| Slc30a4Gene Symbol: Slc30a4 Description: solute carrier family 30 member 4 Alias: zinc transporter 4, Dri 27/ZnT4 protein, dri 27 protein, solute carrier family 30 (zinc transporter), member 4, znT-4 Species: rat Huang L, Gitschier J. A novel gene involved in zinc transport is deficient in the lethal milk mouse. Nat Genet. 1997;17:292-7 pubmed ..The lethal milk mutant has a nonsense mutation at arginine codon 297 in the Znt4 gene. .. Murgia C, Vespignani I, Cerase J, Nobili F, Perozzi G. Cloning, expression, and vesicular localization of zinc transporter Dri 27/ZnT4 in intestinal tissue and cells. Am J Physiol. 1999;277:G1231-9 pubmed ..By subcloning distinct portions of the protein in frame with glutathione-S-transferase, we also provide experimental evidence of their function as zinc-binding and protein-protein-interaction domains. .. Ackland M, Mercer J. The murine mutation, lethal milk, results in production of zinc-deficient milk. J Nutr. 1992;122:1214-8 pubmed ..We conclude that the major effect of the lethal milk mutation is the production of Zn-deficient milk. .. Ranaldi G, Perozzi G, Truong Tran A, Zalewski P, Murgia C. Intracellular distribution of labile Zn(II) and zinc transporter expression in kidney and MDCK cells. Am J Physiol Renal Physiol. 2002;283:F1365-75 pubmed ..All of the mRNAs examined [ZnT1, -T2, -T4, and human Zrt, Irt-like protein 1 (hZIP1)], with the exception of hZIP2, were present in adult rat kidney. .. Kelleher S, Lonnerdal B. Zinc transporters in the rat mammary gland respond to marginal zinc and vitamin A intakes during lactation. J Nutr. 2002;132:3280-5 pubmed ..These results indicate that milk Zn level is maintained through coordinated regulation of mammary gland zinc transporters and documents an effect of vitamin A on zinc homeostasis at the molecular level during lactation. .. Kelleher S, Lonnerdal B. Zn transporter levels and localization change throughout lactation in rat mammary gland and are regulated by Zn in mammary cells. J Nutr. 2003;133:3378-85 pubmed Falcon Perez J, Dell Angelica E. Zinc transporter 2 (SLC30A2) can suppress the vesicular zinc defect of adaptor protein 3-depleted fibroblasts by promoting zinc accumulation in lysosomes. Exp Cell Res. 2007;313:1473-83 pubmed Flach C, Qadri F, Bhuiyan T, Alam N, Jennische E, Holmgren J, et al. Differential expression of intestinal membrane transporters in cholera patients. FEBS Lett. 2007;581:3183-8 pubmed ..Five other transporters were downregulated; aquaporin 10, SLC6A4, TRPM6, SLC23A1 and SLC30A4, which have specificity for water, serotonin (5-HT), magnesium, vitamin C and zinc, respectively... Murgia C, Grosser D, Truong Tran A, Roscioli E, Michalczyk A, Ackland M, et al. Apical localization of zinc transporter ZnT4 in human airway epithelial cells and its loss in a murine model of allergic airway inflammation. Nutrients. 2011;3:910-28 pubmed publisher ..We speculate that ZnT4 is an important regulator of zinc ion accumulation in secretory apical vesicles and that the loss of labile Zn and ZnT4 in airway inflammation contributes to AE vulnerability in diseases such as asthma. ..
| |
