Gene Symbol: Slc14a1
Description: solute carrier family 14 member 1
Alias: HUT11, UT-B, UT3, UTB1, UrT2, urea transporter 1, solute carrier family 14 (urea transporter), member 1 (Kidd blood group), urea transporter B, urea transporter, erythrocyte
Species: rat

Top Publications

  1. Kim Y, Kim W, Lee H, Kim J, Kwon H, Klein J, et al. Urea and NaCl regulate UT-A1 urea transporter in opposing directions via TonEBP pathway during osmotic diuresis. Am J Physiol Renal Physiol. 2009;296:F67-77 pubmed publisher
    ..We conclude that changes in CLC-K1, UT-A1, UT-A3, and TonEBP play important roles in the renal response to osmotic diuresis in an attempt to minimize changes in plasma osmolality and maintain water homeostasis. ..
  2. Couriaud C, Ripoche P, Rousselet G. Cloning and functional characterization of a rat urea transporter: expression in the brain. Biochim Biophys Acta. 1996;1309:197-9 pubmed
    ..When expressed in Xenopus oocytes, the protein induces a 10-fold rise in urea permeability, inhibited by mercurial reagents and phloretin. The rUT11 mRNA is massively expressed in the brain. ..
  3. Timmer R, Klein J, Bagnasco S, Doran J, Verlander J, Gunn R, et al. Localization of the urea transporter UT-B protein in human and rat erythrocytes and tissues. Am J Physiol Cell Physiol. 2001;281:C1318-25 pubmed
    ..UT-B protein is detected in cultured bovine endothelial cells. We conclude that UT-B protein is expressed in more rat tissues than previously reported, as well as in erythrocytes...
  4. Shayakul C, Tsukaguchi H, Berger U, Hediger M. Molecular characterization of a novel urea transporter from kidney inner medullary collecting ducts. Am J Physiol Renal Physiol. 2001;280:F487-94 pubmed
    ..transporters involved in the urinary concentrating mechanism, UT1, UT2 and UT3, herein renamed UrT1-A, UrT1-B, and UrT2, which exhibit distinct spatial distribution in the kidney...
  5. Yang B, Bankir L, Gillespie A, Epstein C, Verkman A. Urea-selective concentrating defect in transgenic mice lacking urea transporter UT-B. J Biol Chem. 2002;277:10633-7 pubmed
    ..The UT-B null mice generated for these studies should also be useful in establishing the role of facilitated urea transport in extrarenal organs expressing UT-B. ..
  6. Kim Y, Kim D, Han K, Jung J, Sands J, Knepper M, et al. Expression of urea transporters in the developing rat kidney. Am J Physiol Renal Physiol. 2002;282:F530-40 pubmed
    ..We conclude that the expression of urea transporters in short-loop DTL and DVR coincides with the development of the ability to produce a concentrated urine. ..
  7. Yang B, Verkman A. Analysis of double knockout mice lacking aquaporin-1 and urea transporter UT-B. Evidence for UT-B-facilitated water transport in erythrocytes. J Biol Chem. 2002;277:36782-6 pubmed
    ..permeability and a low urea reflection coefficient in Xenopus oocytes expressing urea transporter UT-B (former name UT3), suggesting that water and urea share a common aqueous pathway (Yang, B., and Verkman, A. S. (1998) J. Biol. Chem...
  8. Li F, Lei T, Zhu J, Wang W, Sun Y, Chen J, et al. A novel small-molecule thienoquinolin urea transporter inhibitor acts as a potential diuretic. Kidney Int. 2013;83:1076-86 pubmed publisher
    ..PU-14 may establish 'chemical knockout' animal models to study the physiological functions of UTs. ..
  9. Guo L, Meng J, Xuan C, Ge J, Sun W, O Rourke S, et al. High salt-diet reduces SLC14A1 gene expression in the choroid plexus of Dahl salt sensitive rats. Biochem Biophys Res Commun. 2015;461:254-9 pubmed publisher
    ..In contrast, the mRNA levels of UT-B (encoded by SLC14A1 gene) were significantly reduced in the CP of Dahl S rats on high salt diet as compared with Dahl R rats or Dahl ..

More Information


  1. Song W, Qi X, Zhang W, Zhao Y, Cao Y, Wang F, et al. Abnormal Expression of Urea Transporter Protein in a Rat Model of Hepatorenal Syndrome Induced by Succinylated Gelatin. Med Sci Monit. 2015;21:2905-11 pubmed publisher
    ..Increasing the intra-abdominal pressure by succinylated gelatin is also a novel approach for modeling HRS in cirrhotic rats. Compared with control rats, there is an abnormal mRNA expression of UT in ACS rats and HRS rats. ..
  2. Karakashian A, Timmer R, Klein J, Gunn R, Sands J, Bagnasco S. Cloning and characterization of two new isoforms of the rat kidney urea transporter: UT-A3 and UT-A4. J Am Soc Nephrol. 1999;10:230-7 pubmed
    ..It is concluded that there are at least four different rat UT-A urea transporters. ..
  3. Levin E, Quick M, Zhou M. Crystal structure of a bacterial homologue of the kidney urea transporter. Nature. 2009;462:757-61 pubmed publisher
    ..These results establish that the urea transporter operates by a channel-like mechanism and reveal the physical and chemical basis of urea selectivity. ..
  4. Esteva Font C, Phuan P, Lee S, Su T, Anderson M, Verkman A. Structure-activity analysis of thiourea analogs as inhibitors of UT-A and UT-B urea transporters. Biochim Biophys Acta. 2015;1848:1075-80 pubmed publisher
    ..2 mM for inhibition of both UT-A1 and UT-B. Some analogs such as 4-nitrophenyl-thiourea were relatively UT-A1 selective (IC50 1.3 vs. 10 mM), and others such as thioisonicotinamide were UT-B selective (IC50>15 vs. 2.8 mM). ..