Slc25a37

Summary

Gene Symbol: Slc25a37
Description: solute carrier family 25 member 37
Alias: Mscp, RGD1359361, mitoferrin-1, mitochondrial carrier domain containing protein RGD1359361, mitochondrial iron transporter 1, mitochondrial solute carrier-like protein, solute carrier family 25 (mitochondrial iron transporter), member 37
Species: rat
Products:     Slc25a37

Top Publications

  1. Shaw G, Cope J, Li L, Corson K, Hersey C, Ackermann G, et al. Mitoferrin is essential for erythroid iron assimilation. Nature. 2006;440:96-100 pubmed
    ..Erythroblasts generated from murine embryonic stem cells null for Mfrn (also known as Slc25a37) show maturation arrest with severely impaired incorporation of 55Fe into haem...
  2. Paradkar P, Zumbrennen K, Paw B, Ward D, Kaplan J. Regulation of mitochondrial iron import through differential turnover of mitoferrin 1 and mitoferrin 2. Mol Cell Biol. 2009;29:1007-16 pubmed publisher
    b>Mitoferrin 1 and mitoferrin 2 are homologous members of the mitochondrial solute carrier family. Mitoferrin 1 is required for mitochondrial iron delivery in developing erythrocytes...
  3. Chen W, Paradkar P, Li L, Pierce E, Langer N, Takahashi Makise N, et al. Abcb10 physically interacts with mitoferrin-1 (Slc25a37) to enhance its stability and function in the erythroid mitochondria. Proc Natl Acad Sci U S A. 2009;106:16263-8 pubmed publisher
    Mitoferrin-1 (Mfrn1; Slc25a37), a member of the solute carrier family localized in the mitochondrial inner membrane, functions as an essential iron importer for the synthesis of mitochondrial heme and iron-sulfur clusters in erythroblasts...
  4. Lane D, Merlot A, Huang M, Bae D, Jansson P, Sahni S, et al. Cellular iron uptake, trafficking and metabolism: Key molecules and mechanisms and their roles in disease. Biochim Biophys Acta. 2015;1853:1130-44 pubmed publisher
    ..g., Friedreich's ataxia. Increased knowledge of the molecules and their mechanisms of action in iron processing pathways (e.g., ISC biogenesis) will shape the investigation of iron metabolism in human health and disease. ..