Slc27a4

Summary

Gene Symbol: Slc27a4
Description: solute carrier family 27 member 4
Alias: Fatp4, long-chain fatty acid transport protein 4, fatty acid transport protein 4, solute carrier family 27 (fatty acid transporter), member 4
Species: rat
Products:     Slc27a4

Top Publications

  1. Milger K, Herrmann T, Becker C, Gotthardt D, Zickwolf J, Ehehalt R, et al. Cellular uptake of fatty acids driven by the ER-localized acyl-CoA synthetase FATP4. J Cell Sci. 2006;119:4678-88 pubmed
    ..Here, we show that FATP4 is in fact localized to the endoplasmic reticulum and not the plasma membrane as reported previously...
  2. Herrmann T, Buchkremer F, Gosch I, Hall A, Bernlohr D, Stremmel W. Mouse fatty acid transport protein 4 (FATP4): characterization of the gene and functional assessment as a very long chain acyl-CoA synthetase. Gene. 2001;270:31-40 pubmed
    FATP4 (SLC27A4) is a member of the fatty acid transport protein (FATP) family, a group of evolutionarily conserved proteins that are involved in cellular uptake and metabolism of long and very long chain fatty acids...
  3. Stahl A, Hirsch D, Gimeno R, Punreddy S, Ge P, Watson N, et al. Identification of the major intestinal fatty acid transport protein. Mol Cell. 1999;4:299-308 pubmed
    ..Here, we show that FATP4, a member of a large family of FA transport proteins (FATPs), is expressed at high levels on the apical side of ..
  4. Pohl J, Ring A, Korkmaz U, Ehehalt R, Stremmel W. FAT/CD36-mediated long-chain fatty acid uptake in adipocytes requires plasma membrane rafts. Mol Biol Cell. 2005;16:24-31 pubmed
    ..revealed that FAT/CD36 was expressed in both DRMs and detergent-soluble membranes (DSMs), whereas FATP1 and FATP4 were present only in DSMs but not DRMs...
  5. Nickerson J, Alkhateeb H, Benton C, Lally J, Nickerson J, Han X, et al. Greater transport efficiencies of the membrane fatty acid transporters FAT/CD36 and FATP4 compared with FABPpm and FATP1 and differential effects on fatty acid esterification and oxidation in rat skeletal muscle. J Biol Chem. 2009;284:16522-30 pubmed publisher
    In selected mammalian tissues, long chain fatty acid transporters (FABPpm, FAT/CD36, FATP1, and FATP4) are co-expressed...
  6. Feng A, Chen D. [The expression and the significance of L-FABP and FATP4 in the development of nonalcoholic fatty liver disease in rats]. Zhonghua Gan Zang Bing Za Zhi. 2005;13:776-9 pubmed
    To study the effect of liver fatty acid binding protein(L-FABP) and fatty acid transport protein (FATP4) in the development of nonalcoholic fatty liver disease (NAFLD) in rats...
  7. Gertow K, Pietiläinen K, Yki Jarvinen H, Kaprio J, Rissanen A, Eriksson P, et al. Expression of fatty-acid-handling proteins in human adipose tissue in relation to obesity and insulin resistance. Diabetologia. 2004;47:1118-25 pubmed
    ..We quantified mRNA expression of subcutaneous adipose tissue fatty-acid-handling proteins (ALBP, KLBP, FATP1, FATP4, CD36, ACS1) in 17 monozygotic twin-pairs with a range of intra-pair differences (Delta) in BMI and detailed ..
  8. Shim J, Moulson C, Newberry E, Lin M, Xie Y, Kennedy S, et al. Fatty acid transport protein 4 is dispensable for intestinal lipid absorption in mice. J Lipid Res. 2009;50:491-500 pubmed publisher
    FA transport protein 4 (FATP4), one member of a multigene family of FA transporters, was proposed as a major FA transporter in intestinal lipid absorption...
  9. DiRusso C, Darwis D, Obermeyer T, Black P. Functional domains of the fatty acid transport proteins: studies using protein chimeras. Biochim Biophys Acta. 2008;1781:135-43 pubmed publisher
    ..Acsl) Faa1p) as an experimental platform, the phenotypic and functional properties of specific murine FATP1-FATP4 and FATP6-FATP4 protein chimeras were evaluated in order to define elements within these proteins that further ..

More Information

Publications17

  1. Moulson C, Lin M, White J, Newberry E, Davidson N, Miner J. Keratinocyte-specific expression of fatty acid transport protein 4 rescues the wrinkle-free phenotype in Slc27a4/Fatp4 mutant mice. J Biol Chem. 2007;282:15912-20 pubmed
    FATP4 (fatty acid transport protein 4; also known as SLC27A4) is the most widely expressed member of a family of six long chain fatty acid transporters...
  2. Habold C, Reichardt F, Foltzer Jourdainne C, Lignot J. Morphological changes of the rat intestinal lining in relation to body stores depletion during fasting and after refeeding. Pflugers Arch. 2007;455:323-32 pubmed
    ..Refeeding after both fasting phases induces an increase in FATP4 accompanied by a rapid lipid uptake by the enterocytes at the tip of the villi and a rapid extension of the lamina ..
  3. Krammer J, Digel M, Ehehalt F, Stremmel W, Fullekrug J, Ehehalt R. Overexpression of CD36 and acyl-CoA synthetases FATP2, FATP4 and ACSL1 increases fatty acid uptake in human hepatoma cells. Int J Med Sci. 2011;8:599-614 pubmed
    ..The current study investigated whether ACSs and CD36 could regulate hepatic LCFA uptake. FATP2 and FATP4 were both localized to the ER of HuH7 and HepG2 cells as shown by double immunofluorescence in comparison to ..
  4. Jia Z, Moulson C, Pei Z, Miner J, Watkins P. Fatty acid transport protein 4 is the principal very long chain fatty acyl-CoA synthetase in skin fibroblasts. J Biol Chem. 2007;282:20573-83 pubmed
    b>Fatty acid transport protein 4 (FATP4) is a fatty acyl-CoA synthetase that preferentially activates very long chain fatty acid substrates, such as C24:0, to their CoA derivatives...
  5. Herrmann T, Grone H, Langbein L, Kaiser I, Gosch I, Bennemann U, et al. Disturbed epidermal structure in mice with temporally controlled fatp4 deficiency. J Invest Dermatol. 2005;125:1228-35 pubmed
    So far, little is known about the physiological role of fatty acid transport protein 4 (Fatp4, Slc27a4)...
  6. Hall A, Wiczer B, Herrmann T, Stremmel W, Bernlohr D. Enzymatic properties of purified murine fatty acid transport protein 4 and analysis of acyl-CoA synthetase activities in tissues from FATP4 null mice. J Biol Chem. 2005;280:11948-54 pubmed
    b>Fatty acid transport protein 4 (FATP4) is an integral membrane protein expressed in the plasma and internal membranes of the small intestine and adipocyte as well as in the brain, kidney, liver, skin, and heart...
  7. Gimeno R, Hirsch D, Punreddy S, Sun Y, Ortegon A, Wu H, et al. Targeted deletion of fatty acid transport protein-4 results in early embryonic lethality. J Biol Chem. 2003;278:49512-6 pubmed
    Fatty acid transport protein-4 (FATP4) is the major FATP in the small intestine. We previously demonstrated, using in vitro antisense experiments, that FATP4 is required for fatty acid uptake into intestinal epithelial cells...
  8. Herrmann T, van der Hoeven F, Grone H, Stewart A, Langbein L, Kaiser I, et al. Mice with targeted disruption of the fatty acid transport protein 4 (Fatp 4, Slc27a4) gene show features of lethal restrictive dermopathy. J Cell Biol. 2003;161:1105-15 pubmed
    ..To analyze the functional significance of fatty acid transport protein 4 (Fatp4, Slc27a4), we generated mice with a targeted disruption of the Fatp4 gene...