Slc25a28

Summary

Gene Symbol: Slc25a28
Description: solute carrier family 25 member 28
Alias: mitoferrin-2, solute carrier family 25 (mitochondrial iron transporter), member 28
Species: rat
Products:     Slc25a28

Top Publications

  1. Li F, Leibiger B, Leibiger I, Larsson C. Characterization of a putative murine mitochondrial transporter homology of hMRS3/4. Mamm Genome. 2002;13:20-3 pubmed
  2. Shaw G, Cope J, Li L, Corson K, Hersey C, Ackermann G, et al. Mitoferrin is essential for erythroid iron assimilation. Nature. 2006;440:96-100 pubmed
    ..Our data show that mfrn functions as the principal mitochondrial iron importer essential for haem biosynthesis in vertebrate erythroblasts...
  3. Paradkar P, Zumbrennen K, Paw B, Ward D, Kaplan J. Regulation of mitochondrial iron import through differential turnover of mitoferrin 1 and mitoferrin 2. Mol Cell Biol. 2009;29:1007-16 pubmed publisher
    Mitoferrin 1 and mitoferrin 2 are homologous members of the mitochondrial solute carrier family. Mitoferrin 1 is required for mitochondrial iron delivery in developing erythrocytes...
  4. Chen W, Paradkar P, Li L, Pierce E, Langer N, Takahashi Makise N, et al. Abcb10 physically interacts with mitoferrin-1 (Slc25a37) to enhance its stability and function in the erythroid mitochondria. Proc Natl Acad Sci U S A. 2009;106:16263-8 pubmed publisher
  5. Lane D, Merlot A, Huang M, Bae D, Jansson P, Sahni S, et al. Cellular iron uptake, trafficking and metabolism: Key molecules and mechanisms and their roles in disease. Biochim Biophys Acta. 2015;1853:1130-44 pubmed publisher
    ..g., Friedreich's ataxia. Increased knowledge of the molecules and their mechanisms of action in iron processing pathways (e.g., ISC biogenesis) will shape the investigation of iron metabolism in human health and disease. ..