Gene Symbol: Slc13a2
Description: solute carrier family 13 member 2
Alias: Nadc1, mucin, solute carrier family 13 member 2, Na(+)/dicarboxylate cotransporter 1, intestinal sodium/dicarboxylate cotransporter, naDC-1, sodium-dependent dicarboxylate transporter, solute carrier family 13 (sodium-dependent dicarboxylate transporter), member 2
Khatri I, Kovacs S, Forstner J. Cloning of the cDNA for a rat intestinal Na+/dicarboxylate cotransporter reveals partial sequence homology with a rat intestinal mucin. Biochim Biophys Acta. 1996;1309:58-62 pubmed
..fining was the presence of a C-terminal transmembrane region that is homologous with an 87 amino acid hydrophobic region of a rat intestinal mucin, M2. Mucin-related sequences in transporter proteins have not been described before.
Komura M, Fukuta T, Genda T, Hino S, Aoe S, Kawagishi H, et al
. A short-term ingestion of fructo-oligosaccharides increases immunoglobulin A and mucin concentrations in the rat cecum, but the effects are attenuated with the prolonged ingestion. Biosci Biotechnol Biochem. 2014;78:1592-602 pubmed publisher
We examined the effects of fructo-oligosaccharides (FOS) on IgA and mucin secretion in the rat cecum after different ingestion periods. Rats were fed a control diet or a diet containing FOS for 1, 2, 4, and 8 wk...
Sekine T, Watanabe N, Hosoyamada M, Kanai Y, Endou H. Expression cloning and characterization of a novel multispecific organic anion transporter. J Biol Chem. 1997;272:18526-9 pubmed
..Isolation of OAT1 will facilitate elucidation of the molecular basis of drug kinetics and the development of new drugs lacking unwanted side effects. ..
Sekine T, Cha S, Hosoyamada M, Kanai Y, Watanabe N, Furuta Y, et al
. Cloning, functional characterization, and localization of a rat renal Na+-dicarboxylate transporter. Am J Physiol. 1998;275:F298-305 pubmed
..Immunohistochemistry using polyclonal antibodies raised against the 14 amino acids at the COOH terminus of rNaDC-1 revealed that rNaDC-1 is localized exclusively in the luminal membrane of S2 and S3. ..
Chen X, Shayakul C, Berger U, Tian W, Hediger M. Characterization of a rat Na+-dicarboxylate cotransporter. J Biol Chem. 1998;273:20972-81 pubmed
..The data presented provide new insights into the biophysical characteristics and physiological implications of a cloned dicarboxylate transporter. ..
Hering Smith K, Mao W, Schiro F, Coleman Barnett J, Pajor A, Hamm L. Localization of the calcium-regulated citrate transport process in proximal tubule cells. Urolithiasis. 2014;42:209-19 pubmed publisher
..Most of the citrate reabsorption in the proximal tubule is thought to occur via a dicarboxylate transporter NaDC1 located in the apical membrane...
Khatri I, Forstner G, Forstner J. Suggestive evidence for two different mucin genes in rat intestine. Biochem J. 1993;294 ( Pt 2):391-9 pubmed
In the present report we describe the isolation and sequence of a partial cDNA (M2-798) for a rat intestinal mucin designated M2...
Di Giusto G, Anzai N, Endou H, Torres A. Oat5 and NaDC1 protein abundance in kidney and urine after renal ischemic reperfusion injury. J Histochem Cytochem. 2009;57:17-27 pubmed publisher
..to evaluate the abundance of the organic anion transporter 5 (Oat5) and the sodium-dicarboxylate cotransporter 1 (NaDC1) in kidney and urine after renal ischemic reperfusion injury...
Brandoni A, Torres A. Expression of renal Oat5 and NaDC1 transporters in rats with acute biliary obstruction. World J Gastroenterol. 2015;21:8817-25 pubmed publisher
To examine renal expression of organic anion transporter 5 (Oat5) and sodium-dicarboxylate cotransporter 1 (NaDC1), and excretion of citrate in rats with acute extrahepatic cholestasis...