Genomes and Genes
Gene Symbol: Sirt5
Description: sirtuin 5
Alias: NAD-dependent protein deacylase sirtuin-5, mitochondrial, NAD-dependent deacetylase sirtuin-5, NAD-dependent lysine demalonylase and desuccinylase sirtuin-5, mitochondrial, SIR2-like protein 5, regulatory protein SIR2 homolog 5
- Rardin M, He W, Nishida Y, Newman J, Carrico C, Danielson S, et al. SIRT5 regulates the mitochondrial lysine succinylome and metabolic networks. Cell Metab. 2013;18:920-33 pubmed publisher..approach to characterize the lysine succinylome in liver mitochondria and its regulation by the desuccinylase SIRT5. A total of 1,190 unique sites were identified as succinylated, and 386 sites across 140 proteins representing ..
- Verdin E. NADâº in aging, metabolism, and neurodegeneration. Science. 2015;350:1208-13 pubmed publisher..Here we review factors that regulate NAD(+) and discuss how supplementation with NAD(+) precursors may represent a new therapeutic opportunity for aging and its associated disorders, particularly neurodegenerative diseases. ..
- Peng C, Lu Z, Xie Z, Cheng Z, Chen Y, Tan M, et al. The first identification of lysine malonylation substrates and its regulatory enzyme. Mol Cell Proteomics. 2011;10:M111.012658 pubmed publisher..In addition, we demonstrate that Sirt5, a member of the class III lysine deacetylases, can catalyze lysine demalonylation and lysine desuccinylation ..
- Geng Y, Li T, Liu X, Li Z, Fu Y. SIRT1 and SIRT5 activity expression and behavioral responses to calorie restriction. J Cell Biochem. 2011;112:3755-61 pubmed publisherTo investigate the effects of calorie restriction (CR) on behavioral performance and expression of SIRT1 and SIRT5 in rat cerebral tissues...
- Liu B, Che W, Zheng C, Liu W, Wen J, Fu H, et al. SIRT5: a safeguard against oxidative stress-induced apoptosis in cardiomyocytes. Cell Physiol Biochem. 2013;32:1050-9 pubmed publisherb>SIRT5 is located in the mitochondria, and plays a crucial role in the regulation of metabolic process and cellular apoptosis. Cardiomyocytes are abundant in mitochondria...