Slc6a11

Summary

Gene Symbol: Slc6a11
Description: solute carrier family 6 member 11
Alias: Gabt4, Gat3, sodium- and chloride-dependent GABA transporter 3, GABA transporter GAT-3, GAT-3, solute carrier family 6 (neurotransmitter transporter), member 11, solute carrier family 6 (neurotransmitter transporter, GABA), member 11
Species: rat
Products:     Slc6a11

Top Publications

  1. Clark J, Deutch A, Gallipoli P, Amara S. Functional expression and CNS distribution of a beta-alanine-sensitive neuronal GABA transporter. Neuron. 1992;9:337-48 pubmed
  2. Zink M, Vollmayr B, Gebicke Haerter P, Henn F. Reduced expression of GABA transporter GAT3 in helpless rats, an animal model of depression. Neurochem Res. 2009;34:1584-93 pubmed publisher
    ..We found a significant downregulation of the GABA transporter GAT3 in cLH rats...
  3. Mao X, Guo F, Yu J, Min D, Wang Z, Xie N, et al. Up-regulation of GABA transporters and GABA(A) receptor ?1 subunit in tremor rat hippocampus. Neurosci Lett. 2010;486:150-5 pubmed publisher
    ..These data demonstrate that excessive expressions of GAT-1 as well as GAT-3 and GABAR ?1 subunit in TRMs hippocampus may provide the potential therapeutic targets for genetic epilepsy. ..
  4. Jin X, Pare J, Smith Y. GABA transporter subtype 1 and GABA transporter subtype 3 modulate glutamatergic transmission via activation of presynaptic GABA(B) receptors in the rat globus pallidus. Eur J Neurosci. 2012;36:2482-92 pubmed publisher
  5. Melone M, Ciappelloni S, Conti F. A quantitative analysis of cellular and synaptic localization of GAT-1 and GAT-3 in rat neocortex. Brain Struct Funct. 2015;220:885-97 pubmed publisher
    ..These studies provide a basis for understanding the role GAT-1 and GAT-3 play in the modulation of GABA-mediated phasic and tonic inhibition in cerebral cortex. ..
  6. Borden L, Smith K, Hartig P, Branchek T, Weinshank R. Molecular heterogeneity of the gamma-aminobutyric acid (GABA) transport system. Cloning of two novel high affinity GABA transporters from rat brain. J Biol Chem. 1992;267:21098-104 pubmed
    ..The cloning of these transporter genes from rat brain reveals previously undescribed heterogeneity in GABA transporters. ..
  7. Melone M, Cozzi A, Pellegrini Giampietro D, Conti F. Transient focal ischemia triggers neuronal expression of GAT-3 in the rat perilesional cortex. Neurobiol Dis. 2003;14:120-32 pubmed
    ..These findings suggest that ischemia triggers a novel neuronal expression of GAT-3 that is greatest in the perilesional cortex and may contribute to the reported reduction in GABAergic inhibition. ..
  8. Wu Q, Wada M, Shimada A, Yamamoto A, Fujita T. Functional characterization of Zn2(+)-sensitive GABA transporter expressed in primary cultures of astrocytes from rat cerebral cortex. Brain Res. 2006;1075:100-9 pubmed
    ..GABA transport was competitively inhibited by various GABA transport inhibitors, especially GAT2- or GAT3-selective inhibitor...
  9. Jin X, Pare J, Smith Y. Differential localization and function of GABA transporters, GAT-1 and GAT-3, in the rat globus pallidus. Eur J Neurosci. 2011;33:1504-18 pubmed publisher
    ..In conclusion, these data indicate that GAT-1 and GAT-3 represent different target sites through which GABA reuptake may subserve complementary regulation of GABAergic transmission in the rat GP. ..

More Information

Publications15

  1. Sharopov S, Chen R, Sun H, Kolbaev S, Kirischuk S, Luhmann H, et al. Inhibition of different GABA transporter systems is required to attenuate epileptiform activity in the CA3 region of the immature rat hippocampus. Epilepsy Res. 2014;108:182-9 pubmed publisher
    ..We conclude from these results that both GAT-1 and GAT-2/3 act synergistically to regulate the excitability in the immature hippocampus. ..
  2. Fletcher E, Clark M, Furness J. Neuronal and glial localization of GABA transporter immunoreactivity in the myenteric plexus. Cell Tissue Res. 2002;308:339-46 pubmed
    ..In the rat central nervous system, three GABA transporters, GAT1, GAT2 and GAT3, have been cloned and localized by immunohistochemistry...
  3. Vitellaro Zuccarello L, Calvaresi N, De Biasi S. Expression of GABA transporters, GAT-1 and GAT-3, in the cerebral cortex and thalamus of the rat during postnatal development. Cell Tissue Res. 2003;313:245-57 pubmed
  4. Ueda Y, Doi T, Nagatomo K, Tokumaru J, Takaki M, Willmore L. Effect of levetiracetam on molecular regulation of hippocampal glutamate and GABA transporters in rats with chronic seizures induced by amygdalar FeCl3 injection. Brain Res. 2007;1151:55-61 pubmed
    ..These observations together demonstrated the critical molecular mechanism of the anti-epileptic activity of LEV. ..
  5. Minelli A, Barbaresi P, Conti F. Postnatal development of high-affinity plasma membrane GABA transporters GAT-2 and GAT-3 in the rat cerebral cortex. Brain Res Dev Brain Res. 2003;142:7-18 pubmed
  6. Kersanté F, Rowley S, Pavlov I, Gutièrrez Mecinas M, Semyanov A, Reul J, et al. A functional role for both -aminobutyric acid (GABA) transporter-1 and GABA transporter-3 in the modulation of extracellular GABA and GABAergic tonic conductances in the rat hippocampus. J Physiol. 2013;591:2429-41 pubmed publisher
    ..Thus, astrocytic GAT-3 contributes to the regulation of e[GABA] in the hippocampus in vivo and may play an important role in controlling the excitability of hippocampal cells when network activity is increased. ..