Genomes and Genes
Gene Symbol: Slc27a4
Description: solute carrier family 27 member 4
Alias: Fatp4, long-chain fatty acid transport protein 4, fatty acid transport protein 4, solute carrier family 27 (fatty acid transporter), member 4
- Moulson C, Lin M, White J, Newberry E, Davidson N, Miner J. Keratinocyte-specific expression of fatty acid transport protein 4 rescues the wrinkle-free phenotype in Slc27a4/Fatp4 mutant mice. J Biol Chem. 2007;282:15912-20 pubmedFATP4 (fatty acid transport protein 4; also known as SLC27A4) is the most widely expressed member of a family of six long chain fatty acid transporters...
- Habold C, Reichardt F, Foltzer Jourdainne C, Lignot J. Morphological changes of the rat intestinal lining in relation to body stores depletion during fasting and after refeeding. Pflugers Arch. 2007;455:323-32 pubmed..Refeeding after both fasting phases induces an increase in FATP4 accompanied by a rapid lipid uptake by the enterocytes at the tip of the villi and a rapid extension of the lamina ..
- Krammer J, Digel M, Ehehalt F, Stremmel W, Fullekrug J, Ehehalt R. Overexpression of CD36 and acyl-CoA synthetases FATP2, FATP4 and ACSL1 increases fatty acid uptake in human hepatoma cells. Int J Med Sci. 2011;8:599-614 pubmed..The current study investigated whether ACSs and CD36 could regulate hepatic LCFA uptake. FATP2 and FATP4 were both localized to the ER of HuH7 and HepG2 cells as shown by double immunofluorescence in comparison to ..
- Jia Z, Moulson C, Pei Z, Miner J, Watkins P. Fatty acid transport protein 4 is the principal very long chain fatty acyl-CoA synthetase in skin fibroblasts. J Biol Chem. 2007;282:20573-83 pubmedb>Fatty acid transport protein 4 (FATP4) is a fatty acyl-CoA synthetase that preferentially activates very long chain fatty acid substrates, such as C24:0, to their CoA derivatives...
- Herrmann T, Grone H, Langbein L, Kaiser I, Gosch I, Bennemann U, et al. Disturbed epidermal structure in mice with temporally controlled fatp4 deficiency. J Invest Dermatol. 2005;125:1228-35 pubmedSo far, little is known about the physiological role of fatty acid transport protein 4 (Fatp4, Slc27a4)...
- Hall A, Wiczer B, Herrmann T, Stremmel W, Bernlohr D. Enzymatic properties of purified murine fatty acid transport protein 4 and analysis of acyl-CoA synthetase activities in tissues from FATP4 null mice. J Biol Chem. 2005;280:11948-54 pubmedb>Fatty acid transport protein 4 (FATP4) is an integral membrane protein expressed in the plasma and internal membranes of the small intestine and adipocyte as well as in the brain, kidney, liver, skin, and heart...
- Gimeno R, Hirsch D, Punreddy S, Sun Y, Ortegon A, Wu H, et al. Targeted deletion of fatty acid transport protein-4 results in early embryonic lethality. J Biol Chem. 2003;278:49512-6 pubmedFatty acid transport protein-4 (FATP4) is the major FATP in the small intestine. We previously demonstrated, using in vitro antisense experiments, that FATP4 is required for fatty acid uptake into intestinal epithelial cells...
- Herrmann T, van der Hoeven F, Grone H, Stewart A, Langbein L, Kaiser I, et al. Mice with targeted disruption of the fatty acid transport protein 4 (Fatp 4, Slc27a4) gene show features of lethal restrictive dermopathy. J Cell Biol. 2003;161:1105-15 pubmed..To analyze the functional significance of fatty acid transport protein 4 (Fatp4, Slc27a4), we generated mice with a targeted disruption of the Fatp4 gene...