Gene Symbol: Slc6a19
Description: solute carrier family 6 member 19
Alias: B0at1, sodium-dependent neutral amino acid transporter B(0)AT1, b(0)AT1, neutral amino acid transporter, solute carrier family 6 (neurotransmitter transporter), member 19, solute carrier family 6 (neutral amino acid transporter), member 19, system B(0) neutral amino acid transporter AT1
Bröer A, Klingel K, Kowalczuk S, Rasko J, Cavanaugh J, Broer S. Molecular cloning of mouse amino acid transport system B0, a neutral amino acid transporter related to Hartnup disorder. J Biol Chem. 2004;279:24467-76 pubmed
..Thus, the human homologue of this transporter is an excellent functional and positional candidate for Hartnup disorder...
Pinho M, Serrão M, Jose P, Soares da Silva P. Organ specific underexpression renal of Na+-dependent B0AT1 in the SHR correlates positively with overexpression of NHE3 and salt intake. Mol Cell Biochem. 2007;306:9-18 pubmed
..The regulation of B(0)AT1 gene transcription appears to be under the influence of Na(+) delivery, being organ specific. ..
Wolff B, Meirelles K, Meng Q, Pan M, Cooney R. Roux-en-Y gastric bypass alters small intestine glutamine transport in the obese Zucker rat. Am J Physiol Gastrointest Liver Physiol. 2009;297:G594-601 pubmed publisher
..Post-RYGB glutaminase levels were increased, but the reductions in PEPCK-C and G6Pase suggest that RYGB downregulates intestinal gluconeogenesis. ..
Kleta R, Romeo E, Ristic Z, Ohura T, Stuart C, Arcos Burgos M, et al
. Mutations in SLC6A19, encoding B0AT1, cause Hartnup disorder. Nat Genet. 2004;36:999-1002 pubmed
..The protein product of SLC6A19, the Hartnup transporter, is expressed primarily in intestine and renal proximal tubule and functions as a neutral amino acid transporter.
Danilczyk U, Sarao R, Remy C, Benabbas C, Stange G, Richter A, et al
. Essential role for collectrin in renal amino acid transport. Nature. 2006;444:1088-91 pubmed
..Expression of collectrin in Xenopus oocytes and Madin-Darby canine kidney (MDCK) cells enhances amino acid transport by the transporter B(0)AT1. These data identify collectrin as a key regulator of renal amino acid uptake. ..
Pinho M, Serrão M, Soares da Silva P. High-salt intake and the renal expression of amino acid transporters in spontaneously hypertensive rats. Am J Physiol Renal Physiol. 2007;292:F1452-63 pubmed
Ducroc R, Sakar Y, Fanjul C, Barber A, Bado A, Lostao M. Luminal leptin inhibits L-glutamine transport in rat small intestine: involvement of ASCT2 and B0AT1. Am J Physiol Gastrointest Liver Physiol. 2010;299:G179-85 pubmed publisher
..by two sodium-dependent neutral amino acid transporters present at the apical membrane: ASCT2/SLC1A5 and B(0)AT1/SLC6A19. We have demonstrated that leptin is secreted into the stomach lumen after a meal and modulates the transport of ..
Jando J, Camargo S, Herzog B, Verrey F. Expression and regulation of the neutral amino acid transporter B0AT1 in rat small intestine. PLoS ONE. 2017;12:e0184845 pubmed publisher
..of neutral amino acids across the luminal membrane of intestinal enterocytes is mediated by the broad neutral amino acid transporter B0AT1 (SLC6A19)...