Gene Symbol: Slc4a10
Description: solute carrier family 4 member 10
Alias: NCBE, sodium-driven chloride bicarbonate exchanger, Na+ bicarbonate transporter NBCn2-G, Na-bicarbonate cotransporter NBCn2-O, solute carrier family 4, sodium bicarbonate transporter, member 10, solute carrier family 4, sodium bicarbonate transporter-like, member 10
Species: rat
Products:     Slc4a10

Top Publications

  1. Wang C, Yano H, Nagashima K, Seino S. The Na+-driven Cl-/HCO3- exchanger. Cloning, tissue distribution, and functional characterization. J Biol Chem. 2000;275:35486-90 pubmed
    ..tissue distribution, and functional characterization of Na(+)-driven chloride/bicarbonate exchanger (designated NCBE) cloned from the insulin-secreting cell line MIN6 cDNA library...
  2. Praetorius J, Nejsum L, Nielsen S. A SCL4A10 gene product maps selectively to the basolateral plasma membrane of choroid plexus epithelial cells. Am J Physiol Cell Physiol. 2004;286:C601-10 pubmed
    ..transcriptase-polymerase chain reaction (RT-PCR) analysis revealed the expression in the choroid plexus of SLC4A10 mRNA, which encodes a stilbene-sensitive Na+-HCO3- transporter...
  3. Giffard R, Lee Y, Ouyang Y, Murphy S, Monyer H. Two variants of the rat brain sodium-driven chloride bicarbonate exchanger (NCBE): developmental expression and addition of a PDZ motif. Eur J Neurosci. 2003;18:2935-45 pubmed
    ..Here we identify two novel variants of the sodium-driven chloride bicarbonate exchanger (NCBE) from brain...
  4. Lee Y, Ouyang Y, Giffard R. Regulation of the rat brain Na+ -driven Cl-/HCO3 - exchanger involves protein kinase A and a multiprotein signaling complex. FEBS Lett. 2006;580:4865-71 pubmed
    The Na(+)-driven Cl(-)/HCO(3)(-) exchanger (NCBE) plays an important role in the regulation of intracellular pH (pH(i))...
  5. Jacobs S, Ruusuvuori E, Sipilä S, Haapanen A, Damkier H, Kurth I, et al. Mice with targeted Slc4a10 gene disruption have small brain ventricles and show reduced neuronal excitability. Proc Natl Acad Sci U S A. 2008;105:311-6 pubmed publisher
    ..Here we report that disrupting the Slc4a10 gene, which encodes the Na(+)-coupled Cl(-)-HCO(3)(-) exchanger Slc4a10 (NCBE), drastically reduces brain ..
  6. Damkier H, Aalkjaer C, Praetorius J. Na+-dependent HCO3- import by the slc4a10 gene product involves Cl- export. J Biol Chem. 2010;285:26998-7007 pubmed publisher
    The slc4a10 gene encodes an electroneutral Na(+)-dependent HCO(3)(-) importer for which the precise mode of action remains unsettled...
  7. Kao L, Kurtz L, Shao X, Papadopoulos M, Liu L, Bok D, et al. Severe neurologic impairment in mice with targeted disruption of the electrogenic sodium bicarbonate cotransporter NBCe2 (Slc4a5 gene). J Biol Chem. 2011;286:32563-74 pubmed publisher
    ..Our findings are the first demonstration of the fundamental importance of NBCe2 in the biology of the nervous system. ..
  8. Liu Y, Wang D, Jiang D, Qin X, Xie Z, Wang Q, et al. Cloning and functional characterization of novel variants and tissue-specific expression of alternative amino and carboxyl termini of products of slc4a10. PLoS ONE. 2013;8:e55974 pubmed publisher
    Previous studies have shown that the electroneutral Na(+)/HCO(3) (-) cotransporter NBCn2 (SLC4A10) is predominantly expressed in the central nervous system (CNS)...
  9. Coley A, Ruffin V, Moss F, Hopfer U, Boron W. Immunocytochemical identification of electroneutral Na?-coupled HCO?? transporters in freshly dissociated mouse medullary raphé neurons. Neuroscience. 2013;246:451-67 pubmed publisher
    ..Assuming that the transporters are independently distributed among neurons, we can conclude that virtually all chemosensitive MR neurons contain at least one nNCBT. ..

More Information


  1. Stakisaitis D, Meilus V, Juska A, Matusevičius P, Didziapetriene J. Sodium is not required for chloride efflux via chloride/bicarbonate exchanger from rat thymic lymphocytes. Biomed Res Int. 2014;2014:569650 pubmed publisher
    ..The study results allow concluding that Na(+) is not required for Cl(-) efflux via Cl(-)/HCO3 (-) exchanger. NMDG in buffers cannot be used for substituting Na(+) because NMDG inhibits the exchanger. ..
  2. Wang D, Liu Y, Myers E, Guo Y, Xie Z, Jiang D, et al. Effects of Nt-truncation and coexpression of isolated Nt domains on the membrane trafficking of electroneutral Na+/HCO3- cotransporters. Sci Rep. 2015;5:12241 pubmed publisher
    ..Moreover, we identified a new promoter of Slc4a10 encoding NBCn2 and a novel type of Nt-truncated NBCn2 starting with "MHAN"...