Gene Symbol: Slc26a6
Description: solute carrier family 26 member 6
Alias: solute carrier family 26 member 6, solute carrier family 26 (anion exchanger), member 6
Species: rat
Products:     Slc26a6

Top Publications

  1. Gholami K, Muniandy S, Salleh N. Progesterone downregulates oestrogen-induced expression of CFTR and SLC26A6 proteins and mRNA in rats' uteri. J Biomed Biotechnol. 2012;2012:596084 pubmed publisher
    ..To investigate the expression of Cystic Fibrosis Transmembrane Regulator (CFTR) and Cl?/HCO3? exchanger (SLC26A6) under P effect...
  2. Jiang Z, Grichtchenko I, Boron W, Aronson P. Specificity of anion exchange mediated by mouse Slc26a6. J Biol Chem. 2002;277:33963-7 pubmed
    Recently, CFEX, the mouse orthologue of human SLC26A6, was localized to the brush border membrane of proximal tubule cells and was demonstrated to mediate Cl(-)-formate exchange when expressed in Xenopus oocytes...
  3. Alvarez B, Vilas G, Casey J. Metabolon disruption: a mechanism that regulates bicarbonate transport. EMBO J. 2005;24:2499-511 pubmed
    ..b>SLC26A6, a plasma membrane Cl-/HCO3- exchanger with a suggested role in pancreatic HCO3- secretion, was found to bind the ..
  4. Simão S, Gomes P, Pinho M, Soares da Silva P. Identification of SLC26A transporters involved in the Cl?/HCO?? exchange in proximal tubular cells from WKY and SHR. Life Sci. 2013;93:435-40 pubmed publisher
    ..from spontaneously hypertensive rats (SHRs) were endowed with increased Cl(-)/HCO3(-) exchanger activity and slc26a6 protein expression compared with PTE cells immortalized from normotensive Wistar Kyoto (WKY) rats...
  5. Song Y, Yamamoto A, Steward M, Ko S, Stewart A, Soleimani M, et al. Deletion of Slc26a6 alters the stoichiometry of apical Cl-/HCO-3 exchange in mouse pancreatic duct. Am J Physiol Cell Physiol. 2012;303:C815-24 pubmed publisher
    ..luminal pH and volume were measured simultaneously in interlobular pancreatic ducts isolated from wild-type and Slc26a6-null mice...
  6. Lohi H, Lamprecht G, Markovich D, Heil A, Kujala M, Seidler U, et al. Isoforms of SLC26A6 mediate anion transport and have functional PDZ interaction domains. Am J Physiol Cell Physiol. 2003;284:C769-79 pubmed
    ..approach, several new SLC26 family members have been identified, including a kidney- and pancreas-specific gene, SLC26A6. We report the functional characterization of SLC26A6 and two new alternatively spliced variants, named SLC26A6c ..
  7. Thomson R, Wang T, Thomson B, Tarrats L, Girardi A, Mentone S, et al. Role of PDZK1 in membrane expression of renal brush border ion exchangers. Proc Natl Acad Sci U S A. 2005;102:13331-6 pubmed
    Na-H exchanger NHE3 and Cl-anion exchanger CFEX (SLC26A6, PAT1) play principal roles in the reabsorption of Na and Cl in the proximal tubule of the mammalian kidney...
  8. Knauf F, Ko N, Jiang Z, Robertson W, Van Itallie C, Anderson J, et al. Net intestinal transport of oxalate reflects passive absorption and SLC26A6-mediated secretion. J Am Soc Nephrol. 2011;22:2247-55 pubmed publisher
    Mice lacking the oxalate transporter SLC26A6 develop hyperoxalemia, hyperoxaluria, and calcium-oxalate stones as a result of a defect in intestinal oxalate secretion, but what accounts for the absorptive oxalate flux remains unknown...
  9. Fraga S, Luo Y, Jose P, Zandi Nejad K, Mount D, Soares da Silva P. Dopamine D1-like receptor-mediated inhibition of Cl/HCO3- exchanger activity in rat intestinal epithelial IEC-6 cells is regulated by G protein-coupled receptor kinase 6 (GRK 6). Cell Physiol Biochem. 2006;18:347-60 pubmed
    ..The presence of the SLC26A6 anion exchanger was detected by both RT-PCR and immunoblotting analysis in IEC-6 cells, in which three different ..

More Information


  1. Knauf F, Yang C, Thomson R, Mentone S, Giebisch G, Aronson P. Identification of a chloride-formate exchanger expressed on the brush border membrane of renal proximal tubule cells. Proc Natl Acad Sci U S A. 2001;98:9425-30 pubmed
    ..Sequence analysis indicated that CFEX very likely represents the mouse ortholog of human SLC26A6. Immunolocalization studies detected expression of CFEX, but not pendrin, on the brush border membrane of ..
  2. Singh A, Amlal H, Haas P, Dringenberg U, Fussell S, Barone S, et al. Fructose-induced hypertension: essential role of chloride and fructose absorbing transporters PAT1 and Glut5. Kidney Int. 2008;74:438-47 pubmed publisher
    ..jejunal NaCl and water absorption which was significantly decreased in mice whose apical chloride/base exchanger Slc26a6 (PAT1, CFEX) was knocked out...
  3. Lohi H, Kujala M, Kerkela E, Saarialho Kere U, Kestila M, Kere J. Mapping of five new putative anion transporter genes in human and characterization of SLC26A6, a candidate gene for pancreatic anion exchanger. Genomics. 2000;70:102-12 pubmed
    ..3. We have characterized one of them, SLC26A6, in more detail. It maps to chromosome 3p21...
  4. Yang D, Shcheynikov N, Zeng W, Ohana E, So I, Ando H, et al. IRBIT coordinates epithelial fluid and HCO3- secretion by stimulating the transporters pNBC1 and CFTR in the murine pancreatic duct. J Clin Invest. 2009;119:193-202 pubmed publisher
    ..These findings define IRBIT as a key coordinator of epithelial fluid and HCO3- secretion and may have implications to all CFTR-expressing epithelia and to cystic fibrosis...
  5. Freel R, Morozumi M, Hatch M. Parsing apical oxalate exchange in Caco-2BBe1 monolayers: siRNA knockdown of SLC26A6 reveals the role and properties of PAT-1. Am J Physiol Gastrointest Liver Physiol. 2009;297:G918-29 pubmed
    ..was to quantitate the contribution of the anion exchanger PAT-1 (putative anion transporter-1), encoded by SLC26A6, to oxalate transport in a model intestinal epithelium and to discern some characteristics of this exchanger ..
  6. Chavez J, Hernández González E, Wertheimer E, Visconti P, Darszon A, Trevino C. Participation of the Cl-/HCO(3)- exchangers SLC26A3 and SLC26A6, the Cl- channel CFTR, and the regulatory factor SLC9A3R1 in mouse sperm capacitation. Biol Reprod. 2012;86:1-14 pubmed publisher
    ..Alternatively, the [Cl(-)](i) increase might be mediated by anion exchangers. Among them, SLC26A3 and SLC26A6 are good candidates, since, in several cell types, they increase [Cl(-)](i) and interact with cystic fibrosis ..
  7. Jiang Z, Asplin J, Evan A, Rajendran V, Velazquez H, Nottoli T, et al. Calcium oxalate urolithiasis in mice lacking anion transporter Slc26a6. Nat Genet. 2006;38:474-8 pubmed
    ..b>SLC26A6 is an anion exchanger expressed on the apical membrane in many epithelial tissues, including kidney and intestine...
  8. Hassan H, Mentone S, Karniski L, Rajendran V, Aronson P. Regulation of anion exchanger Slc26a6 by protein kinase C. Am J Physiol Cell Physiol. 2007;292:C1485-92 pubmed
    b>SLC26A6 (CFEX, PAT1) is an anion exchanger expressed in several tissues including renal proximal tubule, pancreatic duct, small intestine, liver, stomach, and heart...
  9. Simpson J, Walker N, Supuran C, Soleimani M, Clarke L. Putative anion transporter-1 (Pat-1, Slc26a6) contributes to intracellular pH regulation during H+-dipeptide transport in duodenal villous epithelium. Am J Physiol Gastrointest Liver Physiol. 2010;298:G683-91 pubmed publisher
    ..In conclusion, Pat-1 Cl(-)/HCO(3)(-) exchange contributes to pH(i) regulation in the villous epithelium during H(+)-dipeptide absorption, possibly by providing a HCO(3)(-) import pathway. ..
  10. Wang Z, Petrovic S, Mann E, Soleimani M. Identification of an apical Cl(-)/HCO3(-) exchanger in the small intestine. Am J Physiol Gastrointest Liver Physiol. 2002;282:G573-9 pubmed
    ..downregulated in adenoma (DRA or SLC26A3), pendrin (PDS or SLC26A4), and the putative anion transporter (PAT1 or SLC26A6) has recently been identified...
  11. Yin K, Lei Y, Wen X, Lacruz R, Soleimani M, Kurtz I, et al. SLC26A Gene Family Participate in pH Regulation during Enamel Maturation. PLoS ONE. 2015;10:e0144703 pubmed publisher
    The bicarbonate transport activities of Slc26a1, Slc26a6 and Slc26a7 are essential to physiological processes in multiple organs...
  12. Saksena S, Dwivedi A, Singla A, Gill R, Tyagi S, Borthakur A, et al. Characterization of the 5'-flanking region and regulation of expression of human anion exchanger SLC26A6. J Cell Biochem. 2008;105:454-66 pubmed publisher
    b>SLC26A6 (putative anion transporter 1, PAT1) has been shown to play an important role in mediating the luminal Cl(-)/OH(-)(HCO(3)(-)) exchange process in the intestine...
  13. Xie Q, Welch R, Mercado A, Romero M, Mount D. Molecular characterization of the murine Slc26a6 anion exchanger: functional comparison with Slc26a1. Am J Physiol Renal Physiol. 2002;283:F826-38 pubmed
    We report the molecular and functional characterization of murine Slc26a6, the putative apical chloride-formate exchanger of the proximal tubule. The Slc26a6 transcript is expressed in several tissues, including kidney...