Gene Symbol: Slc25a27
Description: solute carrier family 25, member 27
Alias: Ucp4, mitochondrial uncoupling protein 4, uncoupling protein UCP-4
Species: rat
Products:     Slc25a27

Top Publications

  1. Kitahara T, Li H, Balaban C. Localization of the mitochondrial uncoupling protein family in the rat inner ear. Hear Res. 2004;196:39-48 pubmed
    ..Although UCP2, UCP4 and brain mitochondrial carrier protein-1 (BMCP-1, i.e...
  2. Xu R, Tao Y, Wu C, Yi J, Yang Y, Yang R, et al. Domoic acid induced spinal cord lesions in adult mice: evidence for the possible molecular pathways of excitatory amino acids in spinal cord lesions. Neurotoxicology. 2008;29:700-7 pubmed publisher
    ..In DA-induced spinal cord lesioned mice model, we showed that the decrease of proteasome activity, increase of UCP4 expression by immunohistochemistry and neural cell apoptosis by TUNEL staining, and was accompanied by an decrease ..
  3. Smorodchenko A, Rupprecht A, Fuchs J, Gross J, Pohl E. Role of mitochondrial uncoupling protein 4 in rat inner ear. Mol Cell Neurosci. 2011;47:244-53 pubmed publisher
    The uncoupling protein 4 (UCP4) belongs to the mitochondrial anion transporter family. Protein tissue distribution and functions are still a matter of debate...
  4. Xu Y, Liu Y, Xia C, GAO P, Liu J. Evidence for involvement of uncoupling proteins in cerebral mitochondrial oxidative phosphorylation deficiency of rats exposed to 5,000 m high altitude. Neurochem Res. 2013;38:282-9 pubmed publisher
    ..that total cerebral UCPs activity significantly increased; Q-PCR and western blot showed upregulated expression of UCP4 and UCP5. Moreover, cerebral NEFA concentration increased...
  5. Mao W, Yu X, Zhong A, Li W, Brush J, Sherwood S, et al. UCP4, a novel brain-specific mitochondrial protein that reduces membrane potential in mammalian cells. FEBS Lett. 1999;443:326-30 pubmed
    ..and partially characterized a novel member of the human uncoupling protein family, termed uncoupling protein-4 (UCP4)...
  6. Graw J, von Haefen C, Poyraz D, Möbius N, Sifringer M, Spies C. Chronic alcohol consumption increases the expression of uncoupling protein-2 and -4 in the brain. Alcohol Clin Exp Res. 2013;37:1650-6 pubmed publisher
    ..This study reveals a compensatory effect of UCP-2 and -4 in the brain during chronic alcohol consumption. ..
  7. Liu D, Chan S, de Souza Pinto N, Slevin J, Wersto R, Zhan M, et al. Mitochondrial UCP4 mediates an adaptive shift in energy metabolism and increases the resistance of neurons to metabolic and oxidative stress. Neuromolecular Med. 2006;8:389-414 pubmed
    ..The authors cloned UCP4 cDNA from mouse and rat brain, and demonstrate that UCP4 mRNA is expressed abundantly in brain and at particularly ..
  8. Yasuno K, Ando S, Misumi S, Makino S, Kulski J, Muratake T, et al. Synergistic association of mitochondrial uncoupling protein (UCP) genes with schizophrenia. Am J Med Genet B Neuropsychiatr Genet. 2007;144B:250-3 pubmed
    ..We performed a case-control study using tag SNPs in the mitochondrial uncoupling protein genes, UCP2, UCP4, and BMCP1/UCP5, to investigate their association with schizophrenia...
  9. Smorodchenko A, Rupprecht A, Sarilova I, Ninnemann O, Bräuer A, Franke K, et al. Comparative analysis of uncoupling protein 4 distribution in various tissues under physiological conditions and during development. Biochim Biophys Acta. 2009;1788:2309-19 pubmed publisher
    b>UCP4 is a member of the mitochondrial uncoupling protein subfamily and one of the three UCPs (UCP2, UCP4, UCP5), associated with the nervous system...

More Information


  1. Gao C, Ni Y, Liu G, Chen X, Ji C, Qin D, et al. UCP4 overexpression improves fatty acid oxidation and insulin sensitivity in L6 myocytes. J Bioenerg Biomembr. 2011;43:109-18 pubmed publisher
    ..Previous studies have shown that UCP4 transcription occurs at a considerable level in mouse skeletal muscle; however, the exact functions of UCP4 remain ..
  2. Stuart J, Cadenas S, Jekabsons M, Roussel D, Brand M. Mitochondrial proton leak and the uncoupling protein 1 homologues. Biochim Biophys Acta. 2001;1504:144-58 pubmed
    ..The physiological role of the proton leak, and of the uncoupling protein 1 homologues, remains similarly unclear. ..
  3. Zhang M, Wang B, Ni Y, Liu F, Fei L, Pan X, et al. Overexpression of uncoupling protein 4 promotes proliferation and inhibits apoptosis and differentiation of preadipocytes. Life Sci. 2006;79:1428-35 pubmed
    ..We previously showed that uncoupling protein 4 (UCP4) is differentially expressed in omental adipose tissue in diet-induced obese and normal rats...
  4. Guevara R, Santandreu F, Valle A, Gianotti M, Oliver J, Roca P. Sex-dependent differences in aged rat brain mitochondrial function and oxidative stress. Free Radic Biol Med. 2009;46:169-75 pubmed publisher
    ..Interestingly, levels of UCP4 and UCP5--proteins related to a decrease in ROS production--were also higher in females...
  5. Huang Z, Li J, Du S, Chen G, Qi Y, Huang L, et al. Effects of UCP4 on the Proliferation and Apoptosis of Chondrocytes: Its Possible Involvement and Regulation in Osteoarthritis. PLoS ONE. 2016;11:e0150684 pubmed publisher
    ..Uncoupling protein 4 (UCP4) can protect cells against oxidative stress via reducing ROS production and cell apoptosis...