Gene Symbol: Slc36a1
Description: solute carrier family 36 member 1
Alias: Lyaat1, proton-coupled amino acid transporter 1, LYAAT-1, lysosomal amino acid transporter 1, neutral amino acid/proton symporter, proton/amino acid transporter 1, solute carrier family 36 (proton/amino acid symporter), member 1, ysosomal amino acid transporter 1
Singh A, Amlal H, Haas P, Dringenberg U, Fussell S, Barone S, et al
. Fructose-induced hypertension: essential role of chloride and fructose absorbing transporters PAT1 and Glut5. Kidney Int. 2008;74:438-47 pubmed publisher
..We suggest that fructose-induced hypertension is likely caused by increased salt absorption by the intestine and kidney and the transporters Slc26a6 and Slc2a5 are essential in this process. ..
Holm R, Kall M, Frølund S, Nielsen A, Jensen A, Broberg M, et al
. Rectal absorption of vigabatrin, a substrate of the proton coupled amino acid transporter (PAT1, Slc36a1), in rats. Pharm Res. 2012;29:1134-42 pubmed publisher
To investigate the rectal absorption of vigabatrin in rats, based on the hypothesis that PAT1 (Slc36a1) is involved...
Sagne C, Agulhon C, Ravassard P, Darmon M, Hamon M, El Mestikawy S, et al
. Identification and characterization of a lysosomal transporter for small neutral amino acids. Proc Natl Acad Sci U S A. 2001;98:7206-11 pubmed
..Homology searching in eukaryotic genomes suggests that LYAAT-1 defines a subgroup of lysosomal transporters in the amino acid/auxin permease family. ..
Boll M, Foltz M, Rubio Aliaga I, Kottra G, Daniel H. Functional characterization of two novel mammalian electrogenic proton-dependent amino acid cotransporters. J Biol Chem. 2002;277:22966-73 pubmed
..Phenotypically, the PAT1 transporter possesses the same functional characteristics as the previously described proton-dependent amino acid transport process in apical membranes of intestinal and renal epithelial cells. ..
Wreden C, Johnson J, Tran C, Seal R, Copenhagen D, Reimer R, et al
. The H+-coupled electrogenic lysosomal amino acid transporter LYAAT1 localizes to the axon and plasma membrane of hippocampal neurons. J Neurosci. 2003;23:1265-75 pubmed
Recent work has identified a lysosomal protein that transports neutral amino acids (LYAAT1)...
Nielsen C, Frølund S, Abdulhadi S, Sari H, Langthaler L, Nøhr M, et al
. Sertraline inhibits the transport of PAT1 substrates in vivo and in vitro. Br J Pharmacol. 2013;170:1041-52 pubmed publisher
..was to investigate whether sertraline interacts with the intestinal proton-coupled amino acid transporter 1 PAT1 (SLC36A1)...
Murakami T, Yoshinaga M. Induction of amino acid transporters expression by endurance exercise in rat skeletal muscle. Biochem Biophys Res Commun. 2013;439:449-52 pubmed publisher
..These results suggested that the expression of amino acid transporters for leucine may be induced in response to an increase in the requirement for this amino acid in the cells of working skeletal muscles. ..
Jensen A, Figueiredo Larsen M, Holm R, Broberg M, Brodin B, Nielsen C. PAT1 (SLC36A1) shows nuclear localization and affects growth of smooth muscle cells from rats. Am J Physiol Endocrinol Metab. 2014;306:E65-74 pubmed publisher
..The growth rates of the cells were evaluated, and knockdown of PAT1 led to induced cellular growth, suggesting a role for PAT1 in regulating cellular proliferation of SMCs. ..