Slc16a1

Summary

Gene Symbol: Slc16a1
Description: solute carrier family 16 member 1
Alias: MCT1, RATMCT1, RNMCT1, monocarboxylate transporter 1, MCT 1, solute carrier 16 (monocarboxylic acid transporter), member 1, solute carrier family 16 (monocarboxylate transporter), member 1, solute carrier family 16 (monocarboxylic acid transporters), member 1, solute carrier family 16, member 1 (monocarboxylic acid transporter 1)
Species: rat
Products:     Slc16a1

Top Publications

  1. Jackson V, Price N, Halestrap A. cDNA cloning of MCT1, a monocarboxylate transporter from rat skeletal muscle. Biochim Biophys Acta. 1995;1238:193-6 pubmed
    PCR was used to amplify the coding region of CHO MCT1 cDNA. This was then used to screen a rat skeletal muscle cDNA library which lead to the isolation of a full length cDNA encoding MCT1 from rat...
  2. Takanaga H, Tamai I, Inaba S, Sai Y, Higashida H, Yamamoto H, et al. cDNA cloning and functional characterization of rat intestinal monocarboxylate transporter. Biochem Biophys Res Commun. 1995;217:370-7 pubmed
    A cDNA clone which encodes a monocarboxylate transporter (ratMCT1) was isolated from a rat small intestinal cDNA library, which was screened by using full-length MCT1 cDNA of Chinese hamster ovary cells...
  3. Orsenigo M, Tosco M, Bazzini C, Laforenza U, Faelli A. A monocarboxylate transporter MCT1 is located at the basolateral pole of rat jejunum. Exp Physiol. 1999;84:1033-42 pubmed
    We have functionally expressed and identified a monocarboxylate transporter (MCT1) from rat jejunal enterocyte and we provide evidence for its basolateral localization...
  4. McClelland G, Brooks G. Changes in MCT 1, MCT 4, and LDH expression are tissue specific in rats after long-term hypobaric hypoxia. J Appl Physiol (1985). 2002;92:1573-84 pubmed
    ..We looked at the protein expression of monocarboxylate transporters MCT 1, MCT 2, and MCT 4, along with total lactate dehydrogenase (LDH) and LDH isozymes in skeletal muscle, cardiac ..
  5. Enoki T, Yoshida Y, Hatta H, Bonen A. Exercise training alleviates MCT1 and MCT4 reductions in heart and skeletal muscles of STZ-induced diabetic rats. J Appl Physiol (1985). 2003;94:2433-8 pubmed
    We compared the changes in monocarboxylate transporter 1 (MCT1) and 4 (MCT4) proteins in heart and skeletal muscles in sedentary control and streptozotocin (STZ)-induced diabetic rats (3 wk) and in trained (3 wk) control and STZ-induced ..
  6. Suzuki A, Stern S, Bozdagi O, Huntley G, Walker R, Magistretti P, et al. Astrocyte-neuron lactate transport is required for long-term memory formation. Cell. 2011;144:810-23 pubmed publisher
    ..Disrupting the expression of the astrocytic lactate transporters monocarboxylate transporter 4 (MCT4) or MCT1 causes amnesia, which, like LTP impairment, is rescued by L-lactate but not equicaloric glucose...
  7. Uhernik A, Tucker C, Smith J. Control of MCT1 function in cerebrovascular endothelial cells by intracellular pH. Brain Res. 2011;1376:10-22 pubmed publisher
    Monocarboxylic Acid Transporter 1 (MCT1) is expressed on the plasma membrane of cerebrovascular endothelial cells where it is the only known facilitator of lactic acid transport across the blood brain barrier...
  8. Manoharan C, Wilson M, Sessions R, Halestrap A. The role of charged residues in the transmembrane helices of monocarboxylate transporter 1 and its ancillary protein basigin in determining plasma membrane expression and catalytic activity. Mol Membr Biol. 2006;23:486-98 pubmed
    Monocarboxylate transporters MCT1-MCT4 require basigin (CD147) or embigin (gp70), ancillary proteins with a glutamate residue in their single transmembrane (TM) domain, for plasma membrane (PM) expression and activity...
  9. Wilson M, Meredith D, Halestrap A. Fluorescence resonance energy transfer studies on the interaction between the lactate transporter MCT1 and CD147 provide information on the topology and stoichiometry of the complex in situ. J Biol Chem. 2002;277:3666-72 pubmed
    The monocarboxylate (lactate) transporters MCT1 and MCT4 require the membrane-spanning glycoprotein CD147 for their correct plasma membrane expression and function...

More Information

Publications57

  1. Smith J, Uhernik A, Li L, Liu Z, Drewes L. Regulation of Mct1 by cAMP-dependent internalization in rat brain endothelial cells. Brain Res. 2012;1480:1-11 pubmed publisher
    In the cerebrovascular endothelium, monocarboxylic acid transporter 1 (Mct1) controls blood-brain transport of short chain monocarboxylic and keto acids, including pyruvate and lactate, to support brain energy metabolism...
  2. Smith J, Drewes L. Modulation of monocarboxylic acid transporter-1 kinetic function by the cAMP signaling pathway in rat brain endothelial cells. J Biol Chem. 2006;281:2053-60 pubmed
    b>MCT1 (monocarboxylic acid transporter 1) facilitates bidirectional monocarboxylic acid transport across membranes...
  3. Galic S, Schneider H, Bröer A, Deitmer J, Broer S. The loop between helix 4 and helix 5 in the monocarboxylate transporter MCT1 is important for substrate selection and protein stability. Biochem J. 2003;376:413-22 pubmed
    ..We have mutated residues in this signature sequence in the rat monocarboxylate transporter (MCT1) to elucidate the significance of this region for monocarboxylate transport...
  4. Wilson M, Meredith D, Bunnun C, Sessions R, Halestrap A. Studies on the DIDS-binding site of monocarboxylate transporter 1 suggest a homology model of the open conformation and a plausible translocation cycle. J Biol Chem. 2009;284:20011-21 pubmed publisher
    Site-directed mutagenesis of MCT1 was performed on exofacial lysines Lys(38), Lys(45), Lys(282), and Lys(413)...
  5. Wilson M, Meredith D, Fox J, Manoharan C, Davies A, Halestrap A. Basigin (CD147) is the target for organomercurial inhibition of monocarboxylate transporter isoforms 1 and 4: the ancillary protein for the insensitive MCT2 is EMBIGIN (gp70). J Biol Chem. 2005;280:27213-21 pubmed
    Translocation of monocarboxylate transporters MCT1 and MCT4 to the plasma membrane requires CD147 (basigin) with which they remain tightly associated. However, the importance of CD147 for MCT activity is unclear...
  6. B renz F, Inoue D, Yokoyama H, Tegha Dunghu J, Freiss S, Draeger S, et al. The centriolar satellite protein SSX2IP promotes centrosome maturation. J Cell Biol. 2013;202:81-95 pubmed publisher
    ..It preserves centrosome integrity and faithful mitosis during the rapid cleavage division of blastomeres and in somatic cells...
  7. Lu Y, Zhao H, Wang Y, Han B, Wang T, Zhao H, et al. Electro-acupuncture up-regulates astrocytic MCT1 expression to improve neurological deficit in middle cerebral artery occlusion rats. Life Sci. 2015;134:68-72 pubmed publisher
    ..staining, Western blot and qRT-PCR analyses for the expressions of lactate transporter (monocarboxylate transporter 1, MCT1) and glial fibrillary acidic protein (GFAP)...
  8. Cortés Campos C, Elizondo R, Llanos P, Uranga R, Nualart F, Garcia M. MCT expression and lactate influx/efflux in tanycytes involved in glia-neuron metabolic interaction. PLoS ONE. 2011;6:e16411 pubmed publisher
    ..Here, we demonstrate the presence and function of monocarboxylate transporters (MCTs) in tanycytes. Specifically, MCT1 and MCT4 expression as well as their distribution were analyzed in Sprague Dawley rat brain, and we demonstrate ..
  9. Thomas C, Bishop D, Moore Morris T, Mercier J. Effects of high-intensity training on MCT1, MCT4, and NBC expressions in rat skeletal muscles: influence of chronic metabolic alkalosis. Am J Physiol Endocrinol Metab. 2007;293:E916-22 pubmed
    ..the effects of high-intensity training, with or without induced metabolic alkalosis, on lactate transporter (MCT1 and MCT4) and sodium bicarbonate cotransporter (NBC) content in rat skeletal muscles...
  10. Pullen T, Sylow L, Sun G, Halestrap A, Richter E, Rutter G. Overexpression of monocarboxylate transporter-1 (SLC16A1) in mouse pancreatic β-cells leads to relative hyperinsulinism during exercise. Diabetes. 2012;61:1719-25 pubmed publisher
    ..Activating mutations in the monocarboxylate transporter-1 (MCT1, SLC16A1) promoter have been linked to EIHI...
  11. Korn T, Magnus T, Jung S. Interaction with antigen-specific T cells regulates expression of the lactate transporter MCT1 in primary rat astrocytes: specific link between immunity and homeostasis. Glia. 2005;49:73-83 pubmed
    ..T cells in the presence of MBP resulted in a marked upregulation of the astrocytic lactate transporter MCT1 that is to export lactate into the extracellular space...
  12. Nancolas B, Guo L, Zhou R, Nath K, Nelson D, Leeper D, et al. The anti-tumour agent lonidamine is a potent inhibitor of the mitochondrial pyruvate carrier and plasma membrane monocarboxylate transporters. Biochem J. 2016;473:929-36 pubmed publisher
    ..5 μM) and co-operatively inhibits L-lactate transport by MCT1, MCT2 and MCT4 expressed in Xenopus laevisoocytes with K0.5 and Hill coefficient values of 36-40 μM and 1.65-1...
  13. Tonouchi M, Hatta H, Bonen A. Muscle contraction increases lactate transport while reducing sarcolemmal MCT4, but not MCT1. Am J Physiol Endocrinol Metab. 2002;282:E1062-9 pubmed
    ..05) while again reducing MCT4 (-20%, P < 0.05) but not MCT1 (P > 0.05)...
  14. Liu Z, Sneve M, Haroldson T, Smith J, Drewes L. Regulation of Monocarboxylic Acid Transporter 1 Trafficking by the Canonical Wnt/β-Catenin Pathway in Rat Brain Endothelial Cells Requires Cross-talk with Notch Signaling. J Biol Chem. 2016;291:8059-69 pubmed publisher
    ..pyruvate, and ketone bodies across brain endothelial cells is mediated by monocarboxylic acid transporter 1 (MCT1)...
  15. Lee N, Kang Y. In Vivo and In Vitro Evidence for Brain Uptake of 4-Phenylbutyrate by the Monocarboxylate Transporter 1 (MCT1). Pharm Res. 2016;33:1711-22 pubmed publisher
    ..In addition, [(14)C]4-PBA uptake was inhibited by rMCT1 specific small interfering RNA. The transport mechanism of 4-PBA from blood to brain across the BBB likely involves MCT1.
  16. Leroy C, Pierre K, Simpson I, Pellerin L, Vannucci S, Nehlig A. Temporal changes in mRNA expression of the brain nutrient transporters in the lithium-pilocarpine model of epilepsy in the immature and adult rat. Neurobiol Dis. 2011;43:588-97 pubmed publisher
    ..changes, here we explored the expression of transporters for glucose (GLUT1 and GLUT3) and monocarboxylates (MCT1 and MCT2) during and after status epilepticus (SE) induced by lithium-pilocarpine in PN10, PN21, and adult rats...
  17. Williams A, Jacobs S, Moreno Macias H, Huerta Chagoya A, Churchhouse C, Márquez Luna C, et al. Sequence variants in SLC16A11 are a common risk factor for type 2 diabetes in Mexico. Nature. 2014;506:97-101 pubmed publisher
  18. Pifferi F, Tremblay S, Croteau E, Fortier M, Tremblay Mercier J, Lecomte R, et al. Mild experimental ketosis increases brain uptake of 11C-acetoacetate and 18F-fluorodeoxyglucose: a dual-tracer PET imaging study in rats. Nutr Neurosci. 2011;14:51-8 pubmed publisher
    ..of the transporters of glucose and ketones (glucose transporter 1 (GLUT1) and monocarboxylic acid transporter (MCT1)) was measured in brain microvessel preparations...
  19. Canis M, Mack B, Gires O, Maurer M, Kuschinsky W, Duembgen L, et al. Increased densities of monocarboxylate transport protein MCT1 after chronic administration of nicotine in rat brain. Neurosci Res. 2009;64:429-35 pubmed publisher
    ..as to whether chronic nicotine infusion is accompanied by increased local densities of monocarboxylate transporter MCT1 in the brain...
  20. Enoki T, Yoshida Y, Lally J, Hatta H, Bonen A. Testosterone increases lactate transport, monocarboxylate transporter (MCT) 1 and MCT4 in rat skeletal muscle. J Physiol. 2006;577:433-43 pubmed
    ..In addition, we also examined the effects of testosterone treatment on plasmalemmal MCT1 and MCT4, and lactate transport into giant sarcolemmal vesicles prepared from red and white hindlimb muscles and ..
  21. Bergersen L, Thomas M, Johannsson E, Waerhaug O, Halestrap A, Andersen K, et al. Cross-reinnervation changes the expression patterns of the monocarboxylate transporters 1 and 4: An experimental study in slow and fast rat skeletal muscle. Neuroscience. 2006;138:1105-13 pubmed
    ..In brain, monocarboxylate transporter 1 occurs in astrocytes, ependymocytes, and endothelial cells while monocarboxylate transporter 4 appears ..
  22. Merezhinskaya N, Ogunwuyi S, Mullick F, Fishbein W. Presence and localization of three lactic acid transporters (MCT1, -2, and -4) in separated human granulocytes, lymphocytes, and monocytes. J Histochem Cytochem. 2004;52:1483-93 pubmed
    ..for transcriptional and translational expression of three physiologically-proven lactate transporters, monocarboxylate transporter 1(MCT1), MCT2, and MCT4, using RT-PCR and affinity-purified rabbit antibody (Ab) to the C-terminal ..
  23. Vannucci S, Simpson I. Developmental switch in brain nutrient transporter expression in the rat. Am J Physiol Endocrinol Metab. 2003;285:E1127-34 pubmed
    ..This study investigated the temporal and regional expression of MCT1 and MCT2 mRNA and protein in the BBB and the nonvascular brain during postnatal development in the rat...
  24. Baud O, Fayol L, Gressens P, Pellerin L, Magistretti P, Evrard P, et al. Perinatal and early postnatal changes in the expression of monocarboxylate transporters MCT1 and MCT2 in the rat forebrain. J Comp Neurol. 2003;465:445-54 pubmed
    ..We studied the immunocytochemical expression of the monocarboxylate transporters MCT1 and MCT2 in the rat brain between embryonic day (E) 16 and postnatal day (P) 14...
  25. Takimoto M, Takeyama M, Hamada T. Possible involvement of AMPK in acute exercise-induced expression of monocarboxylate transporters MCT1 and MCT4 mRNA in fast-twitch skeletal muscle. Metabolism. 2013;62:1633-40 pubmed publisher
    The regulatory mechanisms responsible for acute exercise-induced expression of monocarboxylate transporters MCT1 and MCT4 mRNA in skeletal muscle remain unclear...
  26. Lengacher S, Nehiri Sitayeb T, Steiner N, Carneiro L, Favrod C, Preitner F, et al. Resistance to diet-induced obesity and associated metabolic perturbations in haploinsufficient monocarboxylate transporter 1 mice. PLoS ONE. 2013;8:e82505 pubmed publisher
    The monocarboxylate transporter 1 (MCT1 or SLC16A1) is a carrier of short-chain fatty acids, ketone bodies, and lactate in several tissues...
  27. Kekuda R, Manoharan P, Baseler W, Sundaram U. Monocarboxylate 4 mediated butyrate transport in a rat intestinal epithelial cell line. Dig Dis Sci. 2013;58:660-7 pubmed publisher
    ..Conventional assumption is that MCT1 mediates SCFA/HCO3 (-) exchange in the intestine...
  28. Kirat D, Kondo K, Shimada R, Kato S. Dietary pectin up-regulates monocaboxylate transporter 1 in the rat gastrointestinal tract. Exp Physiol. 2009;94:422-33 pubmed publisher
    ..the effect of pectin feeding on the expression level, cellular localization and functional activity of monocarboxylate transporter 1 (MCT1) in the gastrointestinal tract of rats...
  29. Uhernik A, Li L, Lavoy N, Velasquez M, Smith J. Regulation of monocarboxylic acid transporter-1 by cAMP dependent vesicular trafficking in brain microvascular endothelial cells. PLoS ONE. 2014;9:e85957 pubmed publisher
    In this study, a detailed characterization of Monocarboxylic Acid Transporter-1 (Mct1) in cytoplasmic vesicles of cultured rat brain microvascular endothelial cells shows them to be a diverse population of endosomes intrinsic to the ..
  30. Takimoto M, Hamada T. Acute exercise increases brain region-specific expression of MCT1, MCT2, MCT4, GLUT1, and COX IV proteins. J Appl Physiol (1985). 2014;116:1238-50 pubmed publisher
    ..We examined the protein expression of MCT1, MCT2, MCT4, glucose transporter 1 (GLUT1), and cytochrome-c oxidase subunit IV (COX IV) in the rat brain within 24 ..
  31. Lauritzen F, Perez E, Melillo E, Roh J, Zaveri H, Lee T, et al. Altered expression of brain monocarboxylate transporter 1 in models of temporal lobe epilepsy. Neurobiol Dis. 2012;45:165-76 pubmed publisher
    b>Monocarboxylate transporter 1 (MCT1) facilitates the transport of monocarboxylate fuels (lactate, pyruvate and ketone bodies) and acidic drugs, such as valproic acid, across cell membranes...
  32. Morse B, Vijay N, Morris M. Mechanistic modeling of monocarboxylate transporter-mediated toxicokinetic/toxicodynamic interactions between ?-hydroxybutyrate and L-lactate. AAPS J. 2014;16:756-70 pubmed publisher
    ..The Km for renal reabsorption of GHB (650 ?g/mL) was close to its Km for the proton-dependent MCT1 and that for L-lactate (13.5 ?g/mL) close to its Km for the sodium-dependent SMCT1...
  33. Tachikawa M, Murakami K, Martin P, Hosoya K, Ganapathy V. Retinal transfer of nicotinate by H+ -monocarboxylate transporter at the inner blood-retinal barrier. Microvasc Res. 2011;82:385-90 pubmed publisher
    ..These characteristics are consistent with those of H(+)-coupled monocarboxylate transporters (MCTs). MCT1, MCT2, and MCT4 mRNAs were expressed in TR-iBRB2 cells...
  34. Moreira T, Pierre K, Maekawa F, Repond C, Cebere A, Liljequist S, et al. Enhanced cerebral expression of MCT1 and MCT2 in a rat ischemia model occurs in activated microglial cells. J Cereb Blood Flow Metab. 2009;29:1273-83 pubmed publisher
    ..The expression of MCT1 and MCT2 was investigated at 48 h of reperfusion from focal ischemia induced by unilateral extradural compression ..
  35. Canis M, Maurer M, Kuschinsky W, Duembgen L, Duelli R. Increased densities of monocarboxylate transporter MCT1 after chronic hyperglycemia in rat brain. Brain Res. 2009;1257:32-9 pubmed publisher
    ..Previous studies reported an increased expression of monocarboxylate transporter MCT1 in brain following ketotic diet...
  36. König B, Koch A, Giggel K, Dordschbal B, Eder K, Stangl G. Monocarboxylate transporter (MCT)-1 is up-regulated by PPARalpha. Biochim Biophys Acta. 2008;1780:899-904 pubmed publisher
    ..that activation of PPARalpha in rats by clofibrate treatment or fasting increased hepatic mRNA concentration of MCT1. In Fao rat hepatoma cells, incubation with the PPARalpha agonist WY 14,643 increased mRNA concentration of MCT1 ..
  37. Kang K, Jin M, Han H. IGF-I receptor gene activation enhanced the expression of monocarboxylic acid transporter 1 in hepatocarcinoma cells. Biochem Biophys Res Commun. 2006;342:1352-5 pubmed
    ..Immunoblot assay indicated that the expression level of MCT1 was 3...
  38. Becker H, Hirnet D, Fecher Trost C, Sültemeyer D, Deitmer J. Transport activity of MCT1 expressed in Xenopus oocytes is increased by interaction with carbonic anhydrase. J Biol Chem. 2005;280:39882-9 pubmed
    ..II (CA) into Xenopus frog oocytes increased the rate of H+ flux via the rat monocarboxylate transporter isoform 1 (MCT1) expressed in the oocytes...
  39. Wang Y, Tonouchi M, Miskovic D, Hatta H, Bonen A. T3 increases lactate transport and the expression of MCT4, but not MCT1, in rat skeletal muscle. Am J Physiol Endocrinol Metab. 2003;285:E622-8 pubmed
    ..We also examined rates of lactate transport into giant sarcolemmal vesicles and the plasmalemmal MCT1 and MCT4 in these vesicles. Ingestion of T3 markedly increased circulating serum T3 (P < 0...
  40. Dong F, Liu Y, Zhang Z, Guo R, Ma L, Qu X, et al. Postnatal alteration of monocarboxylate transporter 1 expression in the rat corpus callosum. Physiol Res. 2017;66:345-355 pubmed
    In the central nervous system (CNS), monocarboxylate transporter 1 (MCT1) is expressed in astrocytes and endothelial cells but also in oligodendroglia. Oligodendroglia support neurons and axons through lactate transportation by MCT1...
  41. Seo J, Sung Y, Kim K, Shin M, Lee E, Kim C. Effects of Phellinus linteus administration on serotonin synthesis in the brain and expression of monocarboxylate transporters in the muscle during exhaustive exercise in rats. J Nutr Sci Vitaminol (Tokyo). 2011;57:95-103 pubmed
    ..b>MCT1 and MCT4 expression of the gastrocnemius muscles was also increased in response to treatment with 200 mg/kg of PL...
  42. Takahashi T, Friedmacher F, Zimmer J, Puri P. Decreased expression of monocarboxylate transporter 1 and 4 in the branching airway epithelium of nitrofen-induced congenital diaphragmatic hernia. J Pediatr Surg. 2016;51:896-9 pubmed publisher
    ..b>MCT1/4 is strongly expressed by epithelial airway cells throughout lung branching morphogenesis...
  43. Maurer M, Canis M, Kuschinsky W, Duelli R. Correlation between local monocarboxylate transporter 1 (MCT1) and glucose transporter 1 (GLUT1) densities in the adult rat brain. Neurosci Lett. 2004;355:105-8 pubmed
    Monocarboxylate transporters type 1 (MCT1) facilitate the transport of monocarboxylates across cell membranes of the blood-brain barrier and brain parenchymal cells...
  44. Coles L, Litt J, Hatta H, Bonen A. Exercise rapidly increases expression of the monocarboxylate transporters MCT1 and MCT4 in rat muscle. J Physiol. 2004;561:253-61 pubmed
    ..the effect of a single exercise session on the protein and mRNA expression of the monocarboxylate transporters MCT1 and MCT4 in rat soleus (SOL), and red (RG) and white gastrocnemius (WG) muscles...
  45. Hashimoto T, Masuda S, Taguchi S, Brooks G. Immunohistochemical analysis of MCT1, MCT2 and MCT4 expression in rat plantaris muscle. J Physiol. 2005;567:121-9 pubmed
    We addressed the need for histological assessment of myocellular domains occupied by monocarboxylate transporters (MCT1, MCT2 and MCT4)...
  46. Hashimoto T, Hussien R, Brooks G. Colocalization of MCT1, CD147, and LDH in mitochondrial inner membrane of L6 muscle cells: evidence of a mitochondrial lactate oxidation complex. Am J Physiol Endocrinol Metab. 2006;290:E1237-44 pubmed
    ..we examined the cellular locations of mitochondria, lactate dehydrogenase (LDH), the lactate-pyruvate transporter MCT1, and CD147, a purported chaperone protein for MCT1...
  47. Benton C, Yoshida Y, Lally J, Han X, Hatta H, Bonen A. PGC-1alpha increases skeletal muscle lactate uptake by increasing the expression of MCT1 but not MCT2 or MCT4. Physiol Genomics. 2008;35:45-54 pubmed publisher
    We examined the relationship between PGC-1alpha protein; the monocarboxylate transporters MCT1, 2, and 4; and CD147 1) among six metabolically heterogeneous rat muscles, 2) in chronically stimulated red (RTA) and white tibialis (WTA) ..
  48. Ovens M, Davies A, Wilson M, Murray C, Halestrap A. AR-C155858 is a potent inhibitor of monocarboxylate transporters MCT1 and MCT2 that binds to an intracellular site involving transmembrane helices 7-10. Biochem J. 2010;425:523-30 pubmed publisher
    In the present study we characterize the properties of the potent MCT1 (monocarboxylate transporter 1) inhibitor AR-C155858...