Gene Symbol: Slc17a7
Description: solute carrier family 17 member 7
Alias: BNPI, Vglut1, vesicular glutamate transporter 1, brain-specific Na(+)-dependent inorganic phosphate cotransporter, brain-specific Na-dependent inorganic phosphate cotransporter, solute carrier family 17 (sodium-dependent inorganic phosphate cotransporter), member 7, solute carrier family 17 (vesicular glutamate transporter), member 7
Species: rat
Products:     Slc17a7

Top Publications

  1. Zhang G, Li X, Cao H, Zhao H, Geller A. The vesicular glutamate transporter-1 upstream promoter and first intron each support glutamatergic-specific expression in rat postrhinal cortex. Brain Res. 2011;1377:1-12 pubmed publisher
    ..The three vesicular glutamate transporters (VGLUTs) are found in different populations of neurons, and VGLUT1 is the predominant VGLUT in the neocortex, hippocampus, and cerebellar cortex...
  2. Schenck S, Wojcik S, Brose N, Takamori S. A chloride conductance in VGLUT1 underlies maximal glutamate loading into synaptic vesicles. Nat Neurosci. 2009;12:156-62 pubmed publisher
    ..We found that VGLUT1, and not ClC-3 as proposed previously, represents the major Cl(-) permeation pathway in synaptic vesicles...
  3. De Gois S, Schafer M, Defamie N, Chen C, Ricci A, Weihe E, et al. Homeostatic scaling of vesicular glutamate and GABA transporter expression in rat neocortical circuits. J Neurosci. 2005;25:7121-33 pubmed
    ..Here, we reveal a dynamic scaling in vesicular excitatory (vesicular glutamate transporters VGLUT1 and VGLUT2) and inhibitory (vesicular inhibitory amino acid transporter VIAAT) transporter mRNA and synaptic ..
  4. Ni B, Rosteck P, Nadi N, Paul S. Cloning and expression of a cDNA encoding a brain-specific Na(+)-dependent inorganic phosphate cotransporter. Proc Natl Acad Sci U S A. 1994;91:5607-11 pubmed
    We have isolated a brain-specific cDNA that encodes a Na(+)-dependent inorganic phosphate (Pi) cotransporter (BNPI)...
  5. Melo C, Mele M, Curcio M, Comprido D, Silva C, Duarte C. BDNF regulates the expression and distribution of vesicular glutamate transporters in cultured hippocampal neurons. PLoS ONE. 2013;8:e53793 pubmed publisher
    ..b>VGLUT1 expression also increased but only transiently...
  6. Boulland J, Qureshi T, Seal R, Rafiki A, Gundersen V, Bergersen L, et al. Expression of the vesicular glutamate transporters during development indicates the widespread corelease of multiple neurotransmitters. J Comp Neurol. 2004;480:264-80 pubmed
    ..Complementary patterns of expression in glutamatergic terminals have been reported for VGLUT1 and VGLUT2. VGLUT3 shows expression by many cells not considered to be glutamatergic...
  7. Tordera R, Totterdell S, Wojcik S, Brose N, Elizalde N, Lasheras B, et al. Enhanced anxiety, depressive-like behaviour and impaired recognition memory in mice with reduced expression of the vesicular glutamate transporter 1 (VGLUT1). Eur J Neurosci. 2007;25:281-90 pubmed
    Three isoforms of a vesicular glutamate transporter (VGLUT1-3) have been identified...
  8. Wojcik S, Rhee J, Herzog E, Sigler A, Jahn R, Takamori S, et al. An essential role for vesicular glutamate transporter 1 (VGLUT1) in postnatal development and control of quantal size. Proc Natl Acad Sci U S A. 2004;101:7158-63 pubmed
    ..Of the three known transporters, VGLUT1 and VGLUT2 are expressed prominently in the adult brain, but during the first two weeks of postnatal development, ..
  9. Aihara Y, Mashima H, Onda H, Hisano S, Kasuya H, Hori T, et al. Molecular cloning of a novel brain-type Na(+)-dependent inorganic phosphate cotransporter. J Neurochem. 2000;74:2622-5 pubmed
    ..and 92% similarity to the human brain-specific Na(+)-dependent inorganic phosphate (Na(+)/P(i)) cotransporter (BNPI), which is localized exclusively to neuron-rich regions...

More Information


  1. Wilson N, Kang J, Hueske E, Leung T, Varoqui H, Murnick J, et al. Presynaptic regulation of quantal size by the vesicular glutamate transporter VGLUT1. J Neurosci. 2005;25:6221-34 pubmed
    ..altering the strength of glutamatergic synapses based on the recently identified vesicular glutamate transporter VGLUT1. We provide direct evidence that filling in isolated synaptic vesicles is subject to a dynamic equilibrium that is ..
  2. Fremeau R, Kam K, Qureshi T, Johnson J, Copenhagen D, Storm Mathisen J, et al. Vesicular glutamate transporters 1 and 2 target to functionally distinct synaptic release sites. Science. 2004;304:1815-9 pubmed
    ..Consistent with this distribution, inactivation of the VGLUT1 gene silenced a subset of excitatory neurons in the adult...
  3. Wang H, Yu G, Wang Z, Yi S, Su R, Gong Z. Changes in VGLUT1 and VGLUT2 expression in rat dorsal root ganglia and spinal cord following spared nerve injury. Neurochem Int. 2016;99:9-15 pubmed publisher
    ..Spared nerve injury (SNI) induced mechanical allodynia from postoperative day 1 to at least day 14. Expression of VGLUT1 and VGLUT2 in dorsal root ganglia and spinal cord was examined by western blot analyses on different postoperative ..
  4. Zander J, Münster Wandowski A, Brunk I, Pahner I, Gómez Lira G, Heinemann U, et al. Synaptic and vesicular coexistence of VGLUT and VGAT in selected excitatory and inhibitory synapses. J Neurosci. 2010;30:7634-45 pubmed publisher
    ..Using immunoisolation of synaptic vesicles, we now show that VGLUT2 and VGAT, and also VGLUT1 and VGLUT2, coexist in a sizeable pool of vesicles. VGAT immunoisolates transport glutamate in addition to GABA...
  5. Altschuler R, Tong L, Holt A, Oliver D. Immunolocalization of vesicular glutamate transporters 1 and 2 in the rat inferior colliculus. Neuroscience. 2008;154:226-32 pubmed publisher
    ..Vesicular glutamate transporters 1 and 2 (VGLUT1, VGLUT2) most often have complementary non-overlapping distributions and can be used to differentiate ..
  6. Ge S, Li Z, Tang J, Ma Y, Hioki H, Zhang T, et al. Differential expression of VGLUT1 or VGLUT2 in the trigeminothalamic or trigeminocerebellar projection neurons in the rat. Brain Struct Funct. 2014;219:211-29 pubmed publisher
    The vesicular glutamate transporters, VGLUT1 and VGLUT2, reportedly display complementary distribution in the rat brain. However, co-expression of them in single neurons has been reported in some brain areas...
  7. Boulland J, Jenstad M, Boekel A, Wouterlood F, Edwards R, Storm Mathisen J, et al. Vesicular glutamate and GABA transporters sort to distinct sets of vesicles in a population of presynaptic terminals. Cereb Cortex. 2009;19:241-8 pubmed publisher
    ..Our data reconcile previous apparently conflicting reports on the physiology of the dentate afferents from SuM and demonstrate that both glutamate and GABA may be released from a single nerve terminal. ..
  8. Davis E, Zou Y, Ghosh A. Wnts acting through canonical and noncanonical signaling pathways exert opposite effects on hippocampal synapse formation. Neural Dev. 2008;3:32 pubmed publisher
    ..Our observations suggest that the pro- and antisynaptogenic effects of Wnt proteins are associated with the activation of the canonical and noncanonical Wnt signaling pathways. ..
  9. Braud A, Boucher Y, Zerari Mailly F. Vesicular glutamate transporters localization in the rat lingual papillae. Neuroreport. 2010;21:64-7 pubmed publisher
    ..These findings show the specific lingual pattern of distribution for VGluts and suggest that only VGlut 1 takes part in glutamatergic regulation of epithelial and taste cells within the tongue in physiological conditions...
  10. Hermes S, Colbert J, Aicher S. Differential content of vesicular glutamate transporters in subsets of vagal afferents projecting to the nucleus tractus solitarii in the rat. J Comp Neurol. 2014;522:642-53 pubmed publisher
    ..Anterograde tracing from the vagus with CTb or IB4 was combined with immunohistochemistry for VGLUT1 or VGLUT2 in medial NTS and evaluated with confocal microscopy...
  11. Yoshida S, Ina A, Konno J, Wu T, Shutoh F, Nogami H, et al. The ontogenic expressions of multiple vesicular glutamate transporters during postnatal development of rat pineal gland. Neuroscience. 2008;152:407-16 pubmed publisher
    The pineal gland expresses vesicular glutamate transporters 1 and 2 (VGLUT1 and VGLUT2), which are thought to transport glutamate into synaptic-like microvesicles in the pinealocytes...
  12. Stella S, Li S, Sabatini A, Vila A, Brecha N. Comparison of the ontogeny of the vesicular glutamate transporter 3 (VGLUT3) with VGLUT1 and VGLUT2 in the rat retina. Brain Res. 2008;1215:20-9 pubmed publisher the retina, and most glutamatergic neurons express one of the three known vesicular glutamate transporters (VGLUT1, 2, or 3). However, the expression profiles of these transporters vary greatly in the retina...
  13. Wu S, Koshimizu Y, Feng Y, Okamoto K, Fujiyama F, Hioki H, et al. Vesicular glutamate transporter immunoreactivity in the central and peripheral endings of muscle-spindle afferents. Brain Res. 2004;1011:247-51 pubmed
    Expression of vesicular glutamate transporters (VGLUTs: VGLUT1, VGLUT2 and VGLUT3) in muscle spindle afferents was examined in rats...
  14. Persson S, Boulland J, Aspling M, Larsson M, Fremeau R, Edwards R, et al. Distribution of vesicular glutamate transporters 1 and 2 in the rat spinal cord, with a note on the spinocervical tract. J Comp Neurol. 2006;497:683-701 pubmed other spinal levels, we examined the immunocytochemical distribution of vesicle glutamate transporters 1 and 2 (VGLUT1, VGLUT2) at several different levels of the rat spinal cord...
  15. Myers B, McKlveen J, Morano R, Ulrich Lai Y, Solomon M, Wilson S, et al. Vesicular Glutamate Transporter 1 Knockdown in Infralimbic Prefrontal Cortex Augments Neuroendocrine Responses to Chronic Stress in Male Rats. Endocrinology. 2017;158:3579-3591 pubmed publisher
    ..b>vGluT1 is responsible for presynaptic vesicular glutamate packaging in cortical neurons, and knockdown reduces the amount ..
  16. Honma S, Kato A, Shi L, Yatani H, Wakisaka S. Vesicular glutamate transporter immunoreactivity in the periodontal ligament of the rat incisor. Anat Rec (Hoboken). 2012;295:160-6 pubmed publisher
    The distribution of three vesicular glutamate transporter (VGluT) isoforms, VGluT1, VGluT2, and VGluT3, were investigated in the trigeminal ganglion of the periodontal ligament in the rat incisor-a receptive field of trigeminal ganglion ..
  17. Vinatier J, Herzog E, Plamont M, Wojcik S, Schmidt A, Brose N, et al. Interaction between the vesicular glutamate transporter type 1 and endophilin A1, a protein essential for endocytosis. J Neurochem. 2006;97:1111-25 pubmed
    ..The three vesicular glutamate transporters (VGLUT1, -2 and -3) are highly conserved proteins that display similar bioenergetic and pharmacological properties but are ..
  18. Pang Y, Li J, Nakamura K, Wu S, Kaneko T, Mizuno N. Expression of vesicular glutamate transporter 1 immunoreactivity in peripheral and central endings of trigeminal mesencephalic nucleus neurons in the rat. J Comp Neurol. 2006;498:129-41 pubmed
    ..In the present study, we examined expression of vesicular glutamate transporters (VGLUTs), VGLUT1 and VGLUT2, in the primary afferent neurons of the Vmes (Vmes neurons) in neonatal and adult rats...
  19. Foss S, Li H, Santos M, Edwards R, Voglmaier S. Multiple dileucine-like motifs direct VGLUT1 trafficking. J Neurosci. 2013;33:10647-60 pubmed publisher
    ..vesicular glutamate transporters (VGLUTs) package glutamate into synaptic vesicles, and the two principal isoforms VGLUT1 and VGLUT2 have been suggested to influence the properties of release...
  20. Barroso Chinea P, Castle M, Aymerich M, Lanciego J. Expression of vesicular glutamate transporters 1 and 2 in the cells of origin of the rat thalamostriatal pathway. J Chem Neuroanat. 2008;35:101-7 pubmed
    The present study is focused on the analysis of the vesicular glutamate transporters 1 and 2 (VGLUT1 and VGLUT2) used by thalamic neurons giving rise to the thalamostriatal system...
  21. Moriyama S, Iharada M, Omote H, Moriyama Y, Hiasa M. Function and expression of a splicing variant of vesicular glutamate transporter 1. Biochim Biophys Acta Biomembr. 2017;1859:931-940 pubmed publisher
    ..VGLUT consists of three isoforms, VGLUT1, VGLUT2, and VGLUT3...
  22. Nogami H, Ogasawara K, Mimura Y, Mogi K, Shutoh F, Hisano S. Developmentally-regulated expression of tissue-specific splice variant of rat vesicular glutamate transporter 1 in retina and pineal gland. J Neurochem. 2006;99:142-53 pubmed
    ..We have found a splice variant of VGLUT1 mRNA that is expressed almost exclusively in photosensitive tissues, i.e. the retina and the pineal gland...
  23. Rotterman T, Nardelli P, Cope T, Alvarez F. Normal distribution of VGLUT1 synapses on spinal motoneuron dendrites and their reorganization after nerve injury. J Neurosci. 2014;34:3475-92 pubmed publisher
    ..Nerve injury provokes the loss of many proprioceptive IA afferent synapses (VGLUT1-IR boutons) from motoneurons, the reduction of IA EPSPs in motoneurons, and the disappearance of stretch reflexes...
  24. Johnson J, Fremeau R, Duncan J, RENTERIA R, Yang H, Hua Z, et al. Vesicular glutamate transporter 1 is required for photoreceptor synaptic signaling but not for intrinsic visual functions. J Neurosci. 2007;27:7245-55 pubmed
    ..Generally, VGLUT1 and VGLUT2 isoforms show complementary expression in the CNS and retina...
  25. Fattorini G, Antonucci F, Menna E, Matteoli M, Conti F. Co-expression of VGLUT1 and VGAT sustains glutamate and GABA co-release and is regulated by activity in cortical neurons. J Cell Sci. 2015;128:1669-73 pubmed publisher
    In adult neocortex, VGLUT1 (also known as SLC17A7), the main glutamate vesicular transporter, and VGAT (also known as SLC32A1), the γ-aminobutyric acid (GABA) vesicular transporter, are co-expressed in a subset of axon terminals ..
  26. Zink M, Vollmayr B, Gebicke Haerter P, Henn F. Reduced expression of glutamate transporters vGluT1, EAAT2 and EAAT4 in learned helpless rats, an animal model of depression. Neuropharmacology. 2010;58:465-73 pubmed publisher situ-hybridizations in learned helplessness rats, a well established animal model of depression, to assess vGluT1 and EAAT1-4...
  27. Pang Y, Ge S, Nakamura K, Li J, Xiong K, Kaneko T, et al. Axon terminals expressing vesicular glutamate transporter VGLUT1 or VGLUT2 within the trigeminal motor nucleus of the rat: origins and distribution patterns. J Comp Neurol. 2009;512:595-612 pubmed publisher
    ..about the significance of the two types of glutamatergic neurons (those expressing vesicular glutamate transporter VGLUT1 or VGLUT2) in the control of jaw movements...
  28. Fortin D, Nemani V, Voglmaier S, Anthony M, Ryan T, Edwards R. Neural activity controls the synaptic accumulation of alpha-synuclein. J Neurosci. 2005;25:10913-21 pubmed
    ..Furthermore, the dispersion of alpha-synuclein is graded with respect to stimulus intensity. Neural activity thus controls the normal function of alpha-synuclein at the nerve terminal and may influence its role in PD. ..
  29. Zhang G, Cao H, Li X, Zhao H, Geller A. Genetic labeling of both the axons of transduced, glutamatergic neurons in rat postrhinal cortex and their postsynaptic neurons in other neocortical areas by herpes simplex virus vectors that coexpress an axon-targeted ?-galactosidase and wheat germ . Brain Res. 2010;1361:1-11 pubmed publisher
    ..tracer can be restricted to specific subclasses of neurons; in particular, the vesicular glutamate transporter-1 (VGLUT1) promoter supports expression in VGLUT1-containing glutamatergic neurons in rat postrhinal (POR) cortex...
  30. Fattorini G, Verderio C, Melone M, Giovedi S, Benfenati F, Matteoli M, et al. VGLUT1 and VGAT are sorted to the same population of synaptic vesicles in subsets of cortical axon terminals. J Neurochem. 2009;110:1538-46 pubmed publisher
    ..transmission; they are taken up and accumulated in synaptic vesicles by specific vesicular transporters named VGLUT1-3 and VGAT, respectively. Recent studies show that VGLUT2 and VGLUT3 are co-expressed with VGAT...
  31. Tabuchi K, Blundell J, Etherton M, Hammer R, Liu X, Powell C, et al. A neuroligin-3 mutation implicated in autism increases inhibitory synaptic transmission in mice. Science. 2007;318:71-6 pubmed
    ..These data suggest that increased inhibitory synaptic transmission may contribute to human ASDs and that the R451C knockin mice may be a useful model for studying autism-related behaviors. ..
  32. Hajszan T, Alreja M, Leranth C. Intrinsic vesicular glutamate transporter 2-immunoreactive input to septohippocampal parvalbumin-containing neurons: novel glutamatergic local circuit cells. Hippocampus. 2004;14:499-509 pubmed
    ..Thus, the heavy glutamatergic innervation of these septohippocampal GABA cells establishes the morphological basis for the powerful glutamatergic influence upon theta rhythm and hippocampus-associated memory processes. ..
  33. Blaesse P, Ehrhardt S, Friauf E, Nothwang H. Developmental pattern of three vesicular glutamate transporters in the rat superior olivary complex. Cell Tissue Res. 2005;320:33-50 pubmed
    ..Each transporter displayed a characteristic expression pattern. In the adult SOC, VGLUT1 labeling varied from strong in the medial nucleus of the trapezoid body, lateral superior olive, and medial ..
  34. Chih B, Engelman H, Scheiffele P. Control of excitatory and inhibitory synapse formation by neuroligins. Science. 2005;307:1324-8 pubmed
    ..Electrophysiological analysis revealed a predominant reduction of inhibitory synaptic function. Thus, neuroligins control the formation and functional balance of excitatory and inhibitory synapses in hippocampal neurons. ..
  35. Waselus M, Van Bockstaele E. Co-localization of corticotropin-releasing factor and vesicular glutamate transporters within axon terminals of the rat dorsal raphe nucleus. Brain Res. 2007;1174:53-65 pubmed
    ..CRF-labeled axon terminals within the DRN contain immunoreactivity for vesicular glutamate transporters (isoforms vGlut1 and vGlut2) indicative of the excitatory neurotransmitter glutamate...
  36. Oda S, Funato H, Sato F, Adachi Akahane S, Ito M, Takase K, et al. A subset of thalamocortical projections to the retrosplenial cortex possesses two vesicular glutamate transporter isoforms, VGluT1 and VGluT2, in axon terminals and somata. J Comp Neurol. 2014;522:2089-106 pubmed publisher
    Vesicular glutamate transporter isoforms, VGluT1-VGluT3, accumulate glutamate into synaptic vesicles and are considered to be important molecules in glutamatergic transmission...
  37. Tukey D, Lee M, Xu D, Eberle S, Goffer Y, Manders T, et al. Differential effects of natural rewards and pain on vesicular glutamate transporter expression in the nucleus accumbens. Mol Brain. 2013;6:32 pubmed publisher
    ..b>VGLUT1-3 isoforms have distinct expression patterns in the brain, but the effects of external stimuli on their expression ..
  38. Levinson J, Li R, Kang R, Moukhles H, el Husseini A, Bamji S. Postsynaptic scaffolding molecules modulate the localization of neuroligins. Neuroscience. 2010;165:782-93 pubmed publisher
    ..Together, these data suggest that intracellular mechanisms are involved in the targeting of different neuroligin family members to synapses (216). ..
  39. Kirvell S, Elliott M, Kalaria R, Hortobagyi T, Ballard C, Francis P. Vesicular glutamate transporter and cognition in stroke: a case-control autopsy study. Neurology. 2010;75:1803-9 pubmed publisher determine the concentrations of key components of the glutamatergic neurotransmitter system, vesicular glutamate transporter 1 (VGLUT1) and excitatory amino acid transporter EAAT2 (GLT-1), and the ubiquitous synaptic protein, ..
  40. Voglmaier S, Kam K, Yang H, Fortin D, Hua Z, Nicoll R, et al. Distinct endocytic pathways control the rate and extent of synaptic vesicle protein recycling. Neuron. 2006;51:71-84 pubmed
    ..We now find that vesicular glutamate transporter VGLUT1 interacts directly with endophilin, a component of the clathrin-dependent endocytic machinery...
  41. Llorente I, Pérez Rodríguez D, Burgin T, Gonzalo Orden J, Martínez Villayandre B, Fernández López A. Age and meloxicam modify the response of the glutamate vesicular transporters (VGLUTs) after transient global cerebral ischemia in the rat brain. Brain Res Bull. 2013;94:90-7 pubmed publisher
    This study analyzes how age and inflammation modify the response of the vesicular glutamate transporters (VGLUTs), VGLUT1-3 to global brain ischemia/reperfusion (I/R) in brain areas with different I/R vulnerabilities...
  42. Kocsis Z, Molnár C, Watanabe M, Daneels G, Moechars D, Liposits Z, et al. Demonstration of vesicular glutamate transporter-1 in corticotroph cells in the anterior pituitary of the rat. Neurochem Int. 2010;56:479-86 pubmed publisher
    ..In the present study we addressed the putative synthesis of another glutamatergic marker, VGLUT1 by adenohypophysial cells...
  43. Ormel L, Stensrud M, Bergersen L, Gundersen V. VGLUT1 is localized in astrocytic processes in several brain regions. Glia. 2012;60:229-38 pubmed publisher
    ..By confocal microscopy, the authors, in this study, show that vesicles by a family of glutamate transporters 1 (VGLUT1) labeling was clearly present within astrocytic processes (diameter > 1 ?m) in several brain regions; the ..
  44. Commons K, Beck S, Bey V. Two populations of glutamatergic axons in the rat dorsal raphe nucleus defined by the vesicular glutamate transporters 1 and 2. Eur J Neurosci. 2005;21:1577-86 pubmed
    Most glutamatergic neurons in the brain express one of two vesicular glutamate transporters, vGlut1 or vGlut2. Cortical glutamatergic neurons highly express vGlut1, whereas vGlut2 predominates in subcortical areas...
  45. Herzog E, Landry M, Buhler E, Bouali Benazzouz R, Legay C, Henderson C, et al. Expression of vesicular glutamate transporters, VGLUT1 and VGLUT2, in cholinergic spinal motoneurons. Eur J Neurosci. 2004;20:1752-60 pubmed
    ..We report that VGLUT1 and VGLUT2, two subtypes of vesicular glutamate transporters, are expressed in rat spinal motoneurons...
  46. Ni Y, Parpura V. Dual regulation of Ca2+-dependent glutamate release from astrocytes: vesicular glutamate transporters and cytosolic glutamate levels. Glia. 2009;57:1296-305 pubmed publisher
    ..Here, we selectively and efficiently overexpressed individual VGLUT proteins (VGLUT1, 2, or 3) in solitary astrocytes and studied their effects on mechanical stimulation-induced Ca2+-dependent ..
  47. Riazanski V, Deriy L, Shevchenko P, Le B, Gomez E, Nelson D. Presynaptic CLC-3 determines quantal size of inhibitory transmission in the hippocampus. Nat Neurosci. 2011;14:487-94 pubmed publisher
    ..Our observations extend the role of Cl(-) in inhibitory transmission from that of a postsynaptic permeant species to a presynaptic regulatory element. ..
  48. Moss J, Ungless M, Bolam J. Dopaminergic axons in different divisions of the adult rat striatal complex do not express vesicular glutamate transporters. Eur J Neurosci. 2011;33:1205-11 pubmed publisher
    ..axons and terminals in subregions of the adult striatum do not express vesicular glutamate transporters (VGluT1, VGluT2 or VGluT3)...
  49. Barroso Chinea P, Castle M, Aymerich M, Perez Manso M, Erro E, Tuñon T, et al. Expression of the mRNAs encoding for the vesicular glutamate transporters 1 and 2 in the rat thalamus. J Comp Neurol. 2007;501:703-15 pubmed
    ..Three isoforms of the VGLUT have been identified, now known as VGLUT1, VGLUT2, and VGLUT3...
  50. Ewald P, Neuhuber W, Raab M. Vesicular glutamate transporter 1 immunoreactivity in extrinsic and intrinsic innervation of the rat esophagus. Histochem Cell Biol. 2006;125:377-95 pubmed
    ..endings (IGLEs) of the rat esophagus, we investigated also the distribution and co-localization patterns of VGLUT1. Confocal imaging revealed substantial co-localization of VGLUT1-ir with selective markers of IGLEs, i.e...
  51. Massie A, Schallier A, Vermoesen K, Arckens L, Michotte Y. Biphasic and bilateral changes in striatal VGLUT1 and 2 protein expression in hemi-Parkinson rats. Neurochem Int. 2010;57:111-8 pubmed publisher
    ..Important mediators of extracellular glutamate levels are the vesicular glutamate transporters VGLUT1 and VGLUT2 in respectively corticostriatal and thalamostriatal afferents, next to the high-affinity Na(+)/K(+)-..
  52. Wang Y, Pang Y, Dong Y, Zhang F, Li J, Li Y. Localization of vesicular glutamate transporters in the peripheral vestibular system of rat. Neurosci Bull. 2007;23:175-9 pubmed
    To examine the vesicular glutamate transporters (VGluTs: VGluT1-VGluT3) in the peripheral vestibular system.
  53. Wouterlood F, Canto C, Aliane V, Boekel A, Grosche J, Hartig W, et al. Coexpression of vesicular glutamate transporters 1 and 2, glutamic acid decarboxylase and calretinin in rat entorhinal cortex. Brain Struct Funct. 2007;212:303-19 pubmed
    We studied the distribution and coexpression of vesicular glutamate transporters (VGluT1, VGluT2), glutamic acid decarboxylase (GAD) and calretinin (CR, calcium-binding protein) in rat entorhinal cortex, using immunofluorescence staining ..
  54. Berry C, Sceniak M, Zhou L, Sabo S. Developmental up-regulation of vesicular glutamate transporter-1 promotes neocortical presynaptic terminal development. PLoS ONE. 2012;7:e50911 pubmed publisher
    ..Glutamate is loaded into synaptic vesicles for release via the vesicular glutamate transporters VGLUT1 and VGLUT2...
  55. Ge S, Ma Y, Hioki H, Wei Y, Kaneko T, Mizuno N, et al. Coexpression of VGLUT1 and VGLUT2 in trigeminothalamic projection neurons in the principal sensory trigeminal nucleus of the rat. J Comp Neurol. 2010;518:3149-68 pubmed publisher
    b>VGLUT1 and VGLUT2 have been reported to show complementary distributions in most brain regions and have been assumed to define distinct functional elements...
  56. Onoa B, Li H, Gagnon Bartsch J, Elias L, Edwards R. Vesicular monoamine and glutamate transporters select distinct synaptic vesicle recycling pathways. J Neurosci. 2010;30:7917-27 pubmed publisher
    ..vitro and in vivo, we have used the vesicular monoamine transporter VMAT2 and the vesicular glutamate transporter VGLUT1 to compare the localization and recycling of synaptic vesicles that store, respectively, monoamines and glutamate...
  57. Montana V, Ni Y, Sunjara V, Hua X, Parpura V. Vesicular glutamate transporter-dependent glutamate release from astrocytes. J Neurosci. 2004;24:2633-42 pubmed
    ..Taken together, these data indicate that VGLUTs play a functional role in exocytotic glutamate release from astrocytes. ..
  58. Bhargava N, Das M, Edwards D, Stancescu M, Kang J, Hickman J. Coexpression of glutamate vesicular transporter (VGLUT1) and choline acetyltransferase (ChAT) proteins in fetal rat hippocampal neurons in culture. In Vitro Cell Dev Biol Anim. 2010;46:685-92 pubmed publisher
    ..Using this method, a large proportion of glutamatergic (glutamate vesicular transporter, VGLUT1-immunoreactive) neurons, a small fraction of GABAergic (GABA-immunoreactive) neurons, and a large proportion of ..
  59. Ohmomo H, Ina A, Yoshida S, Shutoh F, Ueda S, Hisano S. Postnatal changes in expression of vesicular glutamate transporters in the main olfactory bulb of the rat. Neuroscience. 2009;160:419-26 pubmed publisher
    ..To address this issue, we studied the postnatal ontogeny of vesicular glutamate transporters (VGLUT1 and VGLUT2) in the main olfactory bulb of rats, using in situ hybridization, immunohistochemistry, and their ..
  60. Salazar G, Craige B, Love R, Kalman D, Faundez V. Vglut1 and ZnT3 co-targeting mechanisms regulate vesicular zinc stores in PC12 cells. J Cell Sci. 2005;118:1911-21 pubmed
    ..To address this question, we examined whether zinc transporter 3 and the vesicular glutamate transporter Vglut1 (a transporter that coexists with zinc transporter 3 in brain nerve terminals) were co-targeted to synaptic-like ..
  61. Ko J, Zhang C, Arac D, Boucard A, Brunger A, Sudhof T. Neuroligin-1 performs neurexin-dependent and neurexin-independent functions in synapse validation. EMBO J. 2009;28:3244-55 pubmed publisher
    ..Thus, neuroligin-1 performs diverse synaptic functions by mechanisms that include as essential components of alpha-neurexin binding and neuroligin dimerization, but extend beyond these activities. ..
  62. Hegarty D, Tonsfeldt K, Hermes S, Helfand H, Aicher S. Differential localization of vesicular glutamate transporters and peptides in corneal afferents to trigeminal nucleus caudalis. J Comp Neurol. 2010;518:3557-69 pubmed publisher
    ..studies combined CTb with either calcitonin gene-related peptide (CGRP), substance P (SP), vesicular glutamate transporter 1 (VGluT1), or VGluT2...
  63. Pan P, Marrs J, Ryan T. Vesicular glutamate transporter 1 orchestrates recruitment of other synaptic vesicle cargo proteins during synaptic vesicle recycling. J Biol Chem. 2015;290:22593-601 pubmed publisher
    ..Among these SV cargos is the vesicular glutamate transporter (vGlut). We show here that vGlut1 has a strong influence on the kinetics of retrieval of half of the known SV cargos and that specifically impairing ..
  64. Nakamura M, Sato K, Fukaya M, Araishi K, Aiba A, Kano M, et al. Signaling complex formation of phospholipase Cbeta4 with metabotropic glutamate receptor type 1alpha and 1,4,5-trisphosphate receptor at the perisynapse and endoplasmic reticulum in the mouse brain. Eur J Neurosci. 2004;20:2929-44 pubmed
    ..This close molecular relationship might provide PLCbeta4 with a high-fidelity effector function to mediate various neuronal responses under physiological and pathophysiological conditions. ..
  65. Ohmomo H, Ehara A, Yoshida S, Shutoh F, Ueda S, Hisano S. Temporally distinct expression of vesicular glutamate transporters 1 and 2 during embryonic development of the rat olfactory system. Neurosci Res. 2011;70:376-82 pubmed publisher
    ..the main olfactory bulb morphogenesis in rats, we examined the expression of vesicular glutamate transporters 1 (VGLUT1) and 2 (VGLUT2)...
  66. Hur E, Edwards R, Rommer E, Zaborszky L. Vesicular glutamate transporter 1 and vesicular glutamate transporter 2 synapses on cholinergic neurons in the sublenticular gray of the rat basal forebrain: a double-label electron microscopic study. Neuroscience. 2009;164:1721-31 pubmed publisher
    ..the sublenticular substantia innominata in rats using double-immunolabeling for vesicular glutamate transporters (Vglut1 and Vglut2) and choline acetyltransferase (ChAT) at the electron microscopic level...
  67. Boulland J, Ferhat L, Tallak Solbu T, Ferrand N, Chaudhry F, Storm Mathisen J, et al. Changes in vesicular transporters for gamma-aminobutyric acid and glutamate reveal vulnerability and reorganization of hippocampal neurons following pilocarpine-induced seizures. J Comp Neurol. 2007;503:466-85 pubmed
    ..lobe epilepsy were studied with in situ hybridization and immunohistochemistry experiments for the vesicular glutamate transporter 1 (VGLUT1) and the vesicular GABA transporter (VGAT)...
  68. De Gois S, Jeanclos E, Morris M, Grewal S, Varoqui H, Erickson J. Identification of endophilins 1 and 3 as selective binding partners for VGLUT1 and their co-localization in neocortical glutamatergic synapses: implications for vesicular glutamate transporter trafficking and excitatory vesicle formation. Cell Mol Neurobiol. 2006;26:679-93 pubmed
    ..We screened a yeast two-hybrid library with bait containing the C-terminal amino acids of VGLUT1 and obtained clones that encode endophilin 1 and endophilin 3, proteins considered to play an integral role in ..
  69. Nicolaysen A, Gammelsaeter R, Storm Mathisen J, Gundersen V, Iversen P. The components required for amino acid neurotransmitter signaling are present in adipose tissues. J Lipid Res. 2007;48:2123-32 pubmed
    ..Moreover, all adipose tissues stained for the vesicular glutamate transporter VGLUT1 and the vesicular GABA transporter VGAT in addition to the vesicle marker synaptophysin...
  70. Gleason K, Dondeti V, Hsia H, Cochran E, Gumulak Smith J, Saha M. The vesicular glutamate transporter 1 (xVGlut1) is expressed in discrete regions of the developing Xenopus laevis nervous system. Gene Expr Patterns. 2003;3:503-7 pubmed
    ..By hatching stages xVGlut1 expression reappears in localized tracts within the spinal cord. Expression levels increase throughout development into adulthood. ..
  71. Alvarez F, Titus Mitchell H, Bullinger K, Kraszpulski M, Nardelli P, Cope T. Permanent central synaptic disconnection of proprioceptors after nerve injury and regeneration. I. Loss of VGLUT1/IA synapses on motoneurons. J Neurophysiol. 2011;106:2450-70 pubmed publisher
    ..b>VGLUT1 was used as a marker of proprioceptive synapses on rat motoneurons...
  72. Martín Ibáñez R, Jenstad M, Berghuis P, Edwards R, Hioki H, Kaneko T, et al. Vesicular glutamate transporter 3 (VGLUT3) identifies spatially segregated excitatory terminals in the rat substantia nigra. Eur J Neurosci. 2006;23:1063-70 pubmed
    ..Collectively, our data indicate that VGLUT3 identifies a novel excitatory terminal subset that contributes to the tuning of DA cell excitability in the substantia nigra. ..