Shh

Summary

Gene Symbol: Shh
Description: sonic hedgehog
Alias: ShhNC, sonic hedgehog protein, shh unprocessed N-terminal signaling and C-terminal autoprocessing domains, sonic hedgehog homolog
Species: rat
Products:     Shh

Top Publications

  1. Mastronardi F, daCruz L, Wang H, Boggs J, Moscarello M. The amount of sonic hedgehog in multiple sclerosis white matter is decreased and cleavage to the signaling peptide is deficient. Mult Scler. 2003;9:362-71 pubmed
    We have demonstrated that sonic hedgehog (Shh), vital for oligodendrocyte development, is present in both gray and white matter of normal human brain...
  2. Outram S, Varas A, Pepicelli C, Crompton T. Hedgehog signaling regulates differentiation from double-negative to double-positive thymocyte. Immunity. 2000;13:187-97 pubmed
    ..The hedgehog (Hh) signaling pathway is involved in the development of many tissues. Here we show that sonic hedgehog (Shh) is involved in thymocyte development...
  3. Hasebe M, Ohta E, Imagawa T, Uehara M. Expression of sonic hedgehog regulates morphological changes of rat developing cerebellum in hypothyroidism. J Toxicol Sci. 2008;33:473-7 pubmed
    ..induced by the anti-thyroid drug methimazole (MMI-HT rat), we carried out gene expression analysis (sonic hedgehog (Shh), reelin, and Bax) using quantitative real-time PCR...
  4. Podlasek C, Zelner D, Jiang H, Tang Y, Houston J, McKenna K, et al. Sonic hedgehog cascade is required for penile postnatal morphogenesis, differentiation, and adult homeostasis. Biol Reprod. 2003;68:423-38 pubmed
    ..This process involves coordinated activity of multiple signals. Sonic hedgehog (Shh) forms part of a regulatory cascade that is essential for growth and morphogenesis of many tissues...
  5. Haraguchi R, Mo R, Hui C, Motoyama J, Makino S, Shiroishi T, et al. Unique functions of Sonic hedgehog signaling during external genitalia development. Development. 2001;128:4241-50 pubmed
    ..The sonic hedgehog (Shh) gene and its signaling genes have been found to be dynamically expressed during murine external genitalia ..
  6. Angeloni N, Bond C, Harrington D, Stupp S, Podlasek C. Sonic hedgehog is neuroprotective in the cavernous nerve with crush injury. J Sex Med. 2013;10:1240-50 pubmed publisher
    ..We have shown in previous studies that sonic hedgehog (SHH) is critical for CN regeneration and improves erectile function after crush injury...
  7. Sagai T, Hosoya M, Mizushina Y, Tamura M, Shiroishi T. Elimination of a long-range cis-regulatory module causes complete loss of limb-specific Shh expression and truncation of the mouse limb. Development. 2005;132:797-803 pubmed
    ..in a conserved non-coding region in intron 5 of the Lmbr1 locus, which is 1 Mb away from the sonic hedgehog (Shh) coding sequence, are responsible for mouse and human preaxial polydactyly with mirror-image digit duplications...
  8. Shah D, Hager Theodorides A, Outram S, Ross S, Varas A, Crompton T. Reduced thymocyte development in sonic hedgehog knockout embryos. J Immunol. 2004;172:2296-306 pubmed
    ..In this study we provide genetic evidence that Sonic Hedgehog (Shh) has a role in the control of murine T cell development...
  9. Rajendran R, Jha S, Fernandes K, Banerjee S, Mohammad F, Dias B, et al. Monoaminergic regulation of Sonic hedgehog signaling cascade expression in the adult rat hippocampus. Neurosci Lett. 2009;453:190-4 pubmed publisher
    ..Given the key role of Sonic hedgehog (Shh) in adult neurogenesis, we examined whether monoaminergic perturbations regulate the expression of Shh or its co-..
  10. Lai K, Kaspar B, Gage F, Schaffer D. Sonic hedgehog regulates adult neural progenitor proliferation in vitro and in vivo. Nat Neurosci. 2003;6:21-7 pubmed
    ..Here, we investigated the role of Sonic hedgehog (Shh), a factor vital for neural development, in regulating adult hippocampal neural stem cells...

Detail Information

Publications87

  1. Mastronardi F, daCruz L, Wang H, Boggs J, Moscarello M. The amount of sonic hedgehog in multiple sclerosis white matter is decreased and cleavage to the signaling peptide is deficient. Mult Scler. 2003;9:362-71 pubmed
    We have demonstrated that sonic hedgehog (Shh), vital for oligodendrocyte development, is present in both gray and white matter of normal human brain...
  2. Outram S, Varas A, Pepicelli C, Crompton T. Hedgehog signaling regulates differentiation from double-negative to double-positive thymocyte. Immunity. 2000;13:187-97 pubmed
    ..The hedgehog (Hh) signaling pathway is involved in the development of many tissues. Here we show that sonic hedgehog (Shh) is involved in thymocyte development...
  3. Hasebe M, Ohta E, Imagawa T, Uehara M. Expression of sonic hedgehog regulates morphological changes of rat developing cerebellum in hypothyroidism. J Toxicol Sci. 2008;33:473-7 pubmed
    ..induced by the anti-thyroid drug methimazole (MMI-HT rat), we carried out gene expression analysis (sonic hedgehog (Shh), reelin, and Bax) using quantitative real-time PCR...
  4. Podlasek C, Zelner D, Jiang H, Tang Y, Houston J, McKenna K, et al. Sonic hedgehog cascade is required for penile postnatal morphogenesis, differentiation, and adult homeostasis. Biol Reprod. 2003;68:423-38 pubmed
    ..This process involves coordinated activity of multiple signals. Sonic hedgehog (Shh) forms part of a regulatory cascade that is essential for growth and morphogenesis of many tissues...
  5. Haraguchi R, Mo R, Hui C, Motoyama J, Makino S, Shiroishi T, et al. Unique functions of Sonic hedgehog signaling during external genitalia development. Development. 2001;128:4241-50 pubmed
    ..The sonic hedgehog (Shh) gene and its signaling genes have been found to be dynamically expressed during murine external genitalia ..
  6. Angeloni N, Bond C, Harrington D, Stupp S, Podlasek C. Sonic hedgehog is neuroprotective in the cavernous nerve with crush injury. J Sex Med. 2013;10:1240-50 pubmed publisher
    ..We have shown in previous studies that sonic hedgehog (SHH) is critical for CN regeneration and improves erectile function after crush injury...
  7. Sagai T, Hosoya M, Mizushina Y, Tamura M, Shiroishi T. Elimination of a long-range cis-regulatory module causes complete loss of limb-specific Shh expression and truncation of the mouse limb. Development. 2005;132:797-803 pubmed
    ..in a conserved non-coding region in intron 5 of the Lmbr1 locus, which is 1 Mb away from the sonic hedgehog (Shh) coding sequence, are responsible for mouse and human preaxial polydactyly with mirror-image digit duplications...
  8. Shah D, Hager Theodorides A, Outram S, Ross S, Varas A, Crompton T. Reduced thymocyte development in sonic hedgehog knockout embryos. J Immunol. 2004;172:2296-306 pubmed
    ..In this study we provide genetic evidence that Sonic Hedgehog (Shh) has a role in the control of murine T cell development...
  9. Rajendran R, Jha S, Fernandes K, Banerjee S, Mohammad F, Dias B, et al. Monoaminergic regulation of Sonic hedgehog signaling cascade expression in the adult rat hippocampus. Neurosci Lett. 2009;453:190-4 pubmed publisher
    ..Given the key role of Sonic hedgehog (Shh) in adult neurogenesis, we examined whether monoaminergic perturbations regulate the expression of Shh or its co-..
  10. Lai K, Kaspar B, Gage F, Schaffer D. Sonic hedgehog regulates adult neural progenitor proliferation in vitro and in vivo. Nat Neurosci. 2003;6:21-7 pubmed
    ..Here, we investigated the role of Sonic hedgehog (Shh), a factor vital for neural development, in regulating adult hippocampal neural stem cells...
  11. Kruger M, Mennerich D, Fees S, Schafer R, Mundlos S, Braun T. Sonic hedgehog is a survival factor for hypaxial muscles during mouse development. Development. 2001;128:743-52 pubmed
    Sonic hedgehog (Shh) has been proposed to function as an inductive and trophic signal that controls development of epaxial musculature in vertebrate embryos...
  12. Stone D, Hynes M, Armanini M, Swanson T, Gu Q, Johnson R, et al. The tumour-suppressor gene patched encodes a candidate receptor for Sonic hedgehog. Nature. 1996;384:129-34 pubmed
    The protein Sonic hedgehog (Shh) controls patterning and growth during vertebrate development...
  13. Hashimoto M, Ishii K, Nakamura Y, Watabe K, Kohsaka S, Akazawa C. Neuroprotective effect of sonic hedgehog up-regulated in Schwann cells following sciatic nerve injury. J Neurochem. 2008;107:918-27 pubmed publisher
    The physiological roles of sonic hedgehog (Shh) have been intensively characterized in development of various organs. However, their functions in adult tissues have not been fully elucidated...
  14. Dai R, Zhu S, Xia Y, Mao L, Mei Y, Yao Y, et al. Sonic hedgehog protects cortical neurons against oxidative stress. Neurochem Res. 2011;36:67-75 pubmed publisher
    ..Recent studies have indicated that the sonic hedgehog (SHH) signaling pathway is involved in these diseases, but the underlying mechanisms remains elusive...
  15. Sharpe J, Lettice L, Hecksher Sorensen J, Fox M, Hill R, Krumlauf R. Identification of sonic hedgehog as a candidate gene responsible for the polydactylous mouse mutant Sasquatch. Curr Biol. 1999;9:97-100 pubmed
    ..of the anterior limb bud resulting in ectopic expression of signalling components such as Sonic hedgehog (Shh) and fibroblast growth factor-4 (Fgf4), but little is known about the molecular causes of this misregulation...
  16. Lewis P, Gritli Linde A, Smeyne R, Kottmann A, McMahon A. Sonic hedgehog signaling is required for expansion of granule neuron precursors and patterning of the mouse cerebellum. Dev Biol. 2004;270:393-410 pubmed
    The signals that promote regional growth and development of the brain are not well understood. Sonic hedgehog (Shh) is produced by Purkinje cells of the cerebellum and is a potent inducer of granule cell proliferation...
  17. Vokes S, Ji H, McCuine S, Tenzen T, Giles S, Zhong S, et al. Genomic characterization of Gli-activator targets in sonic hedgehog-mediated neural patterning. Development. 2007;134:1977-89 pubmed
    Sonic hedgehog (Shh) acts as a morphogen to mediate the specification of distinct cell identities in the ventral neural tube through a Gli-mediated (Gli1-3) transcriptional network...
  18. Seifert T, Bauer J, Weissert R, Fazekas F, Storch M. Differential expression of sonic hedgehog immunoreactivity during lesion evolution in autoimmune encephalomyelitis. J Neuropathol Exp Neurol. 2005;64:404-11 pubmed
    The signaling molecule Sonic hedgehog (Shh) is involved in several processes of central nervous system development...
  19. Podlasek C, Meroz C, Tang Y, McKenna K, McVary K. Regulation of cavernous nerve injury-induced apoptosis by sonic hedgehog. Biol Reprod. 2007;76:19-28 pubmed
    ..We hypothesize that decreased Sonic hedgehog (SHH) signaling is a cause of ED in neurological models of impotence by increasing apoptosis in penile smooth muscle...
  20. Wechsler Reya R, Scott M. Control of neuronal precursor proliferation in the cerebellum by Sonic Hedgehog. Neuron. 1999;22:103-14 pubmed
    ..We show that Sonic hedgehog (Shh), which is made by Purkinje cells, regulates the division of granule cell precursors (GCPs)...
  21. Wang Y, Imitola J, Rasmussen S, O Connor K, Khoury S. Paradoxical dysregulation of the neural stem cell pathway sonic hedgehog-Gli1 in autoimmune encephalomyelitis and multiple sclerosis. Ann Neurol. 2008;64:417-27 pubmed publisher
    ..We investigated the sonic hedgehog (Shh)-Gli1 pathway, an important signaling pathway for NSCs, in experimental autoimmune encephalomyelitis (EAE) and ..
  22. Bond C, Angeloni N, Harrington D, Stupp S, Podlasek C. Sonic Hedgehog regulates brain-derived neurotrophic factor in normal and regenerating cavernous nerves. J Sex Med. 2013;10:730-7 pubmed publisher
    ..Sonic hedgehog (SHH) treatment promotes CN regeneration. The mechanism of how this occurs is unknown...
  23. Podlasek C, Zelner D, Harris J, Meroz C, Tang Y, McKenna K, et al. Altered Sonic hedgehog signaling is associated with morphological abnormalities in the penis of the BB/WOR diabetic rat. Biol Reprod. 2003;69:816-27 pubmed
    ..Nerve injury causes ED and disrupts signaling of the Sonic hedgehog (Shh) cascade in the smooth muscle of the corpora cavernosa...
  24. Zhang X, Ramalho Santos M, McMahon A. Smoothened mutants reveal redundant roles for Shh and Ihh signaling including regulation of L/R symmetry by the mouse node. Cell. 2001;106:781-92 pubmed
    ..We show that Smo acts epistatic to Ptc1 to mediate Shh and Ihh signaling in the early mouse embryo...
  25. Wijgerde M, McMahon J, Rule M, McMahon A. A direct requirement for Hedgehog signaling for normal specification of all ventral progenitor domains in the presumptive mammalian spinal cord. Genes Dev. 2002;16:2849-64 pubmed
    ..Surprisingly, in the absence of Sonic hedgehog (Shh), we observe the presence of a Smo-dependent Hh signaling activity operating in the ventral half of the spinal cord ..
  26. Charytoniuk D, Traiffort E, Hantraye P, Hermel J, Galdes A, Ruat M. Intrastriatal sonic hedgehog injection increases Patched transcript levels in the adult rat subventricular zone. Eur J Neurosci. 2002;16:2351-7 pubmed
    The morphogen sonic hedgehog (Shh) is implicated in neural tissue patterning and the growth of brain structures during embryogenesis and postnatal development and is also present in the adult brain...
  27. Fan C, Lee C, Tessier Lavigne M. A role for WNT proteins in induction of dermomyotome. Dev Biol. 1997;191:160-5 pubmed
  28. Liu A, Wang B, Niswander L. Mouse intraflagellar transport proteins regulate both the activator and repressor functions of Gli transcription factors. Development. 2005;132:3103-11 pubmed
    ..Sonic hedgehog (Shh) expression is normal, yet Ptch1 and Gli1, two known targets of Hh signaling, are greatly reduced, consistent with ..
  29. Pan Y, Bai C, Joyner A, Wang B. Sonic hedgehog signaling regulates Gli2 transcriptional activity by suppressing its processing and degradation. Mol Cell Biol. 2006;26:3365-77 pubmed
    Gli2 and Gli3 are the primary transcription factors that mediate Sonic hedgehog (Shh) signals in the mouse. Gli3 mainly acts as a transcriptional repressor, because the majority of full-length Gli3 protein is proteolytically processed...
  30. Mo R, Kim J, Zhang J, Chiang C, Hui C, Kim P. Anorectal malformations caused by defects in sonic hedgehog signaling. Am J Pathol. 2001;159:765-74 pubmed
    ..Sonic hedgehog (Shh) is an endoderm-derived signaling molecule that induces mesodermal gene expression in the chick hindgut...
  31. Chiang C, Litingtung Y, Harris M, Simandl B, Li Y, Beachy P, et al. Manifestation of the limb prepattern: limb development in the absence of sonic hedgehog function. Dev Biol. 2001;236:421-35 pubmed
    The secreted protein encoded by the Sonic hedgehog (Shh) gene is localized to the posterior margin of vertebrate limb buds and is thought to be a key signal in establishing anterior-posterior limb polarity...
  32. Fuse N, Maiti T, Wang B, Porter J, Hall T, Leahy D, et al. Sonic hedgehog protein signals not as a hydrolytic enzyme but as an apparent ligand for patched. Proc Natl Acad Sci U S A. 1999;96:10992-9 pubmed
    The amino-terminal signaling domain of the Sonic hedgehog secreted protein (Shh-N), which derives from the Shh precursor through an autoprocessing reaction mediated by the carboxyl-terminal domain, executes multiple functions in ..
  33. Nery S, Wichterle H, Fishell G. Sonic hedgehog contributes to oligodendrocyte specification in the mammalian forebrain. Development. 2001;128:527-40 pubmed
    This study addresses the role of Sonic hedgehog (Shh) in promoting the generation of oligodendrocytes in the mouse telencephalon...
  34. Ramalho Santos M, Melton D, McMahon A. Hedgehog signals regulate multiple aspects of gastrointestinal development. Development. 2000;127:2763-72 pubmed
    ..These results show that Hedgehog signals are essential for organogenesis of the mammalian gastrointestinal tract and suggest that mutations in members of this signaling pathway may be involved in human gastrointestinal malformations. ..
  35. Fernandez L A, Northcott P, Dalton J, Fraga C, Ellison D, Angers S, et al. YAP1 is amplified and up-regulated in hedgehog-associated medulloblastomas and mediates Sonic hedgehog-driven neural precursor proliferation. Genes Dev. 2009;23:2729-41 pubmed publisher
    ..Activation of the Sonic hedgehog (Shh) signaling pathway is implicated in human medulloblastomas...
  36. Spilde T, Bhatia A, Mehta S, Ostlie D, Hembree M, Preuett B, et al. Defective sonic hedgehog signaling in esophageal atresia with tracheoesophageal fistula. Surgery. 2003;134:345-50 pubmed
    ..We injected Adriamycin into pregnant rats to induce EA/TEF in rat embryos. We first quantified sonic hedgehog (Shh) signaling pathway molecule expression using real-time, semiquantitative reverse-transcriptase polymerase chain ..
  37. Parra L, Zou Y. Sonic hedgehog induces response of commissural axons to Semaphorin repulsion during midline crossing. Nat Neurosci. 2010;13:29-35 pubmed publisher
    ..We found that Sonic Hedgehog (Shh) could activate the repulsive response of pre-crossing axons to Semaphorins...
  38. Yao Q, Renault M, Chapouly C, Vandierdonck S, Belloc I, Jaspard Vinassa B, et al. Sonic hedgehog mediates a novel pathway of PDGF-BB-dependent vessel maturation. Blood. 2014;123:2429-37 pubmed publisher
    ..Sonic hedgehog (Shh) has been suggested to promote the formation of larger and more muscularized vessels, but the underlying mechanisms ..
  39. Dassule H, Lewis P, Bei M, Maas R, McMahon A. Sonic hedgehog regulates growth and morphogenesis of the tooth. Development. 2000;127:4775-85 pubmed
    ..Sonic hedgehog (Shh) encodes a signaling peptide which is present in the oral epithelium prior to invagination and in the tooth ..
  40. Furniss D, Lettice L, Taylor I, Critchley P, Giele H, Hill R, et al. A variant in the sonic hedgehog regulatory sequence (ZRS) is associated with triphalangeal thumb and deregulates expression in the developing limb. Hum Mol Genet. 2008;17:2417-23 pubmed publisher
    ..zone of polarizing activity regulatory sequence (ZRS), a long range limb-specific enhancer of the Sonic Hedgehog (SHH) gene at human chromosome 7q36.3...
  41. Zhao M, Qiao M, Harris S, Chen D, Oyajobi B, Mundy G. The zinc finger transcription factor Gli2 mediates bone morphogenetic protein 2 expression in osteoblasts in response to hedgehog signaling. Mol Cell Biol. 2006;26:6197-208 pubmed
    ..Finally, Sonic hedgehog (Shh) stimulates BMP-2 promoter activity and osteoblast differentiation, and the effects of Shh are mediated by Gli2...
  42. Mandhan P, Quan Q, Beasley S, Sullivan M. Sonic hedgehog, BMP4, and Hox genes in the development of anorectal malformations in Ethylenethiourea-exposed fetal rats. J Pediatr Surg. 2006;41:2041-5 pubmed
    b>shh signaling pathway has been shown to be involved in the morphogenesis of many organ systems...
  43. Niedermaier M, Schwabe G, Fees S, Helmrich A, Brieske N, Seemann P, et al. An inversion involving the mouse Shh locus results in brachydactyly through dysregulation of Shh expression. J Clin Invest. 2005;115:900-9 pubmed
    ..Homozygous mice are characterized by multiple defects strongly resembling those resulting from Sonic hedgehog (Shh) inactivation...
  44. Mao H, Diehl A, Li Y. Sonic hedgehog ligand partners with caveolin-1 for intracellular transport. Lab Invest. 2009;89:290-300 pubmed publisher
    ..transduction in zebrafish embryos by inhibiting the post-translational cholesterol modification of Sonic hedgehog (Shh), leading to decreased levels of mature Shh ligand that is associated with the plasma membrane, and causing ..
  45. St Jacques B, Dassule H, Karavanova I, Botchkarev V, Li J, Danielian P, et al. Sonic hedgehog signaling is essential for hair development. Curr Biol. 1998;8:1058-68 pubmed
    ..Expression of members of the Wnt, Hedgehog and bone morphogenetic protein families (Wnt10b, Sonic hedgehog (Shh) and Bmp2/Bmp4, respectively) in the epidermis correlates with the initiation of hair follicle formation...
  46. Zhao L, Yu Y, Deng C. Protein and mRNA expression of Shh, Smo and Gli1 and inhibition by cyclopamine in hepatocytes of rats with chronic fluorosis. Toxicol Lett. 2014;225:318-24 pubmed publisher
    In order to investigate the Sonic hedgehog (Shh) signaling pathway and the effect of cyclopamine in rat hepatocytes with chronic fluorosis, 48 Wistar rats were randomly divided into 4 groups...
  47. Witte F, Chan D, Economides A, Mundlos S, Stricker S. Receptor tyrosine kinase-like orphan receptor 2 (ROR2) and Indian hedgehog regulate digit outgrowth mediated by the phalanx-forming region. Proc Natl Acad Sci U S A. 2010;107:14211-6 pubmed publisher
  48. Yang Y, Li Q, Deng Z, Zhang Z, Xu J, Qian G, et al. Protection from lipopolysaccharide-induced pulmonary microvascular endothelial cell injury by activation of hedgehog signaling pathway. Mol Biol Rep. 2011;38:3615-22 pubmed publisher
    ..As the priming protein of hedgehog signaling pathway, sonic hedgehog (Shh) may recently be advantage for decreasing endothelial injury and promoting the repair of endothelial barrier ..
  49. Cho S, Kwak S, Woolley T, Lee M, Kim E, Baker R, et al. Interactions between Shh, Sostdc1 and Wnt signaling and a new feedback loop for spatial patterning of the teeth. Development. 2011;138:1807-16 pubmed publisher
    ..Sonic hedgehog (Shh) is one of the key signaling molecules involved in the spatial patterning of teeth and other ectodermal organs such ..
  50. Wu M, Hernandez M, Shen S, Sabo J, Kelkar D, Wang J, et al. Differential modulation of the oligodendrocyte transcriptome by sonic hedgehog and bone morphogenetic protein 4 via opposing effects on histone acetylation. J Neurosci. 2012;32:6651-64 pubmed publisher
    ..In this study, we analyze the effect that the extracellular ligands sonic hedgehog (Shh) and bone morphogenetic protein 4 (BMP4), have on histone acetylation and gene expression in cultured OPCs...
  51. Kraus P, Fraidenraich D, Loomis C. Some distal limb structures develop in mice lacking Sonic hedgehog signaling. Mech Dev. 2001;100:45-58 pubmed
    ..Complex feedback loops exist between Shh in the ZPA, Bmps and their antagonists in the adjacent mesenchyme, Wnt7a in the dorsal ectoderm and Fgfs in the AER...
  52. Lin Y, Roffler S, Yan Y, Yang R. Disruption of Scube2 Impairs Endochondral Bone Formation. J Bone Miner Res. 2015;30:1255-67 pubmed publisher
    ..Recent reports suggested that zebrafish scube2 could facilitate sonic hedgehog (Shh) signaling for proper development of slow muscle...
  53. Zhang D, Wang H, Liu H, Tao T, Wang N, Shen A. nNOS Translocates into the Nucleus and Interacts with Sox2 to Protect Neurons Against Early Excitotoxicity via Promotion of Shh Transcription. Mol Neurobiol. 2016;53:6444-6458 pubmed publisher
    ..Mechanistically, via activating the transcription of Shh (Sonic hedgehog), the downstream target of Sox2, this nNOS-Sox2 complex exerted a neuroprotective function against ..
  54. Kubota K, Yamauchi N, Matsumoto K, Watanabe R, Oozono S, Aramaki S, et al. Expression of hedgehog family genes in the rat uterus during early pregnancy. J Reprod Dev. 2008;54:340-5 pubmed
    ..In mammals, Hh exists in three homologs: Desert hedgehog (Dhh), Indian hedgehog (Ihh) and Sonic hedgehog (Shh). In this study, we cloned full-length cDNAs encoding Dhh and Ihh from the rat uterus...
  55. Apelqvist A, Ahlgren U, Edlund H. Sonic hedgehog directs specialised mesoderm differentiation in the intestine and pancreas. Curr Biol. 1997;7:801-4 pubmed
    ..candidate mediator of endodermally derived signals in the embryonic hindgut is the secreted protein Sonic hedgehog (Shh)...
  56. Dassule H, McMahon A. Analysis of epithelial-mesenchymal interactions in the initial morphogenesis of the mammalian tooth. Dev Biol. 1998;202:215-27 pubmed
    ..In this paper we have investigated the role of four epithelial signaling molecules, Bmp2, Shh, Wnt10a, and Wnt10b, in the early inductive cascades that govern tooth development...
  57. Carpenter D, Stone D, Brush J, Ryan A, Armanini M, Frantz G, et al. Characterization of two patched receptors for the vertebrate hedgehog protein family. Proc Natl Acad Sci U S A. 1998;95:13630-4 pubmed
    The multitransmembrane protein Patched (PTCH) is the receptor for Sonic Hedgehog (Shh), a secreted molecule implicated in the formation of embryonic structures and in tumorigenesis...
  58. Hwang J, Weng Y, Lin J, Bau D, Ko F, Tsai F, et al. Hypoxia-induced compensatory effect as related to Shh and HIF-1alpha in ischemia embryo rat heart. Mol Cell Biochem. 2008;311:179-87 pubmed publisher
    ..increase of IGF-2 and VEGF expression but also the activation of their upstream regulatory genes, HIF-1alpha and Shh. The relationship between HIF-1alpha and Shh was further studied by using cyclopamine and 2-ME2, inhibitor of Shh ..
  59. Fang M, Lu Y, Chen G, Shen L, Pan Y, Wang X. Increased expression of sonic hedgehog in temporal lobe epileptic foci in humans and experimental rats. Neuroscience. 2011;182:62-70 pubmed publisher
    Sonic hedgehog (Shh) is a soluble signaling protein that is crucial in regulating cell proliferation, migration and differentiation, axonal guidance and neural progenitor cell survival during nervous system development...
  60. Allen B, Tenzen T, McMahon A. The Hedgehog-binding proteins Gas1 and Cdo cooperate to positively regulate Shh signaling during mouse development. Genes Dev. 2007;21:1244-57 pubmed
    ..Transcriptional profiling identified Growth-arrest-specific 1 (Gas1) as a general negative target of Shh signaling. Data presented here define Gas1 as a novel positive component of the Shh signaling cascade...
  61. Al Ayadhi L. Relationship between Sonic hedgehog protein, brain-derived neurotrophic factor and oxidative stress in autism spectrum disorders. Neurochem Res. 2012;37:394-400 pubmed publisher
    ..We report here that the serum levels of Sonic hedgehog (SHH) protein and brain-derived neurotrophic factor (BDNF) might be linked to oxidative stress in ASD...
  62. Madhavan L, Daley B, Davidson B, Boudreau R, Lipton J, Cole Strauss A, et al. Sonic Hedgehog Controls the Phenotypic Fate and Therapeutic Efficacy of Grafted Neural Precursor Cells in a Model of Nigrostriatal Neurodegeneration. PLoS ONE. 2015;10:e0137136 pubmed publisher
    ..the roles of two donor NPC molecules, namely glial cell-line derived neurotrophic factor (GDNF) and sonic hedgehog (SHH), in the protection of substantia nigra dopamine neurons in rats treated with 6-hydroxydopamine (6-OHDA)...
  63. Mahlapuu M, Enerback S, Carlsson P. Haploinsufficiency of the forkhead gene Foxf1, a target for sonic hedgehog signaling, causes lung and foregut malformations. Development. 2001;128:2397-406 pubmed
    ..Similar malformations are observed in mutants that are defective in the sonic hedgehog (Shh) signaling pathway, and we show that exogenous Shh activates transcription of Foxf1 in developing lung...
  64. Gao H, Zhang Z, Jiang Z, Wang D, Huang Y, Wang W. [Mutation and expression of WNT8b gene and SHH gene in Hirschsprung disease]. Zhonghua Wei Chang Wai Ke Za Zhi. 2010;13:758-61 pubmed
    To investigate the relationship of WNT8b and SHH genes mutation and Hirschsprung disease(HSCR) in Chinese children. Preoperative whole blood preparations in 72 children with sporadic HSCR from northeast China were collected(study group)...
  65. Unger S, Copland I, Tibboel D, Post M. Down-regulation of sonic hedgehog expression in pulmonary hypoplasia is associated with congenital diaphragmatic hernia. Am J Pathol. 2003;162:547-55 pubmed
    ..The sonic hedgehog (Shh) cascade is crucial for the patterning of the early respiratory system in mice...
  66. Tsukui T, Capdevila J, Tamura K, Ruiz Lozano P, Rodriguez Esteban C, Yonei Tamura S, et al. Multiple left-right asymmetry defects in Shh(-/-) mutant mice unveil a convergence of the shh and retinoic acid pathways in the control of Lefty-1. Proc Natl Acad Sci U S A. 1999;96:11376-81 pubmed
    Asymmetric expression of Sonic hedgehog (Shh) in Hensen's node of the chicken embryo plays a key role in the genetic cascade that controls left-right asymmetry, but its involvement in left-right specification in other vertebrates remains ..
  67. Khalil O, Forrest C, Pisar M, Smith R, Darlington L, Stone T. Prenatal activation of maternal TLR3 receptors by viral-mimetic poly(I:C) modifies GluN2B expression in embryos and sonic hedgehog in offspring in the absence of kynurenine pathway activation. Immunopharmacol Immunotoxicol. 2013;35:581-93 pubmed publisher
    ..The oxidation of tryptophan along the kynurenine pathway is not involved in these effects. ..
  68. Charron F, Stein E, Jeong J, McMahon A, Tessier Lavigne M. The morphogen sonic hedgehog is an axonal chemoattractant that collaborates with netrin-1 in midline axon guidance. Cell. 2003;113:11-23 pubmed
    ..We show that the morphogen Sonic hedgehog (Shh) can mimic the additional chemoattractant activity of the floor plate in vitro and can act directly as a ..
  69. Buttitta L, Mo R, Hui C, Fan C. Interplays of Gli2 and Gli3 and their requirement in mediating Shh-dependent sclerotome induction. Development. 2003;130:6233-43 pubmed
    Sonic hedgehog (Shh) signaling is essential for sclerotome development in the mouse...
  70. Sasaki Y, O Kane S, Dixon J, Dixon M, Ferguson M. Temporal and spatial expression of Pax9 and Sonic hedgehog during development of normal mouse palates and cleft palates in TGF-beta3 null embryos. Arch Oral Biol. 2007;52:260-7 pubmed
    Transforming growth factor-beta (TGF-beta3) gene disruption causes cleft secondary palate. Pax9 and Sonic hedgehog (Shh) genes are involved in the patterning of vertebrate embryonic tissues, including the facial skeleton...
  71. Lee C, Buttitta L, May N, Kispert A, Fan C. SHH-N upregulates Sfrp2 to mediate its competitive interaction with WNT1 and WNT4 in the somitic mesoderm. Development. 2000;127:109-18 pubmed
    ..Noggin and SHH-N have been implicated as the ventralizing signals produced by the notochord...
  72. Bond C, Tang Y, Podlasek C. Neural influences on sonic hedgehog and apoptosis in the rat penis. Biol Reprod. 2008;78:947-56 pubmed publisher
    The role of sonic hedgehog (SHH) in maintaining corpora cavernosal morphology in the adult penis has been established; however, the mechanism of how SHH itself is regulated remains unclear...
  73. Pringle N, Yu W, Guthrie S, Roelink H, Lumsden A, Peterson A, et al. Determination of neuroepithelial cell fate: induction of the oligodendrocyte lineage by ventral midline cells and sonic hedgehog. Dev Biol. 1996;177:30-42 pubmed
    ..tube only when they were cocultured with fragments of notochord or in the presence of purified Sonic hedgehog (Shh) protein...
  74. Sussman C, Davies J, Miller R. Extracellular and intracellular regulation of oligodendrocyte development: roles of Sonic hedgehog and expression of E proteins. Glia. 2002;40:55-64 pubmed
    ..The signaling molecule Sonic hedgehog (Shh) is critical for normal development of oligodendrocytes, although the precise influences of Shh on cells of the ..
  75. Albuisson J, Isidor B, Giraud M, Pichon O, Marsaud T, David A, et al. Identification of two novel mutations in Shh long-range regulator associated with familial pre-axial polydactyly. Clin Genet. 2011;79:371-7 pubmed publisher
    ..MIM #186200) are a group of closely related conditions caused by mutations in a long-range Sonic hedgehog (SHH, MIM *600725) regulator called ZRS...
  76. Murray K, Calaora V, Rottkamp C, Guicherit O, Dubois Dalcq M. Sonic hedgehog is a potent inducer of rat oligodendrocyte development from cortical precursors in vitro. Mol Cell Neurosci. 2002;19:320-32 pubmed
    Sonic Hedgehog (Shh) induces oligodendrocyte development in the ventral neural tube and telencephalon but its role in oligodendrocyte generation in dorsal telencephalon is debated...
  77. Gillick J, Mooney E, Giles S, Bannigan J, Puri P. Notochord anomalies in the adriamycin rat model: A morphologic and molecular basis for the VACTERL association. J Pediatr Surg. 2003;38:469-73; discussion 469-73 pubmed
    ..The second group of embryos were examined using in situ hybridization for the expression of Sonic Hedgehog (Shh), a patterning gene implicated in the etiology of the VACTERL association. Twenty-seven of the 28 (96...
  78. Gold D, Baek S, Schork N, Rose D, Larsen D, Sachs B, et al. RORalpha coordinates reciprocal signaling in cerebellar development through sonic hedgehog and calcium-dependent pathways. Neuron. 2003;40:1119-31 pubmed
  79. Patterson V, Damrau C, Paudyal A, Reeve B, Grimes D, Stewart M, et al. Mouse hitchhiker mutants have spina bifida, dorso-ventral patterning defects and polydactyly: identification of Tulp3 as a novel negative regulator of the Sonic hedgehog pathway. Hum Mol Genet. 2009;18:1719-39 pubmed publisher
    The mammalian Sonic hedgehog (Shh) signalling pathway is essential for embryonic development and the patterning of multiple organs...
  80. Zhou D, Li Y, Zhou L, Tan R, Xiao L, Liang M, et al. Sonic hedgehog is a novel tubule-derived growth factor for interstitial fibroblasts after kidney injury. J Am Soc Nephrol. 2014;25:2187-200 pubmed publisher
    ..Here, we investigated the role of sonic hedgehog (Shh), a secreted extracellular signaling protein, in fibroblast proliferation...
  81. Yang L, Wang Y, Mao H, Fleig S, Omenetti A, Brown K, et al. Sonic hedgehog is an autocrine viability factor for myofibroblastic hepatic stellate cells. J Hepatol. 2008;48:98-106 pubmed
    ..This study evaluates the hypothesis that autocrine production of Sonic hedgehog (Shh) promotes MFB growth...
  82. Garg V, Yamagishi C, Hu T, Kathiriya I, Yamagishi H, Srivastava D. Tbx1, a DiGeorge syndrome candidate gene, is regulated by sonic hedgehog during pharyngeal arch development. Dev Biol. 2001;235:62-73 pubmed
    ..Sonic hedgehog (Shh) is also expressed in the pharyngeal arches and is necessary for normal craniofacial development...
  83. Rice R, Spencer Dene B, Connor E, Gritli Linde A, McMahon A, Dickson C, et al. Disruption of Fgf10/Fgfr2b-coordinated epithelial-mesenchymal interactions causes cleft palate. J Clin Invest. 2004;113:1692-700 pubmed
    ..Using Fgf10-/-, FGF receptor 2b-/- (Fgfr2b-/-), and Sonic hedgehog (Shh) mutant mice, which all exhibit cleft palate, we show that Shh is a downstream target of Fgf10/Fgfr2b signaling...
  84. Levine E, Roelink H, Turner J, Reh T. Sonic hedgehog promotes rod photoreceptor differentiation in mammalian retinal cells in vitro. J Neurosci. 1997;17:6277-88 pubmed
    ..N-terminal recombinant Sonic Hedgehog protein (SHH-N) was added to rat retinal cultures for 3-12 d, and the numbers of retinal cells of various ..
  85. Moore Scott B, Manley N. Differential expression of Sonic hedgehog along the anterior-posterior axis regulates patterning of pharyngeal pouch endoderm and pharyngeal endoderm-derived organs. Dev Biol. 2005;278:323-35 pubmed
    Previous studies have implicated Sonic hedgehog (Shh) as an important regulator of pharyngeal region development. Here we show that Shh is differentially expressed within the pharyngeal endoderm along the anterior-posterior axis...