Slc48a1

Summary

Gene Symbol: Slc48a1
Description: solute carrier family 48 member 1
Alias: HRG-1, Hrg1, heme transporter HRG1, Heme-responsive gene 1 protein homolog, solute carrier family 48 (heme transporter), member 1
Species: rat

Top Publications

  1. Rajagopal A, Rao A, Amigo J, Tian M, Upadhyay S, Hall C, et al. Haem homeostasis is regulated by the conserved and concerted functions of HRG-1 proteins. Nature. 2008;453:1127-31 pubmed publisher
    ..Thus, uncovering the mechanisms of haem transport in C. elegans may provide insights into human disorders of haem metabolism and reveal new drug targets for developing anthelminthics to combat worm infestations. ..
  2. O Callaghan K, Ayllon V, O Keeffe J, Wang Y, Cox O, Loughran G, et al. Heme-binding protein HRG-1 is induced by insulin-like growth factor I and associates with the vacuolar H+-ATPase to control endosomal pH and receptor trafficking. J Biol Chem. 2010;285:381-91 pubmed publisher
    ..Our findings indicate that HRG-1 regulates V-ATPase activity, which is essential for endosomal acidification, heme binding, and receptor trafficking in mammalian cells. Thus, HRG-1 may facilitate tumor growth and cancer progression. ..
  3. White C, Yuan X, Schmidt P, Bresciani E, Samuel T, Campagna D, et al. HRG1 is essential for heme transport from the phagolysosome of macrophages during erythrophagocytosis. Cell Metab. 2013;17:261-70 pubmed publisher
    ..Here, we show that the mammalian homolog of HRG1, a transmembrane heme permease in C...