Gene Symbol: Sgf29
Description: SAGA complex associated factor 29
Alias: Ccdc101, RGD1310609, SAGA-associated factor 29, SAGA-associated factor 29 homolog, coiled-coil domain containing 101, coiled-coil domain-containing protein 101, rSGF29
Orpinell M, Fournier M, Riss A, Nagy Z, Krebs A, Frontini M, et al
. The ATAC acetyl transferase complex controls mitotic progression by targeting non-histone substrates. EMBO J. 2010;29:2381-94 pubmed publisher
..Thus, we have uncovered an essential function for ATAC in regulating Cyclin A activity and consequent mitotic progression. ..
Pieters B, Meulenbroeks E, Belle R, MecinoviÄ‡ J. The Role of Electrostatic Interactions in Binding of Histone H3K4me2/3 to the Sgf29 Tandem Tudor Domain. PLoS ONE. 2015;10:e0139205 pubmed publisher
..we report thermodynamic analyses for the recognition of histone H3K4me3 and H3K4me2 by the tandem tudor domain of Sgf29 and its recognition site variants...
Kurabe N, Katagiri K, Komiya Y, Ito R, Sugiyama A, Kawasaki Y, et al
. Deregulated expression of a novel component of TFTC/STAGA histone acetyltransferase complexes, rat SGF29, in hepatocellular carcinoma: possible implication for the oncogenic potential of c-Myc. Oncogene. 2007;26:5626-34 pubmed
..Both rat (r) SGF29 and c-myc mRNAs were overexpressed in five out of the eight tested rodent tumor cells. rSGF29 directly interacted with rADA3 and co-immunoprecipitated with two other TFTC/STAGA components, rGCN5 and rSPT3...
Murakami S, Chishima S, Uemoto H, Sakamoto E, Sato T, Kurabe N, et al
. The male-specific factor Sry harbors an oncogenic function. Oncogene. 2014;33:2978-86 pubmed publisher
b>Sgf29, a component of the SPT-ADA-GCN5 acetyltransferase (SAGA) complex, binds H3K4me2/3 marks and leads to histone H3 acetylation. Previously, we found that downregulation of Sgf29 suppresses c-Myc-mediated malignant transformation...
Lu R, Wang G. Tudor: a versatile family of histone methylation 'readers'. Trends Biochem Sci. 2013;38:546-55 pubmed publisher
..including Jumonji domain-containing 2A (JMJD2A), p53-binding protein 1 (53BP1), SAGA-associated factor 29 (SGF29), Spindlin1, ubiquitin-like with PHD and RING finger domains 1 (UHRF1), PHD finger protein 1 (PHF1), PHD finger ..
Schram A, Baas R, Jansen P, Riss A, Tora L, Vermeulen M, et al
. A dual role for SAGA-associated factor 29 (SGF29) in ER stress survival by coordination of both histone H3 acetylation and histone H3 lysine-4 trimethylation. PLoS ONE. 2013;8:e70035 pubmed publisher
The SGF29 protein binds to tri-methylated lysine-4 of histone H3 (H3K4me3), which is a histone modification associated with active promoters...