Gene Symbol: Slc39a1
Description: solute carrier family 39 member 1
Alias: zinc transporter ZIP1, solute carrier family 39 (zinc transporter), member 1
Gaither L, Eide D. The human ZIP1 transporter mediates zinc uptake in human K562 erythroleukemia cells. J Biol Chem. 2001;276:22258-64 pubmed
..The observation that hZIP1 is the major zinc transporter in K562 cells, coupled with its expression in many normal cell types, indicates that hZIP1 plays an important role in zinc uptake in human tissues. ..
Kim O, Ariano M, Namkung Y, Marinec P, Kim E, Han J, et al
. D2 dopamine receptor expression and trafficking is regulated through direct interactions with ZIP. J Neurochem. 2008;106:83-95 pubmed publisher
..These results suggest that ZIP can physically interact with the D(2) DAR leading to increased intracellular trafficking to lysosomes with subsequent down-regulation of receptor expression and function. ..
Franklin R, Ma J, Zou J, Guan Z, Kukoyi B, Feng P, et al
. Human ZIP1 is a major zinc uptake transporter for the accumulation of zinc in prostate cells. J Inorg Biochem. 2003;96:435-42 pubmed
..The studies reveal that hZIP1 (SLC39A1) but not hZIP2 (SLC39A2) is expressed in the zinc-accumulating human prostate cell lines, LNCaP and PC-3...
Dufner Beattie J, Langmade S, Wang F, Eide D, Andrews G. Structure, function, and regulation of a subfamily of mouse zinc transporter genes. J Biol Chem. 2003;278:50142-50 pubmed
..These studies suggest that all three of these ZIP proteins may play cell-specific roles in zinc homeostasis rather than primary roles in the acquisition of dietary zinc. ..
Dufner Beattie J, Huang Z, Geiser J, Xu W, Andrews G. Mouse ZIP1 and ZIP3 genes together are essential for adaptation to dietary zinc deficiency during pregnancy. Genesis. 2006;44:239-51 pubmed
..In conclusion, mutations in the ZIP1 and ZIP3 zinc transporter genes are silent when dietary intake of zinc is normal, but can dramatically compromise the success of pregnancy when dietary intake of zinc is limiting. ..
Belloni Olivi L, Marshall C, Laal B, Andrews G, Bressler J. Localization of zip1 and zip4 mRNA in the adult rat brain. J Neurosci Res. 2009;87:3221-30 pubmed publisher
..Because zip4 levels are regulated by dietary Zn, our studies suggest that the brain has the potential of adapting to changes in Zn status. ..
Pan R, Liu K. ZNT-1 Expression Reduction Enhances Free Zinc Accumulation in Astrocytes After Ischemic Stroke. Acta Neurochir Suppl. 2016;121:257-61 pubmed publisher
..These results suggest that hypoxia/reoxygenation blocked zinc efflux, whereas zinc influx may be at a similar level to that in normoxia, providing a novel mechanism for intracellular free zinc accumulation after ischemic stroke. ..