Gene Symbol: Slc30a1
Description: solute carrier family 30 member 1
Alias: zinc transporter 1, solute carrier family 30 (zinc transporter), member 1, znT-1
Species: rat
Products:     Slc30a1

Top Publications

  1. Aguilar Alonso P, Martinez Fong D, Pazos Salazar N, Brambila E, Gonzalez Barrios J, Mejorada A, et al. The increase in zinc levels and upregulation of zinc transporters are mediated by nitric oxide in the cerebral cortex after transient ischemia in the rat. Brain Res. 2008;1200:89-98 pubmed publisher
  2. Levy S, Beharier O, Etzion Y, Mor M, Buzaglo L, Shaltiel L, et al. Molecular basis for zinc transporter 1 action as an endogenous inhibitor of L-type calcium channels. J Biol Chem. 2009;284:32434-43 pubmed publisher
  3. Palmiter R, Findley S. Cloning and functional characterization of a mammalian zinc transporter that confers resistance to zinc. EMBO J. 1995;14:639-49 pubmed
    ..We propose that ZnT-1 transports zinc out of cells and that its absence accounts for the increased sensitivity of mutant cells to zinc toxicity. ..
  4. Beharier O, Etzion Y, Katz A, Friedman H, Tenbosh N, Zacharish S, et al. Crosstalk between L-type calcium channels and ZnT-1, a new player in rate-dependent cardiac electrical remodeling. Cell Calcium. 2007;42:71-82 pubmed
  5. Nolte C, Gore A, Sekler I, Kresse W, Hershfinkel M, Hoffmann A, et al. ZnT-1 expression in astroglial cells protects against zinc toxicity and slows the accumulation of intracellular zinc. Glia. 2004;48:145-55 pubmed
    ..Induction of ZnT-1 may play a protective role when mild episodes of stroke or seizures are followed by a massive brain insult. ..
  6. Pan R, Liu K. ZNT-1 Expression Reduction Enhances Free Zinc Accumulation in Astrocytes After Ischemic Stroke. Acta Neurochir Suppl. 2016;121:257-61 pubmed publisher
    ..These results suggest that hypoxia/reoxygenation blocked zinc efflux, whereas zinc influx may be at a similar level to that in normoxia, providing a novel mechanism for intracellular free zinc accumulation after ischemic stroke. ..
  7. Mellone M, Pelucchi S, Alberti L, Genazzani A, Di Luca M, Gardoni F. Zinc transporter-1: a novel NMDA receptor-binding protein at the postsynaptic density. J Neurochem. 2015;132:159-68 pubmed publisher
    ..Modulation of ZNT-1 expression in hippocampal neurons determined a shrinkage of dendritic spines and a reduction of GluN2A surface levels supporting the involvement of ZNT-1 in the dynamics of the excitatory synapse. ..
  8. Chowanadisai W, Kelleher S, Lonnerdal B. Zinc deficiency is associated with increased brain zinc import and LIV-1 expression and decreased ZnT-1 expression in neonatal rats. J Nutr. 2005;135:1002-7 pubmed
    ..Our results indicate that Zn deficiency results in alterations in Zn transporter expression, which facilitates increased brain Zn uptake and results in the conservation of brain Zn during Zn deficiency. ..
  9. Falcon Perez J, Dell Angelica E. Zinc transporter 2 (SLC30A2) can suppress the vesicular zinc defect of adaptor protein 3-depleted fibroblasts by promoting zinc accumulation in lysosomes. Exp Cell Res. 2007;313:1473-83 pubmed

More Information


  1. Ni H, Jiang Y, Tao L, Jin M, Wu X. ZnT-1, ZnT-3, CaMK II, PRG-1 expressions in hippocampus following neonatal seizure-induced cognitive deficit in rats. Toxicol Lett. 2009;184:145-50 pubmed publisher
    ..timing of cognitive dysfunction following neonatal seizures and the relation of this cognitive impairment to zinc transporter 1 (ZnT-1), 3 (ZnT-3), calcium/calmodulin-dependent protein kinase II (CaMK II), plasticity-related gene 1 (PRG-..
  2. McMahon R, Cousins R. Regulation of the zinc transporter ZnT-1 by dietary zinc. Proc Natl Acad Sci U S A. 1998;95:4841-6 pubmed
  3. Wang Y, Mei X, Zhang L, Lv G. The correlation among the dynamic change of Zn2+, ZnT-1, and brain-derived neurotrophic factor after acute spinal cord injury in rats. Biol Trace Elem Res. 2011;143:351-8 pubmed publisher
    ..The purpose of this study was to investigate the expression of Zn(2+), zinc transporter 1 (ZnT-1), and BDNF, as well as their correlation in spinal cord-injured rats...
  4. Ni H, Jiang Y, Xiao Z, Tao L, Jin M, Wu X. Dynamic pattern of gene expression of ZnT-1, ZnT-3 and PRG-1 in rat brain following flurothyl-induced recurrent neonatal seizures. Toxicol Lett. 2010;194:86-93 pubmed publisher
  5. Qin Y, Thomas D, Fontaine C, Colvin R. Silencing of ZnT1 reduces Zn2+ efflux in cultured cortical neurons. Neurosci Lett. 2009;450:206-10 pubmed publisher
  6. Beharier O, Etzion Y, Levi S, Mor M, Mor M, Dror S, et al. The involvement of ZnT-1, a new modulator of cardiac L-type calcium channels, in [corrected] atrial tachycardia remodeling. [corrected]. Ann N Y Acad Sci. 2010;1188:87-95 pubmed publisher
    ..Finally, in a pilot study, ZnT-1 expression was found to be augmented in the atria of AF patients. These findings position ZnT-1 as a probable missing link in the mechanism underlying atrial tachycardia remodeling. ..
  7. Ohana E, Sekler I, Kaisman T, Kahn N, Cove J, Silverman W, et al. Silencing of ZnT-1 expression enhances heavy metal influx and toxicity. J Mol Med (Berl). 2006;84:753-63 pubmed
    ..Taken together, our results indicate that endogenously-expressed ZnT-1, by modulating LTCC, has a dual role: regulating calcium influx, and attenuating Cd(2+) and Zn(2+) permeation and toxicity in neurons and other cell types. ..
  8. Sankavaram K, Freake H. The effects of transformation and ZnT-1 silencing on zinc homeostasis in cultured cells. J Nutr Biochem. 2012;23:629-34 pubmed publisher
    ..We conclude that ZnT-1 expression is crucial for maintaining zinc homeostasis, in particular, for the enhanced retention of zinc in transformed cells when subjected to zinc deprivation. ..
  9. Andrews G, Wang H, Dey S, Palmiter R. Mouse zinc transporter 1 gene provides an essential function during early embryonic development. Genesis. 2004;40:74-81 pubmed
  10. Segal D, Ohana E, Besser L, Hershfinkel M, Moran A, Sekler I. A role for ZnT-1 in regulating cellular cation influx. Biochem Biophys Res Commun. 2004;323:1145-50 pubmed
    ..Furthermore, ZnT-1 may play a role in cellular ion homeostasis and thereby confer protection against pathophysiological events linked to cellular Ca(2+) or Zn(2+) permeation and cell death. ..
  11. Lazarczyk M, Pons C, Mendoza J, Cassonnet P, Jacob Y, Favre M. Regulation of cellular zinc balance as a potential mechanism of EVER-mediated protection against pathogenesis by cutaneous oncogenic human papillomaviruses. J Exp Med. 2008;205:35-42 pubmed
    ..We report that EVER1 and EVER2 proteins form a complex and interact with the zinc transporter 1 (ZnT-1), as shown by yeast two-hybrid screening, GST pull-down, and immunoprecipitation experiments...
  12. Liu C, He X, Hong X, Kang F, Chen S, Wang Q, et al. Suppression of placental metallothionein 1 and zinc transporter 1 mRNA expressions contributes to fetal heart malformations caused by maternal zinc deficiency. Cardiovasc Toxicol. 2014;14:329-38 pubmed publisher
    ..Metallothionein 1 (MT-1) and zinc transporter 1 (ZnT-1) are two major metabolic factors that are associated with zinc metabolism...