Gene Symbol: Sele
Description: selectin E
Alias: E-selectin, CD62 antigen-like family member E, ELAM-1, LECAM2, endothelial leukocyte adhesion molecule 1, leukocyte-endothelial cell adhesion molecule 2, selectin, endothelial cell
Species: rat
Products:     Sele

Top Publications

  1. Li Y, Wei Y, Wang M, Zhang P, Jiang X, Huang C. Association between the Ser128Arg variant of the E-selectin and risk of coronary artery disease in the central China. Int J Cardiol. 2005;103:33-6 pubmed
    ..21 (CI95%:1.20-4.07). These results suggest that the SR genotype of the E-selectin gene polymorphism in codon 128 is a genetic factor that may determine an individual's susceptibility for CAD in Chinese. ..
  2. Mehta D souza P, Klopocki A, Oganesyan V, Terzyan S, Mather T, Li Z, et al. Glycan Bound to the Selectin Low Affinity State Engages Glu-88 to Stabilize the High Affinity State under Force. J Biol Chem. 2017;292:2510-2518 pubmed publisher
    ..Cells expressing E-selectinE88D rolled but detached faster. Our data support a two-state model for selectins in which Glu-88 must engage ligand to trigger allostery that stabilizes the high affinity state under force. ..
  3. Anuncibay Soto B, Pérez Rodríguez D, Llorente I, Regueiro Purriños M, Gonzalo Orden J, Fernández López A. Age-dependent modifications in vascular adhesion molecules and apoptosis after 48-h reperfusion in a rat global cerebral ischemia model. Age (Dordr). 2014;36:9703 pubmed publisher
    ..These differences should be taken into account in searching for therapeutic targets. ..
  4. Chapon C, Franconi F, Lacoeuille F, Hindré F, Saulnier P, Benoit J, et al. Imaging E-selectin expression following traumatic brain injury in the rat using a targeted USPIO contrast agent. MAGMA. 2009;22:167-74 pubmed publisher
    ..The synthesized nanoparticles were able to non-invasively target the traumatic brain lesion, inducing a specific T2* decrease of about 25% up to at least 70 min post-injection of the targeted contrast agent. ..
  5. Nowak M, Wielkoszyński T, Marek B, Kos Kudła B, Swietochowska E, Sieminska L, et al. Blood serum levels of vascular cell adhesion molecule (sVCAM-1), intercellular adhesion molecule (sICAM-1) and endothelial leucocyte adhesion molecule-1 (ELAM-1) in diabetic retinopathy. Clin Exp Med. 2008;8:159-64 pubmed publisher
    ..005) and with group 1 (81.2 +/- 27.7 ng/ml, p < 0.05). The correlations found between sVCAM-1, sICAM-1 and sELAM-1 and the presence of retinopathy suggest that cellular adhesion and neovascularization may be linked processes. ..
  6. Chuang P, Young B, Thiagarajan R, Cornejo C, Winn R, Harlan J. Cytoplasmic domain of E-selectin contains a non-tyrosine endocytosis signal. J Biol Chem. 1997;272:24813-8 pubmed
    ..Thus, we conclude that there exists a novel non-tyrosine-containing endocytosis signal in the cytoplasmic tail which involves Ser581 and residues membrane-proximal to it. ..
  7. Setiadi H, McEver R. Clustering endothelial E-selectin in clathrin-coated pits and lipid rafts enhances leukocyte adhesion under flow. Blood. 2008;111:1989-98 pubmed
    ..Distribution in both domains markedly enhances E-selectin's ability to mediate leukocyte rolling under flow. ..
  8. Wang X, Yue T, Barone F, Feuerstein G. Demonstration of increased endothelial-leukocyte adhesion molecule-1 mRNA expression in rat ischemic cortex. Stroke. 1995;26:1665-8; discussion 1668-9 pubmed
    ..However, the demonstration of translated ELAM-1 and its cellular localization in the ischemic tissue is required when specific antibodies become available. ..
  9. Aboul Fotouh S, Elgayar N. Atypical antipsychotics such as risperidone, but not paliperidone, worsen vascular endothelial function via upregulation of adhesion molecules VCAM-1, ICAM-1, and E-selectin in diabetic rats. Can J Physiol Pharmacol. 2013;91:1119-26 pubmed publisher
    ..Nevertheless, future investigation for the possible mechanisms underlying the difference noticed between the 2 AAPs is warranted. ..

Scientific Experts

More Information


  1. Abu Amero K, Al Mohanna F, Al Boudari O, Mohamed G, Dzimiri N. The interactive role of type 2 diabetes mellitus and E-selectin S128R mutation on susceptibility to coronary heart disease. BMC Med Genet. 2007;8:35 pubmed
    ..11; p = < 0.001). Our findings indicate therefore that the risk of acquiring CAD in patients with DM2 increases significantly in the presence of the 128R mutant allele of the E-selectin gene. ..
  2. Ruth J, Amin M, Woods J, He X, Samuel S, Yi N, et al. Accelerated development of arthritis in mice lacking endothelial selectins. Arthritis Res Ther. 2005;7:R959-70 pubmed
  3. Ulich T, Howard S, Remick D, Yi E, Collins T, Guo K, et al. Intratracheal administration of endotoxin and cytokines: VIII. LPS induces E-selectin expression; anti-E-selectin and soluble E-selectin inhibit acute inflammation. Inflammation. 1994;18:389-98 pubmed
    ..E-selectin-mediated adhesion of neutrophils to endothelium appears crucial to the full development of the acute inflammation response. ..
  4. Nelson R, Dolich S, Aruffo A, Cecconi O, Bevilacqua M. Higher-affinity oligosaccharide ligands for E-selectin. J Clin Invest. 1993;91:1157-66 pubmed
    ..IC50 values of soluble oligosaccharides determined in competitive binding studies accurately predicted blocking of leukocyte adhesion to recombinant E-selectin-Ig and to cytokine-activated endothelium. ..
  5. Kiely J, Hu Y, Garcia Cardena G, Gimbrone M. Lipid raft localization of cell surface E-selectin is required for ligation-induced activation of phospholipase C gamma. J Immunol. 2003;171:3216-24 pubmed
  6. Yoshida M, Westlin W, Wang N, Ingber D, Rosenzweig A, Resnick N, et al. Leukocyte adhesion to vascular endothelium induces E-selectin linkage to the actin cytoskeleton. J Cell Biol. 1996;133:445-55 pubmed
  7. Du H, Liu N, Wu Z, Chen R, Weng J, Huang H. [Inhibiting effects of interleukin-10 on expression of E-selectin and L-selectin in cerebral ischemia-reperfusion: experiment with rats]. Zhonghua Yi Xue Za Zhi. 2009;89:59-62 pubmed
    ..421 +/- 0.043,) and (0.348 +/- 0.044) respectively, both P < 0.05]. IL-10 suppresses the expression of E-selectin and L-selectin in cerebral ischemia-reperfusion. ..
  8. Mokhtar H, Giribabu N, Muniandy S, Salleh N. Testosterone decreases the expression of endometrial pinopode and L-selectin ligand (MECA-79) in adult female rats during uterine receptivity period. Int J Clin Exp Pathol. 2014;7:1967-76 pubmed
    ..The decrease in uterine pinopodes and MECA-79 expressions during uterine receptivity period by testosterone may cause failure of blastocyst to implant in conditions associated with high level of this hormone. ..
  9. Fries J, Williams A, Atkins R, Newman W, Lipscomb M, Collins T. Expression of VCAM-1 and E-selectin in an in vivo model of endothelial activation. Am J Pathol. 1993;143:725-37 pubmed
    ..Signals other than the expression of endothelial leukocyte adhesion molecules are required in vivo for leukocyte infiltration in this murine model of systemic endothelial activation. ..
  10. Gehad A, Al Banna N, Vaci M, Issekutz A, Mohan K, Latta M, et al. Differing requirements for CCR4, E-selectin, and ?4?1 for the migration of memory CD4 and activated T cells to dermal inflammation. J Immunol. 2012;189:337-46 pubmed publisher
    ..The differentiation from activated to memory CD4 cells increases the dependence on CCR4 for skin homing and decreases the requirement for ESL. ..
  11. Eggenhofer E, Steinmann J, Renner P, Slowik P, Piso P, Geissler E, et al. Mesenchymal stem cells together with mycophenolate mofetil inhibit antigen presenting cell and T cell infiltration into allogeneic heart grafts. Transpl Immunol. 2011;24:157-63 pubmed publisher
  12. de Oliveira A, Peron J, Damazo A, Franco A, Domingos H, Oliani S, et al. Female sex hormones mediate the allergic lung reaction by regulating the release of inflammatory mediators and the expression of lung E-selectin in rats. Respir Res. 2010;11:115 pubmed publisher
    ..Our data could contribute to the understanding of the protective role of estradiol in some cases of asthma symptoms in fertile ans post-menopausal women clinically observed. ..
  13. Garcia Criado F, Lozano F, Barros M, Parreño F, Fresnadillo M, García Sánchez J, et al. P- and E-selectin blockade can control bacterial translocation and modulate systemic inflammatory response. J Invest Surg. 2005;18:167-76 pubmed
    ..01). In conclusion, GM 1998-016 showed a protective effect in an in vivo experimental model of bacterial translocation, downregulating the inflammatory response and the leukocyte-endothelium interactions. ..
  14. Ishibashi S, Maric D, Mou Y, Ohtani R, Ruetzler C, Hallenbeck J. Mucosal tolerance to E-selectin promotes the survival of newly generated neuroblasts via regulatory T-cell induction after stroke in spontaneously hypertensive rats. J Cereb Blood Flow Metab. 2009;29:606-20 pubmed publisher
    ..These studies suggest that E-selectin-specific Tregs can modulate the efficacy of neurogenesis after ischemia and promote repair after brain injury. ..
  15. Takei T, Iida A, Nitta K, Tanaka T, Ohnishi Y, Yamada R, et al. Association between single-nucleotide polymorphisms in selectin genes and immunoglobulin A nephropathy. Am J Hum Genet. 2002;70:781-6 pubmed
    ..67, P=.000016, odds ratio = 1.88 [95% CI 1.41--2.51]). Our results suggest that these eight SNPs in selectin genes may be useful for screening populations susceptible to the IgAN phenotype that involves interstitial infiltration. ..
  16. Hattori H, Sato H, Ito D, Tanahashi N, Murata M, Saito I, et al. A561C polymorphism of E-selectin is associated with ischemic cerebrovascular disease in the Japanese population without diabetes mellitus and hypercholesterolemia. Brain Res. 2006;1108:221-3 pubmed
    ..7% vs. 5.8% (P=0.04). Our results show that E-selectin gene polymorphisms represent an increased risk for ischemic CVD in the Japanese population without diabetes mellitus and hypercholesterolemia. ..
  17. Krauss T, Kuhn W, Lakoma C, Augustin H. Circulating endothelial cell adhesion molecules as diagnostic markers for the early identification of pregnant women at risk for development of preeclampsia. Am J Obstet Gynecol. 1997;177:443-9 pubmed
  18. Mullaly S, Kubes P. The role of TLR2 in vivo following challenge with Staphylococcus aureus and prototypic ligands. J Immunol. 2006;177:8154-63 pubmed
    ..aureus-mediated immune responses. ..
  19. Song S, Yi Z, Zhang M, Mao M, Fu L, Zhao X, et al. Hypoxia inhibits pulmonary artery endothelial cell apoptosis via the e-selectin/biliverdin reductase pathway. Microvasc Res. 2016;106:44-56 pubmed publisher
    ..Taken all together, our data show that the e-selectin/BVR pathway participates in the inhibitory process of hypoxia in PAEC apoptosis which is mediated by the mitochondrial-dependent apoptosis pathway. ..
  20. Hirashiki A, Yamada Y, Murase Y, Suzuki Y, Kataoka H, Morimoto Y, et al. Association of gene polymorphisms with coronary artery disease in low- or high-risk subjects defined by conventional risk factors. J Am Coll Cardiol. 2003;42:1429-37 pubmed
    ..Genotyping of these polymorphisms may prove informative for assessment of the genetic risk of CAD in low- or high-risk men or women. ..