Slc17a6

Summary

Gene Symbol: Slc17a6
Description: solute carrier family 17 member 6
Alias: Dnpi, Vglut2, vesicular glutamate transporter 2, differentation-associated Na-dependent inorganic phosphate cotransporter, differentiation-associated BNPI, differentiation-associated Na(+)-dependent inorganic phosphate cotransporter, solute carrier family 17 (sodium-dependent inorganic phosphate cotransporter), member 6, solute carrier family 17 (vesicular glutamate transporter), member 6
Species: rat
Products:     Slc17a6

Top Publications

  1. Blaesse P, Ehrhardt S, Friauf E, Nothwang H. Developmental pattern of three vesicular glutamate transporters in the rat superior olivary complex. Cell Tissue Res. 2005;320:33-50 pubmed
    ..b>VGLUT2-ir was moderate to strong throughout the SOC, whereas VGLUT3 was only weakly expressed...
  2. Takamori S, Rhee J, Rosenmund C, Jahn R. Identification of differentiation-associated brain-specific phosphate transporter as a second vesicular glutamate transporter (VGLUT2). J Neurosci. 2001;21:RC182 pubmed
    ..as vesicular glutamate transporter with properties very similar to VGLUT1 and propose to rename the protein VGLUT2. VGLUT2 is highly enriched in synaptic vesicles...
  3. Li J, Fujiyama F, Kaneko T, Mizuno N. Expression of vesicular glutamate transporters, VGluT1 and VGluT2, in axon terminals of nociceptive primary afferent fibers in the superficial layers of the medullary and spinal dorsal horns of the rat. J Comp Neurol. 2003;457:236-49 pubmed
    We examined immunohistochemically whether the vesicular glutamate transporters (VGluTs), VGluT1 and VGluT2, might be expressed in synaptic terminals of nociceptive primary afferent fibers within laminae I and II of the medullary and ..
  4. Bérubé Carrière N, Riad M, Dal Bo G, Levesque D, Trudeau L, Descarries L. The dual dopamine-glutamate phenotype of growing mesencephalic neurons regresses in mature rat brain. J Comp Neurol. 2009;517:873-91 pubmed publisher
    Coexpression of tyrosine hydroxylase (TH) and vesicular glutamate transporter 2 (VGLUT2) mRNAs in the ventral tegmental area (VTA) and colocalization of these proteins in axon terminals of the nucleus accumbens (nAcb) have recently been ..
  5. Li J, Xiong K, Dong Y, Fujiyama F, Kaneko T, Mizuno N. Vesicular glutamate transporters, VGluT1 and VGluT2, in the trigeminal ganglion neurons of the rat, with special reference to coexpression. J Comp Neurol. 2003;463:212-20 pubmed
    ..present study, we examined immunohistochemically the expression of vesicular glutamate transporters, VGluT1 and VGluT2, in trigeminal ganglion neurons of the rat...
  6. Landry M, Bouali Benazzouz R, El Mestikawy S, Ravassard P, Nagy F. Expression of vesicular glutamate transporters in rat lumbar spinal cord, with a note on dorsal root ganglia. J Comp Neurol. 2004;468:380-94 pubmed
    ..In the dorsal horn, VGLUT1 is most abundant in mechanosensory/proprioceptive deep afferent fibers. VGLUT2 and VGLUT3 are expressed only at moderate levels in primary sensory afferent fibers and are not used by central ..
  7. Melo C, Mele M, Curcio M, Comprido D, Silva C, Duarte C. BDNF regulates the expression and distribution of vesicular glutamate transporters in cultured hippocampal neurons. PLoS ONE. 2013;8:e53793 pubmed publisher
    ..At DIV7, exogenous application of BDNF rapidly increased VGLUT2 mRNA and protein levels, in a dose-dependent manner. VGLUT1 expression also increased but only transiently...
  8. Kawasaki A, Shutoh F, Nogami H, Hisano S. VGLUT2 expression is up-regulated in neurohypophysial vasopressin neurons of the rat after osmotic stimulation. Neurosci Res. 2006;56:124-7 pubmed
    A second vesicular glutamate transporter (VGLUT2) is detected in magnocellular neurons in the rat hypothalamus. The present study revealed what phenotype of neurons express VGLUT2 mRNA by the histological method...
  9. Alvarez F, Villalba R, Zerda R, Schneider S. Vesicular glutamate transporters in the spinal cord, with special reference to sensory primary afferent synapses. J Comp Neurol. 2004;472:257-80 pubmed
    ..Therefore, we quantitatively investigated VGLUT1 and VGLUT2 content in the central synapses of spinal sensory afferents by using confocal and electron microscopy ..

More Information

Publications74

  1. Kiss J, Csaba Z, Csáki A, Halász B. Demonstration of estrogen receptor ? protein in glutamatergic (vesicular glutamate transporter 2 immunoreactive) neurons of the female rat hypothalamus and amygdala using double-label immunocytochemistry. Exp Brain Res. 2013;226:595-602 pubmed publisher
    ..immunocytochemistry, authors studied the presence of estrogen receptor ? (ER-?) protein in vesicular glutamate transporter 2 (VGluT2) protein-immunoreactive neurons in the female rat hypothalamus and amygdala...
  2. Hegarty D, Tonsfeldt K, Hermes S, Helfand H, Aicher S. Differential localization of vesicular glutamate transporters and peptides in corneal afferents to trigeminal nucleus caudalis. J Comp Neurol. 2010;518:3557-69 pubmed publisher
    ..either calcitonin gene-related peptide (CGRP), substance P (SP), vesicular glutamate transporter 1 (VGluT1), or VGluT2. Corneal afferents were more likely to contain CGRP than SP, and corneal afferents projecting to the rostral ..
  3. Stella S, Li S, Sabatini A, Vila A, Brecha N. Comparison of the ontogeny of the vesicular glutamate transporter 3 (VGLUT3) with VGLUT1 and VGLUT2 in the rat retina. Brain Res. 2008;1215:20-9 pubmed publisher
    ..VGLUT1 is expressed by photoreceptor and bipolar cell terminals, and VGLUT2 appears to be predominately expressed by ganglion cells, and perhaps Müller cells, cone photoreceptor terminals, ..
  4. Hrabovszky E, Csapó A, Kallo I, Wilheim T, Turi G, Liposits Z. Localization and osmotic regulation of vesicular glutamate transporter-2 in magnocellular neurons of the rat hypothalamus. Neurochem Int. 2006;48:753-61 pubmed
    ..In addition to the known synaptic actions of excitatory amino acids in magnocellular nuclei, the new observations suggest novel mechanisms whereby glutamate of endogenous sources can regulate magnocellular neuronal functions. ..
  5. Ni Y, Parpura V. Dual regulation of Ca2+-dependent glutamate release from astrocytes: vesicular glutamate transporters and cytosolic glutamate levels. Glia. 2009;57:1296-305 pubmed publisher
    ..Neither VGLUT1 nor VGLUT2 overexpression changed the amount of glutamate release, whereas overexpression of VGLUT3 significantly enhanced ..
  6. Oda S, Funato H, Sato F, Adachi Akahane S, Ito M, Takase K, et al. A subset of thalamocortical projections to the retrosplenial cortex possesses two vesicular glutamate transporter isoforms, VGluT1 and VGluT2, in axon terminals and somata. J Comp Neurol. 2014;522:2089-106 pubmed publisher
    ..Among them, VGluT2 mRNA is expressed predominantly throughout the dorsal thalamus, whereas VGluT1 mRNA is expressed in a few thalamic ..
  7. Martín Ibáñez R, Jenstad M, Berghuis P, Edwards R, Hioki H, Kaneko T, et al. Vesicular glutamate transporter 3 (VGLUT3) identifies spatially segregated excitatory terminals in the rat substantia nigra. Eur J Neurosci. 2006;23:1063-70 pubmed
    ..Collectively, our data indicate that VGLUT3 identifies a novel excitatory terminal subset that contributes to the tuning of DA cell excitability in the substantia nigra. ..
  8. Hrabovszky E, Turi G, Kallo I, Liposits Z. Expression of vesicular glutamate transporter-2 in gonadotropin-releasing hormone neurons of the adult male rat. Endocrinology. 2004;145:4018-21 pubmed
    ..5%) GnRH neurons express VGLUT2 mRNA in the preoptic region of the adult male rat...
  9. Honma S, Kato A, Shi L, Yatani H, Wakisaka S. Vesicular glutamate transporter immunoreactivity in the periodontal ligament of the rat incisor. Anat Rec (Hoboken). 2012;295:160-6 pubmed publisher
    The distribution of three vesicular glutamate transporter (VGluT) isoforms, VGluT1, VGluT2, and VGluT3, were investigated in the trigeminal ganglion of the periodontal ligament in the rat incisor-a receptive field of trigeminal ganglion ..
  10. Fattorini G, Verderio C, Melone M, Giovedi S, Benfenati F, Matteoli M, et al. VGLUT1 and VGAT are sorted to the same population of synaptic vesicles in subsets of cortical axon terminals. J Neurochem. 2009;110:1538-46 pubmed publisher
    ..Recent studies show that VGLUT2 and VGLUT3 are co-expressed with VGAT...
  11. Yoshida S, Ina A, Konno J, Wu T, Shutoh F, Nogami H, et al. The ontogenic expressions of multiple vesicular glutamate transporters during postnatal development of rat pineal gland. Neuroscience. 2008;152:407-16 pubmed publisher
    The pineal gland expresses vesicular glutamate transporters 1 and 2 (VGLUT1 and VGLUT2), which are thought to transport glutamate into synaptic-like microvesicles in the pinealocytes...
  12. Liu Y, Wong Riley M, Liu J, Jia Y, Liu H, Fujiyama F, et al. Relationship between two types of vesicular glutamate transporters and neurokinin-1 receptor-immunoreactive neurons in the pre-Bötzinger complex of rats: light and electron microscopic studies. Eur J Neurosci. 2003;17:41-8 pubmed
    ..Two types of vesicular glutamate transporters (VGLUT), VGLUT1 and VGLUT2, have been recently implicated in glutamate-mediated transmission...
  13. Yoshida S, Hira Y, Ehara A, Mimura Yamamoto Y, Kawano M, Shutoh F, et al. A rhythmic change of vesicular glutamate transporter (VGLUT) 2 expression in the rat pineal gland. Neurosci Res. 2012;72:16-22 pubmed publisher
    ..control via nocturnal noradrenergic stimulation, and expresses vesicular glutamate transporter (VGLUT) 1, VGLUT2 and a VGLUT1 splice variant (VGLUT1v)...
  14. Riedel A, Westerholz S, Braun K, Edwards R, Arendt T, Hartig W. Vesicular glutamate transporter 3-immunoreactive pericellular baskets ensheath a distinct population of neurons in the lateral septum. J Chem Neuroanat. 2008;36:177-90 pubmed publisher
    ..proteins, tyrosine hydroxylase, tryptophan hydroxylase, vesicular glutamate transporters 1 (VGLUT1) and 2 (VGLUT2) and the vesicular GABA transporter. Thus, in the LS, a separate population of neurons is covered by VGLUT3-ir PBs...
  15. Kiss J, Csáki A, Csaba Z, Halász B. Synaptic contacts of vesicular glutamate transporter 2 fibres on chemically identified neurons of the hypothalamic suprachiasmatic nucleus of the rat. Eur J Neurosci. 2008;28:1760-74 pubmed publisher
    ..revealed via immunocytochemical double-labelling for vesicular glutamate transporter type 1 (VGluT1) and type 2 (VGluT2), and brain sections were imaged via confocal laser-scanning microscopy and electron microscopy...
  16. Ohmomo H, Ehara A, Yoshida S, Shutoh F, Ueda S, Hisano S. Temporally distinct expression of vesicular glutamate transporters 1 and 2 during embryonic development of the rat olfactory system. Neurosci Res. 2011;70:376-82 pubmed publisher
    ..bulb morphogenesis in rats, we examined the expression of vesicular glutamate transporters 1 (VGLUT1) and 2 (VGLUT2)...
  17. Yokoyama T, Nakamuta N, Kusakabe T, Yamamoto Y. Vesicular glutamate transporter 2-immunoreactive afferent nerve terminals in the carotid body of the rat. Cell Tissue Res. 2014;358:271-5 pubmed publisher
    ..b>Vesicular glutamate transporter 2 (VGLUT2) labeling was closely associated with glomus cells immunoreactive to tyrosine hydroxylase ..
  18. Lei W, Deng Y, Liu B, Mu S, Guley N, Wong T, et al. Confocal laser scanning microscopy and ultrastructural study of VGLUT2 thalamic input to striatal projection neurons in rats. J Comp Neurol. 2013;521:1354-77 pubmed publisher
    We examined thalamic input to striatum in rats using immunolabeling for the vesicular glutamate transporter (VGLUT2)...
  19. Perez Manso M, Barroso Chinea P, Aymerich M, Lanciego J. 'Functional' neuroanatomical tract tracing: analysis of changes in gene expression of brain circuits of interest. Brain Res. 2006;1072:91-8 pubmed
    ..a combination of methods comprising (i) fluorescent non-radioactive in situ hybridization for the detection of vGLUT2 mRNA expression combined with retrograde tracing with Fluoro-Gold (FG; analysis performed under the confocal ..
  20. Yang E, Jin M, Hong J, Kim Y, Choi S, Kim T, et al. Expression of vesicular glutamate transporters VGLUT1 and VGLUT2 in the rat dental pulp and trigeminal ganglion following inflammation. PLoS ONE. 2014;9:e109723 pubmed publisher
    ..To address this issue, we investigated expression and protein levels of VGLUT1 and VGLUT2 in the dental pulp and trigeminal ganglion (TG) following complete Freund's adjuvant (CFA) application to the rat ..
  21. Ge S, Ma Y, Hioki H, Wei Y, Kaneko T, Mizuno N, et al. Coexpression of VGLUT1 and VGLUT2 in trigeminothalamic projection neurons in the principal sensory trigeminal nucleus of the rat. J Comp Neurol. 2010;518:3149-68 pubmed publisher
    VGLUT1 and VGLUT2 have been reported to show complementary distributions in most brain regions and have been assumed to define distinct functional elements...
  22. Schnell S, Wessendorf M. Coexpression of the mu-opioid receptor splice variant MOR1C and the vesicular glutamate transporter 2 (VGLUT2) in rat central nervous system. J Comp Neurol. 2008;508:542-64 pubmed publisher
    ..is expressed in rat central nervous system (CNS) by terminals expressing the vesicular glutamate transporter2 (VGLUT2), a marker of glutamatergic neurons...
  23. Hayashi M, Otsuka M, Morimoto R, Hirota S, Yatsushiro S, Takeda J, et al. Differentiation-associated Na+-dependent inorganic phosphate cotransporter (DNPI) is a vesicular glutamate transporter in endocrine glutamatergic systems. J Biol Chem. 2001;276:43400-6 pubmed
    ..Here we report that differentiation-associated Na(+)-dependent inorganic phosphate cotransporter (DNPI), an isoform of BNPI (Aihara, Y., Mashima, H., Onda, H., Hisano, S., Kasuya, H., Hori, T., Yamada, S., Tomura, H...
  24. Halasy K, Hajszan T, Kovács E, Lam T, Leranth C. Distribution and origin of vesicular glutamate transporter 2-immunoreactive fibers in the rat hippocampus. Hippocampus. 2004;14:908-18 pubmed
    This study examined the distribution of vesicular glutamate transporter 2 (VGLUT2)-immunoreactive neuronal structures in the ipsilateral and contralateral hippocampi of unilateral fimbria/fornix transected, unilateral entorhinal cortex ..
  25. Tukey D, Lee M, Xu D, Eberle S, Goffer Y, Manders T, et al. Differential effects of natural rewards and pain on vesicular glutamate transporter expression in the nucleus accumbens. Mol Brain. 2013;6:32 pubmed publisher
    ..Our study shows that natural rewards and pain have distinct effects on the VGLUT expression pattern in the NAc, indicating that glutamate inputs to the NAc are differentially modulated by rewards and pain. ..
  26. Moss J, Ungless M, Bolam J. Dopaminergic axons in different divisions of the adult rat striatal complex do not express vesicular glutamate transporters. Eur J Neurosci. 2011;33:1205-11 pubmed publisher
    ..axons and terminals in subregions of the adult striatum do not express vesicular glutamate transporters (VGluT1, VGluT2 or VGluT3)...
  27. Ge S, Li Z, Tang J, Ma Y, Hioki H, Zhang T, et al. Differential expression of VGLUT1 or VGLUT2 in the trigeminothalamic or trigeminocerebellar projection neurons in the rat. Brain Struct Funct. 2014;219:211-29 pubmed publisher
    The vesicular glutamate transporters, VGLUT1 and VGLUT2, reportedly display complementary distribution in the rat brain. However, co-expression of them in single neurons has been reported in some brain areas...
  28. Danik M, Cassoly E, Manseau F, Sotty F, Mouginot D, Williams S. Frequent coexpression of the vesicular glutamate transporter 1 and 2 genes, as well as coexpression with genes for choline acetyltransferase or glutamic acid decarboxylase in neurons of rat brain. J Neurosci Res. 2005;81:506-21 pubmed
    It is widely believed that expression of the vesicular glutamate transporter genes VGLUT1 and VGLUT2 is restricted to glutamatergic neurons and that the two transporters segregate in different sets of neurons...
  29. Persson S, Boulland J, Aspling M, Larsson M, Fremeau R, Edwards R, et al. Distribution of vesicular glutamate transporters 1 and 2 in the rat spinal cord, with a note on the spinocervical tract. J Comp Neurol. 2006;497:683-701 pubmed
    ..spinal levels, we examined the immunocytochemical distribution of vesicle glutamate transporters 1 and 2 (VGLUT1, VGLUT2) at several different levels of the rat spinal cord...
  30. Barroso Chinea P, Castle M, Aymerich M, Perez Manso M, Erro E, Tuñon T, et al. Expression of the mRNAs encoding for the vesicular glutamate transporters 1 and 2 in the rat thalamus. J Comp Neurol. 2007;501:703-15 pubmed
    ..Three isoforms of the VGLUT have been identified, now known as VGLUT1, VGLUT2, and VGLUT3...
  31. Honma S, Kawano M, Hayashi S, Kawano H, Hisano S. Expression and immunohistochemical localization of vesicular glutamate transporter 2 in the migratory pathway from the rat olfactory placode. Eur J Neurosci. 2004;20:923-36 pubmed
    The localization of vesicular glutamate transporter 2 (VGLUT2) was examined by immunohistochemistry and in situ hybridization histochemistry in the developing rat olfactory region with special relation to the spatiotemporal location of ..
  32. Engelund A, Fahrenkrug J, Harrison A, Hannibal J. Vesicular glutamate transporter 2 (VGLUT2) is co-stored with PACAP in projections from the rat melanopsin-containing retinal ganglion cells. Cell Tissue Res. 2010;340:243-55 pubmed publisher
    ..Here, we describe the presence and co-localization of vesicular glutamate transporter 2 (VGLUT2; a marker of glutamate signaling) and PACAP in ipRGCs and their projections in the brain...
  33. Bai L, Xu H, Collins J, Ghishan F. Molecular and functional analysis of a novel neuronal vesicular glutamate transporter. J Biol Chem. 2001;276:36764-9 pubmed
    ..We report here the molecular cloning and functional characterization of a novel glutamate transporter, VGLUT2, from mouse brain...
  34. Ranson R, Santer R, Watson A. Ageing reduces the number of vesicular glutamate transporter 2 containing immunoreactive inputs to identified rat pelvic motoneurons. Exp Gerontol. 2007;42:506-16 pubmed
    The immunocytochemical localisation of vesicular glutamate transporters, VGLUT1 and VGLUT2, was employed to identify putative glutamatergic axon terminals innervating pelvic motoneurons...
  35. Favier M, Carcenac C, Drui G, Boulet S, El Mestikawy S, Savasta M. High-frequency stimulation of the subthalamic nucleus modifies the expression of vesicular glutamate transporters in basal ganglia in a rat model of Parkinson's disease. BMC Neurosci. 2013;14:152 pubmed publisher
    ..Both VGLUT1 and VGLUT2 have been identified as definitive markers of glutamatergic neurons, but VGLUT 3 is also expressed by non ..
  36. Commons K, Beck S, Bey V. Two populations of glutamatergic axons in the rat dorsal raphe nucleus defined by the vesicular glutamate transporters 1 and 2. Eur J Neurosci. 2005;21:1577-86 pubmed
    Most glutamatergic neurons in the brain express one of two vesicular glutamate transporters, vGlut1 or vGlut2. Cortical glutamatergic neurons highly express vGlut1, whereas vGlut2 predominates in subcortical areas...
  37. Ohmomo H, Ina A, Yoshida S, Shutoh F, Ueda S, Hisano S. Postnatal changes in expression of vesicular glutamate transporters in the main olfactory bulb of the rat. Neuroscience. 2009;160:419-26 pubmed publisher
    ..To address this issue, we studied the postnatal ontogeny of vesicular glutamate transporters (VGLUT1 and VGLUT2) in the main olfactory bulb of rats, using in situ hybridization, immunohistochemistry, and their combination...
  38. Hioki H, Fujiyama F, Taki K, Tomioka R, Furuta T, Tamamaki N, et al. Differential distribution of vesicular glutamate transporters in the rat cerebellar cortex. Neuroscience. 2003;117:1-6 pubmed
    ..and in situ hybridization histochemistry of vesicular glutamate transporters 1 and 2 (VGluT1 and VGluT2)...
  39. Hrabovszky E, Deli L, Turi G, Kallo I, Liposits Z. Glutamatergic innervation of the hypothalamic median eminence and posterior pituitary of the rat. Neuroscience. 2007;144:1383-92 pubmed
    Recent studies have localized the glutamatergic cell marker type-2 vesicular glutamate transporter (VGLUT2) to distinct peptidergic neurosecretory systems that regulate hypophysial functions in rats...
  40. Juge N, Yoshida Y, Yatsushiro S, Omote H, Moriyama Y. Vesicular glutamate transporter contains two independent transport machineries. J Biol Chem. 2006;281:39499-506 pubmed
    ..Here, we established a novel in vitro assay procedure, which includes purification of wild and mutant VGLUT2 and their reconstitution with purified bacterial F(o)F(1)-ATPase (F-ATPase) into liposomes...
  41. Boulland J, Jenstad M, Boekel A, Wouterlood F, Edwards R, Storm Mathisen J, et al. Vesicular glutamate and GABA transporters sort to distinct sets of vesicles in a population of presynaptic terminals. Cereb Cortex. 2009;19:241-8 pubmed publisher
    ..We now demonstrate VGLUT2 as well as the vesicular GABA transporter (VGAT) in a subset of presynaptic terminals in the dentate gyrus of the ..
  42. Barker M, Solinski H, Hashimoto H, Tagoe T, Pilati N, Hamann M. Acoustic overexposure increases the expression of VGLUT-2 mediated projections from the lateral vestibular nucleus to the dorsal cochlear nucleus. PLoS ONE. 2012;7:e35955 pubmed publisher
    ..Amplification of VGLUT-2 expression after acoustic overexposure could be a compensatory mechanism from vestibular inputs in response to hearing loss and to a decrease of VGLUT-1 expression from auditory nerve fibers. ..
  43. Hur E, Edwards R, Rommer E, Zaborszky L. Vesicular glutamate transporter 1 and vesicular glutamate transporter 2 synapses on cholinergic neurons in the sublenticular gray of the rat basal forebrain: a double-label electron microscopic study. Neuroscience. 2009;164:1721-31 pubmed publisher
    ..substantia innominata in rats using double-immunolabeling for vesicular glutamate transporters (Vglut1 and Vglut2) and choline acetyltransferase (ChAT) at the electron microscopic level...
  44. Izumi Y, Sasaki M, Hashimoto S, Sawa T, Amaya F. mTOR signaling controls VGLUT2 expression to maintain pain hypersensitivity after tissue injury. Neuroscience. 2015;308:169-79 pubmed publisher
    ..b>Vesicular glutamate transporter 2 (VGLUT2) expression was increased after the plantar incision, which was inhibited by rapamycin...
  45. Yokota S, Shinozaki Y, Oku Y, Okada Y, Yasui Y. Vesicular glutamate transporter 2-immunoreactive synapses onto phrenic motoneurons in the neonatal rat. Adv Exp Med Biol. 2010;669:189-92 pubmed publisher
    The synaptic organization between vesicular glutamate transporter 2 (VGLUT2)-immunoreactive (ir) axon terminals and phrenic motoneurons in the neonatal rat was examined using a combined retrograde tracing and immunohistochemistry for ..
  46. Brouns I, Pintelon I, Van Genechten J, De Proost I, Timmermans J, Adriaensen D. Vesicular glutamate transporter 2 is expressed in different nerve fibre populations that selectively contact pulmonary neuroepithelial bodies. Histochem Cell Biol. 2004;121:1-12 pubmed
    ..In the present study, antibodies against the vesicular glutamate transporter 2 (VGLUT2), a transmembrane protein responsible for loading glutamate into synaptic vesicles, were ..
  47. Mathur B, Deutch A. Rat meningeal and brain microvasculature pericytes co-express the vesicular glutamate transporters 2 and 3. Neurosci Lett. 2008;435:90-4 pubmed publisher
    ..pericytes of the adult rat, as defined by the presence of NG2 proteoglycan, expressed both VGLUT2- and VGLUT3-immunoreactivity, but did not express VGLUT1...
  48. Wouterlood F, Canto C, Aliane V, Boekel A, Grosche J, Hartig W, et al. Coexpression of vesicular glutamate transporters 1 and 2, glutamic acid decarboxylase and calretinin in rat entorhinal cortex. Brain Struct Funct. 2007;212:303-19 pubmed
    We studied the distribution and coexpression of vesicular glutamate transporters (VGluT1, VGluT2), glutamic acid decarboxylase (GAD) and calretinin (CR, calcium-binding protein) in rat entorhinal cortex, using immunofluorescence staining ..
  49. Altschuler R, Tong L, Holt A, Oliver D. Immunolocalization of vesicular glutamate transporters 1 and 2 in the rat inferior colliculus. Neuroscience. 2008;154:226-32 pubmed publisher
    ..Vesicular glutamate transporters 1 and 2 (VGLUT1, VGLUT2) most often have complementary non-overlapping distributions and can be used to differentiate glutamatergic inputs...
  50. Dal Bo G, St Gelais F, Danik M, Williams S, Cotton M, Trudeau L. Dopamine neurons in culture express VGLUT2 explaining their capacity to release glutamate at synapses in addition to dopamine. J Neurochem. 2004;88:1398-405 pubmed
    ..We found that the majority of isolated dopamine neurons express VGLUT2, but not VGLUT1 or 3. In comparison, serotonin neurons express only VGLUT3...
  51. Hur E, Zaborszky L. Vglut2 afferents to the medial prefrontal and primary somatosensory cortices: a combined retrograde tracing in situ hybridization study [corrected]. J Comp Neurol. 2005;483:351-73 pubmed
    ..To determine the distribution and neocortical projections of vesicular glutamate transporter2 (Vglut2)-containing neurons, we used in situ hybridization and injections of the retrograde tracer Fluoro-Gold into the ..
  52. Lin L, Edwards R, Fremeau R, Fujiyama F, Kaneko T, Talman W. Localization of vesicular glutamate transporters and neuronal nitric oxide synthase in rat nucleus tractus solitarii. Neuroscience. 2004;123:247-55 pubmed
    ..Here we test the hypothesis that nNOS colocalizes with vesicular glutamate transporters (VGluT1 and VGluT2) in the NTS...
  53. Hajszan T, Alreja M, Leranth C. Intrinsic vesicular glutamate transporter 2-immunoreactive input to septohippocampal parvalbumin-containing neurons: novel glutamatergic local circuit cells. Hippocampus. 2004;14:499-509 pubmed
    ..The results of the correlated light and electron microscopic double-labeling immunohistochemistry for VGLUT2 and PV, and single immunostaining for VGLUT2 in colchicine-treated animals, showed that (1) VGLUT2-containing ..
  54. Herzog E, Landry M, Buhler E, Bouali Benazzouz R, Legay C, Henderson C, et al. Expression of vesicular glutamate transporters, VGLUT1 and VGLUT2, in cholinergic spinal motoneurons. Eur J Neurosci. 2004;20:1752-60 pubmed
    ..We report that VGLUT1 and VGLUT2, two subtypes of vesicular glutamate transporters, are expressed in rat spinal motoneurons...
  55. Hrabovszky E, Wittmann G, Turi G, Liposits Z, Fekete C. Hypophysiotropic thyrotropin-releasing hormone and corticotropin-releasing hormone neurons of the rat contain vesicular glutamate transporter-2. Endocrinology. 2005;146:341-7 pubmed
    ..been shown to contain large numbers of glutamatergic neurons expressing type 2 vesicular glutamate transporter (VGLUT2)...
  56. Wang H, Yu G, Wang Z, Yi S, Su R, Gong Z. Changes in VGLUT1 and VGLUT2 expression in rat dorsal root ganglia and spinal cord following spared nerve injury. Neurochem Int. 2016;99:9-15 pubmed publisher
    ..Expression of VGLUT1 and VGLUT2 in dorsal root ganglia and spinal cord was examined by western blot analyses on different postoperative days...
  57. Hermes S, Colbert J, Aicher S. Differential content of vesicular glutamate transporters in subsets of vagal afferents projecting to the nucleus tractus solitarii in the rat. J Comp Neurol. 2014;522:642-53 pubmed publisher
    ..Anterograde tracing from the vagus with CTb or IB4 was combined with immunohistochemistry for VGLUT1 or VGLUT2 in medial NTS and evaluated with confocal microscopy...
  58. De Gois S, Schafer M, Defamie N, Chen C, Ricci A, Weihe E, et al. Homeostatic scaling of vesicular glutamate and GABA transporter expression in rat neocortical circuits. J Neurosci. 2005;25:7121-33 pubmed
    ..Here, we reveal a dynamic scaling in vesicular excitatory (vesicular glutamate transporters VGLUT1 and VGLUT2) and inhibitory (vesicular inhibitory amino acid transporter VIAAT) transporter mRNA and synaptic protein ..
  59. Barroso Chinea P, Castle M, Aymerich M, Lanciego J. Expression of vesicular glutamate transporters 1 and 2 in the cells of origin of the rat thalamostriatal pathway. J Chem Neuroanat. 2008;35:101-7 pubmed
    The present study is focused on the analysis of the vesicular glutamate transporters 1 and 2 (VGLUT1 and VGLUT2) used by thalamic neurons giving rise to the thalamostriatal system...
  60. Boulland J, Qureshi T, Seal R, Rafiki A, Gundersen V, Bergersen L, et al. Expression of the vesicular glutamate transporters during development indicates the widespread corelease of multiple neurotransmitters. J Comp Neurol. 2004;480:264-80 pubmed
    ..Complementary patterns of expression in glutamatergic terminals have been reported for VGLUT1 and VGLUT2. VGLUT3 shows expression by many cells not considered to be glutamatergic...
  61. Montana V, Ni Y, Sunjara V, Hua X, Parpura V. Vesicular glutamate transporter-dependent glutamate release from astrocytes. J Neurosci. 2004;24:2633-42 pubmed
    ..Taken together, these data indicate that VGLUTs play a functional role in exocytotic glutamate release from astrocytes. ..
  62. Waselus M, Van Bockstaele E. Co-localization of corticotropin-releasing factor and vesicular glutamate transporters within axon terminals of the rat dorsal raphe nucleus. Brain Res. 2007;1174:53-65 pubmed
    ..axon terminals within the DRN contain immunoreactivity for vesicular glutamate transporters (isoforms vGlut1 and vGlut2) indicative of the excitatory neurotransmitter glutamate...
  63. Pang Y, Ge S, Nakamura K, Li J, Xiong K, Kaneko T, et al. Axon terminals expressing vesicular glutamate transporter VGLUT1 or VGLUT2 within the trigeminal motor nucleus of the rat: origins and distribution patterns. J Comp Neurol. 2009;512:595-612 pubmed publisher
    ..significance of the two types of glutamatergic neurons (those expressing vesicular glutamate transporter VGLUT1 or VGLUT2) in the control of jaw movements...
  64. Llorente I, Pérez Rodríguez D, Burgin T, Gonzalo Orden J, Martínez Villayandre B, Fernández López A. Age and meloxicam modify the response of the glutamate vesicular transporters (VGLUTs) after transient global cerebral ischemia in the rat brain. Brain Res Bull. 2013;94:90-7 pubmed publisher
    ..Western blot assays showed a lessened age-dependent response to the ischemic damage in VGLUT1 and VGLUT3, while VGLUT2 presented an age and structure-dependent response to challenge...
  65. Hrabovszky E, Halasz J, Meelis W, Kruk M, Liposits Z, Haller J. Neurochemical characterization of hypothalamic neurons involved in attack behavior: glutamatergic dominance and co-expression of thyrotropin-releasing hormone in a subset of glutamatergic neurons. Neuroscience. 2005;133:657-66 pubmed
    ..It now appears that a dense and distinct group of glutamatergic cells expressing vesicular glutamate transporter 2 mRNA extends over the entire hypothalamic attack area...