Serpinb5

Summary

Gene Symbol: Serpinb5
Description: serpin family B member 5
Alias: Maspin, PI-5, Pi5, serpin B5, peptidase inhibitor 5, protease inhibitor 5, serine (or cysteine) peptidase inhibitor, clade B, member 5, serine (or cysteine) proteinase inhibitor, clade B (ovalbumin), member 5, serpin peptidase inhibitor, clade B (ovalbumin), member 5
Species: rat
Products:     Serpinb5

Top Publications

  1. Bailey C, Khalkhali Ellis Z, Kondo S, Margaryan N, Seftor R, Wheaton W, et al. Mammary serine protease inhibitor (Maspin) binds directly to interferon regulatory factor 6: identification of a novel serpin partnership. J Biol Chem. 2005;280:34210-7 pubmed
    Since its reported discovery in 1994, maspin (mammary serine protease inhibitor) has been characterized as a class II tumor suppressor by its ability to promote apoptosis and inhibit cell invasion...
  2. Umekita Y, Hiipakka R, Liao S. Rat and human maspins: structures, metastatic suppressor activity and mutation in prostate cancer cells. Cancer Lett. 1997;113:87-93 pubmed
    The rat homologue of human maspin cDNA was cloned. The deduced amino acid sequence of rat maspin was homologous to human maspin with 88% of the amino acids conserved...
  3. Tokuyama R, Satomura K, Maeda E, Kudoh K, Yamasaki Y, Nagayama M. Maspin is involved in bone matrix maturation by enhancing the accumulation of latent TGF-beta. J Bone Miner Res. 2007;22:1581-91 pubmed
    b>Maspin, a serine protease inhibitor, is expressed by formative osteoblasts...
  4. Buchwalter A, Van Dort C, Schultz S, Smith R, Le I, Abbott J, et al. Expression of VACM-1/cul5 mutant in endothelial cells induces MAPK phosphorylation and maspin degradation and converts cells to the angiogenic phenotype. Microvasc Res. 2008;75:155-68 pubmed
    ..Finally, expression of (S730A)VACM-1 cDNA in RAMEC decreases concentration of maspin, a putative anti-angiogenic factor with a tumor suppressor activity...
  5. Shao L, Shi H, Ayala G, Rowley D, Zhang M. Haploinsufficiency of the maspin tumor suppressor gene leads to hyperplastic lesions in prostate. Cancer Res. 2008;68:5143-51 pubmed publisher
    b>Maspin is a key tumor suppressor gene in prostate and breast cancers with diverse biological functions. However, how maspin regulates prostate tumor progression is not fully understood...
  6. Davaadorj P, Tokuyama R, Ide S, Tadokoro S, Kudoh K, Satomura K. Possible involvement of maspin in tooth development. Histochem Cell Biol. 2010;134:603-14 pubmed publisher
    b>Maspin is a 42 kDa serine protease inhibitor that possesses tumor suppressive and anti-angiogenic activities...