Gene Symbol: Slc39a14
Description: solute carrier family 39 member 14
Alias: zinc transporter ZIP14, solute carrier family 39 (zinc transporter), member 14
Bin B, Fukada T, Hosaka T, Yamasaki S, Ohashi W, Hojyo S, et al
. Biochemical characterization of human ZIP13 protein: a homo-dimerized zinc transporter involved in the spondylocheiro dysplastic Ehlers-Danlos syndrome. J Biol Chem. 2011;286:40255-65 pubmed publisher
..This biochemical characterization of the human ZIP13 protein provides important information for further investigations of its structural characteristics and function. ..
Tuschl K, Meyer E, Valdivia L, Zhao N, Dadswell C, Abdul Sada A, et al
. Mutations in SLC39A14 disrupt manganese homeostasis and cause childhood-onset parkinsonism-dystonia. Nat Commun. 2016;7:11601 pubmed publisher
..a cohort of patients with a novel autosomal recessive manganese transporter defect caused by mutations in SLC39A14. Excessive accumulation of manganese in these patients results in rapidly progressive childhood-onset ..
Aburto Luna V, Treviño S, Santos López G, Moroni González D, Calva Cruz O, Aguilar Alonso P, et al
. Hepatic mobilization of zinc after an experimental surgery, and its relationship with inflammatory cytokines release, and expression of metallothionein and Zip14 transporter. Inflamm Res. 2017;66:167-175 pubmed publisher
..RNAm and protein levels of Zip14 were elevated between 6 and 20 h after surgery. Biochemical changes described in this work could be part of the APR, and directed to respond to the damage produced during surgical trauma. ..
Taylor K, Morgan H, Johnson A, Nicholson R. Structure-function analysis of a novel member of the LIV-1 subfamily of zinc transporters, ZIP14. FEBS Lett. 2005;579:427-32 pubmed
..We investigate here whether ZIP14 (SLC39A14), lacking the initial histidine in this motif, is still able to transport zinc...
Kotani M, Kim K, Ishizaki N, Funaba M, Matsui T. Magnesium and calcium deficiencies additively increase zinc concentrations and metallothionein expression in the rat liver. Br J Nutr. 2013;109:425-32 pubmed publisher
..Because Mg and Ca deficiencies increase hepatic Zn concentration and increase MT expression by different mechanisms, their effects are additive. ..
Ding D, Salvi R, Roth J. Cellular localization and developmental changes of Zip8, Zip14 and transferrin receptor 1 in the inner ear of rats. Biometals. 2014;27:731-44 pubmed publisher
Bogdan A, Miyazawa M, Hashimoto K, Tsuji Y. Regulators of Iron Homeostasis: New Players in Metabolism, Cell Death, and Disease. Trends Biochem Sci. 2016;41:274-286 pubmed publisher
..We also discuss emerging roles of iron in apoptosis and a novel iron-dependent cell death pathway termed 'ferroptosis', the dysregulation of iron metabolism in human pathologies, and the use of iron chelators in cancer therapy. ..
Liuzzi J, Aydemir F, Nam H, Knutson M, Cousins R. Zip14 (Slc39a14) mediates non-transferrin-bound iron uptake into cells. Proc Natl Acad Sci U S A. 2006;103:13612-7 pubmed
..Because NTBI is commonly found in plasma of patients with hemochromatosis and transfusional iron overload, Zip14-mediated NTBI uptake may contribute to the hepatic iron loading that characterizes these diseases. ..
Lane D, Merlot A, Huang M, Bae D, Jansson P, Sahni S, et al
. Cellular iron uptake, trafficking and metabolism: Key molecules and mechanisms and their roles in disease. Biochim Biophys Acta. 2015;1853:1130-44 pubmed publisher
..g., Friedreich's ataxia. Increased knowledge of the molecules and their mechanisms of action in iron processing pathways (e.g., ISC biogenesis) will shape the investigation of iron metabolism in human health and disease. ..