Gene Symbol: Slc15a1
Description: solute carrier family 15 member 1
Alias: Pept1, solute carrier family 15 member 1, intestinal H(+)/peptide cotransporter, oligopeptide transporter, small intestine isoform, peptide transporter 1, pineal gland-specific PEPT1, proton-coupled dipeptide cotransporter, solute carrier family 15 (oligopeptide transporter), member 1
Species: rat
Products:     Slc15a1

Top Publications

  1. Wuensch T, Schulz S, Ullrich S, Lill N, Stelzl T, Rubio Aliaga I, et al. The peptide transporter PEPT1 is expressed in distal colon in rodents and humans and contributes to water absorption. Am J Physiol Gastrointest Liver Physiol. 2013;305:G66-73 pubmed publisher
    The peptide transporter PEPT1, expressed in the brush border membrane of enterocytes, mediates the uptake of di- and tripeptides from luminal protein digestion in the small intestine...
  2. Shimizu Y, Masuda S, Nishihara K, Ji L, Okuda M, Inui K. Increased protein level of PEPT1 intestinal H+-peptide cotransporter upregulates absorption of glycylsarcosine and ceftibuten in 5/6 nephrectomized rats. Am J Physiol Gastrointest Liver Physiol. 2005;288:G664-70 pubmed
    ..H(+)-coupled peptide transporter (PEPT1/SLC15A1) plays an important role in the absorption of small peptides and peptide-like drugs in the small intestine...
  3. Ogihara T, Kano T, Wagatsuma T, Wada S, Yabuuchi H, Enomoto S, et al. Oseltamivir (tamiflu) is a substrate of peptide transporter 1. Drug Metab Dispos. 2009;37:1676-81 pubmed publisher
    ..Uptake by Caco-2 cells (human carcinoma cell line) and HeLa cells transfected with peptide transporter 1 (HeLa/PEPT1) was time- and temperature-dependent and was inhibited by typical PEPT1 inhibitors such as ..
  4. Tramonti G, Xie P, Wallner E, Danesh F, Kanwar Y. Expression and functional characteristics of tubular transporters: P-glycoprotein, PEPT1, and PEPT2 in renal mass reduction and diabetes. Am J Physiol Renal Physiol. 2006;291:F972-80 pubmed
    ..effect of renal mass reduction/hyperglycemia on gene and protein expression of P-glycoprotein (Pgp), PEPT1, and PEPT2 was assessed...
  5. Hussain I, Kellett L, Affleck J, Shepherd J, Boyd R. Expression and cellular distribution during development of the peptide transporter (PepT1) in the small intestinal epithelium of the rat. Cell Tissue Res. 2002;307:139-42 pubmed
    Immunocytochemical distribution in rat small intestine of PepT1, the oligopeptide transporter responsible for nutritionally important peptide uptake from the adult small intestinal lumen, has been measured during development using an ..
  6. Arakawa H, Saito S, Kanagawa M, Kamioka H, Yano K, Morimoto K, et al. Evaluation of a thiodipeptide, L-phenylalanyl-?[CS-N]-L-alanine, as a novel probe for peptide transporter 1. Drug Metab Pharmacokinet. 2014;29:470-4 pubmed publisher
    L-Phenylalanyl-?[CS-N]-l-alanine (Phe-?-Ala), a thiourea dipeptide, was evaluated as a probe for peptide transporter 1 (PEPT1)...
  7. Lu H, Klaassen C. Tissue distribution and thyroid hormone regulation of Pept1 and Pept2 mRNA in rodents. Peptides. 2006;27:850-7 pubmed
    ..The present study investigated the distribution of Pept1 and Pept2 mRNA in 19 tissues of male and female Sprague-Dawley rats and C57BL/6 mice, as well as thyroid hormone ..
  8. Su L, Zhang Y, Cheng Y, Lee W, Ye K, Hu D. Slc15a1 is involved in the transport of synthetic F5-peptide into the seminiferous epithelium in adult rat testes. Sci Rep. 2015;5:16271 pubmed publisher
    ..Here we demonstrated that Slc15a1, a peptide transporter also known as Pept1, was predominantly present in peritubular myoid cells, interstitial ..
  9. Radeva G, Buyse M, Hindlet P, Beaufils B, Walker F, Bado A, et al. Regulation of the oligopeptide transporter, PEPT-1, in DSS-induced rat colitis. Dig Dis Sci. 2007;52:1653-61 pubmed
    ..In conclusion, DSS-induced rat colitis did not alter PepT-1 substrate bioavailability despite certain modifications in PepT-1 expression profile. ..

More Information


  1. Saito H, Terada T, Shimakura J, Katsura T, Inui K. Regulatory mechanism governing the diurnal rhythm of intestinal H+/peptide cotransporter 1 (PEPT1). Am J Physiol Gastrointest Liver Physiol. 2008;295:G395-402 pubmed publisher
    The intestinal H(+)/peptide cotransporter 1 (PEPT1) plays important roles as a nutrient and drug transporter...
  2. Shimakura J, Terada T, Saito H, Katsura T, Inui K. Induction of intestinal peptide transporter 1 expression during fasting is mediated via peroxisome proliferator-activated receptor alpha. Am J Physiol Gastrointest Liver Physiol. 2006;291:G851-6 pubmed
    ..starvation markedly increased the amount of mRNA and protein levels of the intestinal H+/peptide cotransporter (PEPT1) in rats, leading to altered pharmacokinetics of the PEPT1 substrates...
  3. Saito H, Okuda M, Terada T, Sasaki S, Inui K. Cloning and characterization of a rat H+/peptide cotransporter mediating absorption of beta-lactam antibiotics in the intestine and kidney. J Pharmacol Exp Ther. 1995;275:1631-7 pubmed
    A complementary DNA (cDNA) encoding the rat H+/peptide cotransporter (PepT1) was isolated, and the transport characteristics of orally active beta-lactam antibiotics were assessed by measuring uptake into Xenopus oocytes expressing the ..
  4. Shi B, Song D, Xue H, Li N, Li J. PepT1 mediates colon damage by transporting fMLP in rats with bowel resection. J Surg Res. 2006;136:38-44 pubmed
    The intestinal oligopeptide transporter (PepT1) is responsible for the absorption of nutrient di-tripeptide and mediates the transportation of bacterial product N-formylmethionylleucyl-phenylalanine (fMLP) that induces intestinal ..
  5. Darcel N, Liou A, Tome D, Raybould H. Activation of vagal afferents in the rat duodenum by protein digests requires PepT1. J Nutr. 2005;135:1491-5 pubmed
    ..The hypothesis that the oligopeptide transporter PepT1 plays a major role in the initiation of this vago-vagal reflex was tested by recording activation of duodenal ..
  6. Pan X, Terada T, Irie M, Saito H, Inui K. Diurnal rhythm of H+-peptide cotransporter in rat small intestine. Am J Physiol Gastrointest Liver Physiol. 2002;283:G57-64 pubmed
    ..In the present study, we examined the diurnal rhythm of the H+-peptide cotransporter (PEPT1), which transports small peptides and peptide-like drugs in the small intestine and kidney, using rats maintained ..
  7. Gleeson J, Brayden D, Ryan S. Evaluation of PepT1 transport of food-derived antihypertensive peptides, Ile-Pro-Pro and Leu-Lys-Pro using in vitro, ex vivo and in vivo transport models. Eur J Pharm Biopharm. 2017;115:276-284 pubmed publisher
    ..There is debate over their mechanism of uptake across small intestinal epithelia, but paracellular and PepT1 carrier-mediated uptake are thought to be important routes...
  8. Ma G, Shi B, Liu J, Zhang H, YinTao Z, Lou X, et al. Nod2-Rip2 Signaling Contributes to Intestinal Injury Induced by Muramyl Dipeptide Via Oligopeptide Transporter in Rats. Dig Dis Sci. 2015;60:3264-70 pubmed publisher
    b>PepT1 can transport bacterial oligopeptide products and induce intestinal inflammation...
  9. Gangopadhyay A, Thamotharan M, Adibi S. Regulation of oligopeptide transporter (Pept-1) in experimental diabetes. Am J Physiol Gastrointest Liver Physiol. 2002;283:G133-8 pubmed
    ..In conclusion, the data show that 1) uncontrolled diabetes has a tropic effect on Pept-1 and 2) the effect is systemic, and its molecular mechanism appears to be an increase in the stabilization of mRNA encoding Pept-1. ..
  10. Pan X, Terada T, Okuda M, Inui K. The diurnal rhythm of the intestinal transporters SGLT1 and PEPT1 is regulated by the feeding conditions in rats. J Nutr. 2004;134:2211-5 pubmed
    The intestinal Na(+)/glucose cotransporter 1 (SGLT1) and H(+)/peptide cotransporter 1 (PEPT1) play important roles in the absorption of carbohydrate and protein...
  11. Liu J, Shi B, Shi K, Ma G, Zhang H, Lou X, et al. Ghrelin upregulates PepT1 activity in the small intestine epithelium of rats with sepsis. Biomed Pharmacother. 2017;86:669-676 pubmed publisher
    ..We tested whether ghrelin administration affects peptide transporter 1 (PepT1) activity in the intestinal epithelium of rats with sepsis...
  12. Sun B, Zhao X, Wang G, Li N, Li J. Changes of biological functions of dipeptide transporter (PepT1) and hormonal regulation in severe scald rats. World J Gastroenterol. 2003;9:2782-5 pubmed
    To determine the regulatory effects of recombinant human growth hormone (rhGH) on dipeptide transport (PepT1) in normal and severe scald rats...
  13. Fei Y, Sugawara M, Liu J, Li H, Ganapathy V, Ganapathy M, et al. cDNA structure, genomic organization, and promoter analysis of the mouse intestinal peptide transporter PEPT1. Biochim Biophys Acta. 2000;1492:145-54 pubmed
    ..genomic organization, and promoter analysis of the mouse H(+)-coupled low-affinity peptide transporter PEPT1. The mouse PEPT1 cDNA cloned from a kidney cDNA library is approximately 3...
  14. Qandeel H, Duenes J, Zheng Y, Sarr M. Diurnal expression and function of peptide transporter 1 (PEPT1). J Surg Res. 2009;156:123-8 pubmed publisher di/tripeptides, which are transported into the enterocyte exclusively by H(+)/peptide cotransporter 1 (PEPT1). Diurnal changes in expression and function of several other mucosal transporters occur in rat...
  15. Miyamoto K, Shiraga T, Morita K, Yamamoto H, Haga H, Taketani Y, et al. Sequence, tissue distribution and developmental changes in rat intestinal oligopeptide transporter. Biochim Biophys Acta. 1996;1305:34-8 pubmed
    Complementary DNA clones encoding the rat PepT1 small-intestinal oligopeptide transporter were isolated from a jejunal library by cross-hybridization with a rabbit PepT1 cDNA probe...
  16. Naruhashi K, Sai Y, Tamai I, Suzuki N, Tsuji A. PepT1 mRNA expression is induced by starvation and its level correlates with absorptive transport of cefadroxil longitudinally in the rat intestine. Pharm Res. 2002;19:1417-23 pubmed
    To establish how closely intestinal transport activity for beta-lactam antibiotics is correlated with PepT1 expression, absolute expression level of PepT1 mRNA and transport activity were determined longitudinally in the small intestine ..
  17. Ashida K, Katsura T, Saito H, Inui K. Decreased activity and expression of intestinal oligopeptide transporter PEPT1 in rats with hyperthyroidism in vivo. Pharm Res. 2004;21:969-75 pubmed
    To examine the effect of thyroid hormone status on PEPT1 in vivo, the activity and expression of PEPT1 in the small intestine were examined in euthyroid and hyperthyroid rats...
  18. Gaildrat P, Møller M, Mukda S, Humphries A, Carter D, Ganapathy V, et al. A novel pineal-specific product of the oligopeptide transporter PepT1 gene: circadian expression mediated by cAMP activation of an intronic promoter. J Biol Chem. 2005;280:16851-60 pubmed
    The oligopeptide transporter 1, PepT1, is a member of the Slc15 family of 12 membrane-spanning domain transporters; PepT1 has proton/peptide cotransport activity and is selectively expressed in intestinal epithelial cells, where it is ..
  19. Tanaka M, Hong S, Akiyama S, Hu Q, Matsui T. Visualized absorption of anti-atherosclerotic dipeptide, Trp-His, in Sprague-Dawley rats by LC-MS and MALDI-MS imaging analyses. Mol Nutr Food Res. 2015;59:1541-9 pubmed publisher the presence of Gly-Sar, which is a model peptide that is transported via the intestinal proton-coupled peptide transporter 1 (PepT1) transporter. The His-Trp molecular ion was not observed at the intestinal membrane...
  20. Fisher S, Lee I, Swaan P, Eddington N. Evaluation of the effect of ethanol's toxic metabolite acetaldehyde on the gastrointestinal oligopeptide transporter, PEPT1: in vitro and in vivo studies. Alcohol Clin Exp Res. 2008;32:162-70 pubmed examines the effects of the ethanol metabolite, acetaldehyde, on the clinically relevant drug transporter, PEPT1. The metabolism of ethanol and the following acetaldehyde formation is thought to modulate the uptake capacity of ..
  21. Romano A, Barca A, Kottra G, Daniel H, Storelli C, Verri T. Functional expression of SLC15 peptide transporters in rat thyroid follicular cells. Mol Cell Endocrinol. 2010;315:174-81 pubmed publisher
    ..SLC15 transporters could participate to recycling of peptides derived from extracellular and lysosomal thyroglobulin proteolysis, both essential steps for thyroid hormone synthesis. ..
  22. Hang C, Shi J, Sun B, Li J. Apoptosis and functional changes of dipeptide transporter (PepT1) in the rat small intestine after traumatic brain injury. J Surg Res. 2007;137:53-60 pubmed Kreb's solution with radioactive dipeptide ((3)H-Gly-Sar, 10 microCi/mL) to measure the uptake and transport of PepT1 of small intestinal epithelial cells...
  23. Furutani J, Segawa H, Aranami F, Kuwahara S, Sugano M, Bannai K, et al. Dietary inorganic phosphorus regulates the intestinal peptide transporter PepT1. J Ren Nutr. 2013;23:e11-20 pubmed publisher
    ..Pi is often included in foods as an additive (as hidden phosphorus). The intestinal peptide transporter PepT1 mediates protein absorption, which is disturbed in renal insufficiency...
  24. COON S, Rajendran V, Schwartz J, Singh S. Glucose-dependent insulinotropic polypeptide-mediated signaling pathways enhance apical PepT1 expression in intestinal epithelial cells. Am J Physiol Gastrointest Liver Physiol. 2015;308:G56-62 pubmed publisher
    ..insulinotropic polypeptide (GIP), but not glucagon-like peptide 1 (GLP-1) augments H(+) peptide cotransporter (PepT1)-mediated peptide absorption in murine jejunum...
  25. Erickson R, Gum J, Lindstrom M, McKean D, Kim Y. Regional expression and dietary regulation of rat small intestinal peptide and amino acid transporter mRNAs. Biochem Biophys Res Commun. 1995;216:249-57 pubmed
    ..Furthermore this area appears to be a primary site where dietary-induced changes in peptide and amino acid transport occurs. ..
  26. Habold C, Reichardt F, Foltzer Jourdainne C, Lignot J. Morphological changes of the rat intestinal lining in relation to body stores depletion during fasting and after refeeding. Pflugers Arch. 2007;455:323-32 pubmed
    ..Microvilli surface area is preserved through fasting, and apical PepT1 expression increases during both metabolic fasting phases...