Gene Symbol: Sirt6
Description: sirtuin 6
Alias: NAD-dependent protein deacetylase sirtuin-6, NAD-dependent deacetylase sirtuin-6
Species: rat
Products:     Sirt6

Top Publications

  1. Michishita E, Park J, Burneskis J, Barrett J, Horikawa I. Evolutionarily conserved and nonconserved cellular localizations and functions of human SIRT proteins. Mol Biol Cell. 2005;16:4623-35 pubmed
    ..We found that: 1) three nuclear SIRT proteins (SIRT1, SIRT6, and SIRT7) show different subnuclear localizations: SIRT6 and SIRT7 are associated with heterochromatic regions ..
  2. Mostoslavsky R, Chua K, Lombard D, Pang W, Fischer M, Gellon L, et al. Genomic instability and aging-like phenotype in the absence of mammalian SIRT6. Cell. 2006;124:315-29 pubmed
    ..Here, we demonstrate that SIRT6 is a nuclear, chromatin-associated protein that promotes resistance to DNA damage and suppresses genomic ..
  3. Michishita E, McCord R, Berber E, Kioi M, Padilla Nash H, Damian M, et al. SIRT6 is a histone H3 lysine 9 deacetylase that modulates telomeric chromatin. Nature. 2008;452:492-6 pubmed publisher
    ..In mice, deficiency for the Sir2 family member SIRT6 leads to a shortened lifespan and a premature ageing-like phenotype...
  4. Kawahara T, Michishita E, Adler A, Damian M, Berber E, Lin M, et al. SIRT6 links histone H3 lysine 9 deacetylation to NF-kappaB-dependent gene expression and organismal life span. Cell. 2009;136:62-74 pubmed publisher
    ..Deficiency of mammalian SIRT6 leads to shortened life span and an aging-like phenotype in mice, but the underlying molecular mechanisms are ..
  5. Zhong L, D Urso A, Toiber D, Sebastian C, Henry R, Vadysirisack D, et al. The histone deacetylase Sirt6 regulates glucose homeostasis via Hif1alpha. Cell. 2010;140:280-93 pubmed publisher
    b>SIRT6 is a member of a highly conserved family of NAD(+)-dependent deacetylases with various roles in metabolism, stress resistance, and life span...
  6. Shen P, Feng X, Zhang X, Huang X, Liu S, Lu X, et al. SIRT6 suppresses phenylephrine-induced cardiomyocyte hypertrophy though inhibiting p300. J Pharmacol Sci. 2016;132:31-40 pubmed publisher
    b>SIRT6 is a member of the sirtuin family of class III histone deacetylases. It plays important roles in regulating genomic stability, metabolism, stress response and aging...
  7. Koltai E, Szabo Z, Atalay M, Boldogh I, Naito H, Goto S, et al. Exercise alters SIRT1, SIRT6, NAD and NAMPT levels in skeletal muscle of aged rats. Mech Ageing Dev. 2010;131:21-8 pubmed publisher
    ..The age-associated increase in the level of SIRT6 was attenuated by exercise training...
  8. Yang S, Choi J, Chae S, Kim W, Park S, Rhee E, et al. Activation of peroxisome proliferator-activated receptor gamma by rosiglitazone increases sirt6 expression and ameliorates hepatic steatosis in rats. PLoS ONE. 2011;6:e17057 pubmed publisher
    b>Sirt6 has been implicated in the regulation of hepatic lipid metabolism and the development of hepatic steatosis...
  9. Sun H, Wu Y, Fu D, Liu Y, Huang C. SIRT6 regulates osteogenic differentiation of rat bone marrow mesenchymal stem cells partially via suppressing the nuclear factor-?B signaling pathway. Stem Cells. 2014;32:1943-55 pubmed publisher
    Sirtuin 6 (SIRT6) is a NAD-dependent deacetylase involved in lifespan regulation. To evaluate the effect of SIRT6 on osteogenesis, rat bone marrow mesenchymal stem cells (rBMSCs) with enhanced or reduced SIRT6 function were developed...

More Information


  1. Cardus A, Uryga A, Walters G, Erusalimsky J. SIRT6 protects human endothelial cells from DNA damage, telomere dysfunction, and senescence. Cardiovasc Res. 2013;97:571-9 pubmed publisher
    ..The aim of this study was to investigate whether SIRT6, a member of the sirtuin family of NAD(+)-dependent protein deacetylases/ADP-ribosyltransferases, protects ..
  2. Sebastian C, Zwaans B, Silberman D, Gymrek M, Goren A, Zhong L, et al. The histone deacetylase SIRT6 is a tumor suppressor that controls cancer metabolism. Cell. 2012;151:1185-99 pubmed publisher
    ..Here, we identify SIRT6 as a tumor suppressor that regulates aerobic glycolysis in cancer cells...
  3. Wang X, Wang X, Tong M, Gan L, Chen H, Wu S, et al. SIRT6 protects cardiomyocytes against ischemia/reperfusion injury by augmenting FoxO3α-dependent antioxidant defense mechanisms. Basic Res Cardiol. 2016;111:13 pubmed publisher
    b>SIRT6, a member of the NAD(+)-dependent class III deacetylase sirtuin family, has been revealed to play important roles in promoting cellular resistance against oxidative stress...
  4. Nagai K, Matsushita T, Matsuzaki T, Takayama K, Matsumoto T, Kuroda R, et al. Depletion of SIRT6 causes cellular senescence, DNA damage, and telomere dysfunction in human chondrocytes. Osteoarthritis Cartilage. 2015;23:1412-20 pubmed publisher
    b>SIRT6, a member of the sirtuin family of nicotinamide adenine dinucleotide (NAD(+))-dependent protein deacetylases, has been implicated as a key factor in aging-related diseases...
  5. Cai Y, Yu S, Chen S, Pi R, Gao S, Li H, et al. Nmnat2 protects cardiomyocytes from hypertrophy via activation of SIRT6. FEBS Lett. 2012;586:866-74 pubmed publisher
    ..inactive mutant blocked angiotensin II (Ang II)-induced cardiac hypertrophy, which was dependent on activation of SIRT6 through maintaining the intracellular NAD level...
  6. Kanfi Y, Shalman R, Peshti V, Pilosof S, Gozlan Y, Pearson K, et al. Regulation of SIRT6 protein levels by nutrient availability. FEBS Lett. 2008;582:543-8 pubmed publisher
    ..We show here that levels of the mammalian sirtuin, SIRT6, increased upon nutrient deprivation in cultured cells, in mice after fasting, and in rats fed a calorie-..
  7. Tennen R, Bua D, Wright W, Chua K. SIRT6 is required for maintenance of telomere position effect in human cells. Nat Commun. 2011;2:433 pubmed publisher
    ..Here we show that the Sir2 family member SIRT6 is required for maintenance of TPE in human cells...
  8. Hou K, Lin S, Chao L, Hsiang Hua Lai E, Chang C, Shun C, et al. Sirtuin 6 suppresses hypoxia-induced inflammatory response in human osteoblasts via inhibition of reactive oxygen species production and glycolysis-A therapeutic implication in inflammatory bone resorption. Biofactors. 2017;43:170-180 pubmed publisher
    ..The histone deacetylase sirtuin 6 (SIRT6) is a crucial modulator of inflammation and glucose metabolism, and it is also involved in cellular protection ..
  9. Wang N, Luo L, Xu J, Xu M, Zhang X, Zhou X, et al. Obesity accelerates ovarian follicle development and follicle loss in rats. Metabolism. 2014;63:94-103 pubmed publisher
    ..the level of mTORC1 and p-S6K1 proteins significantly increased in the ovaries of HF rats, whereas that of SIRT1, SIRT6, FOXO3a and NRF-1 decreased compared to the NC rats...
  10. Verdin E. NAD⁺ in aging, metabolism, and neurodegeneration. Science. 2015;350:1208-13 pubmed publisher
    ..Here we review factors that regulate NAD(+) and discuss how supplementation with NAD(+) precursors may represent a new therapeutic opportunity for aging and its associated disorders, particularly neurodegenerative diseases. ..
  11. Zhang X, Li L, Xu J, Wang N, Liu W, Lin X, et al. Rapamycin preserves the follicle pool reserve and prolongs the ovarian lifespan of female rats via modulating mTOR activation and sirtuin expression. Gene. 2013;523:82-7 pubmed publisher
    ..mTOR and phosphorylated p70S6K in the rapamycin-treated group, and increased the expression of both SIRT1 and SIRT6 compared to the control group (P<0.05)...
  12. Lee O, Kim J, Kim J, Lee H, Kim E, Bae S, et al. Decreased expression of sirtuin 6 is associated with release of high mobility group box-1 after cerebral ischemia. Biochem Biophys Res Commun. 2013;438:388-94 pubmed publisher
    Sirtuin 6 (SIRT6) belongs to the sirtuin family of NAD(+)-dependent deacetylases and has been implicated in the regulation of metabolism, inflammation, and aging...
  13. Favero G, Rezzani R, Rodella L. Sirtuin 6 nuclear localization at cortical brain level of young diabetic mice: an immunohistochemical study. Acta Histochem. 2014;116:272-7 pubmed publisher
    A study was conducted to assess the physiopathological significance of sirtuin 6 (SIRT6) at the brain cortical level...
  14. Kawakami K, Nakamura A, Goto S. Dietary restriction increases site-specific histone H3 acetylation in rat liver: possible modulation by sirtuins. Biochem Biophys Res Commun. 2012;418:836-40 pubmed publisher
    ..b>SIRT6, one of histone deacetylases, was significantly decreased by DR and thereby may be involved in an increase in the ..
  15. Tian K, Liu Z, Wang J, Xu S, You T, Liu P. Sirtuin-6 inhibits cardiac fibroblasts differentiation into myofibroblasts via inactivation of nuclear factor κB signaling. Transl Res. 2015;165:374-86 pubmed publisher
    ..However, regulation of this phenotypic transformation remains elusive. Here, we show that sirtuin-6 (SIRT6), a member of the sirtuin family of nicotinamide adenine dinucleotide-dependent histone deacetylase, plays a role ..
  16. Mao Q, Gong X, Zhou C, Tu Z, Zhao L, Wang L, et al. Up-regulation of SIRT6 in the hippocampus induced rats with depression-like behavior via the block Akt/GSK3? signaling pathway. Behav Brain Res. 2017;323:38-46 pubmed publisher
    ..the results showed depressive-like behaviors: like body weight, forced swim test and sucrose preference test and SIRT6 was a significant increase in the hippocampal of CUMS rats...
  17. Luo L, Chen X, Fu Y, Xu J, Li L, Lin X, et al. The effects of caloric restriction and a high-fat diet on ovarian lifespan and the expression of SIRT1 and SIRT6 proteins in rats. Aging Clin Exp Res. 2012;24:125-33 pubmed publisher
    ..Immunohistochemical analysis revealed that SIRT1 and SIRT6 proteins were present in the nucleus and cytoplasm of the oocytes...
  18. Yin X, Gao Y, Shi H, Song L, Wang J, Shao J, et al. Overexpression of SIRT6 in the hippocampal CA1 impairs the formation of long-term contextual fear memory. Sci Rep. 2016;6:18982 pubmed publisher
    ..Our previous transcriptome data showed that expression of sirtuins 6 (SIRT6), a member of Histone deacetylases (HDACs) family in the hippocampal cornu ammonis 1 (CA1) was decreased after ..
  19. Lu J, Sun D, Liu Z, Li M, Hong H, Liu C, et al. SIRT6 suppresses isoproterenol-induced cardiac hypertrophy through activation of autophagy. Transl Res. 2016;172:96-112.e6 pubmed publisher
    ..The present study aimed to investigate the role of sirtuin 6 (SIRT6), a sirtuin family member, in regulating cardiomyocyte autophagy, and its implication in prevention of cardiac ..
  20. Yao Q, Zhang P, Qi Y, Chen S, Shen B, Han Y, et al. The role of SIRT6 in the differentiation of vascular smooth muscle cells in response to cyclic strain. Int J Biochem Cell Biol. 2014;49:98-104 pubmed publisher
    ..that cyclic strain modulates the differentiation of VSMCs via a transforming growth factor-?1 (TGF-?1)-Smad-SIRT6 pathway. VSMCs were subjected to cyclic strain using a Flexercell strain unit...
  21. Liszt G, Ford E, Kurtev M, Guarente L. Mouse Sir2 homolog SIRT6 is a nuclear ADP-ribosyltransferase. J Biol Chem. 2005;280:21313-20 pubmed
    ..Here, we report that the distant mammalian Sir2 homolog SIRT6 is a broadly expressed, predominantly nuclear protein...
  22. Yu S, Cai Y, Ye J, Pi R, Chen S, Liu P, et al. Sirtuin 6 protects cardiomyocytes from hypertrophy in vitro via inhibition of NF-?B-dependent transcriptional activity. Br J Pharmacol. 2013;168:117-28 pubmed publisher
    Sirtuin 6 (SIRT6) is involved in regulation of glucose and fat metabolism. However, its possible contribution to cardiac dysfunction remains to be determined...