Gene Symbol: Slc31a1
Description: solute carrier family 31 member 1
Alias: Ctr1, LRRGT00200, high affinity copper uptake protein 1, Copper uptake transporter 1, copper transporter 1, liver regeneration-related protein LRRGT00200, rCTR1, solute carrier family 31 (copper transporter), member 1, solute carrier family 31 (copper transporters), member 1
Species: rat
Products:     Slc31a1

Top Publications

  1. Gambling L, Dunford S, McArdle H. Iron deficiency in the pregnant rat has differential effects on maternal and fetal copper levels. J Nutr Biochem. 2004;15:366-72 pubmed
    ..In all tissues examined, mRNA expression for CTR1, ATOX1, ATP7A, and ATP7B was unchanged by iron deficiency...
  2. Samsonov S, Platonova N, Skvortsov A, Tsymbalenko N, Vasin A, Puchkova L. [Relations between CTR1 gene activity and copper status in different rat organs]. Mol Biol (Mosk). 2006;40:239-51 pubmed
    CTR1 gene (SLC31A1 according to Entrez data base) product is the main candidate for the role of eukaryotic copper importer, whose tissue-specific function is still unclear...
  3. Kelleher S, Lonnerdal B. Mammary gland copper transport is stimulated by prolactin through alterations in Ctr1 and Atp7A localization. Am J Physiol Regul Integr Comp Physiol. 2006;291:R1181-91 pubmed
    ..Milk copper (Cu) concentration declines and directly reflects the stage of lactation. Three Cu-specific transporters (Ctr1, Atp7A, Atp7B) have been identified in the mammary gland; however, the integrated role they play in milk Cu ..
  4. Klomp A, Juijn J, van der Gun L, van den Berg I, Berger R, Klomp L. The N-terminus of the human copper transporter 1 (hCTR1) is localized extracellularly, and interacts with itself. Biochem J. 2003;370:881-9 pubmed
    ..studies and glycosylation-site insertion and deletion mapping to characterize the topology of human copper transporter 1 (hCTR1), the putative human high-affinity copper-import protein...
  5. Ohrvik H, Nose Y, Wood L, Kim B, Gleber S, Ralle M, et al. Ctr2 regulates biogenesis of a cleaved form of mammalian Ctr1 metal transporter lacking the copper- and cisplatin-binding ecto-domain. Proc Natl Acad Sci U S A. 2013;110:E4279-88 pubmed publisher
    ..copper acquisition and intracellular mobilization via cleavage of the copper-binding ecto-domain of the copper transporter 1 (Ctr1)...
  6. Zheng G, Zhang J, Xu Y, Shen X, Song H, Jing J, et al. Involvement of CTR1 and ATP7A in lead (Pb)-induced copper (Cu) accumulation in choroidal epithelial cells. Toxicol Lett. 2014;225:110-8 pubmed publisher
    ..This study investigated the roles of Cu transporter 1 (CTR1) and ATP7A, two Cu transporters, in Pb-induced Cu accumulation in the choroidal epithelial cells...
  7. Zheng G, Chen J, Zheng W. Relative contribution of CTR1 and DMT1 in copper transport by the blood-CSF barrier: implication in manganese-induced neurotoxicity. Toxicol Appl Pharmacol. 2012;260:285-93 pubmed publisher
    The homeostasis of copper (Cu) in the cerebrospinal fluid (CSF) is partially regulated by the Cu transporter-1 (CTR1) and divalent metal transporter-1 (DMT1) at the blood-CSF barrier (BCB) in the choroid plexus...
  8. De Feo C, Aller S, Siluvai G, Blackburn N, Unger V. Three-dimensional structure of the human copper transporter hCTR1. Proc Natl Acad Sci U S A. 2009;106:4237-42 pubmed publisher
    ..Here, we report the structure of the human CTR1 protein solved by electron crystallography to an in plane resolution of 7 A...
  9. Nose Y, Wood L, Kim B, Prohaska J, Fry R, Spears J, et al. Ctr1 is an apical copper transporter in mammalian intestinal epithelial cells in vivo that is controlled at the level of protein stability. J Biol Chem. 2010;285:32385-92 pubmed publisher
    ..The Ctr1 protein is a high-affinity Cu(+) importer that is structurally and functionally conserved in yeast, plants, fruit ..

More Information


  1. Aller S, Unger V. Projection structure of the human copper transporter CTR1 at 6-A resolution reveals a compact trimer with a novel channel-like architecture. Proc Natl Acad Sci U S A. 2006;103:3627-32 pubmed
    Human CTR1 is a high-affinity copper transporter that also mediates the uptake of the anticancer drug cisplatin by largely unknown transport mechanisms...
  2. Liu J, Kim Y, Yan F, Ding Q, Ip V, Jong N, et al. Contributions of rat Ctr1 to the uptake and toxicity of copper and platinum anticancer drugs in dorsal root ganglion neurons. Biochem Pharmacol. 2013;85:207-15 pubmed publisher
    ..This study aimed to understand the role of copper transporter 1 (Ctr1) in the uptake and toxicity of copper and platinum drugs in cultured rat DRG neurons, and the ..
  3. Ciarimboli G. Membrane transporters as mediators of Cisplatin effects and side effects. Scientifica (Cairo). 2012;2012:473829 pubmed publisher
    ..have been associated with cisplatin transport across the plasma membrane and across the cell: the copper transporter 1 (Ctr1), the copper transporter 2 (Ctr2), the P-type copper-transporting ATPases ATP7A and ATP7B, the ..
  4. Lee J, Petris M, Thiele D. Characterization of mouse embryonic cells deficient in the ctr1 high affinity copper transporter. Identification of a Ctr1-independent copper transport system. J Biol Chem. 2002;277:40253-9 pubmed
    ..Previously, we reported that overexpression of the human or mouse Ctr1 copper transporter stimulates copper uptake in mammalian cells, and deletion of one Ctr1 allele in mice gives rise ..
  5. Tokuda E, Okawa E, Ono S. Dysregulation of intracellular copper trafficking pathway in a mouse model of mutant copper/zinc superoxide dismutase-linked familial amyotrophic lateral sclerosis. J Neurochem. 2009;111:181-91 pubmed publisher
    ..These results indicate that the nature of mutant SOD1 toxicity might involve the dysregulation of the copper trafficking pathway, resulting in the disruption of intracellular copper homeostasis. ..
  6. Monnot A, Zheng G, Zheng W. Mechanism of copper transport at the blood-cerebrospinal fluid barrier: influence of iron deficiency in an in vitro model. Exp Biol Med (Maywood). 2012;237:327-33 pubmed publisher
    ..The effect of FeD on cellular Cu retention and transporters Cu transporter-1 (Ctr1), divalent metal transporter 1 (DMT1), antioxidant protein-1 (ATOX1) and ATP7A was examined in choroidal epithelial ..
  7. Scheiber I, Mercer J, Dringen R. Copper accumulation by cultured astrocytes. Neurochem Int. 2010;56:451-60 pubmed publisher
    ..The presence of mRNA and of immunoreactivity of the copper transport protein Ctr1 in astrocyte cultures suggests that Ctr1 contributes to the observed copper accumulation...
  8. Ip V, Liu J, Mercer J, McKeage M. Differential expression of ATP7A, ATP7B and CTR1 in adult rat dorsal root ganglion tissue. Mol Pain. 2010;6:53 pubmed publisher
    ATP7A, ATP7B and CTR1 are metal transporting proteins that control the cellular disposition of copper and platinum drugs, but their expression in dorsal root ganglion (DRG) tissue and their role in platinum-induced neurotoxicity are ..
  9. Sancho Martínez S, Prieto García L, Prieto M, Lopez Novoa J, Lopez Hernandez F. Subcellular targets of cisplatin cytotoxicity: an integrated view. Pharmacol Ther. 2012;136:35-55 pubmed publisher
    ..Perspectives for the key aspects that need to be addressed by future investigation are also outlined. ..