Genomes and Genes
Gene Symbol: Slc14a1
Description: solute carrier family 14 member 1
Alias: HUT11, UT-B, UT3, UTB1, UrT2, urea transporter 1, solute carrier family 14 (urea transporter), member 1 (Kidd blood group), urea transporter B, urea transporter, erythrocyte
- Song W, Qi X, Zhang W, Zhao Y, Cao Y, Wang F, et al. Abnormal Expression of Urea Transporter Protein in a Rat Model of Hepatorenal Syndrome Induced by Succinylated Gelatin. Med Sci Monit. 2015;21:2905-11 pubmed publisher..Increasing the intra-abdominal pressure by succinylated gelatin is also a novel approach for modeling HRS in cirrhotic rats. Compared with control rats, there is an abnormal mRNA expression of UT in ACS rats and HRS rats. ..
- Karakashian A, Timmer R, Klein J, Gunn R, Sands J, Bagnasco S. Cloning and characterization of two new isoforms of the rat kidney urea transporter: UT-A3 and UT-A4. J Am Soc Nephrol. 1999;10:230-7 pubmed..It is concluded that there are at least four different rat UT-A urea transporters. ..
- Levin E, Quick M, Zhou M. Crystal structure of a bacterial homologue of the kidney urea transporter. Nature. 2009;462:757-61 pubmed publisher..These results establish that the urea transporter operates by a channel-like mechanism and reveal the physical and chemical basis of urea selectivity. ..
- Esteva Font C, Phuan P, Lee S, Su T, Anderson M, Verkman A. Structure-activity analysis of thiourea analogs as inhibitors of UT-A and UT-B urea transporters. Biochim Biophys Acta. 2015;1848:1075-80 pubmed publisher..2 mM for inhibition of both UT-A1 and UT-B. Some analogs such as 4-nitrophenyl-thiourea were relatively UT-A1 selective (IC50 1.3 vs. 10 mM), and others such as thioisonicotinamide were UT-B selective (IC50>15 vs. 2.8 mM). ..