Gene Symbol: Slc26a3
Description: solute carrier family 26 member 3
Alias: chloride anion exchanger, down-regulated in adenoma, solute carrier family 26 (anion exchanger), member 3
Melvin J, Park K, Richardson L, Schultheis P, Shull G. Mouse down-regulated in adenoma (DRA) is an intestinal Cl(-)/HCO(3)(-) exchanger and is up-regulated in colon of mice lacking the NHE3 Na(+)/H(+) exchanger. J Biol Chem. 1999;274:22855-61 pubmed
Barmeyer C, Ye J, Sidani S, Geibel J, Binder H, Rajendran V. Characteristics of rat downregulated in adenoma (rDRA) expressed in HEK 293 cells. Pflugers Arch. 2007;454:441-50 pubmed
..We speculate that, in addition to mediating pH-sensitive Cl(-) uptake, rDRA may function as a modifier of other anion transport proteins. ..
Chavez J, Hernández González E, Wertheimer E, Visconti P, Darszon A, Trevino C. Participation of the Cl-/HCO(3)- exchangers SLC26A3 and SLC26A6, the Cl- channel CFTR, and the regulatory factor SLC9A3R1 in mouse sperm capacitation. Biol Reprod. 2012;86:1-14 pubmed publisher
..Alternatively, the [Cl(-)](i) increase might be mediated by anion exchangers. Among them, SLC26A3 and SLC26A6 are good candidates, since, in several cell types, they increase [Cl(-)](i) and interact with cystic ..
Jacob P, Rossmann H, Lamprecht G, Kretz A, Neff C, Lin Wu E, et al
. Down-regulated in adenoma mediates apical Cl-/HCO3- exchange in rabbit, rat, and human duodenum. Gastroenterology. 2002;122:709-24 pubmed
..These data suggest that DRA is the major apical anion exchanger in the duodenum as well as the colon and the likely transport protein for duodenal electroneutral HCO3- secretion...
Chen L, Xu W. [Expression pattern of congenital chloride diarrhea pathogenic gene Slc26a3 in the reproductive tract of male rodents]. Zhonghua Yi Xue Yi Chuan Xue Za Zhi. 2014;31:654-8 pubmed publisher
To determine the expression pattern of Slc26a3 gene in reproductive tract of male rodents to clarify whether the expression pattern is related to the subfertility observed in congenital chloride diarrhea (CLD) disease...
Rajendran V, Black J, Ardito T, Sangan P, Alper S, Schweinfest C, et al
. Regulation of DRA and AE1 in rat colon by dietary Na depletion. Am J Physiol Gastrointest Liver Physiol. 2000;279:G931-42 pubmed
..This indicates that AE1 encodes surface cell-specific aldosterone-regulated Cl/HCO(3) exchange, whereas DRA encodes aldosterone-insensitive Cl/OH exchange...
Hoglund P, Haila S, Socha J, Tomaszewski L, Saarialho Kere U, Karjalainen Lindsberg M, et al
. Mutations of the Down-regulated in adenoma (DRA) gene cause congenital chloride diarrhoea. Nat Genet. 1996;14:316-9 pubmed
..We conclude that DRA is an intestinal anion transport molecule that causes chloride diarrhoea when mutated. ..