Slc17a8

Summary

Gene Symbol: Slc17a8
Description: solute carrier family 17 member 8
Alias: Vglut3, vesicular glutamate transporter 3, solute carrier family 17 (sodium-dependent inorganic phosphate cotransporter), member 8, solute carrier family 17 (vesicular glutamate transporter), member 8
Species: rat
Products:     Slc17a8

Top Publications

  1. Schafer M, Varoqui H, Defamie N, Weihe E, Erickson J. Molecular cloning and functional identification of mouse vesicular glutamate transporter 3 and its expression in subsets of novel excitatory neurons. J Biol Chem. 2002;277:50734-48 pubmed
    We have cloned and functionally characterized a third isoform of a vesicular glutamate transporter (VGLUT3) expressed on synaptic vesicles that identifies a distinct glutamatergic system in the brain that is partly and selectively ..
  2. Fremeau R, Burman J, Qureshi T, Tran C, Proctor J, Johnson J, et al. The identification of vesicular glutamate transporter 3 suggests novel modes of signaling by glutamate. Proc Natl Acad Sci U S A. 2002;99:14488-93 pubmed
    ..We now report the identification of VGLUT3 and its expression by many cells generally considered to release a classical transmitter with properties very ..
  3. Gras C, Herzog E, Bellenchi G, Bernard V, Ravassard P, Pohl M, et al. A third vesicular glutamate transporter expressed by cholinergic and serotoninergic neurons. J Neurosci. 2002;22:5442-51 pubmed
    ..In this study, we characterized a third vesicular glutamate transporter (VGLUT3), highly homologous to VGLUT1 and VGLUT2...
  4. Somogyi J, Baude A, Omori Y, Shimizu H, El Mestikawy S, Fukaya M, et al. GABAergic basket cells expressing cholecystokinin contain vesicular glutamate transporter type 3 (VGLUT3) in their synaptic terminals in hippocampus and isocortex of the rat. Eur J Neurosci. 2004;19:552-69 pubmed
    Vesicular glutamate transporter type 3 (VGLUT3) containing neuronal elements were characterized using antibodies to VGLUT3 and molecular cell markers...
  5. Commons K. Locally collateralizing glutamate neurons in the dorsal raphe nucleus responsive to substance P contain vesicular glutamate transporter 3 (VGLUT3). J Chem Neuroanat. 2009;38:273-81 pubmed publisher
    ..nucleus (DR) is an area enriched with cell bodies and axons containing the third vesicular glutamate transporter, VGLUT3. However, the role of VGLUT3-containing axons in modulating activity of serotonin (5-HT) neurons within the DR ..
  6. Lin L, Talman W. Nitroxidergic neurons in rat nucleus tractus solitarii express vesicular glutamate transporter 3. J Chem Neuroanat. 2005;29:179-91 pubmed
    ..in the NTS. Recently a third class of VGLUT, VGLUT3, was identified, but its distribution in NTS and its anatomical relationship with nNOS have not been shown...
  7. Ormel L, Stensrud M, Chaudhry F, Gundersen V. A distinct set of synaptic-like microvesicles in atroglial cells contain VGLUT3. Glia. 2012;60:1289-300 pubmed publisher
    ..As VGLUT3 is prominently expressed in non-neuronal cells, this prompted us to investigate whether VGLUT3 is also involved in ..
  8. Safieddine S, El Amraoui A, Petit C. The auditory hair cell ribbon synapse: from assembly to function. Annu Rev Neurosci. 2012;35:509-28 pubmed publisher
    ..Here we review this recent knowledge and discuss how it enlightens the way the IHC ribbon synapse develops and functions. ..
  9. Stensrud M, Chaudhry F, Leergaard T, Bjaalie J, Gundersen V. Vesicular glutamate transporter-3 in the rodent brain: vesicular colocalization with vesicular ?-aminobutyric acid transporter. J Comp Neurol. 2013;521:3042-56 pubmed publisher
    Vesicular glutamate transporters (VGLUT1-3) carry glutamate into synaptic vesicles. VGLUT3 has been reported to be localized in nonglutamatergic neuronal populations in the brain...
  10. Landry M, Bouali Benazzouz R, El Mestikawy S, Ravassard P, Nagy F. Expression of vesicular glutamate transporters in rat lumbar spinal cord, with a note on dorsal root ganglia. J Comp Neurol. 2004;468:380-94 pubmed
    ..In the dorsal horn, VGLUT1 is most abundant in mechanosensory/proprioceptive deep afferent fibers. VGLUT2 and VGLUT3 are expressed only at moderate levels in primary sensory afferent fibers and are not used by central projections ..

Detail Information

Publications41

  1. Schafer M, Varoqui H, Defamie N, Weihe E, Erickson J. Molecular cloning and functional identification of mouse vesicular glutamate transporter 3 and its expression in subsets of novel excitatory neurons. J Biol Chem. 2002;277:50734-48 pubmed
    We have cloned and functionally characterized a third isoform of a vesicular glutamate transporter (VGLUT3) expressed on synaptic vesicles that identifies a distinct glutamatergic system in the brain that is partly and selectively ..
  2. Fremeau R, Burman J, Qureshi T, Tran C, Proctor J, Johnson J, et al. The identification of vesicular glutamate transporter 3 suggests novel modes of signaling by glutamate. Proc Natl Acad Sci U S A. 2002;99:14488-93 pubmed
    ..We now report the identification of VGLUT3 and its expression by many cells generally considered to release a classical transmitter with properties very ..
  3. Gras C, Herzog E, Bellenchi G, Bernard V, Ravassard P, Pohl M, et al. A third vesicular glutamate transporter expressed by cholinergic and serotoninergic neurons. J Neurosci. 2002;22:5442-51 pubmed
    ..In this study, we characterized a third vesicular glutamate transporter (VGLUT3), highly homologous to VGLUT1 and VGLUT2...
  4. Somogyi J, Baude A, Omori Y, Shimizu H, El Mestikawy S, Fukaya M, et al. GABAergic basket cells expressing cholecystokinin contain vesicular glutamate transporter type 3 (VGLUT3) in their synaptic terminals in hippocampus and isocortex of the rat. Eur J Neurosci. 2004;19:552-69 pubmed
    Vesicular glutamate transporter type 3 (VGLUT3) containing neuronal elements were characterized using antibodies to VGLUT3 and molecular cell markers...
  5. Commons K. Locally collateralizing glutamate neurons in the dorsal raphe nucleus responsive to substance P contain vesicular glutamate transporter 3 (VGLUT3). J Chem Neuroanat. 2009;38:273-81 pubmed publisher
    ..nucleus (DR) is an area enriched with cell bodies and axons containing the third vesicular glutamate transporter, VGLUT3. However, the role of VGLUT3-containing axons in modulating activity of serotonin (5-HT) neurons within the DR ..
  6. Lin L, Talman W. Nitroxidergic neurons in rat nucleus tractus solitarii express vesicular glutamate transporter 3. J Chem Neuroanat. 2005;29:179-91 pubmed
    ..in the NTS. Recently a third class of VGLUT, VGLUT3, was identified, but its distribution in NTS and its anatomical relationship with nNOS have not been shown...
  7. Ormel L, Stensrud M, Chaudhry F, Gundersen V. A distinct set of synaptic-like microvesicles in atroglial cells contain VGLUT3. Glia. 2012;60:1289-300 pubmed publisher
    ..As VGLUT3 is prominently expressed in non-neuronal cells, this prompted us to investigate whether VGLUT3 is also involved in ..
  8. Safieddine S, El Amraoui A, Petit C. The auditory hair cell ribbon synapse: from assembly to function. Annu Rev Neurosci. 2012;35:509-28 pubmed publisher
    ..Here we review this recent knowledge and discuss how it enlightens the way the IHC ribbon synapse develops and functions. ..
  9. Stensrud M, Chaudhry F, Leergaard T, Bjaalie J, Gundersen V. Vesicular glutamate transporter-3 in the rodent brain: vesicular colocalization with vesicular ?-aminobutyric acid transporter. J Comp Neurol. 2013;521:3042-56 pubmed publisher
    Vesicular glutamate transporters (VGLUT1-3) carry glutamate into synaptic vesicles. VGLUT3 has been reported to be localized in nonglutamatergic neuronal populations in the brain...
  10. Landry M, Bouali Benazzouz R, El Mestikawy S, Ravassard P, Nagy F. Expression of vesicular glutamate transporters in rat lumbar spinal cord, with a note on dorsal root ganglia. J Comp Neurol. 2004;468:380-94 pubmed
    ..In the dorsal horn, VGLUT1 is most abundant in mechanosensory/proprioceptive deep afferent fibers. VGLUT2 and VGLUT3 are expressed only at moderate levels in primary sensory afferent fibers and are not used by central projections ..
  11. Moss J, Ungless M, Bolam J. Dopaminergic axons in different divisions of the adult rat striatal complex do not express vesicular glutamate transporters. Eur J Neurosci. 2011;33:1205-11 pubmed publisher
    ..terminals in subregions of the adult striatum do not express vesicular glutamate transporters (VGluT1, VGluT2 or VGluT3)...
  12. Shutoh F, Ina A, Yoshida S, Konno J, Hisano S. Two distinct subtypes of serotonergic fibers classified by co-expression with vesicular glutamate transporter 3 in rat forebrain. Neurosci Lett. 2008;432:132-6 pubmed publisher
    ..virtually all of serotonin (5-HT) neurons in the midbrain raphe nuclei of rats are known to express vesicular glutamate transporter 3 (VGLUT3), VGLUT3-positive 5-HT fibers have been identified only in the cerebral cortex and ..
  13. Haverkamp S, Wässle H. Characterization of an amacrine cell type of the mammalian retina immunoreactive for vesicular glutamate transporter 3. J Comp Neurol. 2004;468:251-63 pubmed
    ..rat, mouse, and macaque monkey retinae with antibodies against the vesicular glutamate transporter vesicular glutamate transporter 3 (vGluT3) showed a sparse population of amacrine cells...
  14. Guo Z, Longhurst J. Activation of reciprocal pathways between arcuate nucleus and ventrolateral periaqueductal gray during electroacupuncture: involvement of VGLUT3. Brain Res. 2010;1360:77-88 pubmed publisher
    ..The vesicular glutamate transporter 3 (VGLUT3) marks glutamatergic neurons...
  15. Boulland J, Qureshi T, Seal R, Rafiki A, Gundersen V, Bergersen L, et al. Expression of the vesicular glutamate transporters during development indicates the widespread corelease of multiple neurotransmitters. J Comp Neurol. 2004;480:264-80 pubmed
    ..Complementary patterns of expression in glutamatergic terminals have been reported for VGLUT1 and VGLUT2. VGLUT3 shows expression by many cells not considered to be glutamatergic...
  16. Honma S, Kato A, Shi L, Yatani H, Wakisaka S. Vesicular glutamate transporter immunoreactivity in the periodontal ligament of the rat incisor. Anat Rec (Hoboken). 2012;295:160-6 pubmed publisher
    The distribution of three vesicular glutamate transporter (VGluT) isoforms, VGluT1, VGluT2, and VGluT3, were investigated in the trigeminal ganglion of the periodontal ligament in the rat incisor-a receptive field of trigeminal ganglion ..
  17. Lee J, Pradhan J, Maskey D, Park K, Hong S, Suh M, et al. Glutamate co-transmission from developing medial nucleus of the trapezoid body--lateral superior olive synapses is cochlear dependent in kanamycin-treated rats. Biochem Biophys Res Commun. 2011;405:162-7 pubmed publisher
    ..The enhanced VGLUT3 immunoreactivities (IRs) in kanamycin-treated rats and asymmetric VGLUT3 IRs in the LSO of unilaterally cochlear ..
  18. Hioki H, Nakamura H, Ma Y, Konno M, Hayakawa T, Nakamura K, et al. Vesicular glutamate transporter 3-expressing nonserotonergic projection neurons constitute a subregion in the rat midbrain raphe nuclei. J Comp Neurol. 2010;518:668-86 pubmed publisher
    We previously reported that about 80% of vesicular glutamate transporter 3 (VGLUT3)-positive cells displayed immunoreactivity for serotonin, but the others were negative in the rat midbrain raphe nuclei, such as the dorsal (DR) and ..
  19. Commons K, Serock M. Coincidence of neurokinin 1 receptor with the vesicular glutamate transporter 3 (VGLUT3) in the rat forebrain. Neurosci Lett. 2009;464:188-92 pubmed publisher
    The third vesicular glutamate transporter (VGLUT3) is expressed in a subset of cholinergic and GABAergic neurons in the forebrain...
  20. Yang C, Duan L, Qiao P, Zhao L, Guo L. Increased VGLUT3 involved in visceral hyperalgesia in a rat model of irritable bowel syndrome. World J Gastroenterol. 2015;21:2959-66 pubmed publisher
    To investigate the activity of vesicular glutamate transporter-3 (VGLUT3) in a visceral hyperalgesia rat model of irritable bowel syndrome, and the role of mast cells (MCs)...
  21. Wang Y, Pang Y, Dong Y, Zhang F, Li J, Li Y. Localization of vesicular glutamate transporters in the peripheral vestibular system of rat. Neurosci Bull. 2007;23:175-9 pubmed
    To examine the vesicular glutamate transporters (VGluTs: VGluT1-VGluT3) in the peripheral vestibular system.
  22. Riedel A, Westerholz S, Braun K, Edwards R, Arendt T, Hartig W. Vesicular glutamate transporter 3-immunoreactive pericellular baskets ensheath a distinct population of neurons in the lateral septum. J Chem Neuroanat. 2008;36:177-90 pubmed publisher
    ..Recently, vesicular glutamate transporter 3 (VGLUT3)-immunoreactive (-ir) structures outlining unlabeled somata and their proximal dendrites ..
  23. Liu D, Bi Y, Liu Z, Liu H, Li Z. The expression of vesicular glutamate transporter 3 and vesicular monoamine transporter 2 induced by brain-derived neurotrophic factor in dorsal root ganglion neurons in vitro. Brain Res Bull. 2014;100:93-106 pubmed publisher
    The vesicular glutamate transporter 3 (VGLUT3) and the vesicular monoamine transporter 2 (VMAT2) are expressed in dorsal root ganglion (DRG) neurons and play an important role in packing the neurotransmitter into synaptic vesicles...
  24. Harkany T, Holmgren C, Hartig W, Qureshi T, Chaudhry F, Storm Mathisen J, et al. Endocannabinoid-independent retrograde signaling at inhibitory synapses in layer 2/3 of neocortex: involvement of vesicular glutamate transporter 3. J Neurosci. 2004;24:4978-88 pubmed
    ..A third subtype of VGLUTs (VGLUT3) was recently identified and found localized to dendrites of various cell types...
  25. Blaesse P, Ehrhardt S, Friauf E, Nothwang H. Developmental pattern of three vesicular glutamate transporters in the rat superior olivary complex. Cell Tissue Res. 2005;320:33-50 pubmed
    ..VGLUT2-ir was moderate to strong throughout the SOC, whereas VGLUT3 was only weakly expressed...
  26. Martín Ibáñez R, Jenstad M, Berghuis P, Edwards R, Hioki H, Kaneko T, et al. Vesicular glutamate transporter 3 (VGLUT3) identifies spatially segregated excitatory terminals in the rat substantia nigra. Eur J Neurosci. 2006;23:1063-70 pubmed
    ..Here, we show that vesicular glutamate transporter 3 (VGLUT3)-immunoreactive (ir) terminals segregate to the perisomatic region of DA neurons in the ..
  27. Gammelsaeter R, Coppola T, Marcaggi P, Storm Mathisen J, Chaudhry F, Attwell D, et al. A role for glutamate transporters in the regulation of insulin secretion. PLoS ONE. 2011;6:e22960 pubmed publisher
    ..By immunogold cytochemistry we show that insulin containing secretory granules express VGLUT3. Despite the fact that they have a VGLUT, the levels of glutamate in these granules are low, indicating the ..
  28. Jackson J, Bland B, Antle M. Nonserotonergic projection neurons in the midbrain raphe nuclei contain the vesicular glutamate transporter VGLUT3. Synapse. 2009;63:31-41 pubmed publisher
    ..Recent studies have reported that the vesicular glutamate transporter VGLUT3 is found in both serotonergic and nonserotonergic neurons in both the median raphe (MR) and dorsal raphe (DR) ..
  29. Tukey D, Lee M, Xu D, Eberle S, Goffer Y, Manders T, et al. Differential effects of natural rewards and pain on vesicular glutamate transporter expression in the nucleus accumbens. Mol Brain. 2013;6:32 pubmed publisher
    ..Pain also decreases VGLUT3 levels, likely representing a decrease in projections from GABAergic, serotonergic, and/or cholinergic ..
  30. Gras C, Vinatier J, Amilhon B, Guerci A, Christov C, Ravassard P, et al. Developmentally regulated expression of VGLUT3 during early post-natal life. Neuropharmacology. 2005;49:901-11 pubmed
    ..In this study, the post-natal expression of VGLUT3 was determined with specific probes and antiserums in the rat brain and compared with that of VGLUT1 and VGLUT2...
  31. Stella S, Li S, Sabatini A, Vila A, Brecha N. Comparison of the ontogeny of the vesicular glutamate transporter 3 (VGLUT3) with VGLUT1 and VGLUT2 in the rat retina. Brain Res. 2008;1215:20-9 pubmed publisher
    ..The discovery of a third vesicular glutamate transporter, VGLUT3, has brought about speculation concerning its role and function based on its expression in amacrine cells...
  32. Ni Y, Parpura V. Dual regulation of Ca2+-dependent glutamate release from astrocytes: vesicular glutamate transporters and cytosolic glutamate levels. Glia. 2009;57:1296-305 pubmed publisher
    ..Neither VGLUT1 nor VGLUT2 overexpression changed the amount of glutamate release, whereas overexpression of VGLUT3 significantly enhanced Ca2+-dependent glutamate release from astrocytes...
  33. Chung E, Chen L, Chan Y, Yung K. Up-regulation in expression of vesicular glutamate transporter 3 in substantia nigra but not in striatum of 6-hydroxydopamine-lesioned rats. Neurosignals. 2006;15:238-48 pubmed
    ..After the lesion, levels of VGLUT2 immunoreactivity and protein were not modulated. Significant increase of VGLUT3 immunoreactivity was observed in the perikarya of GABAergic substantia nigra pars reticulata neurons (+14...
  34. Yang C, Wei Y, Leng Y, Zhong C, Zhang Y, Wan Y, et al. Vesicular glutamate transporter-3 contributes to visceral hyperalgesia induced by Trichinella spiralis infection in rats. Dig Dis Sci. 2012;57:865-72 pubmed publisher
    According to a recent study, vesicular glutamate transporter-3 (VGLUT3) contributes to injury-induced mechanical hyperalgesia in mice...
  35. Riedel A, Stöber F, Richter K, Fischer K, Miettinen R, Budinger E. VGLUT3-immunoreactive afferents of the lateral septum: ultrastructural evidence for a modulatory role of glutamate. Brain Struct Funct. 2013;218:295-301 pubmed publisher
    ..Recently, a population of vesicular glutamate transporter 3-immunoreactive (VGLUT3-ir) fibers forming prominent pericellular basket-like structures (PBLS) was ..
  36. Mathur B, Deutch A. Rat meningeal and brain microvasculature pericytes co-express the vesicular glutamate transporters 2 and 3. Neurosci Lett. 2008;435:90-4 pubmed publisher
    ..pericytes of the adult rat, as defined by the presence of NG2 proteoglycan, expressed both VGLUT2- and VGLUT3-immunoreactivity, but did not express VGLUT1...
  37. Llorente I, Pérez Rodríguez D, Burgin T, Gonzalo Orden J, Martínez Villayandre B, Fernández López A. Age and meloxicam modify the response of the glutamate vesicular transporters (VGLUTs) after transient global cerebral ischemia in the rat brain. Brain Res Bull. 2013;94:90-7 pubmed publisher
    ..Western blot assays showed a lessened age-dependent response to the ischemic damage in VGLUT1 and VGLUT3, while VGLUT2 presented an age and structure-dependent response to challenge...
  38. Hioki H, Fujiyama F, Nakamura K, Wu S, Matsuda W, Kaneko T. Chemically specific circuit composed of vesicular glutamate transporter 3- and preprotachykinin B-producing interneurons in the rat neocortex. Cereb Cortex. 2004;14:1266-75 pubmed
    The third vesicular glutamate transporter, VGLUT3, is distributed in cell bodies of neocortical neurons and axon terminals mainly in the superficial part of layer II/III of the cerebral cortex...
  39. Peng Z, Wang G, Zeng R, Guo J, Chen C, Gong S. Temporospatial expression and cellular localization of VGLUT3 in the rat cochlea. Brain Res. 2013;1537:100-10 pubmed publisher
    b>Vesicular glutamate transporter 3 (VGLUT3) plays an important role in hearing, and VGLUT3 knockout mice are deaf. However, the mechanisms whereby VGLUT3 exerts its effects in the cochlea are not well established...
  40. Boulland J, Jenstad M, Boekel A, Wouterlood F, Edwards R, Storm Mathisen J, et al. Vesicular glutamate and GABA transporters sort to distinct sets of vesicles in a population of presynaptic terminals. Cereb Cortex. 2009;19:241-8 pubmed publisher
    ..VGLUTs) 1 and 2 are expressed by neurons generally accepted to release glutamate as a neurotransmitter, whereas VGLUT3 appears in populations usually associated with a different classical transmitter...
  41. Herzog E, Gilchrist J, Gras C, Muzerelle A, Ravassard P, Giros B, et al. Localization of VGLUT3, the vesicular glutamate transporter type 3, in the rat brain. Neuroscience. 2004;123:983-1002 pubmed
    We have recently identified a third subtype of glutamate vesicular transporter (VGLUT) named VGLUT3. In the present study, we provide a detailed account of the regional and cellular distributions of VGLUT3 in the rat brain, using specific ..