Gene Symbol: Slc40a1
Description: solute carrier family 40 member 1
Alias: Fpn1, Slc11a3, Slc39a1, solute carrier family 40 member 1, CAR1, cell adhesion regulator, ferroportin-1, solute carrier family 39 (iron-regulated transporter), member 1, solute carrier family 40 (iron-regulated transporter), member 1
Species: rat
Products:     Slc40a1

Top Publications

  1. Zhang D, Senecal T, Ghosh M, Ollivierre Wilson H, Tu T, Rouault T. Hepcidin regulates ferroportin expression and intracellular iron homeostasis of erythroblasts. Blood. 2011;118:2868-77 pubmed publisher
    ..hormone, hepcidin, regulates systemic iron homeostasis by interacting with the iron export protein ferroportin (FPN1) to adjust iron absorption in enterocytes, iron recycling through reticuloendothelial macrophages, and iron release ..
  2. White C, Yuan X, Schmidt P, Bresciani E, Samuel T, Campagna D, et al. HRG1 is essential for heme transport from the phagolysosome of macrophages during erythrophagocytosis. Cell Metab. 2013;17:261-70 pubmed publisher
    ..Our results reveal HRG1 as the long-sought heme transporter for heme-iron recycling in macrophages and suggest that genetic variations in HRG1 could be modifiers of human iron metabolism. ..
  3. Li L, Li Y, Zhao J, Liu Y, Holscher C. Quantitative analysis of iron concentration and expression of ferroportin 1 in the cortex and hippocampus of rats induced by cerebral ischemia. J Clin Neurosci. 2009;16:1466-72 pubmed publisher
    ..Little is known about the relationship between brain ischemia and ferroportin 1 (FP1)...
  4. Carvalho L, Brait D, Vaz M, Lollo P, Morato P, Oesterreich S, et al. Partially Hydrolyzed Guar Gum Increases  Ferroportin Expression in the Colon of Anemic  Growing Rats. Nutrients. 2017;9: pubmed publisher
    ..PHGG seems to have a positive influence on iron absorption through transporter expression, and structural and physiological changes in the colon of anemic growing animals. ..
  5. Shpyleva S, Muskhelishvili L, Tryndyak V, Koturbash I, Tokar E, Waalkes M, et al. Chronic administration of 2-acetylaminofluorene alters the cellular iron metabolism in rat liver. Toxicol Sci. 2011;123:433-40 pubmed publisher
    ..foci might be attributed to increased iron export from the cells, driven by upregulation of ferroportin (Fpn1), the only known non-heme iron exporter...
  6. Urrutia P, Aguirre P, Esparza A, Tapia V, Mena N, Arredondo M, et al. Inflammation alters the expression of DMT1, FPN1 and hepcidin, and it causes iron accumulation in central nervous system cells. J Neurochem. 2013;126:541-9 pubmed publisher
    ..content and on the expression and abundance of the iron transporters divalent metal transporter 1 (DMT1) and Ferroportin 1 (FPN1) in neurons, astrocytes and microglia obtained from rat brain...
  7. Gong J, Xu J, Bezanilla M, van Huizen R, Derin R, Li M. Differential stimulation of PKC phosphorylation of potassium channels by ZIP1 and ZIP2. Science. 1999;285:1565-9 pubmed
    ..Finally, ZIP1 and ZIP2 coexist in the same cell type and are elevated differentially by neurotrophic factors. These results provide a mechanism for specificity and regulation of PKCzeta-targeted phosphorylation. ..
  8. Song N, Wang J, Jiang H, Xie J. Ferroportin1 and hephaestin overexpression attenuate iron-induced oxidative stress in MES23.5 dopaminergic cells. J Cell Biochem. 2010;110:1063-72 pubmed publisher
    ..Our previous in vivo experiments suggested that decreased ferroportin1 (FPN1) and hephaestin (HP) expression might account for the cellular iron accumulation and resulting dopaminergic neurons ..
  9. Nunez M, Tapia V, Rojas A, Aguirre P, Gomez F, Nualart F. Iron supply determines apical/basolateral membrane distribution of intestinal iron transporters DMT1 and ferroportin 1. Am J Physiol Cell Physiol. 2010;298:C477-85 pubmed publisher
    ..This mechanism should be complementary to those based in the transcriptional or translational regulation of iron transport proteins. ..

More Information


  1. Song N, Wang J, Jiang H, Xie J. Ferroportin 1 but not hephaestin contributes to iron accumulation in a cell model of Parkinson's disease. Free Radic Biol Med. 2010;48:332-41 pubmed publisher
    ..Based on our previous in vivo experiments showing that down-regulation of the iron transporters ferroportin 1 (FP1) and hephaestin (HP) might account for the nigral iron accumulation in 6-hydroxydopamine (6-OHDA)-..
  2. Yeh K, Yeh M, Mims L, Glass J. Iron feeding induces ferroportin 1 and hephaestin migration and interaction in rat duodenal epithelium. Am J Physiol Gastrointest Liver Physiol. 2009;296:G55-65 pubmed publisher
    ..b>Ferroportin 1 (FPN1) and hephaestin (Heph) are necessary for transport of iron out of enterocytes, but it is not known ..
  3. Delaby C, Pilard N, Gonçalves A, Beaumont C, Canonne Hergaux F. Presence of the iron exporter ferroportin at the plasma membrane of macrophages is enhanced by iron loading and down-regulated by hepcidin. Blood. 2005;106:3979-84 pubmed
    ..These data are consistent with a direct iron export by ferroportin through the plasma membrane of macrophages and strongly support an efficient posttranscriptional down-regulation of ferroportin by hepcidin in these cells. ..
  4. Mok H, Mendoza M, Prchal J, Balogh P, Schumacher A. Dysregulation of ferroportin 1 interferes with spleen organogenesis in polycythaemia mice. Development. 2004;131:4871-81 pubmed
    Regulatory interferences at the iron transporter ferroportin 1 (Fpn1) cause transient defects in iron homeostasis and erythropoiesis in polycythaemia (Pcm) mutant mice...
  5. Itoh A, Miyabayashi T, Ohno M, Sakano S. Cloning and expressions of three mammalian homologues of Drosophila slit suggest possible roles for Slit in the formation and maintenance of the nervous system. Brain Res Mol Brain Res. 1998;62:175-86 pubmed
  6. Vernay B, Koch M, Vaccarino F, Briscoe J, Simeone A, Kageyama R, et al. Otx2 regulates subtype specification and neurogenesis in the midbrain. J Neurosci. 2005;25:4856-67 pubmed
    ..Altogether, these results demonstrate that Otx2 is required from E10.5 onward to regulate neuronal subtype identity and neurogenesis in the midbrain. ..
  7. Qiao B, Sugianto P, Fung E, del Castillo Rueda A, Morán Jiménez M, Ganz T, et al. Hepcidin-induced endocytosis of ferroportin is dependent on ferroportin ubiquitination. Cell Metab. 2012;15:918-24 pubmed publisher
    ..Our study demonstrates that ubiquitination is the functionally relevant signal for hepcidin-induced ferroportin endocytosis. ..
  8. Sun C, Song N, Xie A, Xie J, Jiang H. High hepcidin level accounts for the nigral iron accumulation in acute peripheral iron intoxication rats. Toxicol Lett. 2012;212:276-81 pubmed publisher
    ..In the present study, we observed a decreased of FPN1 protein level in the SN triggered by peripheral iron overload within 4 h, which correlated with a high hepcidin ..
  9. Gao G, Liu S, Wang H, Zhang T, Yu P, Duan X, et al. Effects of Pregnancy and Lactation on Iron Metabolism in Rats. Biomed Res Int. 2015;2015:105325 pubmed publisher
    ..and serum iron level and the changes in expression of iron metabolism-related proteins, including ferritin, ferroportin 1 (FPN1), ceruloplasmin (Cp), divalent metal transporter 1 (DMT1), transferrin receptor 1 (TfR1), and the major ..
  10. Naz N, Malik I, Sheikh N, Ahmad S, Khan S, Blaschke M, et al. Ferroportin-1 is a 'nuclear'-negative acute-phase protein in rat liver: a comparison with other iron-transport proteins. Lab Invest. 2012;92:842-56 pubmed publisher
    ..These changes could explain iron retention in the cytoplasm and in the nucleus of hepatocytes during APR. ..
  11. Devalia V, Carter K, Walker A, Perkins S, Worwood M, May A, et al. Autosomal dominant reticuloendothelial iron overload associated with a 3-base pair deletion in the ferroportin 1 gene (SLC11A3). Blood. 2002;100:695-7 pubmed
    ..A 3-base pair deletion in exon 5 of the ferroportin 1 gene (SLC11A3) predicting Val162 deletion was found in affected members, but not in unaffected individuals or ..
  12. Meynard D, Kautz L, Darnaud V, Canonne Hergaux F, Coppin H, Roth M. Lack of the bone morphogenetic protein BMP6 induces massive iron overload. Nat Genet. 2009;41:478-81 pubmed publisher
  13. Darshan D, Wilkins S, Frazer D, Anderson G. Reduced expression of ferroportin-1 mediates hyporesponsiveness of suckling rats to stimuli that reduce iron absorption. Gastroenterology. 2011;141:300-9 pubmed publisher increased levels of hepcidin during suckling correlated with reduced or absent duodenal expression of ferroportin 1 (Fpn1), normally a hepcidin target. Fpn1 expression was robust in adults...
  14. Iacovelli J, Mlodnicka A, Veldman P, Ying G, Dunaief J, Schumacher A. Brain and retinal ferroportin 1 dysregulation in polycythaemia mice. Brain Res. 2009;1289:85-95 pubmed publisher
    ..The radiation-induced polycythaemia (Pcm) mutation, a 58-bp microdeletion in the promoter region of ferroportin 1 (Fpn1), disrupts transcriptional and post-transcriptional regulation of this pivotal iron transporter...
  15. De Domenico I, Zhang T, Koening C, Branch R, London N, Lo E, et al. Hepcidin mediates transcriptional changes that modulate acute cytokine-induced inflammatory responses in mice. J Clin Invest. 2010;120:2395-405 pubmed publisher
    ..The results of our study suggest a new function for hepcidin in modulating acute inflammatory responses. ..
  16. Wang J, Jiang H, Xie J. Ferroportin1 and hephaestin are involved in the nigral iron accumulation of 6-OHDA-lesioned rats. Eur J Neurosci. 2007;25:2766-72 pubmed
    ..These results show for the first time that FP1 and HP co-localize in the rat brain, and suggest that decreased expression of these transporters in the SN can account for the increased iron levels. ..
  17. Jiang D, Ke Y, Cheng Y, Ho K, Qian Z. Distribution of ferroportin1 protein in different regions of developing rat brain. Dev Neurosci. 2002;24:94-8 pubmed
    ..The findings also showed that age has a significant effect on the expression of ferroportin1 protein in the cortex, hippocampus, striatum and substantia nigra of the rat brain. ..
  18. De Domenico I, Lo E, Ward D, Kaplan J. Hepcidin-induced internalization of ferroportin requires binding and cooperative interaction with Jak2. Proc Natl Acad Sci U S A. 2009;106:3800-5 pubmed publisher
    ..These results provide a molecular explanation for the dominant inheritance of hepcidin resistant iron overload disease. ..
  19. Leong W, Bowlus C, Tallkvist J, Lonnerdal B. DMT1 and FPN1 expression during infancy: developmental regulation of iron absorption. Am J Physiol Gastrointest Liver Physiol. 2003;285:G1153-61 pubmed
    Two iron transporters, divalent metal transporter1 (DMT1) and ferroportin1 (FPN1) have been identified; however, their role during infancy is unknown...
  20. Hudson D, Curtis S, Smith V, Griffiths T, Wong A, Scudamore C, et al. Human hephaestin expression is not limited to enterocytes of the gastrointestinal tract but is also found in the antrum, the enteric nervous system, and pancreatic {beta}-cells. Am J Physiol Gastrointest Liver Physiol. 2010;298:G425-32 pubmed publisher
    ..The localization of the ferroxidase Hp to the neuronal plexi and the pancreatic beta cells suggests a role for the enzymatic function of Hp in the protection of these specialized cell types from oxidative damage. ..
  21. Yeh K, Yeh M, Glass J. Hepcidin regulation of ferroportin 1 expression in the liver and intestine of the rat. Am J Physiol Gastrointest Liver Physiol. 2004;286:G385-94 pubmed
    ..The possibility that hepcidin regulates the expression of ferroportin 1 (FPT1), the basolateral iron transporter, was examined in rats after administration of LPS, an iron chelator, ..
  22. Yeh K, Yeh M, Glass J. Interactions between ferroportin and hephaestin in rat enterocytes are reduced after iron ingestion. Gastroenterology. 2011;141:292-9, 299.e1 pubmed publisher
    ..Despite the importance of Fpn in iron transport, there is controversy about its topology and functional state upon interaction with Heph...
  23. Croci C, Brandstätter J, Enz R. ZIP3, a new splice variant of the PKC-zeta-interacting protein family, binds to GABAC receptors, PKC-zeta, and Kv beta 2. J Biol Chem. 2003;278:6128-35 pubmed
    ..Subcellular co-expression of ZIP3 binding partners in the retina supported the proposed protein interactions. Our results indicate the formation of a ternary postsynaptic complex containing PKC-zeta, ZIP3, and GABA(C) receptors. ..
  24. Wallace D, Pedersen P, Dixon J, Stephenson P, Searle J, Powell L, et al. Novel mutation in ferroportin1 is associated with autosomal dominant hemochromatosis. Blood. 2002;100:692-4 pubmed
    ..We propose that this mutation disrupts the function of the ferroportin1 protein, leading to impaired iron homeostasis and iron overload. ..
  25. Marciano R, Santamarina A, de Santana A, Silva M, Amancio O, do Nascimento C, et al. Effects of prebiotic supplementation on the expression of proteins regulating iron absorption in anaemic growing rats. Br J Nutr. 2015;113:901-8 pubmed publisher
    ..These results indicate that prebiotics may interfere with the expression of various intestinal proteins and systemic factors involved in the regulation of intestinal Fe absorption in anaemic rats during the growth phase. ..
  26. Thomas C, Oates P. Differences in the uptake of iron from Fe(II) ascorbate and Fe(III) citrate by IEC-6 cells and the involvement of ferroportin/IREG-1/MTP-1/SLC40A1. Pflugers Arch. 2004;448:431-7 pubmed
    ..Ferroportin may function as a modulator of DMT1 activity and play a role in Fe(III) uptake, possibly by affecting the number or affinity of citrate binding sites. ..
  27. Nemeth E, Tuttle M, Powelson J, Vaughn M, Donovan A, Ward D, et al. Hepcidin regulates cellular iron efflux by binding to ferroportin and inducing its internalization. Science. 2004;306:2090-3 pubmed
    ..The posttranslational regulation of ferroportin by hepcidin may thus complete a homeostatic loop: Iron regulates the secretion of hepcidin, which in turn controls the concentration of ferroportin on the cell surface. ..
  28. Oates P, Thomas C. Ferroportin is expressed on the mucous granule membrane of a subpopulation of goblet cells in the duodenum of the rat. Histol Histopathol. 2005;20:681-7 pubmed publisher
    ..The finding of ferroportin in iron deficient goblet cells also suggests an additional role to iron excretion. ..
  29. Haile D. Assignment of Slc11a3 to mouse chromosome 1 band 1B and SLC11A3 to human chromosome 2q32 by in situ hybridization. Cytogenet Cell Genet. 2000;88:328-9 pubmed
  30. Gulec S, Collins J. Silencing the Menkes copper-transporting ATPase (Atp7a) gene in rat intestinal epithelial (IEC-6) cells increases iron flux via transcriptional induction of ferroportin 1 (Fpn1). J Nutr. 2014;144:12-9 pubmed publisher
    ..Increased iron efflux from knockdown cells was likely mediated via transcriptional activation of the ferroportin 1 gene (by an unknown mechanism)...
  31. Kong W, Zhao S, Duan X, Yang Z, Qian Z, Chang Y. Decreased DMT1 and increased ferroportin 1 expression is the mechanisms of reduced iron retention in macrophages by erythropoietin in rats. J Cell Biochem. 2008;104:629-41 pubmed publisher
    ..The expression of divalent metal transporter 1 (DMT1) and ferroportin 1 (FPN1) in peritoneal exudate macrophages was detected by RT-PCR and Western blot...
  32. Wu L, Leenders A, Cooperman S, Meyron Holtz E, Smith S, Land W, et al. Expression of the iron transporter ferroportin in synaptic vesicles and the blood-brain barrier. Brain Res. 2004;1001:108-17 pubmed
    ..several iron transporters, including the iron importer DMT1 (Ireg1, MTP, DCT1) and the iron exporter ferroportin (SLC11A3, Ireg, MTP1) have been cloned and characterized...
  33. Mok H, Jelinek J, Pai S, Cattanach B, Prchal J, Youssoufian H, et al. Disruption of ferroportin 1 regulation causes dynamic alterations in iron homeostasis and erythropoiesis in polycythaemia mice. Development. 2004;131:1859-68 pubmed
    Coding region mutations in the principal basolateral iron transporter of the duodenal enterocyte, ferroportin 1 (FPN1), lead to autosomal dominant reticuloendothelial iron overload in humans...
  34. Han W, Wang C, Su C, Xu X. [Effect of higher iron in diet on iron levels and hepcidin mRNA expression levels in rats]. Wei Sheng Yan Jiu. 2008;37:474-6 pubmed
    ..Higher iron diet could influence the weights, serum iron status, liver hepcidin and duodenum ferroportin mRNA expression levels of the rats. ..
  35. Du F, Qian Z, Luo Q, Yung W, Ke Y. Hepcidin Suppresses Brain Iron Accumulation by Downregulating Iron Transport Proteins in Iron-Overloaded Rats. Mol Neurobiol. 2015;52:101-14 pubmed publisher
    ..release, and also the expression of transferrin receptor-1 (TfR1), divalent metal transporter 1 (DMT1), and ferroportin 1 (Fpn1) in cultured microvascular endothelial cells and neurons...
  36. Drakesmith H, Nemeth E, Ganz T. Ironing out Ferroportin. Cell Metab. 2015;22:777-87 pubmed publisher
    ..Fundamental questions about the structure and biology of ferroportin remain to be answered. ..
  37. Wang G, Shao A, Hu W, Xue F, Zhao H, Jin X, et al. Changes of ferrous iron and its transporters after intracerebral hemorrhage in rats. Int J Clin Exp Pathol. 2015;8:10671-9 pubmed
    ..b>Ferroportin 1 (FPN1) is the unique exporter of ferrous iron from mammalian cells...
  38. Qian Z, Chang Y, Leung G, Du J, Zhu L, Wang Q, et al. Expression of ferroportin1, hephaestin and ceruloplasmin in rat heart. Biochim Biophys Acta. 2007;1772:527-32 pubmed
    ..Here, we investigated expression of iron exporters including ferroportin 1 (Fpn1), ceruloplasmin (CP) and hephaestin (Heph) and provided evidence for their existence in the heart...
  39. di Patti M, Persichini T, Mazzone V, Polticelli F, Colasanti M, Musci G. Interleukin-1beta up-regulates iron efflux in rat C6 glioma cells through modulation of ceruloplasmin and ferroportin-1 synthesis. Neurosci Lett. 2004;363:182-6 pubmed
    ..Moreover, IL-1beta has been found to increase iron efflux from C6 cells, suggesting that both proteins may play a crucial role in iron homeostasis in pathological brain conditions, such as inflammatory and/or neurodegenerative diseases. ..
  40. Kong W, Wu Q, Shen D, Zhao S, Guo P, Duan X, et al. Age-dependent expression of duodenal cytochrome b, divalent metal transporter 1, ferroportin 1, and hephaestin in the duodenum of rats. J Gastroenterol Hepatol. 2015;30:513-20 pubmed publisher
    ..The expression of duodenal cytochrome b (DcytB), divalent metal transporter 1 (DMT1), ferroportin 1 (FPN1), hephaestin, and hepcidin were measured by real-time polymerase chain reaction or Western blot...