Gene Symbol: Slc20a2
Description: solute carrier family 20 member 2
Alias: Ab1-188, Glvr2, Pit-2, RAM-1, Ram1, sodium-dependent phosphate transporter 2, gibbon ape leukemia virus receptor 2, phosphate transporter 2, receptor for amphitropic viruses 1, receptor for amphotropic viruses 1, solute carrier family 20 (phosphate transporter), member 2
Breusegem S, Takahashi H, Giral Arnal H, Wang X, Jiang T, Verlander J, et al
. Differential regulation of the renal sodium-phosphate cotransporters NaPi-IIa, NaPi-IIc, and PiT-2 in dietary potassium deficiency. Am J Physiol Renal Physiol. 2009;297:F350-61 pubmed publisher
Villa Bellosta R, Ravera S, Sorribas V, Stange G, Levi M, Murer H, et al
. The Na+-Pi cotransporter PiT-2 (SLC20A2) is expressed in the apical membrane of rat renal proximal tubules and regulated by dietary Pi. Am J Physiol Renal Physiol. 2009;296:F691-9 pubmed publisher
Miller D, Miller A. A family of retroviruses that utilize related phosphate transporters for cell entry. J Virol. 1994;68:8270-6 pubmed
Kavanaugh M, Miller D, Zhang W, Law W, Kozak S, Kabat D, et al
. Cell-surface receptors for gibbon ape leukemia virus and amphotropic murine retrovirus are inducible sodium-dependent phosphate symporters. Proc Natl Acad Sci U S A. 1994;91:7071-5 pubmed
..Accordingly, depletion of extracellular phosphate increased Ram-1 and Glvr-1 expression 3- to 5-fold. These results suggest simple methods to modulate retroviral receptor expression, with possible applications to human gene therapy...
Miller D, Edwards R, Miller A. Cloning of the cellular receptor for amphotropic murine retroviruses reveals homology to that for gibbon ape leukemia virus. Proc Natl Acad Sci U S A. 1994;91:78-82 pubmed
..Identification of this family of receptors will help define the evolutionary relationship between retroviruses and their cellular receptors...
Frei P, Gao B, Hagenbuch B, Mate A, Biber J, Murer H, et al
. Identification and localization of sodium-phosphate cotransporters in hepatocytes and cholangiocytes of rat liver. Am J Physiol Gastrointest Liver Physiol. 2005;288:G771-8 pubmed
..We conclude that NaPi-IIb is most probably involved in the reabsorption of P(i) from primary hepatic bile and thus might play an important role in the regulation of biliary P(i) concentration...
Prie D, Torres P, Friedlander G. Phosphate handling: new genes, new molecules. Horm Res Paediatr. 2011;76 Suppl 1:71-5 pubmed publisher
..This progress may allow development of new drugs that interfere with phosphate transporters, hormonal receptors or associated proteins to improve treatment and to help prevent secondary hyperparathyroidism. ..
Wada K, Mizuno M, Komori T, Tamura M. Extracellular inorganic phosphate regulates gibbon ape leukemia virus receptor-2/phosphate transporter mRNA expression in rat bone marrow stromal cells. J Cell Physiol. 2004;198:40-7 pubmed
Villa Bellosta R, Sorribas V. Compensatory regulation of the sodium/phosphate cotransporters NaPi-IIc (SCL34A3) and Pit-2 (SLC20A2) during Pi deprivation and acidosis. Pflugers Arch. 2010;459:499-508 pubmed publisher
..5 and 60% of Pi transport at pH 6.0, depending on the pH and the physiological conditions. ..