Slc11a2

Summary

Gene Symbol: Slc11a2
Description: solute carrier family 11 member 2
Alias: Dmt1, Nramp2, natural resistance-associated macrophage protein 2, DMT-1, NRAMP 2, Solute carrier family 11 member 2 (natural resistance-associated macrophage protein 2), divalent cation transporter 1, divalent metal transporter 1, solute carrier family 11 (proton-coupled divalent metal ion transporter), member 2, solute carrier family 11 (proton-coupled divalent metal ion transporters), member 2
Species: rat
Products:     Slc11a2

Top Publications

  1. Gunshin H, Mackenzie B, Berger U, Gunshin Y, Romero M, Boron W, et al. Cloning and characterization of a mammalian proton-coupled metal-ion transporter. Nature. 1997;388:482-8 pubmed
    ..DCT1 is a member of the 'natural-resistance-associated macrophage protein' (Nramp) family and thus its properties provide insight into how these proteins confer resistance to pathogens. ..
  2. Fleming M, Romano M, Su M, Garrick L, Garrick M, Andrews N. Nramp2 is mutated in the anemic Belgrade (b) rat: evidence of a role for Nramp2 in endosomal iron transport. Proc Natl Acad Sci U S A. 1998;95:1148-53 pubmed
    ..Recently, mk has been attributed to a missense mutation in the gene encoding the putative iron transporter protein Nramp2. To investigate the possibility that Nramp2 was also mutated in the b rat, we established linkage of the phenotype ..
  3. Touret N, Furuya W, Forbes J, Gros P, Grinstein S. Dynamic traffic through the recycling compartment couples the metal transporter Nramp2 (DMT1) with the transferrin receptor. J Biol Chem. 2003;278:25548-57 pubmed
    Nramp2 (natural resistance-associated macrophage protein 2, also called DMT1 and Slc11a2) is a proton-dependent cation transporter, which plays a central role in iron homeostasis...
  4. Picard V, Govoni G, Jabado N, Gros P. Nramp 2 (DCT1/DMT1) expressed at the plasma membrane transports iron and other divalent cations into a calcein-accessible cytoplasmic pool. J Biol Chem. 2000;275:35738-45 pubmed
    b>Nramp2, also known as DMT1 and DCT1, is a 12-transmembrane (TM) domain protein responsible for dietary iron uptake in the duodenum and iron acquisition from transferrin in peripheral tissues...
  5. Canonne Hergaux F, Zhang A, Ponka P, Gros P. Characterization of the iron transporter DMT1 (NRAMP2/DCT1) in red blood cells of normal and anemic mk/mk mice. Blood. 2001;98:3823-30 pubmed
    b>Divalent metal transporter 1 (DMT1) is the major transferrin-independent iron uptake system at the apical pole of intestinal cells, but it may also transport iron across the membrane of acidified endosomes in peripheral tissues...
  6. Mackenzie B, Takanaga H, Hubert N, Rolfs A, Hediger M. Functional properties of multiple isoforms of human divalent metal-ion transporter 1 (DMT1). Biochem J. 2007;403:59-69 pubmed
    b>DMT1 (divalent metal-ion transporter 1) is a widely expressed metal-ion transporter that is vital for intestinal iron absorption and iron utilization by most cell types throughout the body, including erythroid precursors...
  7. Li Z, Lai Z, Ya K, Fang D, Ho Y, Lei Y, et al. Correlation between the expression of divalent metal transporter 1 and the content of hypoxia-inducible factor-1 in hypoxic HepG2 cells. J Cell Mol Med. 2008;12:569-79 pubmed publisher
    ..b>Divalent metal transporter 1 (DMT1) is also a key transporter of iron under physiological conditions...
  8. Foot N, Dalton H, Shearwin Whyatt L, Dorstyn L, Tan S, Yang B, et al. Regulation of the divalent metal ion transporter DMT1 and iron homeostasis by a ubiquitin-dependent mechanism involving Ndfips and WWP2. Blood. 2008;112:4268-75 pubmed publisher
    ..Here we report that the divalent metal ion transporter DMT1, the primary nonheme iron transporter in mammals, is regulated by ubiquitination mediated by the Nedd4 family ..
  9. Canonne Hergaux F, Fleming M, Levy J, Gauthier S, Ralph T, Picard V, et al. The Nramp2/DMT1 iron transporter is induced in the duodenum of microcytic anemia mk mice but is not properly targeted to the intestinal brush border. Blood. 2000;96:3964-70 pubmed
    ..carry a glycine to arginine substitution at position 185 in the iron transporter known as Nramp2/DMT1 (divalent metal transporter 1)...

More Information

Publications62

  1. Fleming M, Trenor C, Su M, Foernzler D, Beier D, Dietrich W, et al. Microcytic anaemia mice have a mutation in Nramp2, a candidate iron transporter gene. Nat Genet. 1997;16:383-6 pubmed
    ..of a strong candidate gene for mk, and suggest that the phenotype is a consequence of a missense mutation in Nramp2 (ref. 5), a previously identified gene of unknown function...
  2. Thomas C, Gaffney Stomberg E, Sun B, O Brien K, Kerstetter J, Insogna K. Increasing dietary protein acutely augments intestinal iron transporter expression and significantly increases iron absorption in rats. FASEB J. 2013;27:2476-83 pubmed publisher
    ..revealed that increasing dietary protein from 5 to 40% increased duodenal transcript expression of divalent metal transporter 1 (DMT1) 3.2-fold, duodenal cytochrome b (Dcytb) 1.8-fold, and transferrin receptor (TfR) 1.8-fold...
  3. Ghio A, Piantadosi C, Wang X, Dailey L, Stonehuerner J, Madden M, et al. Divalent metal transporter-1 decreases metal-related injury in the lung. Am J Physiol Lung Cell Mol Physiol. 2005;289:L460-7 pubmed
    ..Based on the fate of iron in airway epithelial cells, we postulated that divalent metal transporter-1 (DMT1) participates in detoxification of metal associated with air pollution particles...
  4. I Bannon D, Portnoy M, Olivi L, Lees P, Culotta V, Bressler J. Uptake of lead and iron by divalent metal transporter 1 in yeast and mammalian cells. Biochem Biophys Res Commun. 2002;295:978-84 pubmed
    Although the divalent metal transporter (DMT1) was suggested to transport a wide range of metals in Xenopus oocytes, recent studies in other models have provided contrasting results...
  5. Monnot A, Zheng G, Zheng W. Mechanism of copper transport at the blood-cerebrospinal fluid barrier: influence of iron deficiency in an in vitro model. Exp Biol Med (Maywood). 2012;237:327-33 pubmed publisher
    ..The effect of FeD on cellular Cu retention and transporters Cu transporter-1 (Ctr1), divalent metal transporter 1 (DMT1), antioxidant protein-1 (ATOX1) and ATP7A was examined in choroidal epithelial Z310 cells...
  6. Gu C, Chen S, Xu X, Zheng L, Li Y, Wu K, et al. Lead and cadmium synergistically enhance the expression of divalent metal transporter 1 protein in central nervous system of developing rats. Neurochem Res. 2009;34:1150-6 pubmed publisher
    b>Divalent metal transporter 1 (DMT1) can transport a large range of ions, including toxic lead (Pb) and cadmium (Cd), across membranes...
  7. Kreimer Birnbaum M, Bannerman R, Russell E, Bernstein S. Pyrrole pigments in normal and congenitally anaemic mice (+:+, W-W v , ha-ha, nb-nb, mk-mk, f-f and sla-Y). Comp Biochem Physiol A Comp Physiol. 1972;43:21-30 pubmed
  8. Abouhamed M, Wolff N, Lee W, Smith C, Thevenod F. Knockdown of endosomal/lysosomal divalent metal transporter 1 by RNA interference prevents cadmium-metallothionein-1 cytotoxicity in renal proximal tubule cells. Am J Physiol Renal Physiol. 2007;293:F705-12 pubmed
    ..The proton-coupled divalent metal transporter DMT1 also transports Cd2+ and is expressed exclusively in endosomes/lysosomes in rat PT cells...
  9. Urrutia P, Aguirre P, Esparza A, Tapia V, Mena N, Arredondo M, et al. Inflammation alters the expression of DMT1, FPN1 and hepcidin, and it causes iron accumulation in central nervous system cells. J Neurochem. 2013;126:541-9 pubmed publisher
    ..on total cell iron content and on the expression and abundance of the iron transporters divalent metal transporter 1 (DMT1) and Ferroportin 1 (FPN1) in neurons, astrocytes and microglia obtained from rat brain...
  10. Xu H, Jin J, DeFelice L, Andrews N, Clapham D. A spontaneous, recurrent mutation in divalent metal transporter-1 exposes a calcium entry pathway. PLoS Biol. 2004;2:E50 pubmed
    Divalent metal transporter-1 (DMT1/DCT1/Nramp2) is the major Fe(2+) transporter mediating cellular iron uptake in mammals...
  11. Yang F, Stonehuerner J, Richards J, Nguyen N, Callaghan K, Haile D, et al. Deficiency in the divalent metal transporter 1 increases bleomycin-induced lung injury. Biometals. 2010;23:657-67 pubmed publisher
    ..In lung cells, divalent metal transporter 1 (DMT1) can participate in metal transport resulting in control of an oxidative stress and tissue damage...
  12. Wolff N, Ghio A, Garrick L, Garrick M, Zhao L, Fenton R, et al. Evidence for mitochondrial localization of divalent metal transporter 1 (DMT1). FASEB J. 2014;28:2134-45 pubmed publisher
    ..Our results show that the divalent metal transporter 1 (DMT1) occurs in the OMM...
  13. Song N, Jiang H, Wang J, Xie J. Divalent metal transporter 1 up-regulation is involved in the 6-hydroxydopamine-induced ferrous iron influx. J Neurosci Res. 2007;85:3118-26 pubmed
    ..We suppose, based on our previous studies, that the newly discovered iron transporter divalent metal transporter 1 (DMT1) might be involved in this SN iron accumulation process...
  14. Suzuki T, Momoi K, Hosoyamada M, Kimura M, Shibasaki T. Normal cadmium uptake in microcytic anemia mk/mk mice suggests that DMT1 is not the only cadmium transporter in vivo. Toxicol Appl Pharmacol. 2008;227:462-7 pubmed
    b>Divalent metal transporter 1 (DMT1) is a mammalian iron (Fe) transporter and also transports Cadmium (Cd) in vitro...
  15. Ohgami R, Campagna D, Antiochos B, Wood E, Sharp J, Barker J, et al. nm1054: a spontaneous, recessive, hypochromic, microcytic anemia mutation in the mouse. Blood. 2005;106:3625-31 pubmed
    ..Linkage studies demonstrate that nm1054 maps to a genetic locus not previously implicated in microcytic anemia or iron phenotypes. ..
  16. Meynard D, Kautz L, Darnaud V, Canonne Hergaux F, Coppin H, Roth M. Lack of the bone morphogenetic protein BMP6 induces massive iron overload. Nat Genet. 2009;41:478-81 pubmed publisher
  17. Ding D, Salvi R, Roth J. Cellular localization and developmental changes of the different isoforms of divalent metal transporter 1 (DMT1) in the inner ear of rats. Biometals. 2014;27:125-34 pubmed publisher
    b>Divalent metal transporter 1 (DMT1) is generally considered to be the major transmembrane protein responsible for the uptake of a variety of divalent cations...
  18. Zheng G, Chen J, Zheng W. Relative contribution of CTR1 and DMT1 in copper transport by the blood-CSF barrier: implication in manganese-induced neurotoxicity. Toxicol Appl Pharmacol. 2012;260:285-93 pubmed publisher
    ..cerebrospinal fluid (CSF) is partially regulated by the Cu transporter-1 (CTR1) and divalent metal transporter-1 (DMT1) at the blood-CSF barrier (BCB) in the choroid plexus...
  19. Wang X, Miller D, Zheng W. Intracellular localization and subsequent redistribution of metal transporters in a rat choroid plexus model following exposure to manganese or iron. Toxicol Appl Pharmacol. 2008;230:167-74 pubmed publisher
    ..e., divalent metal transporter 1 (DMT1), metal transporter protein 1 (MTP1), and transferrin receptor (TfR), in the rat intact choroid ..
  20. Han M, Chang J, Kim J. Loss of divalent metal transporter 1 function promotes brain copper accumulation and increases impulsivity. J Neurochem. 2016;138:918-28 pubmed publisher
    The divalent metal transporter 1 (DMT1) is a major iron transporter required for iron absorption and erythropoiesis. Loss of DMT1 function results in microcytic anemia...
  21. Kong W, Wu Q, Shen D, Zhao S, Guo P, Duan X, et al. Age-dependent expression of duodenal cytochrome b, divalent metal transporter 1, ferroportin 1, and hephaestin in the duodenum of rats. J Gastroenterol Hepatol. 2015;30:513-20 pubmed publisher
    ..The expression of duodenal cytochrome b (DcytB), divalent metal transporter 1 (DMT1), ferroportin 1 (FPN1), hephaestin, and hepcidin were measured by real-time polymerase chain ..
  22. Marciano R, Santamarina A, de Santana A, Silva M, Amancio O, do Nascimento C, et al. Effects of prebiotic supplementation on the expression of proteins regulating iron absorption in anaemic growing rats. Br J Nutr. 2015;113:901-8 pubmed publisher
    ..HP inulin increased the expression of the divalent metal transporter 1 protein in the caecum by 162 % (P= 0·04), and the expression of duodenal cytochrome b reductase in ..
  23. Xiong L, Dion P, Montplaisir J, Levchenko A, Thibodeau P, Karemera L, et al. Molecular genetic studies of DMT1 on 12q in French-Canadian restless legs syndrome patients and families. Am J Med Genet B Neuropsychiatr Genet. 2007;144B:911-7 pubmed
    ..Animal models with mutation in (DMT1) divalent metal transporter 1 gene, an important brain iron transporter, demonstrate a similar iron deficiency profile as found in ..
  24. Thompson K, Molina R, Donaghey T, Schwob J, Brain J, Wessling Resnick M. Olfactory uptake of manganese requires DMT1 and is enhanced by anemia. FASEB J. 2007;21:223-30 pubmed
    ..Divalent metal transporter-1 (DMT1) is the major transporter responsible for intestinal iron absorption and its expression is regulated by body iron ..
  25. Abouhamed M, Gburek J, Liu W, Torchalski B, Wilhelm A, Wolff N, et al. Divalent metal transporter 1 in the kidney proximal tubule is expressed in late endosomes/lysosomal membranes: implications for renal handling of protein-metal complexes. Am J Physiol Renal Physiol. 2006;290:F1525-33 pubmed
    The H+-coupled polyligand transport protein divalent metal transporter 1 (DMT1) plays a key role in mammalian iron homeostasis. It has a widespread pattern of expression including tissues associated with iron acquisition and storage...
  26. Edwards J, Hoke J. Red cell iron uptake in hereditary microcytic anemia. Blood. 1975;46:381-8 pubmed
    ..These results support the hypothesis of a generalized impairment of cellular iron uptake in hereditary microcytic anemia and suggest that there might be a defect in red cell receptor sites for transferrin in this condition. ..
  27. Knopfel M, Zhao L, Garrick M. Transport of divalent transition-metal ions is lost in small-intestinal tissue of b/b Belgrade rats. Biochemistry. 2005;44:3454-65 pubmed
    ..of a divalent metal transporter/divalent cation transporter/solute carrier 11 group A member 2 or 3 (DMT1/DCT1/SLC11A2), a member of the natural-resistance-associated macrophage protein (Nramp) family...
  28. Diaz Castro J, Pulido M, Alferez M, Ochoa J, Rivas E, Hijano S, et al. Goat milk consumption modulates liver divalent metal transporter 1 (DMT1) expression and serum hepcidin during Fe repletion in Fe-deficiency anemia. J Dairy Sci. 2014;97:147-54 pubmed publisher
    ..In spite of the crucial role of hepatocyte divalent metal transporter 1 (DMT1) and hepcidin in Fe metabolism, to date, no studies have directly tested the role of these ..
  29. Ferguson C, Wareing M, Ward D, Green R, Smith C, Riccardi D. Cellular localization of divalent metal transporter DMT-1 in rat kidney. Am J Physiol Renal Physiol. 2001;280:F803-14 pubmed
    ..J Physiol (Lond) 524: 581-586, 2000]. To test the possibility that the divalent metal transporter DMT1 (Gunshin H, Mackenzie B, Berger UV, Gunshin Y, Romero MF, Boron WF, Nussberger S, Gollan JL, and Hediger MA...
  30. Moos T, Morgan E. The significance of the mutated divalent metal transporter (DMT1) on iron transport into the Belgrade rat brain. J Neurochem. 2004;88:233-45 pubmed
    Brain iron transport and distributional pattern of divalent metal transporter I (DMT1) were studied in homozygous Belgrade rats (b/b) which suffer from a mutation in the DMT1 gene...
  31. Wareing M, Ferguson C, Delannoy M, Cox A, McMahon R, Green R, et al. Altered dietary iron intake is a strong modulator of renal DMT1 expression. Am J Physiol Renal Physiol. 2003;285:F1050-9 pubmed
    Divalent metal transporter1 (DMT1; also known as DCT1 or NRAMP2) is an important component of the cellular machinery responsible for dietary iron absorption in the duodenum...
  32. Kim J, Molina R, Donaghey T, Buckett P, Brain J, Wessling Resnick M. Influence of DMT1 and iron status on inflammatory responses in the lung. Am J Physiol Lung Cell Mol Physiol. 2011;300:L659-65 pubmed publisher
    b>Divalent metal transporter 1 (DMT1) is the major iron transporter responsible for duodenal dietary iron absorption and is required for erythropoiesis...
  33. Vivot R, Goitia B, Usach V, Setton Avruj P. DMT1 as a candidate for non-transferrin-bound iron uptake in the peripheral nervous system. Biofactors. 2013;39:476-84 pubmed publisher
    ..b>Divalent metal transporter 1(DMT1) has been widely described in literature as a key player in iron metabolism, but never before in ..
  34. Yanatori I, Yasui Y, Noguchi Y, Kishi F. Inhibition of iron uptake by ferristatin II is exerted through internalization of DMT1 at the plasma membrane. Cell Biol Int. 2015;39:427-34 pubmed publisher
    ..b>DMT1, which mediates iron transport across cell membranes, is located at the plasma membrane of enterocytes and imports ..
  35. Lam Yuk Tseung S, Picard V, Gros P. Identification of a tyrosine-based motif (YGSI) in the amino terminus of Nramp1 (Slc11a1) that is important for lysosomal targeting. J Biol Chem. 2006;281:31677-88 pubmed
    ..Nramp2 (DMT1, Slc11a2) is expressed both at the duodenal brush border where it mediates uptake of dietary iron and ubiquitously at the ..
  36. Mackenzie K, Foot N, Anand S, Dalton H, Chaudhary N, Collins B, et al. Regulation of the divalent metal ion transporter via membrane budding. Cell Discov. 2016;2:16011 pubmed publisher
    ..Here we present evidence that the divalent metal ion transporter (DMT1) is unexpectedly regulated through release in EVs...
  37. Beaumont C, Delaunay J, Hetet G, Grandchamp B, de Montalembert M, Tchernia G. Two new human DMT1 gene mutations in a patient with microcytic anemia, low ferritinemia, and liver iron overload. Blood. 2006;107:4168-70 pubmed
    b>DMT1 mediates the pH-dependent uptake of Fe(2+) from the diet in duodenal enterocytes and in most other cells. It transfers iron from the endosomes to the cytosol following the uptake of the transferrin-transferrin receptor complex...
  38. Kong W, Zhao S, Duan X, Yang Z, Qian Z, Chang Y. Decreased DMT1 and increased ferroportin 1 expression is the mechanisms of reduced iron retention in macrophages by erythropoietin in rats. J Cell Biochem. 2008;104:629-41 pubmed publisher
    ..The expression of divalent metal transporter 1 (DMT1) and ferroportin 1 (FPN1) in peritoneal exudate macrophages was detected by RT-PCR and Western ..
  39. Catoire H, Dion P, Xiong L, Amari M, Gaudet R, Girard S, et al. Restless legs syndrome-associated MEIS1 risk variant influences iron homeostasis. Ann Neurol. 2011;70:170-5 pubmed publisher
    ..in Caenorhabditis elegans and that the RLS-associated haplotype leads to increased expression of ferritin and DMT1 in RLS brain tissues...
  40. Lortz S, Schroter S, Stückemann V, Mehmeti I, Lenzen S. Influence of cytokines on Dmt1 iron transporter and ferritin expression in insulin-secreting cells. J Mol Endocrinol. 2014;52:301-10 pubmed publisher
    ..Therefore the expression of the different divalent metal transporter 1 (Dmt1) isoforms and ferritin (Ft) subunits, responsible for iron import and chelation, was analyzed ..
  41. Du F, Qian Z, Luo Q, Yung W, Ke Y. Hepcidin Suppresses Brain Iron Accumulation by Downregulating Iron Transport Proteins in Iron-Overloaded Rats. Mol Neurobiol. 2015;52:101-14 pubmed publisher
    ..brain-blood barrier, iron uptake and release, and also the expression of transferrin receptor-1 (TfR1), divalent metal transporter 1 (DMT1), and ferroportin 1 (Fpn1) in cultured microvascular endothelial cells and neurons...
  42. Yang L, Zhang B, Yin L, Cai B, Shan H, Zhang L, et al. Tanshinone IIA prevented brain iron dyshomeostasis in cerebral ischemic rats. Cell Physiol Biochem. 2011;27:23-30 pubmed publisher
    ..Expression levels of iron transport proteins including DMT1, TfR, Fpn1 and Heph were assessed by Western blot technique...
  43. Haeger P, Alvarez A, Leal N, Adasme T, Núñez M, Hidalgo C. Increased hippocampal expression of the divalent metal transporter 1 (DMT1) mRNA variants 1B and +IRE and DMT1 protein after NMDA-receptor stimulation or spatial memory training. Neurotox Res. 2010;17:238-47 pubmed publisher
    ..Neurons acquire iron through transferrin receptor-mediated endocytosis and via the divalent metal transporter 1 (DMT1)...
  44. Berradi H, Bertho J, Dudoignon N, Mazur A, Grandcolas L, Baudelin C, et al. Renal anemia induced by chronic ingestion of depleted uranium in rats. Toxicol Sci. 2008;103:397-408 pubmed publisher
    ..messenger RNA (mRNA) and protein levels of spleen iron recycling markers from RBC degradation (DMT1 [divalent metal transporter 1], iron regulated protein 1, HO1, HO2 [heme oxygenase 1 and 2], cluster of differentiation 36), increase ..
  45. Arredondo M, Munoz P, Mura C, Nunez M. DMT1, a physiologically relevant apical Cu1+ transporter of intestinal cells. Am J Physiol Cell Physiol. 2003;284:C1525-30 pubmed
    ..DMT1, also known as Nramp2 and DCT1, is the transporter responsible for intestinal iron uptake...
  46. Techau M, Valdez Taubas J, Popoff J, Francis R, Seaman M, Blackwell J. Evolution of differences in transport function in Slc11a family members. J Biol Chem. 2007;282:35646-56 pubmed
    ..Slc11a1 (formerly Nramp1) is a proton/divalent cation transporter that regulates cation homeostasis in macrophages. Slc11a2 mediates divalent cation uptake via the gut and delivery into cells...
  47. Shu R, Zhang L, Wang C, Li N, Wang H, Xie K, et al. Spinal peroxynitrite contributes to remifentanil-induced postoperative hyperalgesia via enhancement of divalent metal transporter 1 without iron-responsive element-mediated iron accumulation in rats. Anesthesiology. 2015;122:908-20 pubmed publisher
    ..Iron accumulation mediated by divalent metal transporter 1 (DMT1) plays a key role in N-methyl-D-aspartate neurotoxicity...
  48. Mims M, Guan Y, Pospisilova D, Priwitzerova M, Indrak K, Ponka P, et al. Identification of a human mutation of DMT1 in a patient with microcytic anemia and iron overload. Blood. 2005;105:1337-42 pubmed
    b>Divalent metal transporter 1 (DMT1) is a transmembrane protein crucial for duodenal iron absorption and erythroid iron transport...
  49. Lam Yuk Tseung S, Touret N, Grinstein S, Gros P. Carboxyl-terminus determinants of the iron transporter DMT1/SLC11A2 isoform II (-IRE/1B) mediate internalization from the plasma membrane into recycling endosomes. Biochemistry. 2005;44:12149-59 pubmed
    Mutations in DMT1 (Nramp2 and Slc11a2) impair iron metabolism and cause microcytic anemia...
  50. Beisel K, Rocha Sanchez S, Ziegenbein S, Morris K, Kai C, Kawai J, et al. Diversity of Ca2+-activated K+ channel transcripts in inner ear hair cells. Gene. 2007;386:11-23 pubmed
    ..These results suggest that a diversity of splice variants exist in rodent cochlear hair cells and this diversity is similar to that observed for non-mammalian vertebrate hair cells, such as chicken and turtle. ..
  51. Tabuchi M, Yoshimori T, Yamaguchi K, Yoshida T, Kishi F. Human NRAMP2/DMT1, which mediates iron transport across endosomal membranes, is localized to late endosomes and lysosomes in HEp-2 cells. J Biol Chem. 2000;275:22220-8 pubmed
    NRAMP2 (natural resistance-associated macrophage protein 2)/DMT1 (divalent metal transporter 1) is a divalent metal transporter conserved from prokaryotes to higher eukaryotes that exhibits an unusually broad substrate range, including Fe(..
  52. CARLSON E, Tkac I, Magid R, O Connor M, Andrews N, Schallert T, et al. Iron is essential for neuron development and memory function in mouse hippocampus. J Nutr. 2009;139:672-9 pubmed publisher
    ..g. hypoxia due to anemia). We delineated the role of murine Slc11a2 [divalent metal ion transporter-1 (DMT-1)] in hippocampal neuronal iron uptake during development and memory ..
  53. Khomenko T, Szabo S, Deng X, Ishikawa H, Anderson G, McLaren G. Role of iron in the pathogenesis of cysteamine-induced duodenal ulceration in rats. Am J Physiol Gastrointest Liver Physiol. 2009;296:G1277-86 pubmed publisher
    ..also enhanced activation of mucosal iron regulatory protein 1 and increased the expression of divalent metal transporter 1 mRNA and protein...