Gene Symbol: Slbp
Description: stem-loop binding protein
Alias: histone RNA hairpin-binding protein
Whitfield M, Kaygun H, Erkmann J, Townley Tilson W, Dominski Z, Marzluff W. SLBP is associated with histone mRNA on polyribosomes as a component of the histone mRNP. Nucleic Acids Res. 2004;32:4833-42 pubmed
The stem-loop binding protein (SLBP) binds the 3' end of histone mRNA and is present both in nucleus, and in the cytoplasm on the polyribosomes...
Erkmann J, Wagner E, Dong J, Zhang Y, Kutay U, Marzluff W. Nuclear import of the stem-loop binding protein and localization during the cell cycle. Mol Biol Cell. 2005;16:2960-71 pubmed
..pre-mRNAs in the nucleus and translation of mature histone mRNAs in the cytoplasm is the stem-loop binding protein (SLBP). In this work, we have investigated SLBP nuclear transport and subcellular localization during the cell cycle...
Yang X, Purdy M, Marzluff W, Dominski Z. Characterization of 3'hExo, a 3' exonuclease specifically interacting with the 3' end of histone mRNA. J Biol Chem. 2006;281:30447-54 pubmed
..3'hExo removes 3' overhangs of small interfering RNAs, whereas the double-stranded region is resistant to the enzymatic activity. ..
Sullivan K, Mullen T, Marzluff W, Wagner E. Knockdown of SLBP results in nuclear retention of histone mRNA. RNA. 2009;15:459-72 pubmed publisher
..The stem-loop binding protein (SLBP) is required for processing, and following processing, histone mRNA is transported to the cytoplasm, where SLBP ..
Yang X, Torres M, Marzluff W, Dominski Z. Three proteins of the U7-specific Sm ring function as the molecular ruler to determine the site of 3'-end processing in mammalian histone pre-mRNA. Mol Cell Biol. 2009;29:4045-56 pubmed publisher
..the isolated proteins, we identified three well-characterized processing factors: the stem-loop binding protein (SLBP), which interacts with the stem-loop structure upstream of the cleavage site, and both Lsm11 and SmB, which are ..