Gene Symbol: Slc30a2
Description: solute carrier family 30 member 2
Alias: ZnT-2, Znt2, zinc transporter 2, solute carrier family 30 (zinc transporter), member 2
Aguilar Alonso P, Martinez Fong D, Pazos Salazar N, Brambila E, Gonzalez Barrios J, Mejorada A, et al
. The increase in zinc levels and upregulation of zinc transporters are mediated by nitric oxide in the cerebral cortex after transient ischemia in the rat. Brain Res. 2008;1200:89-98 pubmed publisher
..Upregulation of ZnT1, ZnT2, and ZnT4 mRNAs was determined after 8-h postreperfusion, but ZnT3 RNA levels were unaffected...
Asano N, Kondoh M, Ebihara C, Fujii M, Nakanishi T, Soares M, et al
. Expression profiles of zinc transporters in rodent placental models. Toxicol Lett. 2004;154:45-53 pubmed
..This is the first report of expression profiles of ZnTs during differentiation of the placenta in the mouse placenta and rat placental cell models. ..
Song Y, Elias V, Wong C, Scrimgeour A, Ho E. Zinc transporter expression profiles in the rat prostate following alterations in dietary zinc. Biometals. 2010;23:51-8 pubmed publisher
..We found that both zinc concentrations and ZnT2 expression in the prostate dorsolateral lobes were substantially higher than in the ventral lobes (P < 0.05)...
Palmiter R, Cole T, Findley S. ZnT-2, a mammalian protein that confers resistance to zinc by facilitating vesicular sequestration. EMBO J. 1996;15:1784-91 pubmed
..Prolonged exposure of cells expressing ZnT-2 to zinc causes an accretion of intracellular vesicles. We suggest that ZnT-2 protects these cells from zinc toxicity by facilitating zinc transport into an endosomal/lysosomal compartment. ..
Iguchi K, Usui S, Inoue T, Sugimura Y, Tatematsu M, Hirano K. High-level expression of zinc transporter-2 in the rat lateral and dorsal prostate. J Androl. 2002;23:819-24 pubmed
..study, we investigated the expression of zinc transporters in the rat prostate and found that zinc transporter-2 (ZnT2), which sequesters zinc to the lysosome-like compartment, is expressed at high levels in the lateral prostate (LP) ..
Falcon Perez J, Dell Angelica E. Zinc transporter 2 (SLC30A2) can suppress the vesicular zinc defect of adaptor protein 3-depleted fibroblasts by promoting zinc accumulation in lysosomes. Exp Cell Res. 2007;313:1473-83 pubmed
..A survey of the expression and localization of zinc transporter (ZnT) family members identified ZnT2, ZnT3, and ZnT4 as likely mediators of vesicular zinc accumulation in M1 cells...
Iguchi K, Morihara N, Usui S, Hayama M, Sugimura Y, Hirano K. Castration- and aging-induced changes in the expression of zinc transporter and metallothionein in rat prostate. J Androl. 2011;32:144-50 pubmed publisher
..The expression of the zinc transporter Slc30a2 (Znt2) in ventral prostate (VP) of aged rats (21 months) was approximately 21-fold higher than that in VP of ..