Slc5a1

Summary

Gene Symbol: Slc5a1
Description: solute carrier family 5 member 1
Alias: SGLT1, SGLT1a, sodium/glucose cotransporter 1, Na(+)/glucose cotransporter 1, Solute carrier family 5, member alpha 1 (Na+/glucose cotransporter), high affinity sodium-glucose cotransporter, solute carrier family 5 (sodium/glucose cotransporter), member 1
Species: rat
Products:     Slc5a1

Top Publications

  1. Shi J, Zheng H, Yu J, Zhu L, Yan T, Wu P, et al. SGLT-1 Transport and Deglycosylation inside Intestinal Cells Are Key Steps in the Absorption and Disposition of Calycosin-7-O-β-d-Glucoside in Rats. Drug Metab Dispos. 2016;44:283-96 pubmed publisher
    ..This study could contribute to the theoretical foundation and mechanism of absorption and disposition of flavonoid compounds. ..
  2. Fan X, Chan O, Ding Y, Zhu W, Mastaitis J, Sherwin R. Reduction in SGLT1 mRNA Expression in the Ventromedial Hypothalamus Improves the Counterregulatory Responses to Hypoglycemia in Recurrently Hypoglycemic and Diabetic Rats. Diabetes. 2015;64:3564-72 pubmed publisher
    The objective of this study was to determine whether the sodium-glucose transporter SGLT1 in the ventromedial hypothalamus (VMH) plays a role in glucose sensing and in regulating the counterregulatory response to hypoglycemia, and if so, ..
  3. Aoshima H, Yokoyama T, Tanizaki J, Izu H, Yamada M. The sugar specificity of Na+/glucose cotransporter from rat jejunum. Biosci Biotechnol Biochem. 1997;61:979-83 pubmed
    ..The rate-limiting step of the transportation may be the conformational change, i.e., isomerization, of the cotransporter that translocates both the sugar and Na+ from outside to inside. ..
  4. Nagata T, Fukazawa M, Honda K, Yata T, Kawai M, Yamane M, et al. Selective SGLT2 inhibition by tofogliflozin reduces renal glucose reabsorption under hyperglycemic but not under hypo- or euglycemic conditions in rats. Am J Physiol Endocrinol Metab. 2013;304:E414-23 pubmed publisher
    ..b>SGLT1 to renal glucose reabsorption (RGR) and the glycemic levels in vivo...
  5. Balteau M, Tajeddine N, de Meester C, Ginion A, Des Rosiers C, Brady N, et al. NADPH oxidase activation by hyperglycaemia in cardiomyocytes is independent of glucose metabolism but requires SGLT1. Cardiovasc Res. 2011;92:237-46 pubmed publisher
    ..Inhibition of the sodium/glucose cotransporter SGLT1 by phlorizin counteracted HG-induced NOX2 activation and ROS production...
  6. Wong T, Debnam E, Leung P. Involvement of an enterocyte renin-angiotensin system in the local control of SGLT1-dependent glucose uptake across the rat small intestinal brush border membrane. J Physiol. 2007;584:613-23 pubmed
    ..there is a local renin-angiotensin system (RAS) in rat villus enterocytes and assessed the effects of AII on SGLT1-dependent glucose transport across the brush border membrane (BBM)...
  7. Iñigo C, Patel N, Kellett G, Barber A, Lostao M. Luminal leptin inhibits intestinal sugar absorption in vivo. Acta Physiol (Oxf). 2007;190:303-10 pubmed
    ..Luminal leptin effect on intestinal absorption mediated by sodium-dependent glucose transporter 1 (SGLT1) and glucose transporter 2 (GLUT2) as well as intestinal permeability (mannitol absorption) was determined...
  8. Scheepers A, Joost H, Schurmann A. The glucose transporter families SGLT and GLUT: molecular basis of normal and aberrant function. JPEN J Parenter Enteral Nutr. 2004;28:364-71 pubmed
    ..Three members of the SGLT family function as sugar transporters (SGLT1 and SGLT2) or sensors (SGLT3)...
  9. Turk E, Zabel B, Mundlos S, Dyer J, Wright E. Glucose/galactose malabsorption caused by a defect in the Na+/glucose cotransporter. Nature. 1991;350:354-6 pubmed
    ..have previously cloned and sequenced a Na+/glucose cotransporter from normal human ileum and shown that this gene, SGLT1, resides on the distal q arm of chromosome 22...

More Information

Publications56

  1. Nawata C, Dantzler W, Pannabecker T. Alternative channels for urea in the inner medulla of the rat kidney. Am J Physiol Renal Physiol. 2015;309:F916-24 pubmed publisher
    ..cDNAs encoding for Na(+)-glucose transporter 1a (SGLT1a), Na(+)-glucose transporter 1 (NaGLT1), urea transporter (UT)-A2c, and UT-A2d were isolated and cloned from the ..
  2. Kuhre R, Bechmann L, Wewer Albrechtsen N, Hartmann B, Holst J. Glucose stimulates neurotensin secretion from the rat small intestine by mechanisms involving SGLT1 and GLUT2, leading to cell depolarization and calcium influx. Am J Physiol Endocrinol Metab. 2015;308:E1123-30 pubmed publisher
    ..Luminal inhibition of the sodium-glucose cotransporter 1 (SGLT1) (by phloridzin) eliminated glucose-stimulated release as well as secretion stimulated by luminal methyl-α-D-..
  3. Balen D, Ljubojevic M, Breljak D, Brzica H, Zlender V, Koepsell H, et al. Revised immunolocalization of the Na+-D-glucose cotransporter SGLT1 in rat organs with an improved antibody. Am J Physiol Cell Physiol. 2008;295:C475-89 pubmed publisher
    Previously, we characterized localization of Na(+)-glucose cotransporter SGLT1 (Slc5a1) in the rat kidney using a polyclonal antibody against the synthetic COOH-terminal peptide of the rat protein (Saboli? I, Skarica M, Gorboulev V, ..
  4. Houghton S, Iqbal C, Duenes J, Fatima J, Kasparek M, Sarr M. Coordinated, diurnal hexose transporter expression in rat small bowel: implications for small bowel resection. Surgery. 2008;143:79-93 pubmed
    ..mRNA levels of SGLT1 and GLUT5 followed a temporally coordinated, diurnal rhythm in all 3 segments (P < ...
  5. Gaudreault N, Scriven D, Moore E. Characterisation of glucose transporters in the intact coronary artery endothelium in rats: GLUT-2 upregulated by long-term hyperglycaemia. Diabetologia. 2004;47:2081-92 pubmed
    ..We conclude that the high susceptibility of endothelial cells to glucose toxicity may be the result of the subcellular organisation of their GLUTs and the increased expression of GLUT-2. ..
  6. Suzuki T, Fujikura K, Koyama H, Matsuzaki T, Takahashi Y, Takata K. The apical localization of SGLT1 glucose transporter is determined by the short amino acid sequence in its N-terminal domain. Eur J Cell Biol. 2001;80:765-74 pubmed
    b>SGLT1, an isoform of Na+-dependent glucose cotransporters, is localized at the apical plasma membrane in the epithelial cells of the small intestine and the kidney, where it plays a pivotal role in the absorption and reabsorption of ..
  7. Drozdowski L, Woudstra T, Wild G, Clandindin M, Thomson A. The age-associated decline in the intestinal uptake of glucose is not accompanied by changes in the mRNA or protein abundance of SGLT1. Mech Ageing Dev. 2003;124:1035-45 pubmed
    ..immunohistochemistry were used to determine the effects of age on the BBM sodium-dependent glucose transporter, SGLT1, and the BLM Na+K(+)-ATPase...
  8. Pan X, Terada T, Okuda M, Inui K. The diurnal rhythm of the intestinal transporters SGLT1 and PEPT1 is regulated by the feeding conditions in rats. J Nutr. 2004;134:2211-5 pubmed
    The intestinal Na(+)/glucose cotransporter 1 (SGLT1) and H(+)/peptide cotransporter 1 (PEPT1) play important roles in the absorption of carbohydrate and protein...
  9. Bouche C, Serdy S, Kahn C, Goldfine A. The cellular fate of glucose and its relevance in type 2 diabetes. Endocr Rev. 2004;25:807-30 pubmed
    ..This review is focused on the cellular fate of glucose and relevance to human type 2 diabetes. ..
  10. Bhutta H, Deelman T, Ashley S, Rhoads D, Tavakkoli A. Disrupted circadian rhythmicity of the intestinal glucose transporter SGLT1 in Zucker diabetic fatty rats. Dig Dis Sci. 2013;58:1537-45 pubmed publisher
    ..We studied the circadian rhythm of intestinal transporter sodium glucose co-transporter type 1 (SGLT1) in an obese diabetic rat. We compared obese Zucker diabetic fatty (ZDF) rats to lean ZDF littermates...
  11. Coon S, Kekuda R, Saha P, Talukder J, Sundaram U. Constitutive nitric oxide differentially regulates Na-H and Na-glucose cotransport in intestinal epithelial cells. Am J Physiol Gastrointest Liver Physiol. 2008;294:G1369-75 pubmed publisher
    Previous in vivo studies suggest that constitutive nitric oxide (cNO) can regulate Na- glucose cotransport (SGLT1) and Na-H exchange (NHE3) in rabbit intestinal villus cells...
  12. Elfeber K, Stümpel F, Gorboulev V, Mattig S, Deussen A, Kaissling B, et al. Na(+)-D-glucose cotransporter in muscle capillaries increases glucose permeability. Biochem Biophys Res Commun. 2004;314:301-5 pubmed
    By immunohistochemistry, we demonstrated the localization of the Na(+)-D-glucose cotransporter SGLT1 in capillaries of rat heart and skeletal muscle, but not in capillaries of small intestine and submandibular gland...
  13. Martin M, Turk E, Lostao M, Kerner C, Wright E. Defects in Na+/glucose cotransporter (SGLT1) trafficking and function cause glucose-galactose malabsorption. Nat Genet. 1996;12:216-20 pubmed
    ..ion gradients to drive 'active' transport of substrates into cells, for example, the Na+/glucose cotransporter (SGLT1) couples sugar transport to Na+ gradients across the intestinal brush border...
  14. Lee W, Kanai Y, Wells R, Hediger M. The high affinity Na+/glucose cotransporter. Re-evaluation of function and distribution of expression. J Biol Chem. 1994;269:12032-9 pubmed
    ..structure, functional characterization, and tissue distribution of the high affinity Na+/glucose cotransporter SGLT1 from rat kidney. Rat SGLT1 (665 amino acid residues) is 86-87% identical to SGLT1 from rabbit, pig, and human...
  15. Xia X, Wang G, Peng Y, Tu M, Jen J, Fang H. The endogenous CXXC motif governs the cadmium sensitivity of the renal Na+/glucose co-transporter. J Am Soc Nephrol. 2005;16:1257-65 pubmed
    ..It is reported here that the renal brush-border membrane Na+/glucose co-transporter-1 (SGLT1) is a molecular target for Cd2+ toxicity...
  16. Grefner N, Gromova L, Gruzdkov A, Komissarchik I. [The interaction between SGLT1 or GLUT2 glucose transporter and the cytoskeleton in the enterocyte as well as Caco2 cell during hexose absorption]. Tsitologiia. 2014;56:749-57 pubmed
    The distribution of cytoskeleton elements (microtubules and actin filaments) and SGLT1 or GLUT2 glucose transporter in enterocyte of rat intestine and Caco2 cell during hexose absorption has been considered...
  17. Gaudreault N, Scriven D, Moore E. Asymmetric subcellular distribution of glucose transporters in the endothelium of small contractile arteries. Endothelium. 2006;13:317-24 pubmed
  18. Sabolic I, Skarica M, Gorboulev V, Ljubojevic M, Balen D, Herak Kramberger C, et al. Rat renal glucose transporter SGLT1 exhibits zonal distribution and androgen-dependent gender differences. Am J Physiol Renal Physiol. 2006;290:F913-26 pubmed
    SGLT1 (SLC5A1) mediates a part of glucose and galactose reabsorption in the mammalian proximal tubule (PT), but the detailed localization of the transporter along the tubule is still disputable...
  19. Wiley L, Lever J, Pape C, Kidder G. Antibodies to a renal Na+/glucose cotransport system localize to the apical plasma membrane domain of polar mouse embryo blastomeres. Dev Biol. 1991;143:149-61 pubmed
    ..The onset of cell surface expression of this antigen precedes development of the stable polar phenotype. ..
  20. Miró Queralt M, Guinovart J, Planas J. Sodium tungstate decreases sucrase and Na+/D-glucose cotransporter in the jejunum of diabetic rats. Am J Physiol Gastrointest Liver Physiol. 2008;295:G479-84 pubmed publisher
    ..the effects of 30 days of oral administration of tungstate on disaccharidase and Na+/D-glucose cotransporter (SGLT1) activity in the jejunum of control and streptozotocin-induced diabetic rats...
  21. Stearns A, Balakrishnan A, Rhoads D, Ashley S, Tavakkolizadeh A. Diurnal expression of the rat intestinal sodium-glucose cotransporter 1 (SGLT1) is independent of local luminal factors. Surgery. 2009;145:294-302 pubmed publisher
    The intestinal sodium-glucose cotransporter 1 (SGLT1) is responsible for all secondary active transport of dietary glucose, and it presents a potential therapeutic target for obesity and diabetes...
  22. Iqbal C, Fatima J, Duenes J, Houghton S, Kasparek M, Sarr M. Expression and function of intestinal hexose transporters after small intestinal denervation. Surgery. 2009;146:100-12 pubmed publisher
    ..determine the role of intestinal innervation in gene expression and function of the membrane hexose transporters, SGLT1, GLUT2, and GLUT5 in the enterocyte...
  23. Coon S, Kekuda R, Saha P, Sundaram U. Reciprocal regulation of the primary sodium absorptive pathways in rat intestinal epithelial cells. Am J Physiol Cell Physiol. 2011;300:C496-505 pubmed publisher
    ..occurs predominantly by two primary pathways that include Na/H exchange (NHE3) and Na-glucose cotransport (SGLT1) on the brush border membrane (BBM) of villus cells...
  24. Bodega F, Sironi C, Armilli M, Porta C, Agostoni E. Evidence for Na+-glucose cotransporter in type I alveolar epithelium. Histochem Cell Biol. 2010;134:129-36 pubmed publisher
    ..Physiol. 422: 44P, 1990). In this research we checked by immunofluorescence whether Na(+)-glucose cotransporter (SGLT1) is also expressed in alveolar type I cells...
  25. Pessoa T, Campos L, Carraro Lacroix L, Girardi A, Malnic G. Functional role of glucose metabolism, osmotic stress, and sodium-glucose cotransporter isoform-mediated transport on Na+/H+ exchanger isoform 3 activity in the renal proximal tubule. J Am Soc Nephrol. 2014;25:2028-39 pubmed publisher
    Na(+)-glucose cotransporter 1 (SGLT1)-mediated glucose uptake leads to activation of Na(+)-H(+) exchanger 3 (NHE3) in the intestine by a process that is not dependent on glucose metabolism...
  26. Kanwal A, Nizami H, Mallapudi S, Putcha U, Mohan G, Banerjee S. Inhibition of SGLT1 abrogates preconditioning-induced cardioprotection against ischemia-reperfusion injury. Biochem Biophys Res Commun. 2016;472:392-8 pubmed publisher
    Recently, we reported Na+/glucose co-transporter (SGLT1) expression in mouse and human heart. We speculated that SGLT1 might play an important role in ischemic preconditioning-induced cardioprotection...
  27. Mahmood S, Sodhi C, Ganguly N. Expression of sodium-glucose co-transporter and brush border disaccharidases in Giardia lamblia infected rat intestine. Indian J Biochem Biophys. 2002;39:185-90 pubmed
    ..The level of mRNA encoding Na+/glucose co-transporter (SGLT1) and brush border sucrase and lactase activities were also analyzed. At the peak of infection, i...
  28. Azevedo M, Lima C, Fernandes Ferreira M, Almeida M, Wilson J, Pereira Wilson C. Rosmarinic acid, major phenolic constituent of Greek sage herbal tea, modulates rat intestinal SGLT1 levels with effects on blood glucose. Mol Nutr Food Res. 2011;55 Suppl 1:S15-25 pubmed publisher
    ..constituent--rosmarinic acid (RA)--on the levels and localization of the intestinal Na+/glucose cotransporter-1 (SGLT1), the facilitative glucose transporter 2 and glucagon-like peptide-1 (GLP-1)...
  29. Stearns A, Balakrishnan A, Rhoads D, Tavakkolizadeh A. Rapid upregulation of sodium-glucose transporter SGLT1 in response to intestinal sweet taste stimulation. Ann Surg. 2010;251:865-71 pubmed publisher
    We set out to examine the short-term regulation of the intestinal sodium/glucose cotransporter SGLT1 by its substrate glucose and sweet taste analogs...
  30. Sabino Silva R, Freitas H, Lamers M, Okamoto M, Santos M, Machado U. Na+-glucose cotransporter SGLT1 protein in salivary glands: potential involvement in the diabetes-induced decrease in salivary flow. J Membr Biol. 2009;228:63-9 pubmed publisher
    Oral health complications in diabetes include decreased salivary secretion. The SLC5A1 gene encodes the Na(+)-glucose cotransporter SGLT1 protein, which not only transports glucose, but also acts as a water channel...
  31. Stearns A, Balakrishnan A, Rounds J, Rhoads D, Ashley S, Tavakkolizadeh A. Capsaicin-sensitive vagal afferents modulate posttranscriptional regulation of the rat Na+/glucose cotransporter SGLT1. Am J Physiol Gastrointest Liver Physiol. 2008;294:G1078-83 pubmed publisher
    the intestinal Na(+)/glucose cotransporter (SGLT1) displays rapid anticipatory diurnal rhythms in mRNA and protein expression. The vagus nerve has been implicated in the entrainment of some transporters...
  32. Vernaleken A, Veyhl M, Gorboulev V, Kottra G, Palm D, Burckhardt B, et al. Tripeptides of RS1 (RSC1A1) inhibit a monosaccharide-dependent exocytotic pathway of Na+-D-glucose cotransporter SGLT1 with high affinity. J Biol Chem. 2007;282:28501-13 pubmed
    ..named RS1 that mediates transcriptional and post-transcriptional regulation of Na(+)-D-glucose cotransporter SGLT1. The post-transcriptional regulation occurs at the trans-Golgi network (TGN)...
  33. Ducroc R, Guilmeau S, Akasbi K, Devaud H, Buyse M, Bado A. Luminal leptin induces rapid inhibition of active intestinal absorption of glucose mediated by sodium-glucose cotransporter 1. Diabetes. 2005;54:348-54 pubmed
    ..The slower action of leptin on the serosal side of mucosa seems indirect and is likely mediated by endogenous CCK. They demonstrate that gut leptin is a major regulator of rapid intestinal glucose transport. ..
  34. Sabino Silva R, Alves Wagner A, Burgi K, Okamoto M, Alves A, Lima G, et al. SGLT1 protein expression in plasma membrane of acinar cells correlates with the sympathetic outflow to salivary glands in diabetic and hypertensive rats. Am J Physiol Endocrinol Metab. 2010;299:E1028-37 pubmed publisher
    ..We hypothesized that sodium-glucose cotransporter 1 (SGLT1) participates in salivary dysfunctions through a sympathetic- and protein kinase A (PKA)-mediated pathway...
  35. Lane R, Dvorak B, Maclennan N, Dvorakova K, Halpern M, Pham T, et al. IGF alters jejunal glucose transporter expression and serum glucose levels in immature rats. Am J Physiol Regul Integr Comp Physiol. 2002;283:R1450-60 pubmed
    ..glucose levels via increased jejunal glucose transporter 2 (GLUT2) and high-affinity Na(+)-glucose cotransporter (SGLT1) expression...
  36. Tabatabai N, Sharma M, Blumenthal S, Petering D. Enhanced expressions of sodium-glucose cotransporters in the kidneys of diabetic Zucker rats. Diabetes Res Clin Pract. 2009;83:e27-30 pubmed publisher
    Diabetes-mediated changes in mRNA expressions of kidney glucose transporters SGLT1 and SGLT2 were investigated in Zucker rats. SGLTs expressions in pre-diabetic obese rats were similar to leans...
  37. Balakrishnan A, Stearns A, Rounds J, Irani J, Giuffrida M, Rhoads D, et al. Diurnal rhythmicity in glucose uptake is mediated by temporal periodicity in the expression of the sodium-glucose cotransporter (SGLT1). Surgery. 2008;143:813-8 pubmed publisher
    ..To address this gap, we assessed temporal changes in glucose transport mediated by the Na(+)/glucose cotransporter SGLT1. SGLT1 expression was assessed at 4 times during the day: ZT3, ZT9, ZT15, and ZT21 (ZT, Zeitgeber time; lights on ..
  38. Day A, Gee J, DuPont M, Johnson I, Williamson G. Absorption of quercetin-3-glucoside and quercetin-4'-glucoside in the rat small intestine: the role of lactase phlorizin hydrolase and the sodium-dependent glucose transporter. Biochem Pharmacol. 2003;65:1199-206 pubmed
    ..have been proposed: active uptake of the quercetin glucoside by the sodium-dependent glucose transporter (SGLT1) with subsequent deglycosylation within the enterocyte by cytosolic beta-glucosidase, or luminal hydrolysis of the ..
  39. Manoharan P, Gayam S, Arthur S, Palaniappan B, Singh S, Dick G, et al. Chronic and selective inhibition of basolateral membrane Na-K-ATPase uniquely regulates brush border membrane Na absorption in intestinal epithelial cells. Am J Physiol Cell Physiol. 2015;308:C650-6 pubmed publisher
    ..g., Na-glucose cotransport (SGLT1)]...
  40. Morgan E, Mace O, Affleck J, Kellett G. Apical GLUT2 and Cav1.3: regulation of rat intestinal glucose and calcium absorption. J Physiol. 2007;580:593-604 pubmed
    We have proposed a model of intestinal glucose absorption in which transport by SGLT1 induces rapid insertion and activation of GLUT2 in the apical membrane by a PKC betaII-dependent mechanism...
  41. Osswald C, Baumgarten K, Stümpel F, Gorboulev V, Akimjanova M, Knobeloch K, et al. Mice without the regulator gene Rsc1A1 exhibit increased Na+-D-glucose cotransport in small intestine and develop obesity. Mol Cell Biol. 2005;25:78-87 pubmed
    ..is an intracellular 617-amino-acid protein that is involved in the regulation of the Na(+)-d-glucose cotransporter SGLT1. We generated and characterized RS1 knockout (RS1(-/-) mice...
  42. Oliveira T, Candeia Medeiros N, Cavalcante Araújo P, Melo I, Fávaro Pípi E, Fátima L, et al. SGLT1 activity in lung alveolar cells of diabetic rats modulates airway surface liquid glucose concentration and bacterial proliferation. Sci Rep. 2016;6:21752 pubmed publisher
    ..We investigated the role of alveolar epithelial SGLT1 activity on ASL glucose concentration and bacterial proliferation...
  43. Lambert R, Srodulski S, Peng X, Margulies K, Despa F, Despa S. Intracellular Na+ Concentration ([Na+]i) Is Elevated in Diabetic Hearts Due to Enhanced Na+-Glucose Cotransport. J Am Heart Assoc. 2015;4:e002183 pubmed publisher
    ..Myocyte Na(+)-glucose cotransport is enhanced in T2D, which increases Na(+) influx and causes Na(+) overload. Higher [Na(+)]i may contribute to arrhythmogenesis and oxidative stress in diabetic hearts. ..
  44. Wild G, Searles L, Koski K, Drozdowski L, Begum Hasan J, Thomson A. Oral polyamine administration modifies the ontogeny of hexose transporter gene expression in the postnatal rat intestine. Am J Physiol Gastrointest Liver Physiol. 2007;293:G453-60 pubmed
    ..membrane (BBM) sucrase-isomaltase (SI) and the sugar transporters sodium-dependent glucose transporter 1 (SGLT1) and glucose transporter 2 (GLUT2)...
  45. Yang Q, Tian Y, Wada J, Kashihara N, Wallner E, Peterson D, et al. Expression characteristics and relevance of sodium glucose cotransporter-1 in mammalian renal tubulogenesis. Am J Physiol Renal Physiol. 2000;279:F765-77 pubmed
    ..The data suggest that SGLT-1 exhibits a restricted spatiotemporal expression with functional activity confined to the corresponding tubular segments, and it selectively maintains renal tubulogenesis during development...
  46. Arthur S, Coon S, Kekuda R, Sundaram U. Regulation of sodium glucose co-transporter SGLT1 through altered glycosylation in the intestinal epithelial cells. Biochim Biophys Acta. 2014;1838:1208-14 pubmed publisher
    Inhibition of constitutive nitric oxide (cNO) production inhibits SGLT1 activity by a reduction in the affinity for glucose without a change in Vmax in intestinal epithelial cells (IEC-18)...
  47. Huang C, Hsiao J, Lu Y, Lee T, Yu L. Anti-apoptotic PI3K/Akt signaling by sodium/glucose transporter 1 reduces epithelial barrier damage and bacterial translocation in intestinal ischemia. Lab Invest. 2011;91:294-309 pubmed publisher
    ..Previous in vitro studies showed that activation of sodium/glucose transporter 1 (SGLT1) prevented the epithelial apoptosis and permeability rise induced by microbial products...