Gene Symbol: Slc4a2
Description: solute carrier family 4 member 2
Alias: Ae2, Aep2, anion exchange protein 2, AE 2, AE2 Cl-/HCO3-exchanger, variant AE2b, B3RP-2, Solute carrier family 4, member 2, anion exchange protein 2, anion exchanger 2, band 3-related protein 2, non-erythroid band 3-like protein, solute carrier family 4 (anion exchanger), member 2
Species: rat
Products:     Slc4a2

Top Publications

  1. Lindsey A, Schneider K, Simmons D, Baron R, Lee B, Kopito R. Functional expression and subcellular localization of an anion exchanger cloned from choroid plexus. Proc Natl Acad Sci U S A. 1990;87:5278-82 pubmed
    We have isolated rat brain cDNA clones encoding AE2, a homologue of the erythrocyte anion exchanger, band 3 (AE1)...
  2. Schwabe K, Cetin Y. Guanylin and functional coupling proteins in the hepatobiliary system of rat and guinea pig. Histochem Cell Biol. 2012;137:589-97 pubmed publisher
    ..cyclase C (Gucy2c), Proteinkinase GII (Pkrg2), CFTR and the solute carrier family 4, anion exchanger, member 2 (Slc4a2) in the hepatobiliary system of rat and guinea pig...
  3. Banales J, Masyuk T, Bogert P, Huang B, Gradilone S, Lee S, et al. Hepatic cystogenesis is associated with abnormal expression and location of ion transporters and water channels in an animal model of autosomal recessive polycystic kidney disease. Am J Pathol. 2008;173:1637-46 pubmed publisher
    ..of vesicles contain three proteins (ie, the water channel AQP1, the chloride channel CFTR, and the anion exchanger AE2) that account for ion-driven water transport...
  4. Banales J, Arenas F, Rodriguez Ortigosa C, Saez E, Uriarte I, Doctor R, et al. Bicarbonate-rich choleresis induced by secretin in normal rat is taurocholate-dependent and involves AE2 anion exchanger. Hepatology. 2006;43:266-75 pubmed
    ..small hairpin RNA adenoviral constructs were used to demonstrate the involvement of the Na+-independent anion exchanger 2 (AE2) through gene silencing in normal rat cholangiocytes...
  5. Quentin F, Eladari D, Frische S, Cambillau M, Nielsen S, Alper S, et al. Regulation of the Cl-/HCO3- exchanger AE2 in rat thick ascending limb of Henle's loop in response to changes in acid-base and sodium balance. J Am Soc Nephrol. 2004;15:2988-97 pubmed
    The Cl(-)/HCO(3)(-) exchanger AE2 is believed to be involved in transcellular bicarbonate reabsorption that occurs in the thick ascending limb of Henle's loop (TAL)...
  6. Aitman T, Gotoda T, Evans A, Imrie H, Heath K, Trembling P, et al. Quantitative trait loci for cellular defects in glucose and fatty acid metabolism in hypertensive rats. Nat Genet. 1997;16:197-201 pubmed
  7. Wang Z, Schultheis P, Shull G. Three N-terminal variants of the AE2 Cl-/HCO3- exchanger are encoded by mRNAs transcribed from alternative promoters. J Biol Chem. 1996;271:7835-43 pubmed
    Multiple AE2 Cl-/HCO3- exchanger mRNAs have been identified in rat...
  8. Holappa K, Mustonen M, Parvinen M, Vihko P, Rajaniemi H, Kellokumpu S. Primary structure of a sperm cell anion exchanger and its messenger ribonucleic acid expression during spermatogenesis. Biol Reprod. 1999;61:981-6 pubmed
    ..We have now identified this putative sperm cell anion exchanger as the AE2 isoform of this gene family...
  9. Xiong Y, Li Y, Xiong Y, Zhao Y, Tang F, Wang X. Exhaustive running exercise induce tyrosine phosphorylation of band 3 in rat erythrocytes. Cell Physiol Biochem. 2013;32:1060-71 pubmed publisher
    ..Furthermore, it appears that exhaustive running exercise induced band 3 phosphorylation is due to the oxidation of critical sulfydryl groups of a membrane phosphatase (PTP). ..

More Information


  1. Frische S, Zolotarev A, Kim Y, Praetorius J, Alper S, Nielsen S, et al. AE2 isoforms in rat kidney: immunohistochemical localization and regulation in response to chronic NH4Cl loading. Am J Physiol Renal Physiol. 2004;286:F1163-70 pubmed
    ..The purpose of this study was to describe the segmental and cellular distribution of the AE2 isoforms in the rat kidney and to evaluate whether the expression levels of these AE2 isoforms are regulated ..
  2. Chow A, Zhou W, Jacobson R. Regulation of AE2 Cl-/HCO3- exchanger during intestinal development. Am J Physiol. 1996;271:G330-7 pubmed
    The Na(+)-independent Cl-/HCO3- exchangers in many tissues are encoded by AE2, which is a member of the anion-exchanger (AE) gene family. Molecular regulation of AE2 remains mostly unknown...
  3. Wang W, Ren X, Cai Y, Chen L, Zhang W, Xu J. Rifampicin Induces Bicarbonate-Rich Choleresis in Rats: Involvement of Anion Exchanger 2. Dig Dis Sci. 2016;61:126-36 pubmed publisher
    ..After rifampicin treatment, the expression level of anion exchanger 2 (AE2) increased, while the location of hepatic transporters did not change...
  4. Morgan P, Pastorekova S, Stuart Tilley A, Alper S, Casey J. Interactions of transmembrane carbonic anhydrase, CAIX, with bicarbonate transporters. Am J Physiol Cell Physiol. 2007;293:C738-48 pubmed
    ..HEK293 cells the functional and physical interactions between CAIX and the parietal cell Cl(-)/HCO(3)(-) exchanger AE2 or the putative Cl(-)/HCO(3)(-) exchanger SLC26A7...
  5. Ogata T. Bicarbonate secretion by rat bile duct brush cells indicated by immunohistochemical localization of CFTR, anion exchanger AE2, Na+/HCO3 -cotransporter, carbonic anhydrase II, Na+/H+ exchangers NHE1 and NHE3, H+/K+-ATPase, and Na+/K+-ATPase. Med Mol Morphol. 2006;39:44-8 pubmed reaction, cystic fibrosis transmembrane conductance regulator (CFTR) and Cl(-)/HCO(3) (-) exchanger (AE2), was found on the microvilli (MV) and along the basolateral membrane (BLM) of BCs...
  6. Simon J, Deshmukh G, Couch F, Merajver S, Weber B, Van Vooren P, et al. Chromosomal mapping of the rat Slc4a family of anion exchanger genes, Ae1, Ae2, and Ae3. Mamm Genome. 1996;7:380-2 pubmed
  7. Aranda V, Martinez I, Melero S, Lecanda J, Banales J, Prieto J, et al. Shared apical sorting of anion exchanger isoforms AE2a, AE2b1, and AE2b2 in primary hepatocytes. Biochem Biophys Res Commun. 2004;319:1040-6 pubmed
    AE2 (SLC4A2) is the member of the Na(+)-independent anion exchanger (AE) family putatively involved in the secretion of bicarbonate to bile...
  8. Praetorius J, Nejsum L, Nielsen S. A SCL4A10 gene product maps selectively to the basolateral plasma membrane of choroid plexus epithelial cells. Am J Physiol Cell Physiol. 2004;286:C601-10 pubmed
  9. Roussa E, Romero M, Schmitt B, Boron W, Alper S, Thevenod F. Immunolocalization of anion exchanger AE2 and Na(+)-HCO(-)(3) cotransporter in rat parotid and submandibular glands. Am J Physiol. 1999;277:G1288-96 pubmed
    ..We investigated localization of Cl(-)/HCO(-)(3) exchanger isoform AE2 and of Na(+)-HCO(-)(3) cotransporter (NBC) in rat parotid gland (PAR) and submandibular gland (SMG) by immunoblot ..
  10. Wang W, Praetorius J, Li C, Praetorius H, Kwon T, Fr√łkiaer J, et al. Vacuolar H+-ATPase expression is increased in acid-secreting intercalated cells in kidneys of rats with hypercalcaemia-induced alkalosis. Acta Physiol (Oxf). 2007;189:359-68 pubmed
    ..In contrast, electroneutral Na(+)-HCO cotransporter NBCn1 and Cl(-)/HCO anion exchanger AE2 expression was markedly reduced in the inner stripe of the outer medulla (to 26 +/- 9% and 65 +/- 6%, respectively)...
  11. Kudrycki K, Newman P, Shull G. cDNA cloning and tissue distribution of mRNAs for two proteins that are related to the band 3 Cl-/HCO3- exchanger. J Biol Chem. 1990;265:462-71 pubmed
    ..Band 3 mRNAs were observed in many tissues but high levels of expression occurred only in spleen and kidney. Five Band 3 transcripts, ranging in size from 3.6 to 4.9 kilobases, were detected, including three that are expressed in heart. ..
  12. Stewart A, Kurschat C, Vaughan Jones R, Shmukler B, Alper S. Acute regulation of mouse AE2 anion exchanger requires isoform-specific amino acid residues from most of the transmembrane domain. J Physiol. 2007;584:59-73 pubmed
    The widely expressed anion exchanger polypeptide AE2/SLC4A2 is acutely inhibited by acidic intracellular (pH(i)), by acidic extracellular pH (pH(o)), and by the calmodulin inhibitor, calmidazolium, whereas it is acutely activated by NH(4)(..
  13. Kao L, Kurtz L, Shao X, Papadopoulos M, Liu L, Bok D, et al. Severe neurologic impairment in mice with targeted disruption of the electrogenic sodium bicarbonate cotransporter NBCe2 (Slc4a5 gene). J Biol Chem. 2011;286:32563-74 pubmed publisher
    ..Our findings are the first demonstration of the fundamental importance of NBCe2 in the biology of the nervous system. ..
  14. Loqman M, Bush P, Farquharson C, Hall A. Suppression of mammalian bone growth by membrane transport inhibitors. J Cell Biochem. 2013;114:658-68 pubmed publisher
    ..We investigated the role of the Na(+)/H(+) antiporter (NHE1) and anion exchanger (AE2) in bone lengthening and GP chondrocyte hypertrophy in Sprague-Dawley 7-day-old rat (P7) bone rudiments using the ..
  15. Bernardino R, Martins A, Socorro S, Alves M, Oliveira P. Effect of prediabetes on membrane bicarbonate transporters in testis and epididymis. J Membr Biol. 2013;246:877-83 pubmed publisher
    ..Herein, we analyzed protein and mRNA levels of the most relevant HCO?? transporters of the SLC4 family [anion exchanger 2 (AE2), Na?-driven Cl?/HCO?? exchanger (NDCBE), electrogenic Na?/HCO?? cotransporter 1 (NBCe1), ..