Gene Symbol: Slc2a5
Description: solute carrier family 2 member 5
Alias: solute carrier family 2, facilitated glucose transporter member 5, GLUT-5, fructose transporter, glucose transporter type 5, small intestine, solute carrier family 2 (facilitated glucose transporter), member 5, solute carrier family 2 (facilitated glucose/fructose transporter), member 5
Species: rat
Products:     Slc2a5

Top Publications

  1. Barone S, Fussell S, Singh A, Lucas F, Xu J, Kim C, et al. Slc2a5 (Glut5) is essential for the absorption of fructose in the intestine and generation of fructose-induced hypertension. J Biol Chem. 2009;284:5056-66 pubmed publisher
    ..Here we demonstrate that Glut5 (Slc2a5) deletion reduced fructose absorption by approximately 75% in the jejunum and decreased the concentration of serum ..
  2. Suzuki T, Douard V, Mochizuki K, Goda T, Ferraris R. Diet-induced epigenetic regulation in vivo of the intestinal fructose transporter Glut5 during development of rat small intestine. Biochem J. 2011;435:43-53 pubmed publisher
    ..children, but little is known about ontogenetic mechanisms regulating Glut5 [glucose transporter 5; encoded by the Slc2a5 (solute carrier family 2 member 5) gene]...
  3. Sakar Y, Nazaret C, Letteron P, Ait Omar A, Avenati M, Viollet B, et al. Positive regulatory control loop between gut leptin and intestinal GLUT2/GLUT5 transporters links to hepatic metabolic functions in rodents. PLoS ONE. 2009;4:e7935 pubmed publisher
    ..This loop appears to be a new mechanism (possibly pathogenic) by which fructose consumption rapidly becomes highly lipogenic and deleterious. ..
  4. Rand E, Depaoli A, Davidson N, Bell G, Burant C. Sequence, tissue distribution, and functional characterization of the rat fructose transporter GLUT5. Am J Physiol. 1993;264:G1169-76 pubmed
    ..In addition, there was quantitatively more GLUT5 mRNA detected in the proximal as opposed to the distal small intestine...
  5. Patel C, Douard V, Yu S, Gao N, Ferraris R. Transport, metabolism, and endosomal trafficking-dependent regulation of intestinal fructose absorption. FASEB J. 2015;29:4046-58 pubmed publisher
    ..We hypothesized that glucose transporter (GLUT) protein, member 5 (GLUT5) is the primary fructose transporter and that fructose absorption via GLUT5, metabolism via ketohexokinase (KHK), as well as GLUT5 trafficking ..
  6. Jiang L, David E, Espina N, Ferraris R. GLUT-5 expression in neonatal rats: crypt-villus location and age-dependent regulation. Am J Physiol Gastrointest Liver Physiol. 2001;281:G666-74 pubmed
    The rat fructose transporter normally appears after completion of weaning but can be precociously induced by early feeding of a high-fructose diet...
  7. Hajduch E, Litherland G, Turban S, Brot Laroche E, Hundal H. Insulin regulates the expression of the GLUT5 transporter in L6 skeletal muscle cells. FEBS Lett. 2003;549:77-82 pubmed
    Skeletal muscle, a primary insulin target tissue, expresses the GLUT5 fructose transporter. Although insulin has no acute effect on GLUT5 expression and function in muscle, we show here that long-term (24 h) insulin treatment of L6 muscle ..
  8. Houghton S, Zarroug A, Duenes J, Fernandez Zapico M, Sarr M. The diurnal periodicity of hexose transporter mRNA and protein levels in the rat jejunum: role of vagal innervation. Surgery. 2006;139:542-9 pubmed
    ..10 for all). Vagal innervation appears to differentially mediate the diurnal changes in hexose transporter mRNA and protein expression in the rat jejunum by posttranscriptional, and/or posttranslational processes. ..
  9. Douard V, Cui X, Soteropoulos P, Ferraris R. Dexamethasone sensitizes the neonatal intestine to fructose induction of intestinal fructose transporter (Slc2A5) function. Endocrinology. 2008;149:409-23 pubmed
    ..The expression of the rat intestinal fructose transporter GLUT5 [Slc2A5, a member of the glucose transporter family (GLUT)] can be specifically induced by its ..

More Information


  1. Nomura N, Verdon G, Kang H, Shimamura T, Nomura Y, Sonoda Y, et al. Structure and mechanism of the mammalian fructose transporter GLUT5. Nature. 2015;526:397-401 pubmed publisher
    The altered activity of the fructose transporter GLUT5, an isoform of the facilitated-diffusion glucose transporter family, has been linked to disorders such as type 2 diabetes and obesity...
  2. Douard V, Choi H, Elshenawy S, Lagunoff D, Ferraris R. Developmental reprogramming of rat GLUT5 requires glucocorticoid receptor translocation to the nucleus. J Physiol. 2008;586:3657-73 pubmed publisher
    ..consumption has increased dramatically but little is known about mechanisms regulating the intestinal fructose transporter GLUT5 in vivo...
  3. Singh A, Amlal H, Haas P, Dringenberg U, Fussell S, Barone S, et al. Fructose-induced hypertension: essential role of chloride and fructose absorbing transporters PAT1 and Glut5. Kidney Int. 2008;74:438-47 pubmed publisher
    ..dietary fructose intake enhanced expression of this transporter as well as the fructose-absorbing transporter Slc2a5 (Glut5) in the small intestine of wild type mice...
  4. Houghton S, Iqbal C, Duenes J, Fatima J, Kasparek M, Sarr M. Coordinated, diurnal hexose transporter expression in rat small bowel: implications for small bowel resection. Surgery. 2008;143:79-93 pubmed
    ..Transporter-mediated glucose uptake was greater in duodenum and jejunum compared with ileum. Regulation of hexose absorption in rat small bowel seems to be site-specific and mediated by multiple mechanisms. ..
  5. Shu H, Isenberg K, Cormier R, Benz A, Zorumski C. Expression of fructose sensitive glucose transporter in the brains of fructose-fed rats. Neuroscience. 2006;140:889-95 pubmed
    ..Increased brain expression of glucose transporter 5 is likely to be important in the role of fructose as an alternative energy source. ..
  6. Darakhshan F, Hajduch E, Kristiansen S, Richter E, Hundal H. Biochemical and functional characterization of the GLUT5 fructose transporter in rat skeletal muscle. Biochem J. 1998;336 ( Pt 2):361-6 pubmed
    Previous work has demonstrated that human skeletal muscle and adipose tissue both express the GLUT5 fructose transporter, but to date the issue of whether this protein is also expressed in skeletal muscle and adipose tissue of rodents has ..
  7. Mochizuki K, Sakaguchi N, Goda T. Triiodothyronine (T3) and fructose coordinately enhance expression of the GLUT5 gene in the small intestine of rats during weaning period. Biosci Biotechnol Biochem. 2007;71:1345-7 pubmed
    ..These results suggest that T(3) and fructose coordinately enhance jejunal expression of the GLUT5 gene in rats during weaning period. ..
  8. Inukai K, Asano T, Katagiri H, Ishihara H, Anai M, Fukushima Y, et al. Cloning and increased expression with fructose feeding of rat jejunal GLUT5. Endocrinology. 1993;133:2009-14 pubmed
    ..Thus, an increase in fructose absorption up-regulates GLUT5 expression in the jejunum. These results are consistent with the notion that GLUT5 plays a major role in fructose absorption in the small intestine. ..