Gene Symbol: Slc34a2
Description: solute carrier family 34 member 2
Alias: sodium-dependent phosphate transport protein 2B, Na(+)-dependent phosphate cotransporter 2B, Na(+)/Pi cotransporter 2B, naPi-2b, rNaPi IIb, sodium-phosphate transport protein 2B, sodium/phosphate cotransporter 2B, solute carrier family 34 (sodium phosphate), member 2, solute carrier family 34 (type II sodium/phosphate contransporter), member 2, solute carrier family 34 (type II sodium/phosphate cotransporter), member 2, type IIb sodium-phosphate transporter
Species: rat
Products:     Slc34a2

Top Publications

  1. Villa Bellosta R, Sorribas V. Role of rat sodium/phosphate cotransporters in the cell membrane transport of arsenate. Toxicol Appl Pharmacol. 2008;232:125-34 pubmed publisher
    ..Our data agree with current toxicokinetic knowledge, and they explain the asymmetric excretion of trivalent and pentavalent arsenic species into bile and urine. ..
  2. Shibasaki Y, Etoh N, Hayasaka M, Takahashi M, Kakitani M, Yamashita T, et al. Targeted deletion of the tybe IIb Na(+)-dependent Pi-co-transporter, NaPi-IIb, results in early embryonic lethality. Biochem Biophys Res Commun. 2009;381:482-6 pubmed publisher
    ..Expression patterns of NaPi-IIb suggest that NaPi-IIb plays an important role in Pi absorption from maternal circulation. ..
  3. Xu Y, Yeung C, Setiawan I, Avram C, Biber J, Wagenfeld A, et al. Sodium-inorganic phosphate cotransporter NaPi-IIb in the epididymis and its potential role in male fertility studied in a transgenic mouse model. Biol Reprod. 2003;69:1135-41 pubmed
  4. Frei P, Gao B, Hagenbuch B, Mate A, Biber J, Murer H, et al. Identification and localization of sodium-phosphate cotransporters in hepatocytes and cholangiocytes of rat liver. Am J Physiol Gastrointest Liver Physiol. 2005;288:G771-8 pubmed
    ..We conclude that NaPi-IIb is most probably involved in the reabsorption of P(i) from primary hepatic bile and thus might play an important role in the regulation of biliary P(i) concentration...
  5. Hilfiker H, Hattenhauer O, Traebert M, Forster I, Murer H, Biber J. Characterization of a murine type II sodium-phosphate cotransporter expressed in mammalian small intestine. Proc Natl Acad Sci U S A. 1998;95:14564-9 pubmed
    ..Expression of the type IIb protein in the brush borders of enterocytes and transport characteristics suggest that the described type IIb Na/Pi-cotransporter represents a candidate for small intestinal apical Na/Pi-cotransport. ..
  6. Giral H, Cranston D, Lanzano L, Caldas Y, Sutherland E, Rachelson J, et al. NHE3 regulatory factor 1 (NHERF1) modulates intestinal sodium-dependent phosphate transporter (NaPi-2b) expression in apical microvilli. J Biol Chem. 2012;287:35047-56 pubmed publisher
    P(i) uptake in the small intestine occurs predominantly through the NaPi-2b (SLC34a2) co-transporter. NaPi-2b is regulated by changes in dietary P(i) but the mechanisms underlying this regulation are largely undetermined...
  7. Suyama T, Okada S, Ishijima T, Iida K, Abe K, Nakai Y. High phosphorus diet-induced changes in NaPi-IIb phosphate transporter expression in the rat kidney: DNA microarray analysis. PLoS ONE. 2012;7:e29483 pubmed publisher
    ..These data suggest that NaPi-IIb is upregulated in the kidney in response to the active excretion of phosphate in HP diet-fed rats. ..
  8. Xu H, Inouye M, Missey T, Collins J, Ghishan F. Functional characterization of the human intestinal NaPi-IIb cotransporter in hamster fibroblasts and Xenopus oocytes. Biochim Biophys Acta. 2002;1567:97-105 pubmed
  9. Jin C, Zoidis E, Ghirlanda C, Schmid C. Dexamethasone and cyclic AMP regulate sodium phosphate cotransporter (NaPi-IIb and Pit-1) mRNA and phosphate uptake in rat alveolar type II epithelial cells. Lung. 2010;188:51-61 pubmed publisher
    ..1 mmol/l cAMP treatment. Although NaPi-IIb mRNA expression was maintained to some extent by AT II cells kept in primary culture, Pi uptake was more closely related to Pit-1 mRNA expression. ..

More Information


  1. Homann V, Rosin Steiner S, Stratmann T, Arnold W, Gaengler P, Kinne R. Sodium-phosphate cotransporter in human salivary glands: molecular evidence for the involvement of NPT2b in acinar phosphate secretion and ductal phosphate reabsorption. Arch Oral Biol. 2005;50:759-68 pubmed
    ..These findings suggest a secondary active secretion of phosphate into the primary saliva. Ductal cells appear to be able to reabsorb phosphate, thereby modifying the phosphate concentration in the final saliva. ..
  2. Ratcliffe S, Jugdaohsingh R, Vivancos J, Marron A, Deshmukh R, Ma J, et al. Identification of a mammalian silicon transporter. Am J Physiol Cell Physiol. 2017;312:C550-C561 pubmed publisher
    ..Here we report the identification of a mammalian efflux Si transporter, namely Slc34a2 (also termed NaPiIIb), a known sodium-phosphate cotransporter, which was upregulated in rat kidney following ..
  3. McHaffie G, Graham C, Kohl B, Strunck Warnecke U, Werner A. The role of an intracellular cysteine stretch in the sorting of the type II Na/phosphate cotransporter. Biochim Biophys Acta. 2007;1768:2099-106 pubmed
    ..Our results suggest that the modified cysteine motif prevents the constructs from basolateral sorting. Additional sorting determinants located downstream of the cysteine stretch may release the cargo to the apical compartment. ..
  4. Arima K, Hines E, Kiela P, Drees J, Collins J, Ghishan F. Glucocorticoid regulation and glycosylation of mouse intestinal type IIb Na-P(i) cotransporter during ontogeny. Am J Physiol Gastrointest Liver Physiol. 2002;283:G426-34 pubmed
    ..We also demonstrate that Na-P(i)-IIb is an N-linked glycoprotein and that glycosylation is age dependent. ..
  5. Hashimoto M, Wang D, Kamo T, Zhu Y, Tsujiuchi T, Konishi Y, et al. Isolation and localization of type IIb Na/Pi cotransporter in the developing rat lung. Am J Pathol. 2000;157:21-7 pubmed
    ..probed with HG80 was the rat counterpart of sodium-dependent phosphate transporter type IIb and was designated rNaPi IIb. In situ hybridization showed that rNaPi IIb was expressed in type II alveolar cells, suggesting a role in the ..
  6. Xu H, Bai L, Collins J, Ghishan F. Molecular cloning, functional characterization, tissue distribution, and chromosomal localization of a human, small intestinal sodium-phosphate (Na+-Pi) transporter (SLC34A2). Genomics. 1999;62:281-4 pubmed
    ..We have isolated a cDNA (HGMW-approved symbol SLC34A2) encoding a novel human small intestinal Na(+)-P(i) transporter...
  7. Feild J, Zhang L, Brun K, Brooks D, Edwards R. Cloning and functional characterization of a sodium-dependent phosphate transporter expressed in human lung and small intestine. Biochem Biophys Res Commun. 1999;258:578-82 pubmed
    ..This novel transporter, designated human NaPi-3b (Genbank AF111856), appears to be an isoform of the mammalian renal type II co-transporter family. ..
  8. Xu H, Uno J, Inouye M, Xu L, Drees J, Collins J, et al. Regulation of intestinal NaPi-IIb cotransporter gene expression by estrogen. Am J Physiol Gastrointest Liver Physiol. 2003;285:G1317-24 pubmed
    ..This stimulation is associated with increased NaPi-IIb mRNA and protein expression. Thus the effect of estrogen on intestinal Pi absorption may be partially due to activation of NaPi-IIb gene transcription. ..
  9. Miyoshi K, Shillingford J, Smith G, Grimm S, Wagner K, Oka T, et al. Signal transducer and activator of transcription (Stat) 5 controls the proliferation and differentiation of mammary alveolar epithelium. J Cell Biol. 2001;155:531-42 pubmed
    ..These data demonstrate that signaling via the PrlR and Stat5 is critical for the proliferation and differentiation of mammary alveoli during pregnancy. ..
  10. Prie D, Torres P, Friedlander G. Phosphate handling: new genes, new molecules. Horm Res Paediatr. 2011;76 Suppl 1:71-5 pubmed publisher
    ..This progress may allow development of new drugs that interfere with phosphate transporters, hormonal receptors or associated proteins to improve treatment and to help prevent secondary hyperparathyroidism. ..
  11. Lundquist P, Murer H, Biber J. Type II Na+-Pi cotransporters in osteoblast mineral formation: regulation by inorganic phosphate. Cell Physiol Biochem. 2007;19:43-56 pubmed
    ..Their expression thus seem regulated by phosphate in a manner consistent with their playing a role in transcellular P(i) flux during mineralization. ..
  12. Kirchner S, Muduli A, Casirola D, Prum K, Douard V, Ferraris R. Luminal fructose inhibits rat intestinal sodium-phosphate cotransporter gene expression and phosphate uptake. Am J Clin Nutr. 2008;87:1028-38 pubmed
    ..Consumption of fructose that supplies approximately 10% of caloric intake by Americans clearly affects absorption of Pi and may promote Pi homeostasis in patients with impaired renal function. ..