binding but increase in D2-stimulated G-protein activation, dopamine transporter binding and behavioural sensitization in brains of mice treated with a chronic escalating dose 'binge' cocaine administration paradigm. Eur J Neurosci. 2008;28:759-70 pubmed publisher
  41. Womersley J, Hsieh J, Kellaway L, Gerhardt G, Russell V. Maternal separation affects dopamine transporter function in the spontaneously hypertensive rat: an in vivo electrochemical study. Behav Brain Funct. 2011;7:49 pubmed publisher
    ..It was hypothesized that maternal separation would alter dopamine regulation by the transporter (DAT) in ways that distinguish SHR from control rat strains...
  42. Sorkina T, Miranda M, Dionne K, Hoover B, Zahniser N, Sorkin A. RNA interference screen reveals an essential role of Nedd4-2 in dopamine transporter ubiquitination and endocytosis. J Neurosci. 2006;26:8195-205 pubmed
    The function of the dopamine transporter (DAT) to terminate dopamine neurotransmission is regulated by endocytic trafficking of DAT...
  43. Tien L, Kaizaki A, Pang Y, Cai Z, Bhatt A, Fan L. Neonatal exposure to lipopolysaccharide enhances accumulation of ?-synuclein aggregation and dopamine transporter protein expression in the substantia nigra in responses to rotenone challenge in later life. Toxicology. 2013;308:96-103 pubmed publisher
    ..in postnatal day 5, P5, neonatal rats) to examine the protein levels of ?-synuclein and dopamine transporters (DAT) in the adult rat...
  44. Samuvel D, Jayanthi L, Manohar S, Kaliyaperumal K, See R, Ramamoorthy S. Dysregulation of dopamine transporter trafficking and function after abstinence from cocaine self-administration in rats: evidence for differential regulation in caudate putamen and nucleus accumbens. J Pharmacol Exp Ther. 2008;325:293-301 pubmed publisher
    ..alterations produced by cocaine on dopamine (DA) neurotransmission raise the possibility that dopamine transporter (DAT)-expressing neurons may modify DA transport in response to repeated cocaine exposure to maintain the appropriate ..
  45. Novick A, Forster G, Hassell J, Davies D, Scholl J, Renner K, et al. Increased dopamine transporter function as a mechanism for dopamine hypoactivity in the adult infralimbic medial prefrontal cortex following adolescent social stress. Neuropharmacology. 2015;97:194-200 pubmed publisher
    ..Increased expression of the DA transporter (DAT) is also seen in the adult infralimbic mPFC following adolescent defeat...
  46. Parnas M, Gaffaney J, Zou M, Lever J, Newman A, Vaughan R. Labeling of dopamine transporter transmembrane domain 1 with the tropane ligand N-[4-(4-azido-3-[125I]iodophenyl)butyl]-2beta-carbomethoxy-3beta-(4-chlorophenyl)tropane implicates proximity of cocaine and substrate active sites. Mol Pharmacol. 2008;73:1141-50 pubmed publisher
    ..tropane ([(125)I]MFZ 2-24) was used to investigate the site for cocaine binding on the dopamine transporter (DAT)...
  47. Cheng Z, Zhong Y, Yang X. Expression of the dopamine transporter in rat and bullfrog retinas. Neuroreport. 2006;17:773-7 pubmed
    ..This expression profile of the dopamine transporter suggests that dopamine may be taken up not only in the synapses but also extrasynaptically by dopamine transporter, diffusely distributed in both plexiform layers. ..
  48. Zoratto F, Romano E, Pascale E, Pucci M, Falconi A, Dell Osso B, et al. Down-regulation of serotonin and dopamine transporter genes in individual rats expressing a gambling-prone profile: A possible role for epigenetic mechanisms. Neuroscience. 2017;340:101-116 pubmed publisher
    ..Elucidation of epigenetic changes occurring during GD progression may pave the way to the development of new therapeutic strategies through specific modulation of epigenetic factors. ..
  49. Zhang H, Li S, Wang M, Vukusic B, Pristupa Z, Liu F. Regulation of dopamine transporter activity by carboxypeptidase E. Mol Brain. 2009;2:10 pubmed publisher
    The dopamine transporter (DAT) plays a critical role in terminating the action of dopamine by rapid reuptake into the presynaptic neuron...
  50. Zhu J, Bardo M, Bruntz R, Stairs D, Dwoskin L. Individual differences in response to novelty predict prefrontal cortex dopamine transporter function and cell surface expression. Eur J Neurosci. 2007;26:717-28 pubmed
    ..differences in response to novelty based on inescapable or free-choice novelty tests predict dopamine transporter (DAT) function and trafficking as well as nicotine-induced modulation of DAT...
  51. Wersinger C, Prou D, Vernier P, Sidhu A. Modulation of dopamine transporter function by alpha-synuclein is altered by impairment of cell adhesion and by induction of oxidative stress. FASEB J. 2003;17:2151-3 pubmed
    ..Here, we suggest that modulation of the functional activity of the dopamine transporter (DAT) by alpha-synuclein may be a key factor in the preferential degeneration of mesencephalic dopamine (DA)-..
  52. Moszczynska A, Saleh J, Zhang H, Vukusic B, Lee F, Liu F. Parkin disrupts the alpha-synuclein/dopamine transporter interaction: consequences toward dopamine-induced toxicity. J Mol Neurosci. 2007;32:217-27 pubmed
    ..we have reported that alpha-synuclein directly couples to the carboxyl tail of the dopamine transporter (DAT) and that the alpha-synuclein/DAT protein complex formation accelerates DAT-mediated cellular dopamine (DA) uptake ..
  53. Adriani W, Boyer F, Gioiosa L, Macri S, Dreyer J, Laviola G. Increased impulsive behavior and risk proneness following lentivirus-mediated dopamine transporter over-expression in rats' nucleus accumbens. Neuroscience. 2009;159:47-58 pubmed publisher
    ..We used lentivirus tools for over-expressing or silencing the dopamine transporter (DAT) and we evaluated the resulting behavioral profiles in terms of motivation and self-control...