Gene Symbol: Slc30a5
Description: solute carrier family 30 member 5
Alias: zinc transporter 5, solute carrier family 30 (zinc transporter), member 5
Cragg R, Christie G, Phillips S, Russi R, Kury S, Mathers J, et al
. A novel zinc-regulated human zinc transporter, hZTL1, is localized to the enterocyte apical membrane. J Biol Chem. 2002;277:22789-97 pubmed
..The localization, regulatory properties, and function of hZTL1 indicate a role in regulating the absorption of dietary zinc across the apical enterocyte membrane. ..
Falcon Perez J, Dell Angelica E. Zinc transporter 2 (SLC30A2) can suppress the vesicular zinc defect of adaptor protein 3-depleted fibroblasts by promoting zinc accumulation in lysosomes. Exp Cell Res. 2007;313:1473-83 pubmed
Petkovic V, Miletta M, EblÃ© A, FlÃ¼ck C, Mullis P. Alteration of ZnT5-mediated zinc import into the early secretory pathway affects the secretion of growth hormone from rat pituitary cells. Horm Res Paediatr. 2014;82:245-51 pubmed publisher
..b>Slc30a5 (ZnT5) was reported to have the highest gene expression among all zinc transporters in primary mouse pituitary ..
Lacourse K, Swanberg L, Gillespie P, Rehfeld J, Saunders T, Samuelson L. Pancreatic function in CCK-deficient mice: adaptation to dietary protein does not require CCK. Am J Physiol. 1999;276:G1302-9 pubmed
..Altered somatostatin concentrations in brain and duodenum of CCK-deficient mice suggest that other regulatory pathways are modified to compensate for the CCK deficiency. ..
Kambe T, Narita H, Yamaguchi Iwai Y, Hirose J, Amano T, Sugiura N, et al
. Cloning and characterization of a novel mammalian zinc transporter, zinc transporter 5, abundantly expressed in pancreatic beta cells. J Biol Chem. 2002;277:19049-55 pubmed
..We have identified a novel mammalian zinc transporter, zinc transporter 5 (ZnT-5), by virtue of its similarity to ZRC1, a zinc transporter of Saccharomyces cerevisiae, a member of ..
Inoue K, Matsuda K, Itoh M, Kawaguchi H, Tomoike H, Aoyagi T, et al
. Osteopenia and male-specific sudden cardiac death in mice lacking a zinc transporter gene, Znt5. Hum Mol Genet. 2002;11:1775-84 pubmed
..These results indicate that Znt5 protein plays an important role in maturation of osteoblasts and in maintenance of the cells involved in the cardiac conduction system, partly owing to dysregulated expression of IEGs and HSPs. ..