Gene Symbol: Sirt7
Description: sirtuin 7
Alias: NAD-dependent protein deacetylase sirtuin-7, NAD-dependent deacetylase sirtuin-7, SIR2-like protein 7, regulatory protein SIR2 homolog 7
Michishita E, Park J, Burneskis J, Barrett J, Horikawa I. Evolutionarily conserved and nonconserved cellular localizations and functions of human SIRT proteins. Mol Biol Cell. 2005;16:4623-35 pubmed
..This study examines seven human proteins homologous to Sir2 (SIRT1 through SIRT7) for cellular localization, expression profiles, protein deacetylation activity, and effects on human cell ..
Barber M, Michishita Kioi E, Xi Y, Tasselli L, Kioi M, Moqtaderi Z, et al
. SIRT7 links H3K18 deacetylation to maintenance of oncogenic transformation. Nature. 2012;487:114-8 pubmed publisher
Sirtuin proteins regulate diverse cellular pathways that influence genomic stability, metabolism and ageing. SIRT7 is a mammalian sirtuin whose biochemical activity, molecular targets and physiological functions have been unclear...
Grummt I. The nucleolus—guardian of cellular homeostasis and genome integrity. Chromosoma. 2013;122:487-97 pubmed
..This review focuses on the mechanisms that link cell physiology to rDNA silencing, a prerequisite for nucleolar integrity and cell survival. ..
Verdin E. NADâº in aging, metabolism, and neurodegeneration. Science. 2015;350:1208-13 pubmed publisher
..Here we review factors that regulate NAD(+) and discuss how supplementation with NAD(+) precursors may represent a new therapeutic opportunity for aging and its associated disorders, particularly neurodegenerative diseases. ..
Reddy B, Maitra S, Jhelum P, Kumar K, Bagul P, Kaur G, et al
. Sirtuin 1 and 7 mediate resveratrol-induced recovery from hyper-anxiety in high-fructose-fed prediabetic rats. J Biosci. 2016;41:407-17 pubmed
..In conclusion, our study showed that hyper-anxiety associated with prediabetic condition is ameliorated by resveratrol through modulation of sirtuins, which is more or less similar to metformin. ..
Grob A, Roussel P, Wright J, McStay B, Hernandez Verdun D, Sirri V. Involvement of SIRT7 in resumption of rDNA transcription at the exit from mitosis. J Cell Sci. 2009;122:489-98 pubmed publisher
..The nucleolar Sirtuin7 (SIRT7) was reported to be involved in the regulation of ribosomal gene (rDNA) transcription, but there are no data ..
Yu W, Zhou H, Lin R, Fu Y, Wang W. Short?term calorie restriction activates SIRT1?4 and ?7 in cardiomyocytes in vivo and in vitro. Mol Med Rep. 2014;9:1218-24 pubmed publisher
..These results suggest that CR may attenuate age?associated changes through reducing BW. Moreover, short?term CR may activate SIRT1 as well as SIRT2?4 and ?7 expression in cardiomyocytes in vivo and in vitro. ..
Wronska A, Lawniczak A, Wierzbicki P, Kmiec Z. Age-Related Changes in Sirtuin 7 Expression in Calorie-Restricted and Refed Rats. Gerontology. 2016;62:304-10 pubmed publisher
..While the physiological functions of SIRT7 are still poorly understood, SIRT7 has recently been shown to affect ribosome biogenesis, mitochondrial gene ..
Wang H, Liu S, Liu S, Wei W, Zhou X, Lin F, et al
. Enhanced expression and phosphorylation of Sirt7 activates smad2 and ERK signaling and promotes the cardiac fibrosis differentiation upon angiotensin-II stimulation. PLoS ONE. 2017;12:e0178530 pubmed publisher
..However, regulation of this phenotypic transformation remains unclear. Here, we showed that sirtuin-7 (Sirt7) plays an important role in the regulation of MFs differentiation...