Gene Symbol: sialidase
Description: neuraminidase 3
Alias: sialidase-3, N-acetyl-alpha-neuraminidase 3, ganglioside sialidase, membrane sialidase, sialidase 3 (membrane sialidase)
Sasaki A, Hata K, Suzuki S, Sawada M, Wada T, Yamaguchi K, et al
. Overexpression of plasma membrane-associated sialidase attenuates insulin signaling in transgenic mice. J Biol Chem. 2003;278:27896-902 pubmed
Plasma membrane-associated sialidase is a key enzyme for ganglioside hydrolysis, thereby playing crucial roles in regulation of cell surface functions...
Monti E, Bassi M, Papini N, Riboni M, Manzoni M, Venerando B, et al
. Identification and expression of NEU3, a novel human sialidase associated to the plasma membrane. Biochem J. 2000;349:343-51 pubmed
..Among these enzymes, plasma-membrane-associated sialidase(s) have a pivotal role in modulating the ganglioside content of the lipid bilayer, suggesting their involvement ..
Hasegawa T, Feijoo Carnero C, Wada T, Itoyama Y, Miyagi T. Differential expression of three sialidase genes in rat development. Biochem Biophys Res Commun. 2001;280:726-32 pubmed
..understand the roles of the sialidases during development, we investigated expression pattern of three types of sialidase in developing rat brain and liver...
Da Silva J, Hasegawa T, Miyagi T, Dotti C, Abad Rodriguez J. Asymmetric membrane ganglioside sialidase activity specifies axonal fate. Nat Neurosci. 2005;8:606-15 pubmed
..Here we show that plasma membrane ganglioside sialidase (PMGS) asymmetrically accumulates at the tip of one neurite of the unpolarized rat neuron, inducing actin ..
Kappagantula S, Andrews M, Cheah M, Abad Rodriguez J, Dotti C, Fawcett J. Neu3 sialidase-mediated ganglioside conversion is necessary for axon regeneration and is blocked in CNS axons. J Neurosci. 2014;34:2477-92 pubmed publisher
..We show that activation of Neu3 sialidase, also known as Neuraminidase-3, causing conversion of GD1a and GT1b to GM1 ganglioside, is an essential step in ..
Lipina C, Nardi F, GRACE H, Hundal H. NEU3 sialidase as a marker of insulin sensitivity: Regulation by fatty acids. Cell Signal. 2015;27:1742-50 pubmed publisher
The plasma membrane-associated enzyme NEU3 sialidase functions to cleave sialic acid residues from the ganglioside GM3 thereby promoting its degradation, and has been implicated in the modulation of insulin action...